{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:24:03Z","timestamp":1776313443656,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003385","name":"Georg-August-Universit\u00e4t G\u00f6ttingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003385","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Melanocytic nevi in lymph nodes (NNs) are an important histological differential diagnosis of initial sentinel lymph node (SN) metastasis in melanoma. Our aim was to associate NN in SNs with clinicopathologic features and survival rates in 1, 250 patients with SN biopsy for melanoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>To compare patients with present and absent NN, we used Fisher's exact test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, and multivariate logistic regression models in this retrospective observational study based on a prospectively maintained institutional database.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>NN prevalence in axillary, cervical, and groin SNs was 16.5%, 19.4%, and 9.8%, respectively. NN were observed in combination with all growth patterns of melanoma, but more frequently when the primary was histologically associated with a cutaneous nevus. We observed a decreasing NN prevalence with increasing SN metastasis diameter. Multiple logistic regression determined a significantly increased NN probability for SNs of the neck or axilla, for individuals with\u2009\u2265\u200950 cutaneous nevi, midline primary melanomas, and for individuals who reported non-cutaneous malignancies in their parents. Cancer in parents was also significantly more frequently reported by melanoma patients who had more than 50 cutaneous nevi. In SN-negative patients, NN indicated a tendency for slightly lower melanoma-specific survival.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We found a highly significant association between NN diagnosis and multiple cutaneous nevi and provided circumstantial evidence that cutaneous nevi in the drainage area of lymph nodes are particularly important. The trend toward lower melanoma-specific survival in SN-negative patients with NN suggests that careful differentiation of SN metastases is important.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-021-03894-y","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T19:03:36Z","timestamp":1642705416000},"page":"3125-3134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Melanocytic nevi in sentinel lymph nodes: association with cutaneous nevi and clinical relevance in patients with cutaneous melanomas"],"prefix":"10.1007","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3260-5410","authenticated-orcid":false,"given":"Lutz","family":"Kretschmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Schnabel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kromer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Bauer-B\u00fcntzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Bremmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"K\u00fcck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Julius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Mitteldorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Sch\u00f6n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"3894_CR1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/ajcp\/72.1.97","volume":"72","author":"ME Bell","year":"1979","unstructured":"Bell ME, Hill DP, Bhargava MK (1979) Lymphatic invasion in pigmented nevi. Am J Clin Pathol 72:97\u2013100","journal-title":"Am J Clin Pathol"},{"key":"3894_CR2","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1097\/00000478-200305000-00011","volume":"27","author":"DA Biddle","year":"2003","unstructured":"Biddle DA, Evans HL, Kemp BL, El-Naggar AK, Harvell JD, White WL, Iskandar SS, Prieto VG (2003) Intraparenchymal nevus cell aggregates in lymph nodes: a possible diagnostic pitfall with malignant melanoma and carcinoma. Am J Surg Pathol 27:673\u2013681","journal-title":"Am J Surg Pathol"},{"key":"3894_CR3","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/cup.12580","volume":"42","author":"AR Bowen","year":"2015","unstructured":"Bowen AR, Duffy KL, Clayton FC, Andtbacka RH, Florell SR (2015) Benign melanocytic lymph node deposits in the setting of giant congenital