{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:04:11Z","timestamp":1740107051794,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Chinese Society of Clinical Oncology (CSCO) Tumor Research Fund","award":["Y-2019AZZD-0038"],"award-info":[{"award-number":["Y-2019AZZD-0038"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82150005"],"award-info":[{"award-number":["82150005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Medical and health public welfare foundation project","award":["YWJKJJHKYJ"],"award-info":[{"award-number":["YWJKJJHKYJ"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s00432-022-04182-z","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T08:09:58Z","timestamp":1659082198000},"page":"3171-3184","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognosis of different extrathoracic metastasis patterns in patients with M1c lung adenocarcinoma receiving immunotherapy"],"prefix":"10.1007","volume":"149","author":[{"given":"Fang","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meili","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhuo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiqin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"issue":"1","key":"4182_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41568-018-0081-9","volume":"19","author":"NK Altorki","year":"2019","unstructured":"Altorki NK, Markowitz GJ, Gao D, Port JL, Saxena A, Stiles B et al (2019) The lung microenvironment: an important regulator of tumour growth and metastasis. Nat Rev Cancer 19(1):9\u201331. https:\/\/doi.org\/10.1038\/s41568-018-0081-9","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"4182_CR2","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1148\/rg.2018170081","volume":"38","author":"BW Carter","year":"2018","unstructured":"Carter BW, Lichtenberger JP 3rd, Benveniste MK, de Groot PM, Wu CC, Erasmus JJ et al (2018) Revisions to the TNM staging of lung cancer: rationale, significance, and clinical application. Radiographics 38(2):374\u2013391. https:\/\/doi.org\/10.1148\/rg.2018170081","journal-title":"Radiographics"},{"key":"4182_CR3","doi-asserted-by":"publisher","unstructured":"Chansky K, Detterbeck FC, Nicholson AG, Rusch VW, Valli\u00e8res E, Groome P, et al. (2017) The IASLC lung cancer staging project: external validation of the revision of the TNM stage groupings\u00a0in the eighth edition of the TNM classification of lung\u00a0Cancer. J Thorac Oncol 12(7):1109\u20131121. https:\/\/doi.org\/10.1016\/j.jtho.2017.04.011","DOI":"10.1016\/j.jtho.2017.04.011"},{"key":"4182_CR4","doi-asserted-by":"publisher","unstructured":"Chardin D, Paquet M, Schiappa R, Darcourt J, Bailleux C, Poudenx M, et al. (2020) Baseline metabolic tumor volume as a strong predictive and prognostic biomarker in patients with non-small cell lung cancer treated with PD1 inhibitors: a prospective study. J Immunother Cancer. https:\/\/doi.org\/10.1136\/jitc-2020-000645.","DOI":"10.1136\/jitc-2020-000645"},{"issue":"8","key":"4182_CR5","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nrc3775","volume":"14","author":"Z Chen","year":"2014","unstructured":"Chen Z, Fillmore CM, Hammerman PS, Kim CF, Wong KK (2014) Non-small-cell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer 14(8):535\u2013546. https:\/\/doi.org\/10.1038\/nrc3775","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"4182_CR6","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.cell.2020.06.012","volume":"182","author":"YJ Chen","year":"2020","unstructured":"Chen YJ, Roumeliotis TI, Chang YH, Chen CT, Han CL, Lin MH et al (2020) Proteogenomics of non-smoking lung cancer in East Asia delineates molecular signatures of pathogenesis and progression. Cell 182(1):226\u201344.e17. https:\/\/doi.org\/10.1016\/j.cell.2020.06.012","journal-title":"Cell"},{"key":"4182_CR7","doi-asserted-by":"publisher","unstructured":"S\u00e1nchez de Cos Escu\u00edn J, Abal Arca J, Melchor \u00cd\u00f1iguez R, Miravet Sorribes L, N\u00fa\u00f1ez Ares A, Hern\u00e1ndez Hern\u00e1ndez JR, et al. (2014) Tumor, node and metastasis classification of lung cancer\u2014M1a versus M1b\u2014analysis of M descriptors and other prognostic factors. Lung Cancer 84(2):182\u2013189. https:\/\/doi.org\/10.1016\/j.lungcan.2014.02.006.","DOI":"10.1016\/j.lungcan.2014.02.006"},{"key":"4182_CR8","doi-asserted-by":"publisher","unstructured":"Duraiswamy J, Freeman GJ, Coukos G (2014) Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors\u2013response. Cancer Res 74(2):633\u2013634; discussion 5. https:\/\/doi.org\/10.1158\/0008-5472.Can-13-2752.","DOI":"10.1158\/0008-5472.Can-13-2752"},{"key":"4182_CR9","doi-asserted-by":"publisher","unstructured":"Eberhardt