{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:15:54Z","timestamp":1777508154037,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Intensity-modulated helical tomotherapy (HT) is a promising technique in preparation for bone marrow transplantation. Nevertheless, radiation-sensitive organs can be substantially compromised due to suboptimal delivery techniques of total body irradiation (TBI). To reduce the potential burden of radiation toxicity to organs at risk (OAR), high-quality coverage and homogeneity are essential. We investigated dosimetric data from kidney, lung and thorax, liver, and spleen in relation to peripheral blood kinetics. To further advance intensity-modulated total body irradiation (TBI), the potential for dose reduction to lung and kidney was considered in the analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Patients and methods<\/jats:title>\n                <jats:p>46 patients undergoing TBI were included in this analysis, partially divided into dose groups (2, 4, 8, and 12\u00a0Gy). HT was performed using a rotating gantry to ensuring optimal reduction of radiation to the lungs and kidneys and to provide optimal coverage of other OAR. Common dosimetric parameters, such as D05, D95, and D50, were calculated and analysed. Leukocytes, neutrophils, platelets, creatinine, GFR, haemoglobin, overall survival, and graft-versus-host disease were related to the dosimetric evaluation using statistical tests.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean D95 of the lung is 48.23%, less than half the prescribed and unreduced dose. The D95 of the chest is almost twice as high at 84.95%. Overall liver coverage values ranged from 96.79% for D95 to 107% for D05. The average dose sparing of all patients analysed resulted in an average D95 of 68.64% in the right kidney and 69.31% in the left kidney. Average D95 in the spleen was 94.28% and D05 was 107.05%. Homogeneity indexes ranged from 1.12 for liver to 2.28 for lung. The additional significance analyses conducted on these blood kinetics showed a significant difference between the 2 Gray group and the other three groups for leukocyte counts. Further statistical comparisons of the dose groups showed no significant differences. However, there were significant changes in the dose of OAR prescribed with dose sparing (e.g., lung vs. rib and kidney).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Using intensity-modulated helical tomotherapy to deliver TBI is a feasible method in preparation for haematopoietic stem cell transplantation. Significant dose sparing in radiosensitive organs such as the lungs and kidneys is achievable with good overall quality of coverage. Peripheral blood kinetics support the positive impact of HT and its advantages strongly encourage its implementation within clinical routine.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-023-04657-7","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T12:03:12Z","timestamp":1677672192000},"page":"7007-7015","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Whole body irradiation with intensity-modulated helical tomotherapy prior to haematopoietic stem cell transplantation: analysis of organs at risk by dose and its effect on blood kinetics"],"prefix":"10.1007","volume":"149","author":[{"given":"M\u00fcmtaz","family":"K\u00f6ksal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Baumert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Jazmati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Schoroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Garbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Scafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo R.","family":"Sarria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Leitzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Massoth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achilles","family":"Delis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annkristin","family":"Heine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Holderried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Brossart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"M\u00fcdder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard