{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:06:34Z","timestamp":1790676394635,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s00432-022-04164-1","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T15:03:35Z","timestamp":1658588615000},"page":"3089-3107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["AURKA is a prognostic potential therapeutic target in skin cutaneous melanoma modulating the tumor microenvironment, apoptosis, and hypoxia"],"prefix":"10.1007","volume":"149","author":[{"given":"ShengYong","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan Fen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"issue":"1","key":"4164_CR1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","volume":"18","author":"D Aran","year":"2017","unstructured":"Aran D, Hu Z, Butte AJ (2017) xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol 18(1):220. https:\/\/doi.org\/10.1186\/s13059-017-1349-1","journal-title":"Genome Biol"},{"issue":"10","key":"4164_CR2","doi-asserted-by":"publisher","first-page":"e1468956","DOI":"10.1080\/2162402x.2018.1468956","volume":"7","author":"DL Bajor","year":"2018","unstructured":"Bajor DL, Mick R, Riese MJ, Huang AC, Sullivan B, Richman LP, Torigian DA, George SM, Stelekati E, Chen F, Melenhorst JJ, Lacey SF, Xu X, Wherry EJ, Gangadhar TC, Amaravadi RK, Schuchter LM, Vonderheide RH (2018) Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma. Oncoimmunology 7(10):e1468956. https:\/\/doi.org\/10.1080\/2162402x.2018.1468956","journal-title":"Oncoimmunology"},{"issue":"1","key":"4164_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s13059-016-1113-y","volume":"17","author":"E Becht","year":"2016","unstructured":"Becht E, Giraldo NA, Lacroix L, Buttard B, Elarouci N, Petitprez F, Selves J, Laurent-Puig P, Saut\u00e8s-Fridman C, Fridman WH, de Reyni\u00e8s A (2016) Erratum to: Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression. Genome Biol 17(1):249. https:\/\/doi.org\/10.1186\/s13059-016-1113-y","journal-title":"Genome Biol"},{"issue":"4","key":"4164_CR4","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","volume":"39","author":"G Bindea","year":"2013","unstructured":"Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, Bruneval P, Fridman WH, Becker C, Pag\u00e8s F, Speicher MR, Trajanoski Z, Galon J (2013) Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39(4):782\u2013795. https:\/\/doi.org\/10.1016\/j.immuni.2013.10.003","journal-title":"Immunity"},{"issue":"5","key":"4164_CR5","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","volume":"24","author":"M Binnewies","year":"2018","unstructured":"Binnewies M, Roberts EW, Kersten K, Chan V (2018) Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med 24(5):541\u2013550. https:\/\/doi.org\/10.1038\/s41591-018-0014-x","journal-title":"Nat Med"},{"key":"4164_CR6","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12967-014-0216-z","volume":"12","author":"E Caputo","year":"2014","unstructured":"Caputo E, Miceli R, Motti ML, Tat\u00e9 R, Fratangelo F, Botti G, Mozzillo N, Carriero MV, Cavalcanti E, Palmieri G, Ciliberto G, Pirozzi G, Ascierto PA (2014) AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment. J Transl Med 12:216. https:\/\/doi.org\/10.1186\/s12967-014-0216-z","journal-title":"J Transl Med"},{"issue":"2","key":"4164_CR7","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1073\/pnas.0408197102","volume":"102","author":"ML Chen","year":"2005","unstructured":"Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K (2005) Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci USA 102(2):419\u2013424. https:\/\/doi.org\/10.1073\/pnas.0408197102","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"4164_CR8","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/onc.2012.628","volume":"33","author":"AB