{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:32:23Z","timestamp":1785843143300,"version":"3.56.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>There are currently few data on the outcome of acute myeloid leukemia (AML) in adolescents after allogeneic HSCT. The aim of this study is to describe the outcome and its specific risk factors for children, adolescents and young adults after a first allogeneic HSCT for AML.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this retrospective study, we compared the outcome of AML patients receiving a first allogeneic HSCT between 2005 and 2017 according to their age at transplantation\u2019s time: children (&lt;\u200915\u00a0years, <jats:italic>n<\/jats:italic>\u2009=\u2009564), adolescent and post-adolescent (APA) patients (15\u201325\u00a0years, <jats:italic>n<\/jats:italic>\u2009=\u2009647) and young adults (26\u201340\u00a0years; <jats:italic>n<\/jats:italic>\u2009=\u20091434).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>With a median follow-up of 4.37\u00a0years (min\u2013max 0.18\u201314.73\u00a0years), the probability of 2-year overall survival (OS) was 71.4% in children, 61.1% in APA patients and 62.9% in young adults (<jats:italic>p<\/jats:italic>\u2009=\u20090.0009 for intergroup difference). Both relapse and non-relapse mortality (NRM) Cumulative Incidence (CI) estimated at 2\u00a0years were different between the age groups (30.8% for children, 35.2% for APA patients and 29.4% for young adults\u2014<jats:italic>p<\/jats:italic>\u2009=\u20090.0254, and 7.0% for children, 10.6% for APA patients and 14.2% for young adults, p\u2009&lt;\u20090.0001; respectively). Whilst there was no difference between the three groups for grade I to IV acute GVHD CI at 3\u00a0months, the chronic GVHD CI at 2\u00a0years was higher in APA patients and young adults (31.4% and 36.4%, respectively) in comparison to the children (17.5%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In multivariable analysis, factors associated with death were AML cytogenetics (HR1.73 [1.29\u20132.32] for intermediate risk 1, HR 1.50 [1.13\u20132.01] for intermediate risk 2, HR 2.22 [1.70\u20132.89] for high cytogenetics risk compared to low risk), use of TBI\u2009\u2265\u20098 Grays (HR 1.33 [1.09\u20131.61]), disease status at transplant (HR 1.40 [1.10\u20131.78] for second Complete Remission (CR), HR 2.26 [1.02\u20134.98] for third CR and HR 3.07 [2.44\u20133.85] for active disease, compared to first CR), graft source (HR 1.26 [1.05\u20131.50] for Peripheral Blood Stem Cells compared to Bone Marrow) and donor age (HR 1.01 (1\u20131.02] by increase of 1 year).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Age is an independent risk factor for NRM and extensive chronic GVHD. This study suggests that APA patients with AML could be beneficially treated with a chemotherapy-based MAC regimen and bone marrow as a stem cells source.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-021-03761-w","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T13:02:26Z","timestamp":1630760546000},"page":"2083-2097","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improved outcome in children compared to adolescents and young adults after allogeneic hematopoietic stem cell transplant for acute myeloid leukemia: a retrospective study from the Francophone Society of Bone Marrow Transplantation and Cell Therapy (SFGM-TC)"],"prefix":"10.1007","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-5611","authenticated-orcid":false,"given":"C\u00e9cile","family":"Pochon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Detrait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Hugues","family":"Dalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Dh\u00e9din","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Chalandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eolia","family":"Brissot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Forcade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Sirvent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Izzadifar-Legrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricette","family":"Michallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Renard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Yakoub-Agha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques-Olivier","family":"Bay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Kanold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"Cornillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude Eric","family":"Bulabois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Angoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Balza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Chevallier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Rialland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Beguin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Lise","family":"M\u00e9nard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Neven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Paillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Raus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Albuisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Remen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Th\u00e9r\u00e8se","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,4]]},"reference":[{"key":"3761_CR1","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/bmt.2016.293","volume":"52","author":"A-L Alloin","year":"2017","unstructured":"Alloin A-L, Leverger G, Dalle J-H, Galambrun C, Bertrand Y, Baruchel A et al (2017) Cytogenetics and outcome of allogeneic transplantation in first remission of acute myeloid leukemia: the French pediatric experience. Bone Marrow Transplant 52:516\u2013521","journal-title":"Bone Marrow Transplant"},{"key":"3761_CR2","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1182\/blood-2005-09-3724","volume":"107","author":"FR Appelbaum","year":"2006","unstructured":"Appelbaum FR, Gundacker H, Head DR, Slovak ML, Willman CL, Godwin JE et al (2006) Age and acute myeloid leukemia. Blood 107:3481\u20133485","journal-title":"Blood"},{"key":"3761_CR3","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1016\/j.bbmt.2018.06.026","volume":"24","author":"F Ayuk","year":"2018","unstructured":"Ayuk F, Beelen DW, Bornh\u00e4user M, Stelljes M, Zabelina T, Finke J et al (2018) Relative impact of HLA matching and non-HLA donor characteristics on outcomes of allogeneic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 24:2558\u20132567","journal-title":"Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant"},{"key":"3761_CR4","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","volume":"15","author":"A Bacigalupo","year":"2009","unstructured":"Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V et al (2009) Defining the Intensity of Conditioning Regimens: Working Definitions. Biol Blood Marrow Transplant 15:1628\u20131633","journal-title":"Biol Blood Marrow Transplant"},{"key":"3761_CR5","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.leukres.2015.05.003","volume":"39","author":"JM Bastida","year":"2015","unstructured":"Bastida JM, Cabrero M, Lopez-Godino O, Lopez-Parra M, Sanchez-Guijo F, Lopez-Corral L et al (2015) Influence of donor age in allogeneic stem cell transplant outcome in acute myeloid leukemia and myelodisplastic syndrome. Leuk Res 39:828\u2013834","journal-title":"Leuk Res"},{"key":"3761_CR6","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.bbmt.2017.05.011","volume":"23","author":"M Bitan","year":"2017","unstructured":"Bitan M, Ahn KW, Millard HR, Pulsipher MA, Abdel-Azim H, Auletta JJ et al (2017) Personalized prognostic risk score for long-term survival for children with acute leukemia after allogeneic transplantation. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 23:1523\u20131530","journal-title":"Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant"},{"issue":"1","key":"3761_CR7","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nm.4439","volume":"24","author":"H Bolouri","year":"2018","unstructured":"Bolouri H, Farrar JE, Triche T Jr, Ries RE, Lim EL, Alonzo TA et al (2018) The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions. Nat Med 24(1):103\u2013112","journal-title":"Nat Med"},{"issue":"24","key":"3761_CR8","doi-asserted-by":"publisher","first-page":"3871","DOI":"10.1182\/blood-2013-08-519009","volume":"122","author":"C Bredeson","year":"2013","unstructured":"Bredeson C, LeRademacher J, Kato K, Dipersio J, Agura E, Devine S et al (2013) Prospective cohort study comparing intravenous busulfan to total body irradiation in hematopoietic cell transplantation. Blood 