C.","family":"Schmeel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"issue":"6","key":"4657_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2021.100761","volume":"6","author":"M Alexandru","year":"2021","unstructured":"Alexandru M, Rodica A, Dragos-Eugen G, Mihai-Teodor G (2021) Assessing the spleen as an organ at risk in radiation therapy and its relationship with radiation-induced lymphopenia: a retrospective study and literature review. Adv Radiat Oncol 6(6):100761","journal-title":"Adv Radiat Oncol"},{"issue":"1","key":"4657_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jnci.2015.08.001","volume":"28","author":"R Benson","year":"2016","unstructured":"Benson R, Madan R, Kilambi R, Chander S (2016) Radiation induced liver disease: a clinical update. J Egypt Natl Canc Inst 28(1):7\u201311","journal-title":"J Egypt Natl Canc Inst"},{"issue":"4","key":"4657_CR3","doi-asserted-by":"publisher","first-page":"e183","DOI":"10.1016\/S2352-3026(19)30031-6","volume":"6","author":"J Bola\u00f1os-Meade","year":"2019","unstructured":"Bola\u00f1os-Meade J, Cooke KR, Gamper CJ, Ali SA, Ambinder RF, Borrello IM et al (2019) Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial. Lancet Haematol 6(4):e183\u2013e193","journal-title":"Lancet Haematol"},{"issue":"3","key":"4657_CR4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/bmt.2015.278","volume":"51","author":"X Cahu","year":"2016","unstructured":"Cahu X, Labopin M, Giebel S, Aljurf M, Kyrcz-Krzemien S, Soci\u00e9 G et al (2016) Impact of conditioning with TBI in adult patients with T-cell ALL who receive a myeloablative allogeneic stem cell transplantation: a report from the acute leukemia working party of EBMT. Bone Marrow Transplant 51(3):351\u2013357","journal-title":"Bone Marrow Transplant"},{"issue":"11","key":"4657_CR5","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1038\/sj.bjc.6601751","volume":"90","author":"SA Carruthers","year":"2004","unstructured":"Carruthers SA, Wallington MM (2004) Total body irradiation and pneumonitis risk: a review of outcomes. Br J Cancer 90(11):2080\u20132084","journal-title":"Br J Cancer"},{"issue":"2","key":"4657_CR6","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.ijrobp.2016.10.046","volume":"97","author":"AS Chadha","year":"2017","unstructured":"Chadha AS, Liu G, Chen HC, Das P, Minsky BD, Mahmood U et al (2017) Does unintentional splenic radiation predict outcomes after pancreatic cancer radiation therapy? Int J Radiat Oncol Biol Phys 97(2):323\u2013332","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"4657_CR7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.adro.2018.02.005","volume":"3","author":"AL Chin","year":"2018","unstructured":"Chin AL, Aggarwal S, Pradhan P, Bush K, von Eyben R, Koong AC et al (2018) The role of bone marrow and spleen irradiation in the development of acute hematologic toxicity during chemoradiation for esophageal cancer. Adv Radiat Oncol 3(3):297\u2013304","journal-title":"Adv Radiat Oncol"},{"issue":"5","key":"4657_CR8","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","volume":"31","author":"JD Cox","year":"1995","unstructured":"Cox JD, Stetz J, Pajak TF (1995) Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC). Int J Radiat Oncol Biol Phys 31(5):1341\u20131346","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"9","key":"4657_CR9","doi-asserted-by":"publisher","first-page":"4859","DOI":"10.21873\/anticanres.11049","volume":"36","author":"F De Felice","year":"2016","unstructured":"De Felice F, Grapulin L, Musio D, Pomponi J, Di Felice C, Iori AP et al (2016) Treatment complications and long-term outcomes of total body irradiation in patients with acute lymphoblastic leukemia: a single institute experience. AR 36(9):4859\u20134864","journal-title":"AR"},{"key":"4657_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5452","author":"CS Dejonckheere","year":"2022","unstructured":"Dejonckheere CS, B\u00f6hner AMC, Schmitz E, Holderried TAW, Schmeel LC, Brossart P et al (2022) Peripheral blood kinetics following total body irradiation and allogeneic hematopoietic stem cell transplantation: Timing matters. Cancer Med. https:\/\/doi.org\/10.1002\/cam4.5452","journal-title":"Cancer Med"},{"issue":"1","key":"4657_CR11","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/1748-717X-8-92","volume":"8","author":"A Gruen","year":"2013","unstructured":"Gruen