melanocytic nevi: the large congenital nodal nevus. J Cutan Pathol 42:832\u2013839","journal-title":"J Cutan Pathol"},{"key":"3894_CR4","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1097\/00000478-199607000-00006","volume":"20","author":"KF Carson","year":"1996","unstructured":"Carson KF, Wen DR, Li PX, Lana AM, Bailly C, Morton DL, Cochran AJ (1996) Nodal nevi and cutaneous melanomas. Am J Surg Pathol 20:834\u2013840","journal-title":"Am J Surg Pathol"},{"key":"3894_CR5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.ijscr.2016.10.040","volume":"29","author":"J Davis","year":"2016","unstructured":"Davis J, Patil J, Aydin N, Mishra A, Misra S (2016) Capsular nevus versus metastatic malignant melanoma\u2014a diagnostic dilemma. Int J Surg Case Rep 29:20\u201324","journal-title":"Int J Surg Case Rep"},{"key":"3894_CR6","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1111\/jdv.15814","volume":"33","author":"FSA de Beer","year":"2019","unstructured":"de Beer FSA, van Diest PJ, Sigurdsson V, El Sharouni M (2019) Intra-nodal nevi in sentinel node-negative patients with cutaneous melanoma does not influence survival. J Eur Acad Dermatol Venereol 33:2291\u20132295","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"3894_CR7","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/bjd.12692","volume":"170","author":"B Echeverr\u00eda","year":"2014","unstructured":"Echeverr\u00eda B, Bulliard JL, Guill\u00e9n C, Nagore E (2014) Indicators for the total number of melanocytic naevi: an adjunct for screening campaigns. Observational study on 292 patients. Br J Dermatol 170:144\u2013149","journal-title":"Br J Dermatol"},{"key":"3894_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ejca.2021.03.001","volume":"149","author":"MA El Sharouni","year":"2021","unstructured":"El Sharouni MA, Laeijendecker AE, Suijkerbuijk KP, Witkamp AJ, Sigurdsson V, van Diest PJ, van Gils CH, Blokx WA (2021) High discordance rate in assessing sentinel node positivity in cutaneous melanoma: expert review may reduce unjustified adjuvant treatment. Eur J Cancer 149:105\u2013113","journal-title":"Eur J Cancer"},{"key":"3894_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/1097-0142(19820115)49:2<269::AID-CNCR2820490212>3.0.CO;2-D","volume":"49","author":"RA Erlandson","year":"1982","unstructured":"Erlandson RA, Rosen PP (1982) Electron microscopy of a nevus cell aggregate associated with an axillary lymph node. Cancer 49:269\u2013272","journal-title":"Cancer"},{"key":"3894_CR10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1136\/jcp.47.3.245","volume":"47","author":"CJ Fisher","year":"1994","unstructured":"Fisher CJ, Hill S, Millis RR (1994) Benign lymph node inclusions mimicking metastatic carcinoma. J Clin Pathol 47:245\u2013247","journal-title":"J Clin Pathol"},{"key":"3894_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00000372-200202000-00001","volume":"24","author":"D Fontaine","year":"2002","unstructured":"Fontaine D, Parkhill W, Greer W, Walsh N (2002) Nevus cells in lymph nodes: an association with congenital cutaneous nevi. Am J Dermatopathol 24:1\u20135","journal-title":"Am J Dermatopathol"},{"key":"3894_CR12","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1309\/AJCPG83CMAVFBWLC","volume":"139","author":"T Gambichler","year":"2013","unstructured":"Gambichler T, Scholl L, St\u00fccker M, Bechara FG, Hoffmann K, Altmeyer P, Othlinghaus N (2013) Clinical characteristics and survival data of melanoma patients with nevus cell aggregates within sentinel lymph nodes. Am J Clin Pathol 139:566\u2013573","journal-title":"Am J Clin Pathol"},{"key":"3894_CR13","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14951","author":"T Gambichler","year":"2021","unstructured":"Gambichler T, Rohrmoser EM, Horny K, Sucker A, Schadendorf D, Skrygan M, Susok L, St\u00fccker M, Becker JC (2021) Comparison of mutation profiles in primary melanomas and corresponding nodal naevi using next-generation sequencing. Clin Exp Dermatol. https:\/\/doi.org\/10.1111\/ced.14951","journal-title":"Clin Exp Dermatol"},{"key":"3894_CR14","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1097\/DAD.0000000000001645","volume":"42","author":"M Gonz\u00e0lez-Farr\u00e9","year":"2020","unstructured":"Gonz\u00e0lez-Farr\u00e9 M, Ronen