{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:34:42Z","timestamp":1770341682644,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1804262"],"award-info":[{"award-number":["U1804262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Projects of Central Government Guides for Local Science and Technology Development","award":["20200715"],"award-info":[{"award-number":["20200715"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Some studies indicated that gender is associated with prognostic of cancer, However, currently the prognostic value of gender for gastric cardia adenocarcinoma (GCA) survival is unclear. The aim of our study is to reveal the influence of gender on the prognosis of patients with GCA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Patients and methods<\/jats:title>\n                <jats:p>A total of 42,345 cases Chinese GCA patients were enrolled from our previously established GCA and esophageal cancer databases. The clinicopathological characteristics were retrieved from medical records in hospital. The follow-up was performed through letter, telephone or home interview. Among GCA patients, there were 32,544 (76.9%) male patients with the median age 62\u00a0years (range 17\u201397) and 9,801 (23.1%) female patients with the median age 61\u00a0years (range 17\u201395\u00a0years). The Chi-square test and Kaplan\u2013Meier method were used to compare the continuous variables and survival. Cox proportional hazards model was used for competing risk analyses, hazard ratios (HRs) and 95% confidence intervals (CIs) were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Men had shorter GCA-specific survival than women by multivariate analysis (HR 1.114; 95% CI 1.061 to 1.169; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Whether premenopausal, perimenopausal or postmenopausal, the survival of women was better than that of men (premenopausal <jats:italic>vs.<\/jats:italic> male, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; perimenopausal <jats:italic>vs.<\/jats:italic> male, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; postmenopausal <jats:italic>vs.<\/jats:italic> male, <jats:italic>P<\/jats:italic>\u2009=\u20090.035). It was worth noting that in patients with stages I, II, III, and IV, female patients survive longer than male patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.049; <jats:italic>P<\/jats:italic>\u2009=\u20090.011; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; <jats:italic>P<\/jats:italic>\u2009=\u20090.044, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Gender is an independent prognostic factor for patients with GCA. In comparison with men, women have a significantly better outcome. Smoking and drinking may be protective factors for male GCA patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-022-04470-8","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T19:05:06Z","timestamp":1668452706000},"page":"5205-5217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Survival influence of gender on 42,345 patients with gastric cardia adenocarcinoma"],"prefix":"10.1007","volume":"149","author":[{"given":"Rui Hua","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue Ke","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling Ling","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Li","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"De Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing Feng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng Xia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia Jia","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong Min","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue Na","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan Ze","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao Miao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing Song","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He Lin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia Xin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye Zhen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu You","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"issue":"13","key":"4470_CR1","doi-asserted-by":"publisher","first-page":"6114","DOI":"10.1002\/cam4.2497","volume":"8","author":"E Abdi","year":"2019","unstructured":"Abdi E, Latifi-Navid S, Zahri S, Yazdanbod A, Pourfarzi F (2019) Risk factors predisposing to cardia gastric adenocarcinoma: insights and new perspectives. Cancer Med 8(13):6114\u20136126. https:\/\/doi.org\/10.1002\/cam4.2497","journal-title":"Cancer Med"},{"issue":"11","key":"4470_CR2","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s10552-018-1079-z","volume":"29","author":"N