A, Ebell W, Wlodarczyk W, Neumann O, Kuehl JS, Stromberger C et al (2013) Total body irradiation (TBI) using helical tomotherapy in children and young adults undergoing stem cell transplantation. Radiat Oncol 8(1):92","journal-title":"Radiat Oncol"},{"key":"4657_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ejmp.2019.03.032","volume":"60","author":"A Haraldsson","year":"2019","unstructured":"Haraldsson A, Engellau J, Lenhoff S, Engelholm S, B\u00e4ck S, Engstr\u00f6m PE (2019) Implementing safe and robust total marrow irradiation using helical tomotherapy \u2013 a practical guide. Phys Med 60:162\u2013167","journal-title":"Phys Med"},{"issue":"4","key":"4657_CR13","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/ejh.13675","volume":"107","author":"A Haraldsson","year":"2021","unstructured":"Haraldsson A, Wichert S, Engstr\u00f6m PE, Lenhoff S, Turkiewicz D, Warsi S et al (2021) Organ sparing total marrow irradiation compared to total body irradiation prior to allogeneic stem cell transplantation. Eur J Haematol 107(4):393\u2013407","journal-title":"Eur J Haematol"},{"issue":"10","key":"4657_CR14","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1118\/1.2044428","volume":"32","author":"SK Hui","year":"2005","unstructured":"Hui SK, Kapatoes J, Fowler J, Henderson D, Olivera G, Manon RR et al (2005) Feasibility study of helical tomotherapy for total body or total marrow irradiationa): TBI and TMI using helical tomotherapy. Med Phys 32(10):3214\u20133224","journal-title":"Med Phys"},{"issue":"4","key":"4657_CR15","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1016\/j.ijrobp.2006.02.021","volume":"65","author":"HB Kal","year":"2006","unstructured":"Kal HB, van Kempen-Harteveld ML (2006) Renal dysfunction after total body irradiation: dose\u2013effect relationship. Int J Radiat Oncol Biol Phys 65(4):1228\u20131232","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"4657_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4103\/0971-6203.103606","volume":"37","author":"T Kataria","year":"2012","unstructured":"Kataria T, Sharma K, Subramani V, Karrthick K, Bisht S (2012) Homogeneity index: an objective tool for assessment of conformal radiation treatments. J Med Phys 37(4):207","journal-title":"J Med Phys"},{"issue":"6","key":"4657_CR17","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.semnephrol.2010.09.009","volume":"30","author":"A Kogon","year":"2010","unstructured":"Kogon A, Hingorani S (2010) Acute kidney injury in hematopoietic cell transplantation. Semin Nephrol 30(6):615\u2013626","journal-title":"Semin Nephrol"},{"issue":"1","key":"4657_CR18","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s40001-022-00886-7","volume":"27","author":"M K\u00f6ksal","year":"2022","unstructured":"K\u00f6ksal M, Baumert J, Schoroth F, M\u00fcdder T, Scafa D, Koch D et al (2022) Helical versus static approaches to delivering tomotherapy to the junctional target for patients taller than 135 cm undergoing total body irradiation. Eur J Med Res 27(1):265","journal-title":"Eur J Med Res"},{"issue":"1","key":"4657_CR19","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s40001-022-00918-2","volume":"27","author":"M K\u00f6ksal","year":"2022","unstructured":"K\u00f6ksal M, Baumert J, Schoroth F, Scafa D, Koch D, Leitzen C et al (2022) Lung sparing and ribcage coverage in total body irradiation delivered by helical tomotherapy. Eur J Med Res 27(1):287","journal-title":"Eur J Med Res"},{"key":"4657_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04565-2","author":"M K\u00f6ksal","year":"2023","unstructured":"K\u00f6ksal M, Kersting L, Schoroth F, Garbe S, Koch D, Scafa D et al (2023) Total marrow irradiation versus total body irradiation using intensity-modulated helical tomotherapy. J Cancer Res Clin Oncol. https:\/\/doi.org\/10.1007\/s00432-022-04565-2","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"4657_CR21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.4143\/crt.2015.476","volume":"49","author":"CH Maeng","year":"2017","unstructured":"Maeng CH, Ko YH, Lim DH, Kang ES, Choi JY, Kim WS et al (2017) Comparison of total body irradiation (TBI) conditioning with non-TBI for autologous stem cell transplantation in newly diagnosed or relapsed mature T- and NK-cell non-Hodgkin lymphoma. Cancer Res Treat 