WE, Mitchell A, Crowley J, Kondo H, Kim YT, Turrisi A, 3rd, et al. (2015) The IASLC lung cancer staging project: proposals for the revision of the M descriptors in the forthcoming eighth edition of the TNM classification of lung cancer. J Thorac Oncol 10(11):1515\u20131522. https:\/\/doi.org\/10.1097\/jto.0000000000000673.","DOI":"10.1097\/jto.0000000000000673"},{"issue":"1","key":"4182_CR10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","volume":"11","author":"P Goldstraw","year":"2016","unstructured":"Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE et al (2016) The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol 11(1):39\u201351. https:\/\/doi.org\/10.1016\/j.jtho.2015.09.009","journal-title":"J Thorac Oncol"},{"issue":"1","key":"4182_CR11","doi-asserted-by":"publisher","first-page":"16902","DOI":"10.1038\/s41598-019-52913-z","volume":"9","author":"F Guisier","year":"2019","unstructured":"Guisier F, Cousse S, Jeanvoine M, Thiberville L, Salaun M (2019) A rationale for surgical debulking to improve anti-PD1 therapy outcome in non small cell lung cancer. Sci Rep 9(1):16902. https:\/\/doi.org\/10.1038\/s41598-019-52913-z","journal-title":"Sci Rep"},{"issue":"9","key":"4182_CR12","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1200\/jco.20.03570","volume":"39","author":"NH Hanna","year":"2021","unstructured":"Hanna NH, Robinson AG, Temin S, Baker S Jr, Brahmer JR, Ellis PM et al (2021) Therapy for stage IV non-small-cell lung cancer with driver alterations: ASCO and OH (CCO) joint guideline update. J Clin Oncol 39(9):1040\u20131091. https:\/\/doi.org\/10.1200\/jco.20.03570","journal-title":"J Clin Oncol"},{"issue":"6","key":"4182_CR13","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.cllc.2014.06.006","volume":"15","author":"YY He","year":"2014","unstructured":"He YY, Zhang XC, Yang JJ, Niu FY, Zeng Z, Yan HH et al (2014) Prognostic significance of genotype and number of metastatic sites in advanced non-small-cell lung cancer. Clin Lung Cancer 15(6):441\u2013447. https:\/\/doi.org\/10.1016\/j.cllc.2014.06.006","journal-title":"Clin Lung Cancer"},{"issue":"5","key":"4182_CR14","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.7150\/jca.28601","volume":"10","author":"F Hu","year":"2019","unstructured":"Hu F, Zhang B, Li C, Xu J, Wang H, Gu P et al (2019) Prognosis of EGFR-mutant advanced lung adenocarcinoma patients with different intrathoracic metastatic patterns. J Cancer 10(5):1254\u20131262. https:\/\/doi.org\/10.7150\/jca.28601","journal-title":"J Cancer"},{"issue":"1","key":"4182_CR15","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12943-021-01411-w","volume":"20","author":"C Jiang","year":"2021","unstructured":"Jiang C, Zhang N, Hu X, Wang H (2021) Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms. Mol Cancer 20(1):117. https:\/\/doi.org\/10.1186\/s12943-021-01411-w","journal-title":"Mol Cancer"},{"key":"4182_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.629722","volume":"11","author":"SI Kim","year":"2020","unstructured":"Kim SI, Cassella CR, Byrne KT (2020) Tumor burden and immunotherapy: impact on immune infiltration and therapeutic outcomes. Front Immunol 11:629722. https:\/\/doi.org\/10.3389\/fimmu.2020.629722","journal-title":"Front Immunol"},{"issue":"8","key":"4182_CR17","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1038\/s41591-018-0096-5","volume":"24","author":"D Lambrechts","year":"2018","unstructured":"Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O et al (2018) Phenotype molding of stromal cells in the lung tumor microenvironment. Nat Med 24(8):1277\u20131289. https:\/\/doi.org\/10.1038\/s41591-018-0096-5","journal-title":"Nat Med"},{"issue":"2","key":"4182_CR18","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.21037\/tlcr-20-1019","volume":"10","author":"Y Liu","year":"2021","unstructured":"Liu Y, Chen P, Wang H, Wu S, Zhao S, He Y et al (2021) The landscape of immune checkpoints expression in non-small cell lung cancer: a narrative review. Transl Lung Cancer Res 10(2):1029\u20131038. https:\/\/doi.org\/10.21037\/tlcr-20-1019","journal-title":"Transl Lung Cancer Res"},{"issue":"8","key":"4182_CR19","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1093\/annonc\/mdz167","volume":"30","author":"J Mazieres","year":"2019","unstructured":"Mazieres J, Drilon A, Lusque A, Mhanna L, Cortot AB, Mezquita L et al (2019) Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry. Ann Oncol 30(8):1321\u20131328. https:\/\/doi.org\/10.1093\/annonc\/mdz167","journal-title":"Ann Oncol"},{"issue":"7","key":"4182_CR20","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.jtho.2021.03.017","volume":"16","author":"RM