{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:52:13Z","timestamp":1788817933915,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the foundation of aerospace center hospital","award":["20190301-YN-16"],"award-info":[{"award-number":["20190301-YN-16"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00432-021-03757-6","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T23:40:06Z","timestamp":1628466006000},"page":"1761-1769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Differential diagnosis of appendiceal serrated lesions and polyps and low-grade appendiceal mucinous neoplasm: analysis of 88 cases"],"prefix":"10.1007","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-9962","authenticated-orcid":false,"given":"Yiyan","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhai","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"3757_CR1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/404308","author":"N Al-Brahim","year":"2013","unstructured":"Al-Brahim N, Al-Kandari I, Munahai M et al (2013) Clinicopathological study of 25 cases of diverticular disease of the appendix: experience from Farwaniya hospital. Pathol Res Int. https:\/\/doi.org\/10.1155\/2013\/404308","journal-title":"Pathol Res Int"},{"key":"3757_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ijscr.2017.02.027","volume":"33","author":"ML Altieri","year":"2017","unstructured":"Altieri ML, Piozzi GN, Salvatori P, Mirra M et al (2017) Appendiceal diverticulitis, a rare relevant pathology: presentation of a case report and review of the literature. Int J Surg Case Rep 33:31\u201334. https:\/\/doi.org\/10.1016\/j.ijscr.2017.02.027","journal-title":"Int J Surg Case Rep"},{"key":"3757_CR3","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.5858\/2005-129-1037-SSPMIP","volume":"129","author":"CG Ball","year":"2005","unstructured":"Ball CG, Dupre MP, Falck V, Hui S et al (2005) Sessile serrated polyp mimicry in patients with solitary rectal ulcer syndrome: is there evidence of a preneoplastic change. Arch Pathol Lab Med 129:1037\u20131040. https:\/\/doi.org\/10.5858\/2005-129-1037-SSPMIP","journal-title":"Arch Pathol Lab Med"},{"key":"3757_CR4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1309\/AJCP1UJPX6UURLCH","volume":"133","author":"A Bellizzi","year":"2010","unstructured":"Bellizzi A, Rock J, Marsh W et al (2010) Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal. Am J Clin Pathol 133:623\u2013632. https:\/\/doi.org\/10.1309\/AJCP1UJPX6UURLCH","journal-title":"Am J Clin Pathol"},{"key":"3757_CR5","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1002\/1097-0142(19950201)75:3<757::AID-CNCR2820750303>3.0.CO;2-F","volume":"75","author":"NJ Carr","year":"1995","unstructured":"Carr NJ, McCarthy WF, Sobin LH (1995) Epithelial noncarcinoid tumors and tumor-like lesions of the appendix. A clinicopathologic study of 184 patients with a multivariate analysis of prognostic factors. Cancer 75:757\u2013768. https:\/\/doi.org\/10.1002\/1097-0142(19950201)75:3%3c757::AID-CNCR2820750303%3e3.0.CO;2-F","journal-title":"Cancer"},{"key":"3757_CR6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/PAS.0000000000000535","volume":"40","author":"NJ Carr","year":"2016","unstructured":"Carr NJ, Cecil TD, Mohamed F et al (2016) A consensus for classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal neoplasia: the results of the peritoneal surface oncology group international (PSOGI) modified Delphi Process. Am J Surg Pathol 40:14\u201326. https:\/\/doi.org\/10.1097\/PAS.0000000000000535","journal-title":"Am J Surg Pathol"},{"key":"3757_CR7","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.humpath.2015.02.017","volume":"46","author":"EK Choi","year":"2015","unstructured":"Choi EK, Kim D, Divatia M et al (2015) Molecular alterations of appendiceal serrated lesions. Hum Pathol 46:1062\u20131066. https:\/\/doi.org\/10.1016\/j.humpath.2015.02.017","journal-title":"Hum Pathol"},{"key":"3757_CR8","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1136\/gutjnl-2016-312893","volume":"67","author":"JR Davenport","year":"2018","unstructured":"Davenport JR, Su T, Zhao Z et al (2018) Modifiable lifestyle factors associated with risk of serrated polyps, conventional adenomas and hyperplastic polyps. Gut 67:456\u2013465. https:\/\/doi.org\/10.1136\/gutjnl-2016-312893","journal-title":"Gut"},{"key":"3757_CR9","first-page":"349","volume":"89","author":"H Goldman","year":"1970","unstructured":"Goldman H, Ming S, Hickock DF (1970) Nature and significance of hyperplastic polyps of the human colon. Arch Pathol 89:349\u2013354","journal-title":"Arch Pathol"},{"key":"3757_CR10","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1365-2559.2005.02180.x","volume":"47","author":"T Higuchi","year":"2005","unstructured":"Higuchi T, Sugihara K, Jass JR (2005) Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 47:32\u201340. https:\/\/doi.org\/10.1111\/j.1365-2559.2005.02180.x","journal-title":"Histopathology"},{"key":"3757_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1365-2559.2006.02549.x","volume":"50","author":"JR Jass","year":"2007","unstructured":"Jass JR (2007) Classification of colorectal cancer based on correlation of clinical, morphological, and molecular features. Histopathology 50:113\u2013130. https:\/\/doi.org\/10.1111\/j.1365-2559.2006.02549.x","journal-title":"Histopathology"},{"key":"3757_CR12","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1046\/j.1365-2559.2000.01028.x","volume":"37","author":"JR Jass","year":"2000","unstructured":"Jass JR, Young J, Leggett BA (2000) Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum. Histopathology 