49(1):92\u2013103","journal-title":"Cancer Res Treat"},{"issue":"3","key":"4657_CR22","doi-asserted-by":"publisher","first-page":"S70","DOI":"10.1016\/j.ijrobp.2009.06.091","volume":"76","author":"LB Marks","year":"2010","unstructured":"Marks LB, Bentzen SM, Deasy JO, Kong FM, Bradley JD, Vogelius IS et al (2010) Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys 76(3):S70\u2013S76","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"4657_CR23","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00066-014-0607-3","volume":"190","author":"S Marnitz","year":"2014","unstructured":"Marnitz S, Zich A, Martus P, Budach V, Jahn U, Neumann O et al (2014) Long-term results of total body irradiation in adults with acute lymphoblastic leukemia. Strahlenther Onkol 190(5):453\u2013458","journal-title":"Strahlenther Onkol"},{"issue":"12","key":"4657_CR24","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.3390\/cancers13122946","volume":"13","author":"M Oertel","year":"2021","unstructured":"Oertel M, Kittel C, Martel J, Mikesch JH, Glashoerster M, Stelljes M et al (2021) Pulmonary toxicity after total body irradiation\u2014an underrated complication? Estimation of risk via normal tissue complication probability calculations and correlation with clinical data. Cancers 13(12):2946","journal-title":"Cancers"},{"issue":"7","key":"4657_CR25","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/bmt.2010.237","volume":"46","author":"JA Pe\u00f1agar\u00edcano","year":"2011","unstructured":"Pe\u00f1agar\u00edcano JA, Chao M, Van Rhee F, Moros EG, Corry PM, Ratanatharathorn V (2011) Clinical feasibility of TBI with helical tomotherapy. Bone Marrow Transplant 46(7):929\u2013935","journal-title":"Bone Marrow Transplant"},{"issue":"27","key":"4657_CR26","doi-asserted-by":"publisher","first-page":"4570","DOI":"10.1200\/JCO.2008.20.9692","volume":"27","author":"O Ringd\u00e9n","year":"2009","unstructured":"Ringd\u00e9n O, Labopin M, Ehninger G, Niederwieser D, Olsson R, Basara N et al (2009) Reduced intensity conditioning compared with myeloablative conditioning using unrelated donor transplants in patients with acute myeloid leukemia. JCO 27(27):4570\u20134577","journal-title":"JCO"},{"issue":"1","key":"4657_CR27","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3390\/curroncol28010089","volume":"28","author":"M Sabloff","year":"2021","unstructured":"Sabloff M, Tisseverasinghe S, Babadagli ME, Samant R (2021) Total body irradiation for hematopoietic stem cell transplantation: what can we agree on? Curr Oncol 28(1):903\u2013917","journal-title":"Curr Oncol"},{"issue":"1","key":"4657_CR28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1053\/j.ackd.2013.08.007","volume":"21","author":"D Sawinski","year":"2014","unstructured":"Sawinski D (2014) The kidney effects of hematopoietic stem cell transplantation. Adv Chronic Kidney Dis 21(1):96\u2013105","journal-title":"Adv Chronic Kidney Dis"},{"issue":"1","key":"4657_CR29","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/cancers13010022","volume":"13","author":"C Schr\u00f6der","year":"2020","unstructured":"Schr\u00f6der C, Buchali A, Windisch P, Vu E, Basler L, Zwahlen DR et al (2020) Impact of low-dose irradiation of the lung and heart on toxicity and pulmonary function parameters after thoracic radiotherapy. Cancers 13(1):22","journal-title":"Cancers"},{"issue":"4","key":"4657_CR30","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.ijrobp.2006.10.047","volume":"67","author":"TE Schultheiss","year":"2007","unstructured":"Schultheiss TE, Wong J, Liu A, Olivera G, Somlo G (2007) Image-guided total marrow and total lymphatic irradiation using helical tomotherapy. Int J Radiat Oncol Biol Phys 67(4):1259\u20131267","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"4657_CR31","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.ijrobp.2019.08.010","volume":"105","author":"A Shinde","year":"2019","unstructured":"Shinde A, Yang D, Frankel P, Liu A, Han C, Del Vecchio B et al (2019) Radiation-related toxicities using organ sparing total marrow irradiation transplant conditioning regimens. Int J Radiat Oncol Biol Phys 105(5):1025\u20131033","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"4657_CR32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1177\/153303460900800105","volume":"8","author":"PW