D'Assoro","year":"2014","unstructured":"D\u2019Assoro AB, Liu T, Quatraro C, Amato A, Opyrchal M, Leontovich A, Ikeda Y, Ohmine S, Lingle W, Suman V, Ecsedy J, Iankov I, Di Leonardo A, Ayers-Inglers J, Degnim A, Billadeau D, McCubrey J, Ingle J, Salisbury JL, Galanis E (2014) The mitotic kinase Aurora\u2013a promotes distant metastases by inducing epithelial-to-mesenchymal transition in ER\u03b1(+) breast cancer cells. Oncogene 33(5):599\u2013610. https:\/\/doi.org\/10.1038\/onc.2012.628","journal-title":"Oncogene"},{"key":"4164_CR9","doi-asserted-by":"publisher","first-page":"129448","DOI":"10.1016\/j.bbagen.2019.129448","volume":"1","author":"VB de Souza","year":"2020","unstructured":"de Souza VB, Kawano DF (2020) Structural basis for the design of allosteric inhibitors of the Aurora kinase A enzyme in the cancer chemotherapy. Biochim Biophys Acta 1:129448. https:\/\/doi.org\/10.1016\/j.bbagen.2019.129448","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"4164_CR10","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","volume":"18","author":"NT Doncheva","year":"2019","unstructured":"Doncheva NT, Morris JH (2019) Cytoscape StringApp: network analysis and visualization of proteomics data. J Proteome Res 18(2):623\u2013632. https:\/\/doi.org\/10.1021\/acs.jproteome.8b00702","journal-title":"J Proteome Res"},{"issue":"5","key":"4164_CR11","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrc3218","volume":"12","author":"KT Flaherty","year":"2012","unstructured":"Flaherty KT, Hodi FS, Fisher DE (2012) From genes to drugs: targeted strategies for melanoma. Nat Rev Cancer 12(5):349\u2013361. https:\/\/doi.org\/10.1038\/nrc3218","journal-title":"Nat Rev Cancer"},{"key":"4164_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1476-4598-3-9","volume":"3","author":"C Garnis","year":"2004","unstructured":"Garnis C, Buys TP, Lam WL (2004) Genetic alteration and gene expression modulation during cancer progression. Mol Cancer 3:9. https:\/\/doi.org\/10.1186\/1476-4598-3-9","journal-title":"Mol Cancer"},{"issue":"6","key":"4164_CR13","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1158\/1078-0432.ccr-17-2267","volume":"24","author":"TN Gide","year":"2018","unstructured":"Gide TN, Wilmott JS, Scolyer RA, Long GV (2018) Primary and acquired resistance to immune checkpoint inhibitors in metastatic melanoma. Clin Cancer Res 24(6):1260\u20131270. https:\/\/doi.org\/10.1158\/1078-0432.ccr-17-2267","journal-title":"Clin Cancer Res"},{"issue":"9","key":"4164_CR14","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1038\/bjc.2013.608","volume":"109","author":"JA Goos","year":"2013","unstructured":"Goos JA, Coupe VM, Diosdado B, Delis-Van Diemen PM, Karga C, Beli\u00ebn JA, Carvalho B, van den Tol MP, Verheul HM, Geldof AA, Meijer GA, Hoekstra OS, Fijneman RJ (2013) Aurora kinase A (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis. Br J Cancer 109(9):2445\u20132452. https:\/\/doi.org\/10.1038\/bjc.2013.608","journal-title":"Br J Cancer"},{"issue":"Suppl 7","key":"4164_CR15","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12918-018-0634-2","volume":"12","author":"M Guo","year":"2018","unstructured":"Guo M, Lu S, Huang H, Wang Y, Yang MQ, Yang Y, Fan Z, Jiang B, Deng Y (2018) Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer. BMC Syst Biol 12(Suppl 7):118. https:\/\/doi.org\/10.1186\/s12918-018-0634-2","journal-title":"BMC Syst Biol"},{"issue":"20","key":"4164_CR16","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1056\/NEJMra021902","volume":"347","author":"WC Hahn","year":"2002","unstructured":"Hahn WC, Weinberg RA (2002) Rules for making human tumor