Afshar","year":"2018","unstructured":"Afshar N, English DR, Thursfield V, Mitchell PL, Te Marvelde L, Farrugia H, Giles GG, Milne RL (2018a) Differences in cancer survival by sex: a population-based study using cancer registry data. Cancer Causes Control 29(11):1059\u20131069. https:\/\/doi.org\/10.1007\/s10552-018-1079-z","journal-title":"Cancer Causes Control"},{"issue":"11","key":"4470_CR3","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s10552-018-1079-z","volume":"29","author":"N Afshar","year":"2018","unstructured":"Afshar N, English DR, Thursfield V, Mitchell PL, Te Marvelde L, Farrugia H, Giles GG, Milne RL (2018b) Differences in cancer survival by gender: a population-based study using cancer registry data. Cancer Causes Control 29(11):1059\u20131069. https:\/\/doi.org\/10.1007\/s10552-018-1079-z","journal-title":"Cancer Causes Control"},{"issue":"16","key":"4470_CR4","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1016\/j.ejca.2008.07.031","volume":"44","author":"E Chandanos","year":"2008","unstructured":"Chandanos E, Lagergren J (2008) Oestrogen and the enigmatic male predominance of gastric cancer. Eur J Cancer 44(16):2397\u20132403. https:\/\/doi.org\/10.1016\/j.ejca.2008.07.031","journal-title":"Eur J Cancer"},{"issue":"6","key":"4470_CR5","doi-asserted-by":"publisher","first-page":"5673","DOI":"10.3892\/ol.2019.10983","volume":"18","author":"C Chen","year":"2019","unstructured":"Chen C, Gong X, Yang X, Shang X, Du Q, Liao Q, Xie R, Chen Y, Xu J (2019) The roles of estrogen and estrogen receptors in gastrointestinal disease. Oncol Lett 18(6):5673\u20135680. https:\/\/doi.org\/10.3892\/ol.2019.10983","journal-title":"Oncol Lett"},{"issue":"12","key":"4470_CR6","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1136\/gutjnl-2014-308915","volume":"64","author":"A Colquhoun","year":"2015","unstructured":"Colquhoun A, Arnold M, Ferlay J, Goodman KJ, Forman D, Soerjomataram I (2015) Global patterns of cardia and non-cardia gastric cancer incidence in 2012. Gut 64(12):1881\u20131888. https:\/\/doi.org\/10.1136\/gutjnl-2014-308915","journal-title":"Gut"},{"key":"4470_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1136\/gut.2008.161331","volume":"58","author":"MH Derakhshan","year":"2009","unstructured":"Derakhshan MH, Liptrot S, Paul J et al (2009) Oesophageal and gastric intestinal-type adenocarcinomas show the same male predominance due to a 17 year delayed development in females. Gut 58:16\u201323","journal-title":"Gut"},{"issue":"30","key":"4470_CR8","doi-asserted-by":"publisher","first-page":"4634","DOI":"10.3748\/wjg.v11.i30.4634","volume":"11","author":"SG Gao","year":"2005","unstructured":"Gao SG, Wang LD, Fan ZM, Li JL, He X, Guo RF, Xie DL, He XW, Gao SS, Guo HQ, Wang JK, Feng XS, Ma BG (2005) Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China. World J Gastroenterol 11(30):4634\u20134637. https:\/\/doi.org\/10.3748\/wjg.v11.i30.4634","journal-title":"World J Gastroenterol"},{"issue":"10159","key":"4470_CR9","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","volume":"392","author":"GBD 2017 Causes of Death Collaborators","year":"2018","unstructured":"GBD 2017 Causes of Death Collaborators (2018) Global, regional, and national age-gender-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392(10159):1736\u20131788. https:\/\/doi.org\/10.1016\/S0140-6736(18)32203-7","journal-title":"Lancet"},{"key":"4470_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4","volume-title":"AJCC cancer staging manual","author":"FL Greene","year":"2002","unstructured":"Greene FL (2002) AJCC cancer staging manual, 6th edn. Springer, Berlin, Heidelberg","edition":"6"},{"key":"4470_CR11","volume-title":"Esophageal cancer","author":"Henan Medical College","year":"1983","unstructured":"Henan Medical College (1983) Esophageal cancer. People\u2019s Health Publishing House, Beijing"},{"issue":"20","key":"4470_CR12","doi-asserted-by":"publisher","first-page":"6391","DOI":"10.1158\/1078-0432.CCR-09-0877","volume":"15","author":"A Hendifar","year":"2009","unstructured":"Hendifar A, Yang D, Lenz F, Lurje G, Pohl A, Lenz C, Ning Y, Zhang W, Lenz HJ (2009) Gender disparities in metastatic colorectal cancer survival. Clin Cancer Res 15(20):6391\u20136397. https:\/\/doi.org\/10.1158\/1078-0432.CCR-09-0877","journal-title":"Clin Cancer Res"},{"issue":"18","key":"4470_CR13","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1200\/JCO.2011.38.0584","volume":"30","author":"A Joosse","year":"2012","unstructured":"Joosse A, Collette S, Suciu S, Nijsten T, Lejeune F, Kleeberg UR, Coebergh JW, Eggermont AM, de Vries E (2012) Superior outcome of women with stage I\/II cutaneous melanoma: pooled analysis of four European Organisation