122(24):3871\u20133878","journal-title":"Blood"},{"issue":"1","key":"3761_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1200\/JCO.2007.15.4245","volume":"27","author":"T B\u00fcchner","year":"2009","unstructured":"B\u00fcchner T, Berdel WE, Haferlach C, Haferlach T, Schnittger S, M\u00fcller-Tidow C et al (2009) Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group. J Clin Oncol 27(1):61\u201369","journal-title":"J Clin Oncol"},{"key":"3761_CR10","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/bmt.2013.171","volume":"49","author":"MJ Burke","year":"2014","unstructured":"Burke MJ, Gossai N, Cao Q, Macmillan ML, Warlick E, Verneris MR (2014) Similar outcomes between adolescent\/young adults and children with AML following allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 49:174\u2013178","journal-title":"Bone Marrow Transplant"},{"key":"3761_CR11","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.leukres.2017.10.010","volume":"63","author":"A Candoni","year":"2017","unstructured":"Candoni A, De Marchi F, Zannier ME, Lazzarotto D, Fil\u00ec C, Dubbini MV et al (2017) High prognostic value of pre-allogeneic stem cell transplantation minimal residual disease detection by WT1 gene expression in AML transplanted in cytologic complete remission. Leuk Res 63:22\u201327","journal-title":"Leuk Res"},{"key":"3761_CR12","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1002\/cncr.28342","volume":"119","author":"J Canner","year":"2013","unstructured":"Canner J, Alonzo TA, Franklin J, Freyer DR, Gamis A, Gerbing RB et al (2013) Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent\/young adult and younger patients: a report from the Children\u2019s Oncology Group. Cancer 119:4162\u20134169","journal-title":"Cancer"},{"key":"3761_CR13","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.1182\/blood-2013-10-530006","volume":"122","author":"RE Champlin","year":"2013","unstructured":"Champlin RE (2013) Busulfan or TBI: answer to an age-old question. Blood 122:3856\u20133857","journal-title":"Blood"},{"key":"3761_CR14","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1182\/blood-2013-07-514448","volume":"122","author":"EA Copelan","year":"2013","unstructured":"Copelan EA, Hamilton BK, Avalos B, Ahn KW, Bolwell BJ, Zhu X et al (2013) Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI. Blood 122:3863\u20133870","journal-title":"Blood"},{"key":"3761_CR15","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/bmt.2013.185","volume":"49","author":"E de Berranger","year":"2014","unstructured":"de Berranger E, Cousien A, Petit A, de Latour PR, Galambrun C, Bertrand Y et al (2014) Impact on long-term OS of conditioning regimen in allogeneic BMT for children with AML in first CR: TBI+CY versus BU+CY: a report from the Soci\u00e9t\u00e9 Fran\u00e7aise de Greffe de Moelle et de Th\u00e9rapie Cellulaire. Bone Marrow Transplant 49:382\u2013388","journal-title":"Bone Marrow Transplant"},{"key":"3761_CR16","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","volume":"11","author":"AH Filipovich","year":"2005","unstructured":"Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ et al (2005) National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 11:945\u2013956","journal-title":"Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant."},{"key":"3761_CR17","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1182\/blood-2004-03-0803","volume":"104","author":"N Flomenberg","year":"2004","unstructured":"Flomenberg N, Baxter-Lowe LA, Confer D, Fernandez-Vina M, Filipovich A, Horowitz M et al (2004) Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 104:1923\u20131930","journal-title":"Blood"},{"key":"3761_CR18","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/ajh.24632","volume":"92","author":"S Gaballa","year":"2017","unstructured":"Gaballa S, Saliba R, Oran B, Brammer JE, Chen J, Rondon G et al (2017) Relapse risk and survival in patients with FLT3 mutated acute myeloid leukemia undergoing stem cell transplantation. Am J Hematol 92:331\u2013337","journal-title":"Am J Hematol"},{"key":"3761_CR19","unstructured":"Gilleece MH, Labopin M, Yakoub-Agha I, Volin L, Soci\u00e9 G, Ljungman P et al (2021) Measurable residual disease, conditioning regimen intensity and age predict outcome of allogeneic hematopoietic cell transplantation for acute myeloid leukemia in first remission: a registry analysis