S, Keiser E, Prieto VG, Aung PP (2020) Three types of nodal melanocytic nevi in sentinel lymph nodes of patients with melanoma: pitfalls, immunohistochemistry, and a review of the literature. Am J Dermatopathol 42:739\u2013744","journal-title":"Am J Dermatopathol"},{"key":"3894_CR15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1365-2559.1993.tb00493.x","volume":"23","author":"K Hara","year":"1993","unstructured":"Hara K (1993) Melanocytic lesions in lymph nodes associated with congenital naevus. Histopathology 23:445\u2013451","journal-title":"Histopathology"},{"key":"3894_CR16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1001\/archderm.135.1.47","volume":"135","author":"SL Harrison","year":"1999","unstructured":"Harrison SL, Buettner PG, MacLennan R (1999) Body-site distribution of melanocytic nevi in young Australian children. Arch Dermatol 135:47\u201352","journal-title":"Arch Dermatol"},{"key":"3894_CR17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1309\/Y5QAD623MYA21PUY","volume":"121","author":"JB Holt","year":"2004","unstructured":"Holt JB, Sangueza OP, Levine EA, Shen P, Bergman S, Geisinger KR, Creager AJ (2004) Nodal melanocytic nevi in sentinel lymph nodes. Correlation with melanoma-associated cutaneous nevi. Am J Clin Pathol 121:58\u201363","journal-title":"Am J Clin Pathol"},{"key":"3894_CR18","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1111\/cup.13805","volume":"47","author":"J Hu","year":"2020","unstructured":"Hu J, Ren M, Cai X, Zhang Y, Lv JJ, Kong YY (2020) Nevus cell aggregates massively occupying parenchyma of an external iliac lymph node: a case report and review of the literature. J Cutan Pathol 47:1175\u20131180","journal-title":"J Cutan Pathol"},{"key":"3894_CR19","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.jaad.2018.04.016","volume":"79","author":"HJ Kim","year":"2018","unstructured":"Kim HJ, Seo JW, Roh MS, Lee JH, Song KH (2018) Clinical features and prognosis of Asian patients with acral lentiginous melanoma who have nodal nevi in their sentinel lymph node biopsy specimen. J Am Acad Dermatol 79:706\u2013713","journal-title":"J Am Acad Dermatol"},{"key":"3894_CR20","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1242\/dev.128.8.1467","volume":"128","author":"R Kos","year":"2001","unstructured":"Kos R, Reedy MV, Johnson RL, Erickson CA (2001) The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos. Development 128:1467\u20131479","journal-title":"Development"},{"key":"3894_CR21","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00259-014-2914-4","volume":"42","author":"L Kretschmer","year":"2015","unstructured":"Kretschmer L, Bertsch HP, Bardzik P, Meller J, Hellriegel S, Thoms KM, Schon MP, Sahlmann CO (2015) The impact of nodal tumour burden on lymphoscintigraphic imaging in patients with melanomas. Eur J Nucl Med Mol Imaging 42:231\u2013240","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"3894_CR22","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/2000656X.2019.1582427","volume":"53","author":"L Kretschmer","year":"2019","unstructured":"Kretschmer L, Hellriegel S, Cevik N, Hartmann F, Thoms KM, Sch\u00f6n MP (2019) Axillary sentinel node biopsy in prone position for melanomas on the upper back or nape. J Plast Surg Hand Surg 53:221\u2013226","journal-title":"J Plast Surg Hand Surg"},{"key":"3894_CR23","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1038\/s41379-021-00835-5","volume":"34","author":"L Kretschmer","year":"2021","unstructured":"Kretschmer L, Mitteldorf C, Hellriegel S, Leha A, Fichtner A, Str\u00f6bel P, Sch\u00f6n MP, Bremmer F (2021) The sentinel node invasion level (SNIL) as a prognostic parameter in melanoma. Mod Pathol 34:1839\u20131849","journal-title":"Mod Pathol"},{"key":"3894_CR24","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41588-020-0611-8","volume":"52","author":"MT Landi","year":"2020","unstructured":"Landi MT, Bishop DT, MacGregor S, Machiela MJ, Stratigos AJ, Ghiorzo P, Brossard M, Calista D, Choi J, Fargnoli MC, Zhang T, Rodolfo M, Trower AJ, Menin C, Martinez J, Hadjisavvas A, Song L, Stefanaki I, Scolyer R, Yang R, Goldstein AM, Potrony M, Kypreou KP, Pastorino L, Queirolo P, Pellegrini C, Cattaneo L, Zawistowski M, Gimenez-Xavier P, Rodriguez A, Elefanti L, Manoukian S, Rivoltini L, Smith