for Research and Treatment of Cancer phase III trials. J Clin Oncol 30(18):2240\u20132247. https:\/\/doi.org\/10.1200\/JCO.2011.38.0584","journal-title":"J Clin Oncol"},{"issue":"3","key":"4470_CR14","doi-asserted-by":"publisher","first-page":"172","DOI":"10.5230\/jgc.2013.13.3.172","volume":"13","author":"MJ Kim","year":"2013","unstructured":"Kim MJ, Cho SI, Lee KO, Han HJ, Song TJ, Park SH (2013) Effects of 17\u03b2-estradiol and estrogen receptor antagonists on the proliferation of gastric cancer cell lines. J Gastric Cancer 13(3):172\u2013178. https:\/\/doi.org\/10.5230\/jgc.2013.13.3.172","journal-title":"J Gastric Cancer"},{"issue":"4","key":"4470_CR15","doi-asserted-by":"publisher","first-page":"575","DOI":"10.5056\/jnm16138","volume":"22","author":"YS Kim","year":"2016","unstructured":"Kim YS, Kim N, Kim GH (2016) Sex and gender differences in gastroesophageal reflux disease. J Neurogastroenterol Motil 22(4):575\u2013588. https:\/\/doi.org\/10.5056\/jnm16138","journal-title":"J Neurogastroenterol Motil"},{"issue":"3","key":"4470_CR16","doi-asserted-by":"publisher","first-page":"141","DOI":"10.4166\/kjg.2019.73.3.141","volume":"73","author":"SA Kim","year":"2019","unstructured":"Kim SA, Choi BY, Song KS, Park CH, Eun CS, Han DS, Kim YS, Kim HJ (2019) Prediagnostic smoking and alcohol drinking and gastric cancer survival: a Korean prospective cohort study. Korean J Gastroenterol 73(3):141\u2013151. https:\/\/doi.org\/10.4166\/kjg.2019.73.3.141","journal-title":"Korean J Gastroenterol"},{"issue":"9","key":"4470_CR17","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1093\/jjco\/hyx094","volume":"47","author":"FL Kinoshita","year":"2017","unstructured":"Kinoshita FL, Ito Y, Morishima T, Miyashiro I, Nakayama T (2017) Sex differences in lung cancer survival: long-term trends using population-based cancer registry data in Osaka Japan. Jpn J Clin Oncol 47(9):863\u2013869. https:\/\/doi.org\/10.1093\/jjco\/hyx094","journal-title":"Jpn J Clin Oncol"},{"issue":"1","key":"4470_CR18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s10147-015-0868-6","volume":"21","author":"K Kotake","year":"2016","unstructured":"Kotake K, Asano M, Ozawa H, Kobayashi H, Sugihara K (2016) Gender differences in colorectal cancer survival in Japan. Int J Clin Oncol 21(1):194\u2013203. https:\/\/doi.org\/10.1007\/s10147-015-0868-6","journal-title":"Int J Clin Oncol"},{"issue":"7","key":"4470_CR19","first-page":"1021","volume":"28","author":"D Kurt","year":"2007","unstructured":"Kurt D, Saruhan BG, Kanay Z, Yokus B, Kanay BE, Unver O, Hatipoglu S (2007) Effect of ovariectomy and female gender hormones administration upon gastric ulceration induced by cold and immobility restraint stress. Saudi Med J 28(7):1021\u20131027","journal-title":"Saudi Med J"},{"issue":"9","key":"4470_CR20","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1002\/ijc.21651","volume":"118","author":"L Mellemkjaer","year":"2006","unstructured":"Mellemkjaer L, Friis S, Olsen JH, Sc\u00e9lo G, Hemminki K, Tracey E, Andersen A, Brewster DH, Pukkala E, McBride ML, Kliewer EV, Tonita JM, Kee-Seng C, Pompe-Kirn V, Martos C, Jonasson JG, Boffetta P, Brennan P (2006) Risk of second cancer among women with breast cancer. Int J Cancer 118(9):2285\u20132292. https:\/\/doi.org\/10.1002\/ijc.21651","journal-title":"Int J Cancer"},{"issue":"8","key":"4470_CR21","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1002\/cam4.452","volume":"4","author":"MI Patel","year":"2015","unstructured":"Patel MI, Bang A, Gillett D, Cheluvappa R, Smith DP (2015) Poor survival of females with bladder cancer is limited to those aged 70 years or over: a population-wide linkage study, New South Wales Australia. Cancer Med 4(8):1145\u20131152. https:\/\/doi.org\/10.1002\/cam4.452","journal-title":"Cancer Med"},{"key":"4470_CR22","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ejca.2017.07.013","volume":"84","author":"C Radkiewicz","year":"2017","unstructured":"Radkiewicz C, Johansson ALV, Dickman PW, Lambe M, Edgren G (2017) Gender differences in cancer risk and survival: a Swedish cohort study. Eur J Cancer 84:130\u2013140. https:\/\/doi.org\/10.1016\/j.ejca.2017.07.013","journal-title":"Eur J Cancer"},{"issue":"3","key":"4470_CR23","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/ijc.20616","volume":"113","author":"GD Tran","year":"2005","unstructured":"Tran GD, Sun XD, Abnet CC, Fan JH, Dawsey SM, Dong ZW, Mark SD, Qiao YL, Taylor PR (2005) Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer 113(3):456\u2013463. https:\/\/doi.org\/10.1002\/ijc.20616","journal-title":"Int J Cancer"},{"issue":"2","key":"4470_CR24","doi-asserted-by":"publisher","first-page":"815","DOI":"10.7314\/apjcp.2015.16.2.815","volume":"16","author":"A