of 2292 patients by the Acute Leukemia Working Party European Society of Blood Cancer J. Am J Hematol 11(5):88"},{"key":"3761_CR20","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","volume":"18","author":"H Glucksberg","year":"1974","unstructured":"Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA et al (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation 18:295\u2013304","journal-title":"Transplantation"},{"key":"3761_CR21","doi-asserted-by":"publisher","first-page":"5797","DOI":"10.1200\/JCO.2007.13.5244","volume":"26","author":"JT Horan","year":"2008","unstructured":"Horan JT, Alonzo TA, Lyman GH, Gerbing RB, Lange BJ, Ravindranath Y et al (2008) Impact of disease risk on efficacy of matched related bone marrow transplantation for pediatric acute myeloid leukemia: the Children\u2019s Oncology Group. J Clin Oncol off J Am Soc Clin Oncol 26:5797\u20135801","journal-title":"J Clin Oncol off J Am Soc Clin Oncol"},{"key":"3761_CR22","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.clml.2018.02.002","volume":"18","author":"JC Jaime-P\u00e9rez","year":"2018","unstructured":"Jaime-P\u00e9rez JC, Padilla-Medina JR, Fern\u00e1ndez LT, Herrera-Garza JL, Guti\u00e9rrez-Aguirre CH, Tar\u00edn-Arzaga L et al (2018) Outcomes of adolescents and young adults with acute myeloid leukemia treated in a Single Latin American Center. Clin Lymphoma Myeloma Leuk 18:286\u2013292","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"3761_CR23","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1182\/blood.V98.7.2043","volume":"98","author":"C Kollman","year":"2001","unstructured":"Kollman C, Howe CW, Anasetti C, Antin JH, Davies SM, Filipovich AH et al (2001) Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 98:2043\u20132051","journal-title":"Blood"},{"issue":"11","key":"3761_CR24","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1007\/s00277-018-3419-1","volume":"97","author":"T Konuma","year":"2018","unstructured":"Konuma T, Mizuno S, Kondo T, Yamaguchi H, Fukuda T, Uchida N et al (2018) Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT). Ann Hematol 97(11):2173\u20132183","journal-title":"Ann Hematol"},{"issue":"1","key":"3761_CR25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1056\/NEJMoa1506002","volume":"374","author":"N Kr\u00f6ger","year":"2016","unstructured":"Kr\u00f6ger N, Solano C, Wolschke C, Bandini G, Patriarca F, Pini M et al (2016) Antilymphocyte globulin for prevention of chronic graft-versus-host disease. N Engl J Med 374(1):43\u201353","journal-title":"N Engl J Med"},{"key":"3761_CR26","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/cncr.24026","volume":"115","author":"S Lee","year":"2009","unstructured":"Lee S, Kim Y-J, Chung N-G, Lim J, Lee D-G, Kim H-J et al (2009) The extent of minimal residual disease reduction after the first 4-week imatinib therapy determines outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia. Cancer 115:561\u2013570","journal-title":"Cancer"},{"key":"3761_CR27","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.bbmt.2006.03.015","volume":"12","author":"AW Loren","year":"2006","unstructured":"Loren AW, Bunin GR, Boudreau C, Champlin RE, Cnaan A, Horowitz MM et al (2006) Impact of donor and recipient sex and parity on outcomes of HLA-identical sibling allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 12:758\u2013769","journal-title":"Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant"},{"issue":"6","key":"3761_CR28","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1053\/j.seminoncol.2012.09.005","volume":"39","author":"L Luznik","year":"2012","unstructured":"Luznik L, O\u2019Donnell PV, Fuchs EJ (2012) Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation. Semin Oncol 39(6):683\u2013693","journal-title":"Semin Oncol"},{"key":"3761_CR29","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.bbmt.2011.10.031","volume":"18","author":"NS Majhail","year":"2012","unstructured":"Majhail NS, Brazauskas R, Hassebroek A, Bredeson CN, Hahn T, Hale GA et al (2012) Outcomes of allogeneic hematopoietic cell transplantation for adolescent and young adults compared with children and older adults with acute myeloid leukemia. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 18:861\u2013873","journal-title":"Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant"},{"key":"3761_CR30","first-page":"100792","volume":"26","author":"N Martinez-Cibrian","year":"2020","unstructured":"Martinez-Cibrian N, Zeiser R, Perez-Simon JA (2020) Graft-versus-host disease\u00a0prophylaxis: Pathophysiology-based review on current approaches and future directions. Blood Rev 26:100792","journal-title":"Blood Rev"},{"issue":"25","key":"3761_CR31","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1056\/NEJMoa1706640","volume":"377","author":"FM Marty","year":"2017","unstructured":"Marty FM, Ljungman P, Chemaly RF, Maertens J, Dadwal SS, Duarte RF et al (2017) Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation [Internet]. N Engl J Med. https:\/\/doi.org\/10.1056\/NEJMoa1706640 (Massachusetts Medical Society; 2017 [cited 2021 Jan 6])","journal-title":"N Engl J Med"},{"key":"3761_CR32","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1200\/JCO.2013.48.8114","volume":"31","author":"A Nagler","year":"2013","unstructured":"Nagler A, Rocha V, Labopin M, Unal A, Ben Othman T, Campos A et al (2013) Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen\u2013a report from the acute leukemia working party of the European group for blood and marrow transplantation. J Clin Oncol off J Am Soc Clin Oncol 31:3549\u20133556","journal-title":"J Clin Oncol off J Am Soc Clin Oncol"},{"key":"3761_CR33","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.clml.2016.09.011","volume":"17","author":"SS Nasir","year":"2017","unstructured":"Nasir SS, Giri S, Nunnery S, Martin MG (2017) Outcome of adolescents and young adults compared with pediatric patients with acute myeloid and promyelocytic leukemia. Clin Lymphoma Myeloma Leuk 17:126-132.e1","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"3761_CR34","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.clml.2015.12.010","volume":"16","author":"N Pemmaraju","year":"2016","unstructured":"Pemmaraju N, Kantarjian H, Ravandi F, Nogueras-Gonzalez GM, Huang X, O\u2019Brien S et al (2016) Patient Characteristics and outcomes in adolescents and young adults (AYA) with acute myeloid leukemia (AML). Clin Lymphoma Myeloma Leuk 16:213-222.e2","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"3761_CR35","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1182\/blood-2004-04-1674","volume":"104","author":"EW Petersdorf","year":"2004","unstructured":"Petersdorf EW, Anasetti C, Martin PJ, Gooley T, Radich J, Malkki M et al (2004) Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood 104:2976\u20132980","journal-title":"Blood"},{"issue":"10","key":"3761_CR36","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1038\/s41375-018-0071-7","volume":"32","author":"M Rasche","year":"2018","unstructured":"Rasche M, Zimmermann M, Borschel L, Bourquin J-P, Dworzak M, Klingebiel T et al (2018) Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012. Leukemia 32(10):2167\u20132177","journal-title":"Leukemia"},{"key":"3761_CR37","first-page":"111","volume":"15","author":"A Ruggeri","year":"2018","unstructured":"Ruggeri A, Labopin M, Bacigalupo A, Afanasyev B, Cornelissen JJ, Elmaagacli A et al (2018) Post-transplant cyclophosphamide for graft-versus-host disease\u00a0prophylaxis\u00a0in HLA matched sibling or matched unrelated donor transplant for patients with acute leukemia, on behalf of ALWP-EBMT. Hematol Oncol 15:111\u2013140","journal-title":"Hematol Oncol"},{"issue":"8","key":"3761_CR38","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/sj.leu.2403009","volume":"17","author":"RF Schlenk","year":"2003","unstructured":"Schlenk RF, Benner A, Hartmann F, del Valle F, Weber C, Pralle H et al (2003) Risk-adapted postremission therapy in acute myeloid leukemia: results of the German multicenter AML HD93 treatment trial. Leukemia 17(8):1521\u20131528","journal-title":"Leukemia"},{"key":"3761_CR39","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.bbmt.2018.02.006","volume":"24","author":"BE Shaw","year":"2018","unstructured":"Shaw BE, Logan BR, Spellman SR, Marsh SGE, Robinson J, Pidala J et al (2018) Development of an unrelated donor selection score predictive of survival after HCT: donor age matters most. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 24:1049\u20131056","journal-title":"Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant"},{"key":"3761_CR40","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/bjh.15137","volume":"180","author":"NK Steckel","year":"2018","unstructured":"Steckel NK, Groth C, Mikesch J-H, Trenschel R, Ottinger H, Kordelas L et al (2018) High-dose melphalan-based sequential conditioning chemotherapy followed by allogeneic haematopoietic stem cell transplantation in adult patients with relapsed or refractory acute myeloid leukaemia. Br J Haematol 180:840\u2013853","journal-title":"Br J Haematol"},{"key":"3761_CR41","doi-asserted-by":"crossref","unstructured":"St\u00f6lzel F, Mohr B, Kramer M, Oelschl\u00e4gel U, Bochtler T, Berdel WE et al (2016) Karyotype complexity and prognosis in acute myeloid\u00a0leukemia. Blood Cancer J 6(1):e386","DOI":"10.1038\/bcj.2015.114"},{"key":"3761_CR42","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s12185-015-1825-x","volume":"102","author":"D Tomizawa","year":"2015","unstructured":"Tomizawa D, Watanabe T, Hanada R, Horibe K, Horikoshi Y, Iwamoto S et al (2015) Outcome of adolescent patients with acute myeloid leukemia treated with pediatric protocols. Int J Hematol 102:318\u2013326","journal-title":"Int J Hematol"},{"key":"3761_CR43","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.bbmt.2017.05.009","volume":"23","author":"D Tomizawa","year":"2017","unstructured":"Tomizawa D, Tanaka S, Kondo T, Hashii Y, Arai Y, Kudo K et al (2017) Allogeneic Hematopoietic Stem Cell Transplantation for Adolescents and Young Adults with Acute Myeloid Leukemia. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 23:1515\u20131522","journal-title":"Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant"},{"issue":"2","key":"3761_CR44","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1089\/jayao.2016.0060","volume":"6","author":"M Vignon","year":"2017","unstructured":"Vignon M, Andreoli A, Dh\u00e9din N, Lenglin\u00e9 E, Masson E, Robin M et al (2017) Graft-versus-host disease in adolescents and young adults (15\u201324 Years Old) after allogeneic hematopoietic stem cell transplantation for acute leukemia in first complete remission. J Adolesc Young Adult Oncol 6(2):299\u2013306","journal-title":"J Adolesc Young Adult Oncol"},{"issue":"1","key":"3761_CR45","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/pbc.25713","volume":"63","author":"L Wennstr\u00f6m","year":"2016","unstructured":"Wennstr\u00f6m L, Wendtland Edslev P, Abrahamsson J, Maxwell N\u00f8rgaard J, Fl\u00f8isand Y, Forestier E et al (2016) Acute Myeloid Leukemia in Adolescents and Young Adults Treated in Pediatric and Adult Departments in the Nordic Countries. Pediatr Blood Cancer 63(1):83\u201392","journal-title":"Pediatr Blood Cancer"},{"key":"3761_CR46","doi-asserted-by":"publisher","first-page":"4170","DOI":"10.1002\/cncr.28344","volume":"119","author":"WG Woods","year":"2013","unstructured":"Woods WG, Franklin ARK, Alonzo TA, Gerbing RB, Donohue KA, Othus M et al (2013) Outcome of adolescents and young adults with acute myeloid leukemia treated on COG trials compared to CALGB and SWOG trials. Cancer 119:4170\u20134179","journal-title":"Cancer"},{"key":"3761_CR47","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.bbmt.2010.09.012","volume":"17","author":"A Woolfrey","year":"2011","unstructured":"Woolfrey A, Klein JP, Haagenson M, Spellman S, Petersdorf E, Oudshoorn M et al (2011) HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 17:885\u2013892","journal-title":"Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03761-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-021-03761-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03761-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T04:04:30Z","timestamp":1658117070000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-021-03761-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,4]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["3761"],"URL":"https:\/\/doi.org\/10.1007\/s00432-021-03761-w","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,4]]},"assertion":[{"value":"14 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of or competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Patients provided written informed consent authorizing the use of their personal information for research purposes. The study protocol was approved by the scientific council of the SFGM-TC and by the institutional review boards at each center participating. The study was in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}