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Statements regarding the effectiveness of visual examination of the oral cavity for early detection are not necessarily transferable between different health care systems. Our clinical-epidemiological and methodological aim was thus to conduct a prospective regional study in dental practices under everyday conditions, assess the frequency and type of oral mucosal changes, and evaluate the dental examination methodology.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A prospective observational study was conducted, combining a feasibility study of early detection of oral cancer and its documentation with phase I \u2018modelling\u2019 to conceptualize complex interventions in health services research. Dentists in private practice continuously recruited patients over 6\u00a0months and used two different sheets for the documentation of suspicious lesions. Statistical analysis involved descriptive statistics and tests for differences (Welch test) or association (Chi-squared test).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty-five dentists (mean age: 50\u00a0years, 24% females) participated in this study. Eleven dentists achieved the overall aim of recruiting 200 patients. Around 4200 patients (mean age: 52\u00a0years, 57.5% females) participated. The prevalence of suspicious lesions was 8.5%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>It became apparent that a study in cooperation with dentists in private practice to generate clinical-epidemiological data on the early detection of oral mucosal lesions under everyday conditions can be carried out successfully. Further studies with a corresponding level of evidence should be carried out to be able to draw conclusions about the effectiveness of the early detection measure under everyday practice conditions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-022-03962-x","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T10:02:23Z","timestamp":1646560943000},"page":"1375-1387","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Early detection of oral cancer: a key role for dentists?"],"prefix":"10.1007","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-0619","authenticated-orcid":false,"given":"Katrin","family":"Hertrampf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"J\u00fcrgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00fcrgen","family":"Wenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Wiltfang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Waldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,6]]},"reference":[{"key":"3962_CR1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.adaj.2019.01.026","volume":"150","author":"A Abadeh","year":"2019","unstructured":"Abadeh A, Ali AA, Bradley G, Magalhaes MA (2019) Increase in detection of oral cancer and precursor lesions by dentists: evidence from an oral and maxillofacial pathology service. 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