{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:30:53Z","timestamp":1788820253691,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Posterior fossa tumor is a type of brain tumor that is located at the borders of both the brain stem and cerebellum. The cerebellum is the brain region in charge of balance and coordination. Pediatric patients diagnosed with posterior fossa tumor have been reported to fall frequently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study is to investigate the effectiveness of balance and coordination training in these children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized control clinical trial (ClinicalTrials.gov Identifier: NCT04528316) was carried out between September 2020 and April 2021 at Children\u2019s Cancer Hospital-57357. The inclusion criteria were patients with posterior fossa tumor in maintenance phase and, age between 5 and 12\u00a0years. The exclusion criteria were patients who had a genetic disorder or suffer from mental retardation, a chronic lung disease, severe cardiomyopathy, or a neuromuscular disease that does not relate to tumor. The study participants were randomly assigned into three groups: Group I\/Control group: they received Pilates core stability exercises program, Group II\/Postural stability group: they received the same program plus HUMAC balance program, and Group III\/Coordination group: they received the same program plus coordination exercises of BOT-2. The\u00a0semi-parametric proportional odds\u00a0model was used to compare follow-up scores of the Postural stability group vs Control, and Coordination group vs Control, while adjusting for baseline values. All tests were two sided, with alpha set to 0.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty children including 38 boys and 22 girls were enrolled in this study. In all three groups, postural stability and coordination improved significantly in terms of modified clinical test of sensory integration of balance, center of pressure, limits of stability, bilateral coordination, and upper-limb coordination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current study supports the value of adding postural stability and coordination training to the physiotherapy plan for children with posterior fossa tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number and date of registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier: NCT04528316 on August 27, 2020.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00432-022-04490-4","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T03:03:55Z","timestamp":1671159835000},"page":"5637-5644","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of physical activity on postural stability and coordination in children with posterior fossa tumor: randomized control phase III trial"],"prefix":"10.1007","volume":"149","clinical-trial-number":[{"clinical-trial-number":"nct04528316","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-1769","authenticated-orcid":false,"given":"Mahmoud","family":"Usama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten","family":"Abdelaziem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa M.","family":"Rashed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eslam","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El Beltagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Zekri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"4490_CR1","unstructured":"American Society of Clinical Oncology (2019) Exercise during cancer treatment. 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It was also approved by SMAC (Scientific and Medical Advisory Committee), CCHE 57357, Cairo on 13 November 2019. The study was approved by the institutional review board (IRB) at CCHE 57357 (CCHE-IRB: 6\/2020) (CHHE-IRB: 10\/2021), the ethics committee in the Central Directorate for Research and Health Development, Ministry of Health and Population (IORG0005704\/IRB0000687) and the Research Ethical Committee, Faculty of Physical Therapy, Cairo University (P.T.REC\/012\/002490).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants and their parents or relatives completed written consent forms after an explanation of the experimental methodology was given. Informed consent has been reviewed and approved by the IRB and CCHE. All patients\u2019 information was secured in REDCap Database.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"It was approved by central nervous system (CNS) study team members, CCHE 57357 on 3 July 2021. It was also approved by SMAC (Scientific and Medical Advisory Committee), CCHE 57357, Cairo.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}