cells. N Engl J Med 347(20):1593\u20131603. https:\/\/doi.org\/10.1056\/NEJMra021902","journal-title":"N Engl J Med"},{"issue":"5","key":"4164_CR17","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674. https:\/\/doi.org\/10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"issue":"5","key":"4164_CR18","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","volume":"21","author":"S Jhunjhunwala","year":"2021","unstructured":"Jhunjhunwala S, Hammer C (2021) Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion. Nat Rev Cancer 21(5):298\u2013312. https:\/\/doi.org\/10.1038\/s41568-021-00339-z","journal-title":"Nat Rev Cancer"},{"key":"4164_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00442-9","author":"S Kalaora","year":"2022","unstructured":"Kalaora S, Nagler A, Wargo JA (2022) Mechanisms of immune activation and regulation: lessons from melanoma. Nat Rev Cancer. https:\/\/doi.org\/10.1038\/s41568-022-00442-9","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"4164_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1189\/jlb.4MR1116-466R","volume":"102","author":"J Keirsse","year":"2017","unstructured":"Keirsse J, Van Damme H, Van Ginderachter JA, Laoui D (2017) Exploiting tumor-associated dendritic cell heterogeneity for novel cancer therapies. J Leukoc Biol 102(2):317\u2013324. https:\/\/doi.org\/10.1189\/jlb.4MR1116-466R","journal-title":"J Leukoc Biol"},{"key":"4164_CR21","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","volume":"27","author":"T Korn","year":"2009","unstructured":"Korn T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 cells. Annu Rev Immunol 27:485\u2013517. https:\/\/doi.org\/10.1146\/annurev.immunol.021908.132710","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"4164_CR22","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.cell.2008.07.025","volume":"134","author":"MO Li","year":"2008","unstructured":"Li MO, Flavell RA (2008) TGF-beta: a master of all T cell trades. Cell 134(3):392\u2013404. https:\/\/doi.org\/10.1016\/j.cell.2008.07.025","journal-title":"Cell"},{"issue":"W1","key":"4164_CR23","doi-asserted-by":"publisher","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","volume":"48","author":"T Li","year":"2020","unstructured":"Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B, Liu XS (2020) TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res 48(W1):W509-w514. https:\/\/doi.org\/10.1093\/nar\/gkaa407","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"4164_CR24","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.pop.2015.07.006","volume":"42","author":"MA Linares","year":"2015","unstructured":"Linares MA, Zakaria A, Nizran P (2015) Skin cancer. Prim Care 42(4):645\u2013659. https:\/\/doi.org\/10.1016\/j.pop.2015.07.006","journal-title":"Prim Care"},{"issue":"6","key":"4164_CR25","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.3892\/ol.2012.660","volume":"3","author":"ZG Liu","year":"2012","unstructured":"Liu ZG, Yi W, Tao YL, Chan HC, Zeng MS, Xia YF (2012) Aurora-A is an efficient marker for predicting poor prognosis in human nasopharyngeal carcinoma with aggressive local invasion: 208 cases with a 10-year follow-up from a single institution. Oncol Lett 3(6):1237\u20131244. https:\/\/doi.org\/10.3892\/ol.2012.660","journal-title":"Oncol Lett"},{"issue":"21","key":"4164_CR26","doi-asserted-by":"publisher","first-page":"3771","DOI":"10.1093\/bioinformatics\/bty411","volume":"34","author":"CJ Liu","year":"2018","unstructured":"Liu CJ, Hu FF, Xia MX, Han L, Zhang Q, Guo AY (2018) GSCALite: a web server for gene set cancer analysis. Bioinformatics (oxford, England) 34(21):3771\u20133772. https:\/\/doi.org\/10.1093\/bioinformatics\/bty411","journal-title":"Bioinformatics (oxford, England)"},{"issue":"2","key":"4164_CR27","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.cell.2018.03.034","volume":"173","author":"TM Malta","year":"2018","unstructured":"Malta TM, Sokolov A, Gentles AJ, Burzykowski T, Poisson L, Weinstein JN, Kami\u0144ska B, Huelsken J, Omberg L, Gevaert O, Colaprico A, Czerwi\u0144ska P, Mazurek S, Mishra L, Heyn H, Krasnitz A, Godwin AK, Lazar AJ, Stuart JM, Hoadley KA, Laird PW, Noushmehr H, Wiznerowicz M (2018) Machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell 173(2):338-354.e315. https:\/\/doi.org\/10.1016\/j.cell.2018.03.034","journal-title":"Cell"},{"key":"4164_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030545","author":"A Mehdi","year":"2021","unstructured":"Mehdi A, Rabbani SA (2021) Role of methylation in pro- and anti-cancer immunity. Cancers. https:\/\/doi.org\/10.3390\/cancers13030545","journal-title":"Cancers"},{"issue":"3","key":"4164_CR29","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2217\/epi-2017-0118","volume":"10","author":"V Modhukur","year":"2018","unstructured":"Modhukur V, Iljasenko T, Metsalu T, Lokk K, Laisk-Podar T, Vilo J (2018) MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data. Epigenomics 10(3):277\u2013288. https:\/\/doi.org\/10.2217\/epi-2017-0118","journal-title":"Epigenomics"},{"issue":"2","key":"4164_CR30","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/ijc.33283","volume":"148","author":"\u00c1 Nagy","year":"2021","unstructured":"Nagy \u00c1, Gy\u0151rffy B (2021) muTarget: a platform linking gene expression changes and mutation status in solid tumors. Int J Cancer 148(2):502\u2013511. https:\/\/doi.org\/10.1002\/ijc.33283","journal-title":"Int J Cancer"},{"issue":"1","key":"4164_CR31","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12943-022-01528-6","volume":"21","author":"PR Pandey","year":"2022","unstructured":"Pandey PR, Young KH, Kumar D (2022) RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics. Mol Cancer 21(1):58. https:\/\/doi.org\/10.1186\/s12943-022-01528-6","journal-title":"Mol Cancer"},{"issue":"13","key":"4164_CR32","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.2174\/0929867324666170727120315","volume":"26","author":"RC Panicker","year":"2019","unstructured":"Panicker RC, Coyne AG, Srinivasan R (2019) Allosteric targeting of Aurora A kinase using small molecules: a step forward towards next generation medicines? Curr Med Chem 26(13):2234\u20132242. https:\/\/doi.org\/10.2174\/0929867324666170727120315","journal-title":"Curr Med Chem"},{"issue":"6","key":"4164_CR33","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.jid.2017.01.021","volume":"137","author":"JA Puig-Butille","year":"2017","unstructured":"Puig-Butille JA, Vinyals A, Ferreres JR, Aguilera P, Cabr\u00e9 E, Tell-Mart\u00ed G, Marcoval J, Mateo F, Palomero L, Badenas C, Piulats JM, Malvehy J, Pujana MA, Puig S, Fabra \u00c0 (2017) AURKA overexpression is driven by FOXM1 and MAPK\/ERK activation in melanoma cells harboring BRAF or NRAS mutations: impact on melanoma prognosis and therapy. J Invest Dermatol 137(6):1297\u20131310. https:\/\/doi.org\/10.1016\/j.jid.2017.01.021","journal-title":"J Invest Dermatol"},{"issue":"4","key":"4164_CR34","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s00262-020-02748-9","volume":"70","author":"S Punt","year":"2021","unstructured":"Punt S, Malu S, McKenzie JA, Manrique SZ, Doorduijn EM, Mbofung RM, Williams L, Silverman DA, Ashkin EL, Dominguez AL, Wang Z, Chen JQ, Maiti SN, Tieu TN, Liu C, Xu C, Forget MA, Haymaker C, Khalili JS, Satani N, Muller F, Cooper LJN, Overwijk WW, Amaria RN, Bernatchez C, Heffernan TP, Peng W, Roszik J, Hwu P (2021) Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity. Cancer