Shueng","year":"2009","unstructured":"Shueng PW, Lin SC, Chong NS, Lee HY, Tien HJ, Wu LJ et al (2009) Total marrow irradiation with helical tomotherapy for bone marrow transplantation of multiple myeloma: first experience in Asia. Technol Cancer Res Treat 8(1):29\u201337","journal-title":"Technol Cancer Res Treat"},{"issue":"5","key":"4657_CR33","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/bmt.2008.1","volume":"41","author":"A Stein","year":"2008","unstructured":"Stein A, Forman SJ (2008) Allogeneic transplantation for ALL in adults. Bone Marrow Transplant 41(5):439\u2013446","journal-title":"Bone Marrow Transplant"},{"issue":"10","key":"4657_CR34","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1182\/blood.V93.10.3259.410k13_3259_3266","volume":"93","author":"SI Strasser","year":"1999","unstructured":"Strasser SI, Sullivan KM, Myerson D, Spurgeon CL, Storer B, Schoch HG et al (1999) Cirrhosis of the liver in long-term marrow transplant survivors. Blood 93(10):3259\u20133266","journal-title":"Blood"},{"issue":"4","key":"4657_CR35","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s11604-018-0728-1","volume":"36","author":"S Takamatsu","year":"2018","unstructured":"Takamatsu S, Kozaka K, Kobayashi S, Yoneda N, Yoshida K, Inoue D et al (2018) Pathology and images of radiation-induced hepatitis: a review article. Jpn J Radiol 36(4):241\u2013256","journal-title":"Jpn J Radiol"},{"key":"4657_CR36","unstructured":"The spleen as an organ at risk in paediatric radiotherapy: a SIOP-Europe radiation oncology working group report. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33271483\/"},{"issue":"1","key":"4657_CR37","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.zemedi.2019.05.002","volume":"30","author":"T Wilhelm-Buchstab","year":"2020","unstructured":"Wilhelm-Buchstab T, Leitzen C, Schmeel LC, Simon B, Koch D, Schmeel FC et al (2020) Total body irradiation: significant dose sparing of lung tissue achievable by helical tomotherapy. Z Med Phys 30(1):17\u201323","journal-title":"Z Med Phys"},{"issue":"1","key":"4657_CR38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ijrobp.2008.04.071","volume":"73","author":"JYC Wong","year":"2009","unstructured":"Wong JYC, Rosenthal J, Liu A, Schultheiss T, Forman S, Somlo G (2009) Image-Guided Total-Marrow Irradiation Using Helical Tomotherapy in Patients With Multiple Myeloma and Acute Leukemia Undergoing Hematopoietic Cell Transplantation. Int J Radiat Oncol Biol Phys 73(1):273\u2013279","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"4657_CR39","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ijrobp.2018.04.071","volume":"101","author":"JYC Wong","year":"2018","unstructured":"Wong JYC, Filippi AR, Dabaja BS, Yahalom J, Specht L (2018) Total body irradiation: guidelines from the international lymphoma radiation oncology group (ILROG). Int J Radiat Oncol Biol Phys 101(3):521\u2013529","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"4657_CR40","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1038\/bmt.2012.53","volume":"47","author":"A Xhaard","year":"2012","unstructured":"Xhaard A, Nahon P, Robin M, Baudry C, Ades L, de Latour RP et al (2012) Hepatic GVHD leading to cirrhosis after allogeneic hematopoietic SCT. Bone Marrow Transplant 47(11):1484\u20131485","journal-title":"Bone Marrow Transplant"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-04657-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-023-04657-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-04657-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T17:15:41Z","timestamp":1690478141000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-023-04657-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["4657"],"URL":"https:\/\/doi.org\/10.1007\/s00432-023-04657-7","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]},"assertion":[{"value":"25 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"As this analysis was conducted for routine quality assurance in line with requirements of the German radiation protection law, ethical approval was not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All data relevant to this publication have been included into the manuscript\u2019s body.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and materials"}}]}}