37:295\u2013301. https:\/\/doi.org\/10.1046\/j.1365-2559.2000.01028.x","journal-title":"Histopathology"},{"key":"3757_CR13","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/00000478-199006000-00003","volume":"14","author":"TA Longacre","year":"1990","unstructured":"Longacre TA, Fenoglio-Preiser CM (1990) Mixed hyperplastic adenomatous polyps\/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol 14:524\u2013537. https:\/\/doi.org\/10.1097\/00000478-199006000-00003","journal-title":"Am J Surg Pathol"},{"key":"3757_CR14","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1309\/AJCPUPMRP1RTDSU2","volume":"13","author":"P Melissa","year":"2010","unstructured":"Melissa P (2010) Looking through a keyhole serrated neoplasia in the vermiform appendix. Am J Clin Pathol 13:529\u2013532. https:\/\/doi.org\/10.1309\/AJCPUPMRP1RTDSU2","journal-title":"Am J Clin Pathol"},{"key":"3757_CR15","first-page":"141","volume-title":"Appendiceal serrated lesions and polyps. Appendiceal mucinous neoplasm In: WHO classification of tumours editorial board Digestive System Tumours","author":"J Misdraji","year":"2019","unstructured":"Misdraji J, Carr NJ, Pai RK (2019) Appendiceal serrated lesions and polyps. Appendiceal mucinous neoplasm In: WHO classification of tumours editorial board Digestive System Tumours. IARC Press, pp 141\u2013146"},{"key":"3757_CR16","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/his.12564","volume":"66","author":"MJ O\u2019Brien","year":"2015","unstructured":"O\u2019Brien MJ, Zhao Q, Yang S et al (2015) Colorectal serrated pathway cancers and precursors. Histopathology 66:49\u201365. https:\/\/doi.org\/10.1111\/his.12564","journal-title":"Histopathology"},{"key":"3757_CR17","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.humpath.2013.10.021","volume":"45","author":"RK Pai","year":"2013","unstructured":"Pai RK, Hartman DJ, Gonzalo DH et al (2013) Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating a distinctly different serrated neoplastic pathway in the appendix. Hum Pathol 45:227\u2013235. https:\/\/doi.org\/10.1016\/j.humpath.2013.10.021","journal-title":"Hum Pathol"},{"key":"3757_CR18","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1309\/BF5KLH7J547AXAA0","volume":"126","author":"AA Renshaw","year":"2006","unstructured":"Renshaw AA, Kish R, Gould EW (2006) Sessile serrated adenoma is associated with appendicitis in patients 30 years or older. Am J Clin Pathol 126:875\u2013877. https:\/\/doi.org\/10.1309\/BF5KLH7J547AXAA0","journal-title":"Am J Clin Pathol"},{"key":"3757_CR19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/j.1365-2559.1992.tb00429.x","volume":"21","author":"GT Williams","year":"1992","unstructured":"Williams GT, Du Boulay CE, Roche WR (1992) Benign epithelial neoplasms of the appendix: classification and clinical associations. Histopathology 21:447\u2013451. https:\/\/doi.org\/10.1111\/j.1365-2559.1992.tb00429.x","journal-title":"Histopathology"},{"key":"3757_CR20","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1097\/PAS.0b013e31806bee6d","volume":"31","author":"RK Yantiss","year":"2007","unstructured":"Yantiss RK, Panczykowsk A, Misdraji J et al (2007) A Comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix. Am J Surg Pathol 31:1742\u20131753. https:\/\/doi.org\/10.1097\/PAS.0b013e31806bee6d","journal-title":"Am J Surg Pathol"},{"key":"3757_CR21","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1007\/s11605-011-1487-9","volume":"15","author":"A Yucel","year":"2011","unstructured":"Yucel A, Pergel A, Kocakusak A et al (2011) Multiple caeco-appendiceal fistulas and diverticulosis: a newly defined congenital anomaly of the appendix-report of the first case. J Gastrointest Surg 15:2111\u20132113. https:\/\/doi.org\/10.1007\/s11605-011-1487-9","journal-title":"J Gastrointest Surg"},{"key":"3757_CR22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5152\/tjg.2014.4056","volume":"25","author":"Y Yuyucu Karabulut","year":"2014","unstructured":"Yuyucu Karabulut Y, Sava\u015f B, Kur\u015fun N et al (2014) Serrated lesions of the appendix: do they differ from their colorectal counterparts. Turk J Gastroenterol 25:29\u201334. https:\/\/doi.org\/10.5152\/tjg.2014.4056","journal-title":"Turk J Gastroenterol"},{"key":"3757_CR23","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3109\/00365521.2011.565070","volume":"46","author":"P Zauber","year":"2011","unstructured":"Zauber P, Berman R, Marolta S et al (2011) Ki-RAS gene mutations are invariably present in low-grade mucinous tumors of vermiform appendix. Scand J Gastroenterol 46:869\u2013874. https:\/\/doi.org\/10.3109\/00365521.2011.565070","journal-title":"Scand J Gastroenterol"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03757-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-021-03757-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03757-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T23:30:24Z","timestamp":1655076624000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-021-03757-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,9]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["3757"],"URL":"https:\/\/doi.org\/10.1007\/s00432-021-03757-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-714928\/v1","asserted-by":"object"}]},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,9]]},"assertion":[{"value":"13 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study had been approved by the Aerospace Center Hospital Institutional Review Board (Approval No: 20190301-YN-16).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"No conflict of interest exits in the submission of this manuscript, and the manuscript is approved by all authors for publication. The work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}