Immunol Immunother 70(4):1101\u20131113. https:\/\/doi.org\/10.1007\/s00262-020-02748-9","journal-title":"Cancer Immunol Immunother"},{"issue":"5","key":"4164_CR35","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.ccr.2010.10.002","volume":"18","author":"K Rakhra","year":"2010","unstructured":"Rakhra K, Bachireddy P, Zabuawala T, Zeiser R, Xu L, Kopelman A, Fan AC, Yang Q, Braunstein L, Crosby E, Ryeom S, Felsher DW (2010) CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell 18(5):485\u2013498. https:\/\/doi.org\/10.1016\/j.ccr.2010.10.002","journal-title":"Cancer Cell"},{"issue":"2","key":"4164_CR36","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.urolonc.2009.12.003","volume":"30","author":"S Scarpini","year":"2012","unstructured":"Scarpini S, Roupr\u00eat M, Renard-Penna R, Camparo P, Cussenot O, Comp\u00e9rat E (2012) Impact of the expression of Aurora-A, p53, and MIB-1 on the prognosis of urothelial carcinomas of the upper urinary tract. Urol Oncol 30(2):182\u2013187. https:\/\/doi.org\/10.1016\/j.urolonc.2009.12.003","journal-title":"Urol Oncol"},{"issue":"10151","key":"4164_CR37","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/s0140-6736(18)31559-9","volume":"392","author":"D Schadendorf","year":"2018","unstructured":"Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S (2018) Melanoma. Lancet (london, England) 392(10151):971\u2013984. https:\/\/doi.org\/10.1016\/s0140-6736(18)31559-9","journal-title":"Lancet (london, England)"},{"issue":"2","key":"4164_CR38","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41590-020-00834-9","volume":"22","author":"NE Scharping","year":"2021","unstructured":"Scharping NE, Rivadeneira DB, Menk AV, Vignali PDA, Ford BR, Rittenhouse NL, Peralta R, Wang Y, Wang Y, DePeaux K (2021) Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nat Immunol 22(2):205\u2013215. https:\/\/doi.org\/10.1038\/s41590-020-00834-9","journal-title":"Nat Immunol"},{"key":"4164_CR39","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022277","author":"J Seoane","year":"2017","unstructured":"Seoane J, Gomis RR (2017) TGF-\u03b2 family signaling in tumor suppression and cancer progression. Cold Spring Harbor Perspect Biol. https:\/\/doi.org\/10.1101\/cshperspect.a022277","journal-title":"Cold Spring Harbor Perspect Biol"},{"issue":"1","key":"4164_CR40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD (2019) Cancer statistics. CA A Cancer J Clin 69(1):7\u201334. https:\/\/doi.org\/10.3322\/caac.21551","journal-title":"CA A Cancer J Clin"},{"issue":"14","key":"4164_CR41","doi-asserted-by":"publisher","first-page":"i436","DOI":"10.1093\/bioinformatics\/btz363","volume":"35","author":"G Sturm","year":"2019","unstructured":"Sturm G, Finotello F, Petitprez F, Zhang JD, Baumbach J, Fridman WH, List M, Aneichyk T (2019) Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology. Bioinformatics (oxford, England) 35(14):i436\u2013i445. https:\/\/doi.org\/10.1093\/bioinformatics\/btz363","journal-title":"Bioinformatics (oxford, England)"},{"issue":"4","key":"4164_CR42","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.3892\/ijo.2015.2842","volume":"46","author":"K Umene","year":"2015","unstructured":"Umene K, Yanokura M, Banno K, Irie H, Adachi M, Iida M, Nakamura K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D (2015) Aurora kinase A has a significant role as a therapeutic target and clinical biomarker in endometrial cancer. Int J Oncol 46(4):1498\u20131506. https:\/\/doi.org\/10.3892\/ijo.2015.2842","journal-title":"Int J Oncol"},{"key":"4164_CR43","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv406","author":"AE Vilgelm","year":"2016","unstructured":"Vilgelm AE, Johnson CA, Prasad