Memmott","year":"2021","unstructured":"Memmott RM, Wolfe AR, Carbone DP, Williams TM (2021) Predictors of response, progression-free survival, and overall survival in patients with lung cancer treated with immune checkpoint inhibitors. J Thorac Oncol 16(7):1086\u20131098. https:\/\/doi.org\/10.1016\/j.jtho.2021.03.017","journal-title":"J Thorac Oncol"},{"issue":"6","key":"4182_CR21","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3978\/j.issn.1000-9604.2013.11.10","volume":"25","author":"P Obara","year":"2013","unstructured":"Obara P, Pu Y (2013) Prognostic value of metabolic tumor burden in lung cancer. Chin J Cancer Res 25(6):615\u2013622. https:\/\/doi.org\/10.3978\/j.issn.1000-9604.2013.11.10","journal-title":"Chin J Cancer Res"},{"key":"4182_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109996","volume":"127","author":"J Qu","year":"2020","unstructured":"Qu J, Jiang M, Wang L, Zhao D, Qin K, Wang Y et al (2020) Mechanism and potential predictive biomarkers of immune checkpoint inhibitors in NSCLC. Biomed Pharmacother 127:109996. https:\/\/doi.org\/10.1016\/j.biopha.2020.109996","journal-title":"Biomed Pharmacother"},{"key":"4182_CR23","doi-asserted-by":"publisher","unstructured":"Rami-Porta R (2021) Future perspectives on the TNM staging for lung cancer. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers13081940.","DOI":"10.3390\/cancers13081940"},{"key":"4182_CR24","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.lungcan.2021.10.002","volume":"162","author":"A Schakenraad","year":"2021","unstructured":"Schakenraad A, Hashemi S, Twisk J, Houda I, Ulas E, Daniels JMA et al (2021) The effect of tumor size and metastatic extent on the efficacy of first line pembrolizumab monotherapy in patients with high PD-L1 expressing advanced NSCLC tumors. Lung Cancer 162:36\u201341. https:\/\/doi.org\/10.1016\/j.lungcan.2021.10.002","journal-title":"Lung Cancer"},{"issue":"10299","key":"4182_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/s0140-6736(21)00312-3","volume":"398","author":"AA Thai","year":"2021","unstructured":"Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS (2021) Lung cancer. Lancet 398(10299):535\u2013554. https:\/\/doi.org\/10.1016\/s0140-6736(21)00312-3","journal-title":"Lancet"},{"issue":"6","key":"4182_CR26","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1136\/thoraxjnl-2012-202297","volume":"68","author":"S Walters","year":"2013","unstructured":"Walters S, Maringe C, Coleman MP, Peake MD, Butler J, Young N et al (2013) Lung cancer survival and stage at diagnosis in Australia, Canada, Denmark, Norway, Sweden and the UK: a population-based study, 2004\u20132007. Thorax 68(6):551\u2013564. https:\/\/doi.org\/10.1136\/thoraxjnl-2012-202297","journal-title":"Thorax"},{"issue":"4","key":"4182_CR27","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.ctrv.2013.10.001","volume":"40","author":"SL Wood","year":"2014","unstructured":"Wood SL, Pernemalm M, Crosbie PA, Whetton AD (2014) The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat Rev 40(4):558\u2013566. https:\/\/doi.org\/10.1016\/j.ctrv.2013.10.001","journal-title":"Cancer Treat Rev"},{"key":"4182_CR28","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1146\/annurev-med-051718-013524","volume":"71","author":"CY Yang","year":"2020","unstructured":"Yang CY, Yang JC, Yang PC (2020) Precision management of advanced non-small cell lung cancer. Annu Rev Med 71:117\u2013136. https:\/\/doi.org\/10.1146\/annurev-med-051718-013524","journal-title":"Annu Rev Med"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-022-04182-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-022-04182-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-022-04182-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T12:07:17Z","timestamp":1688213237000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-022-04182-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["4182"],"URL":"https:\/\/doi.org\/10.1007\/s00432-022-04182-z","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"type":"print","value":"0171-5216"},{"type":"electronic","value":"1432-1335"}],"subject":[],"published":{"date-parts":[[2022,7,27]]},"assertion":[{"value":"20 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all patients before the collection of information.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"This study was approved by the institutional review board of the Shanghai Chest Hospital (Shanghai, China; approval number: IS21127), and carried out in accordance with the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}