BH, Loizidou MA, Del Regno L, Massi D, Mandala M, Khosrotehrani K, Akslen LA, Amos CI, Andresen PA, Avril MF, Azizi E, Soyer HP, Bataille V, Dalmasso B, Bowdler LM, Burdon KP, Chen WV, Codd V, Craig JE, D\u0119bniak T, Falchi M, Fang S, Friedman E, Simi S, Galan P, Garcia-Casado Z, Gillanders EM, Gordon S, Green A, Gruis NA, Hansson J, Harland M, Harris J, Helsing P, Henders A, Ho\u010devar M, H\u00f6iom V, Hunter D, Ingvar C, Kumar R, Lang J, Lathrop GM, Lee JE, Li X, Lubi\u0144ski J, Mackie RM, Malt M, Malvehy J, McAloney K, Mohamdi H, Molven A, Moses EK, Neale RE, Novakovi\u0107 S, Nyholt DR, Olsson H, Orr N, Fritsche LG, Puig-Butille JA, Qureshi AA, Radford-Smith GL, Randerson-Moor J, Requena C, Rowe C, Samani NJ, Sanna M, Schadendorf D, Schulze HJ, Simms LA, Smithers M, Song F, Swerdlow AJ, van der Stoep N, Kukutsch NA, Visconti A, Wallace L, Ward SV, Wheeler L, Sturm RA, Hutchinson A, Jones K, Malasky M, Vogt A, Zhou W, Pooley KA, Elder DE, Han J, Hicks B, Hayward NK, Kanetsky PA, Brummett C, Montgomery GW, Olsen CM, Hayward C, Dunning AM, Martin NG, Evangelou E, Mann GJ, Long G, Pharoah PDP, Easton DF, Barrett JH, Cust AE, Abecasis G, Duffy DL, Whiteman DC, Gogas H, De Nicolo A, Tucker MA, Newton-Bishop JA, Peris K, Chanock SJ, Demenais F, Brown KM, Puig S, Nagore E, Shi J, Iles MM, Law MH (2020) Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. Nat Genet 52:494\u2013504","journal-title":"Nat Genet"},{"key":"3894_CR25","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/PAS.0000000000001393","volume":"44","author":"C Lezcano","year":"2020","unstructured":"Lezcano C, Pulitzer M, Moy AP, Hollmann TJ, Jungbluth AA, Busam KJ (2020) Immunohistochemistry for PRAME in the distinction of nodal nevi from metastatic melanoma. Am J Surg Pathol 44:503\u2013508","journal-title":"Am J Surg Pathol"},{"key":"3894_CR26","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3109\/00313027409077346","volume":"6","author":"SW McCarthy","year":"1974","unstructured":"McCarthy SW, Palmer AA, Bale PM, Hirst E (1974) Naevus cells in lymph nodes. Pathology 6:351\u2013358","journal-title":"Pathology"},{"key":"3894_CR27","first-page":"1145","volume":"19","author":"CSL M\u00fcller","year":"2021","unstructured":"M\u00fcller CSL, M\u00fcller SG, Vogt T, Pf\u00f6hler C (2021) Current concepts of ectopic nodal inclusions with special emphasis on nodal nevi. J Dtsch Dermatol Ges 19:1145\u20131157","journal-title":"J Dtsch Dermatol Ges"},{"key":"3894_CR28","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1158\/1055-9965.EPI-10-0233","volume":"19","author":"JA Newton-Bishop","year":"2010","unstructured":"Newton-Bishop JA, Chang YM, Iles MM, Taylor JC, Bakker B, Chan M, Leake S, Karpavicius B, Haynes S, Fitzgibbon E, Elliott F, Kanetsky PA, Harland M, Barrett JH, Bishop DT (2010) Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom. Cancer Epidemiol Biomark Prev 19:2043\u20132054","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"3894_CR29","first-page":"563","volume":"11","author":"A Pflugfelder","year":"2013","unstructured":"Pflugfelder A, Kochs C, Blum A, Capellaro M, Czeschik C, Dettenborn T, Dill D, Dippel E, Eigentler T, Feyer P, Follmann M, Frerich B, Ganten MK, Gartner J, Gutzmer R, Hassel J, Hauschild A, Hohenberger P, Hubner J, Kaatz M, Kleeberg UR, Kolbl O, Kortmann RD, Krause-Bergmann A, Kurschat P, Leiter U, Link H, Loquai C, Loser C, Mackensen A, Meier F, Mohr P, Mohrle M, Nashan D, Reske S, Rose C, Sander C, Satzger I, Schiller M, Schlemmer HP, Strittmatter G, Sunderkotter C, Swoboda L, Trefzer U, Voltz R, Vordermark D, Weichenthal M, Werner A, Wesselmann S, Weyergraf AJ, Wick W, Garbe C, Schadendorf D, D. German Society of (2013) S3-guideline \u201cdiagnosis, therapy and follow-up of melanoma\u201d\u2014short version. J Dtsch Dermatol Ges 11:563\u2013602","journal-title":"J Dtsch Dermatol Ges"},{"key":"3894_CR30","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.prp.2015.01.003","volume":"211","author":"S Piana","year":"2015","unstructured":"Piana S, Tagliavini E, Ragazzi M, Zanelli M, Zalaudek I, Ciarrocchi A, Valli R (2015) Lymph node melanocytic nevi: pathogenesis and differential diagnoses, with special reference to p16 reactivity. Pathol Res Pract 211:381\u2013388","journal-title":"Pathol Res