Ulas","year":"2015","unstructured":"Ulas A, Tokluoglu S, Kos M, Silay K, Akinci S, Oksuzoglu B, Alkis N (2015) Lung cancer in women, a different disease: survival differences by gender in Turkey. Asian Pac J Cancer Prev 16(2):815\u2013822. https:\/\/doi.org\/10.7314\/apjcp.2015.16.2.815","journal-title":"Asian Pac J Cancer Prev"},{"issue":"4","key":"4470_CR25","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/ijc.2910590414","volume":"59","author":"LD Wang","year":"1994","unstructured":"Wang LD, Shi ST, Zhou Q, Goldstein S, Hong JY, Shao P, Qiu SL, Yang CS (1994) Changes in p53 and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric-cardia carcinogenesis. Int J Cancer 59(4):514\u2013519. https:\/\/doi.org\/10.1002\/ijc.2910590414","journal-title":"Int J Cancer"},{"key":"4470_CR26","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/(SICI)1097-4644(1997)28\/29+<159::AID-JCB19>3.0.CO;2-C","volume":"28\u201329","author":"LD Wang","year":"1997","unstructured":"Wang LD, Zhou Q, Yang CS (1997) Esophageal and gastric cardia epithelial cell proliferation in northern Chinese subjects living in a high-incidence area. J Cell Biochem Suppl 28\u201329:159\u2013165","journal-title":"J Cell Biochem Suppl"},{"issue":"6","key":"4470_CR27","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1442-2050.2006.00620.x","volume":"19","author":"LD Wang","year":"2006","unstructured":"Wang LD, Qin YR, Fan ZM, Kwong D, Guan XY, Tsao GS, Sham J, Li JL, Feng XS (2006) Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China. Dis Esophagus 19(6):459\u2013467. https:\/\/doi.org\/10.1111\/j.1442-2050.2006.00620.x","journal-title":"Dis Esophagus"},{"key":"4470_CR28","unstructured":"Wang QM, Yuan L, Qi YJ, Ma ZY, Wang LD (2010) Estrogen analogues: promising target for prevention and treatment of esophageal squamous cell carcinoma in high risk areas. Med Sci Monit 16(7):HY19\u201322"},{"issue":"1","key":"4470_CR29","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s12032-010-9457-8","volume":"28","author":"QM Wang","year":"2011","unstructured":"Wang QM, Qi YJ, Jiang Q, Ma YF, Wang LD (2011) Relevance of serum estradiol and estrogen receptor beta expression from a high-incidence area for esophageal squamous cell carcinoma in China. Med Oncol 28(1):188\u2013193. https:\/\/doi.org\/10.1007\/s12032-010-9457-8","journal-title":"Med Oncol"},{"issue":"8","key":"4470_CR30","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.jacc.2017.06.054","volume":"70","author":"B Xi","year":"2017","unstructured":"Xi B, Veeranki SP, Zhao M, Ma C, Yan Y, Mi J (2017) Relationship of alcohol consumption to all-cause, cardiovascular, and cancer-related mortality in US Adults. J Am Coll Cardiol 70(8):913\u2013922. https:\/\/doi.org\/10.1016\/j.jacc.2017.06.054","journal-title":"J Am Coll Cardiol"},{"key":"4470_CR31","doi-asserted-by":"publisher","unstructured":"Zhang LQ, Song X, Zhao XK, Huang J, Zhang P, Wang LW, Meng H, Ku JW, Kong GQ, Jiang T, Li XM, Lv XL, Ma T, Yuan G, Wu MJ, Hu SJ, Lv S, Zhang TJ, Ji LF, Fan ZM, Wang NC, Zhang YW, Zhou FY, Wang LD (2017a) Association of genotypes of rs671 withinALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas. Cancer Biol Med 14(1):60\u201365. https:\/\/doi.org\/10.20892\/j.issn.2095-3941.2016.0089","DOI":"10.20892\/j.issn.2095-3941.2016.0089"},{"key":"4470_CR32","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.biopha.2017.07.020","volume":"93","author":"D Zhang","year":"2017","unstructured":"Zhang D, Ku J, Liu R, Wu H, Liang G, Wei Y, Chen P, Zhao X, Liu S, Li Y, Yao J, Song X, Wang L (2017b) Characterization of serum estradiol level and tissue estrogen receptor immunostaining with clinical response and reproductive factor changes in Chinese female patients with esophageal squamous cell carcinoma. Biomed Pharmacother 93:879\u2013884. https:\/\/doi.org\/10.1016\/j.biopha.2017.07.020","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-022-04470-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-022-04470-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-022-04470-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T14:18:10Z","timestamp":1689430690000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-022-04470-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["4470"],"URL":"https:\/\/doi.org\/10.1007\/s00432-022-04470-8","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,14]]},"assertion":[{"value":"27 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Medical Ethics Committee of the First Affiliated Hospital of Zhengzhou University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The written informed consent was given to each patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}