N, Yang J, Chen SC, Ayers GD, Pawlikowski JS, Raman D, Sosman JA, Kelley M, Ecsedy JA, Shyr Y, Levy SE, Richmond A (2016) Connecting the dots: therapy-induced senescence and a tumor-suppressive immune microenvironment. J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/djv406","journal-title":"J Natl Cancer Inst"},{"key":"4164_CR44","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa424","author":"M Wang","year":"2021","unstructured":"Wang M, Ngo V, Wang W (2021) Deciphering the genetic code of DNA methylation. Brief Bioinform. https:\/\/doi.org\/10.1093\/bib\/bbaa424","journal-title":"Brief Bioinform"},{"issue":"2","key":"4164_CR45","doi-asserted-by":"publisher","first-page":"e56919","DOI":"10.1371\/journal.pone.0056919","volume":"8","author":"J Xu","year":"2013","unstructured":"Xu J, Wu X, Zhou WH, Liu AW, Wu JB, Deng JY, Yue CF, Yang SB, Wang J, Yuan ZY, Liu Q (2013) Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer. PLoS ONE 8(2):e56919. https:\/\/doi.org\/10.1371\/journal.pone.0056919","journal-title":"PLoS ONE"},{"issue":"6","key":"4164_CR46","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1002\/med.21399","volume":"36","author":"M Yan","year":"2016","unstructured":"Yan M, Wang C, He B, Yang M, Tong M, Long Z, Liu B, Peng F, Xu L, Zhang Y, Liang D, Lei H, Subrata S, Kelley KW, Lam EW, Jin B, Liu Q (2016) Aurora-A kinase: a potent oncogene and target for cancer therapy. Med Res Rev 36(6):1036\u20131079. https:\/\/doi.org\/10.1002\/med.21399","journal-title":"Med Res Rev"},{"key":"4164_CR47","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/ncomms3612","volume":"4","author":"K Yoshihara","year":"2013","unstructured":"Yoshihara K, Shahmoradgoli M, Mart\u00ednez E, Vegesna R, Kim H, Torres-Garcia W, Trevi\u00f1o V, Shen H, Laird PW, Levine DA, Carter SL, Getz G, Stemke-Hale K, Mills GB, Verhaak RG (2013) Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun 4:2612. https:\/\/doi.org\/10.1038\/ncomms3612","journal-title":"Nat Commun"},{"issue":"D1","key":"4164_CR48","doi-asserted-by":"publisher","first-page":"D900","DOI":"10.1093\/nar\/gky939","volume":"47","author":"H Yuan","year":"2019","unstructured":"Yuan H, Yan M, Zhang G, Liu W, Deng C, Liao G, Xu L, Luo T, Yan H, Long Z, Shi A, Zhao T, Xiao Y, Li X (2019) CancerSEA: a cancer single-cell state atlas. Nucleic Acids Res 47(D1):D900-d908. https:\/\/doi.org\/10.1093\/nar\/gky939","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"4164_CR49","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/s41423-020-0488-6","volume":"17","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Zhang Z (2020) The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Cell Mol Immunol 17(8):807\u2013821. https:\/\/doi.org\/10.1038\/s41423-020-0488-6","journal-title":"Cell Mol Immunol"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-022-04164-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-022-04164-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-022-04164-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T12:06:21Z","timestamp":1688213181000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-022-04164-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,23]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["4164"],"URL":"https:\/\/doi.org\/10.1007\/s00432-022-04164-1","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,23]]},"assertion":[{"value":"6 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they do not have any conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of the Second Affiliated Hospital of Lanzhou University. Patients\/participants provided their written informed consent to participate in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}