Pract"},{"key":"3894_CR31","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/CMR.0000000000000328","volume":"27","author":"S Ribero","year":"2017","unstructured":"Ribero S, Longo C, Specchio F, Piana S, Castagnetti F, Moscarella E, Lallas A, Alfano R, Argenziano G (2017) Lymph nodes\u2019 capsular naevi are associated with high naevus count in melanoma patients: a case-control study. Melanoma Res 27:274\u2013276","journal-title":"Melanoma Res"},{"key":"3894_CR32","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/bjd.19171","volume":"184","author":"S Ribero","year":"2021","unstructured":"Ribero S, Zugna D, Spector T, Bataille V (2021) Natural history of naevi: a two-wave study. Br J Dermatol 184:289\u2013295","journal-title":"Br J Dermatol"},{"key":"3894_CR33","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/1097-0142(197701)39:1<164::AID-CNCR2820390127>3.0.CO;2-T","volume":"39","author":"RL Ridolfi","year":"1977","unstructured":"Ridolfi RL, Rosen PP, Thaler H (1977) Nevus cell aggregates associated with lymph nodes: estimated frequency and clinical significance. Cancer 39:164\u2013171","journal-title":"Cancer"},{"key":"3894_CR34","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1053\/j.semdp.2008.04.002","volume":"25","author":"RA Scolyer","year":"2008","unstructured":"Scolyer RA, Murali R, McCarthy SW, Thompson JF (2008) Pathologic examination of sentinel lymph nodes from melanoma patients. Semin Diagn Pathol 25:100\u2013111","journal-title":"Semin Diagn Pathol"},{"key":"3894_CR35","doi-asserted-by":"publisher","first-page":"153105","DOI":"10.1016\/j.prp.2020.153105","volume":"216","author":"SHC See","year":"2020","unstructured":"See SHC, Finkelman BS, Yeldandi AV (2020) The diagnostic utility of PRAME and p16 in distinguishing nodal nevi from nodal metastatic melanoma. Pathol Res Pract 216:153105","journal-title":"Pathol Res Pract"},{"key":"3894_CR36","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.ejso.2016.04.057","volume":"42","author":"OJ Smith","year":"2016","unstructured":"Smith OJ, Coelho JA, Trevatt AE, Ross GL (2016) Clinical significance of intra-nodal naevi in sentinel node biopsies for malignant melanoma. Eur J Surg Oncol 42:1427\u20131431","journal-title":"Eur J Surg Oncol"},{"key":"3894_CR37","first-page":"1235","volume":"15","author":"F Steward","year":"1931","unstructured":"Steward F, Copeland M (1931) Neurogenic sarcoma. Am J Cancer 15:1235\u20131320","journal-title":"Am J Cancer"},{"key":"3894_CR38","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1093\/ajcp\/84.2.220","volume":"84","author":"C Subramony","year":"1985","unstructured":"Subramony C, Lewin JR (1985) Nevus cells within lymph nodes. Possible metastases from a benign intradermal nevus. Am J Clin Pathol 84:220\u2013223","journal-title":"Am J Clin Pathol"},{"key":"3894_CR39","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/bjc.2017.182","volume":"117","author":"P W\u00e4ster","year":"2017","unstructured":"W\u00e4ster P, Orfanidis K, Eriksson I, Rosdahl I, Seifert O, \u00d6llinger K (2017) UV radiation promotes melanoma dissemination mediated by the sequential reaction axis of cathepsins-TGF-\u03b21-FAP-\u03b1. Br J Cancer 117:535\u2013544","journal-title":"Br J Cancer"},{"key":"3894_CR40","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1002\/jso.26135","volume":"122","author":"TS Yamashita","year":"2020","unstructured":"Yamashita TS, Pockaj BA, Bagaria SP, Flotte TJ, Fahy AS, de Azevedo RU, Harmsen WS, Block MS, Jakub JW (2020) Clinical significance of SLN benign capsular nevi in patients with melanoma. J Surg Oncol 122:1043\u20131049","journal-title":"J Surg Oncol"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03894-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-021-03894-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03894-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T21:27:10Z","timestamp":1663968430000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-021-03894-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["3894"],"URL":"https:\/\/doi.org\/10.1007\/s00432-021-03894-y","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,20]]},"assertion":[{"value":"6 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None declared.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}