{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:08:26Z","timestamp":1763536106535,"version":"3.37.3"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Major science and technology project of Sichuan Province-Sichuan Province \"14th Five-Year Plan\" life and health major science and technology project","award":["No.2022ZDZX0033","No.2022ZDZX0033","No.2022ZDZX0033","No.2022ZDZX0033","No.2022ZDZX0033","No.2022ZDZX0033"],"award-info":[{"award-number":["No.2022ZDZX0033","No.2022ZDZX0033","No.2022ZDZX0033","No.2022ZDZX0033","No.2022ZDZX0033","No.2022ZDZX0033"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s00432-023-04680-8","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T22:16:42Z","timestamp":1679869002000},"page":"7259-7273","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The evaluation of tumor microenvironment infiltration and the identification of angiogenesis-related subgroups in skin cutaneous melanoma"],"prefix":"10.1007","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7233-059X","authenticated-orcid":false,"given":"Junpeng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangjun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Huai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-6872","authenticated-orcid":false,"given":"Xiaolu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"4680_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ejcsup.2013.07.012","volume":"11","author":"Z Ali","year":"2013","unstructured":"Ali Z, Yousaf N, Larkin J (2013) Melanoma epidemiology, biology and prognosis. EJC Suppl 11:81\u201391. https:\/\/doi.org\/10.1016\/j.ejcsup.2013.07.012","journal-title":"EJC Suppl"},{"key":"4680_CR2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s13402-020-00501-z","volume":"43","author":"H Bagheri","year":"2020","unstructured":"Bagheri H, Pourhanifeh MH, Derakhshan M et al (2020b) CXCL-10 a new candidate for melanoma therapy? Cell Oncol (dordr) 43:353\u2013365. https:\/\/doi.org\/10.1007\/s13402-020-00501-z","journal-title":"Cell Oncol (dordr)"},{"key":"4680_CR3","doi-asserted-by":"publisher","first-page":"424","DOI":"10.3389\/fonc.2020.00424","volume":"10","author":"KW Bi","year":"2020","unstructured":"Bi KW, Wei XG, Qin XX et al (2020) BTK has potential to be a prognostic factor for lung adenocarcinoma and an indicator for tumor microenvironment remodeling a study based on TCGA data mining. Front Oncol 10:424. https:\/\/doi.org\/10.3389\/fonc.2020.00424","journal-title":"Front Oncol"},{"key":"4680_CR4","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2018.29.e40","volume":"29","author":"G Bogani","year":"2018","unstructured":"Bogani G, Tagliabue E, Signorelli M et al (2018) A score system for complete cytoreduction in selected recurrent ovarian cancer patients undergoing secondary cytoreductive surgery predictors- and nomogram-based analyses. J Gynecol Oncol 29:e40. https:\/\/doi.org\/10.3802\/jgo.2018.29.e40","journal-title":"J Gynecol Oncol"},{"key":"4680_CR5","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018 GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394\u2013424. https:\/\/doi.org\/10.3322\/caac.21492","journal-title":"CA Cancer J Clin"},{"key":"4680_CR6","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10144","volume":"473","author":"P Carmeliet","year":"2011","unstructured":"Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298\u2013307. https:\/\/doi.org\/10.1038\/nature10144","journal-title":"Nature"},{"key":"4680_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.suc.2019.09.005","volume":"100","author":"S Carr","year":"2020","unstructured":"Carr S, Smith C, Wernberg J (2020) Epidemiology and risk factors of melanoma. Surg Clin North Am 100:1\u201312. https:\/\/doi.org\/10.1016\/j.suc.2019.09.005","journal-title":"Surg Clin North Am"},{"key":"4680_CR8","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3389\/fonc.2019.00361","volume":"9","author":"S Chen","year":"2019","unstructured":"Chen S, Liu Y, Yang J et al (2019) Development and validation of a nomogram for predicting survival in male patients with breast cancer. Front Oncol 9:361. https:\/\/doi.org\/10.3389\/fonc.2019.00361","journal-title":"Front Oncol"},{"key":"4680_CR9","doi-asserted-by":"publisher","first-page":"13225","DOI":"10.18632\/aging.203003","volume":"13","author":"J Chen","year":"2021","unstructured":"Chen J, Huang L, Quan J et al (2021) TRIM14 regulates melanoma malignancy via PTEN\/PI3K\/AKT and STAT3 pathways. Aging (albany NY). 13:13225\u201313238. https:\/\/doi.org\/10.18632\/aging.203003","journal-title":"Aging (albany NY)."},{"key":"4680_CR10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.semcancer.2019.06.015","volume":"59","author":"WC Cho","year":"2019","unstructured":"Cho WC, Jour G, Aung PP (2019) Role of angiogenesis in melanoma progression Update on key angiogenic mechanisms and other associated components. Semin Cancer Biol 59:175\u2013186. https:\/\/doi.org\/10.1016\/j.semcancer.2019.06.015","journal-title":"Semin Cancer Biol"},{"key":"4680_CR11","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/546927","volume":"2012","author":"D Dewing","year":"2012","unstructured":"Dewing D, Emmett M, Pritchard Jones R (2012) The roles of angiogenesis in malignant melanoma trends in basic science research over the last 100 years. ISRN Oncol. 2012:546927. https:\/\/doi.org\/10.5402\/2012\/546927","journal-title":"ISRN Oncol."},{"key":"4680_CR12","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s00709-016-1038-z","volume":"254","author":"B Dvo\u0159\u00e1nkov\u00e1","year":"2017","unstructured":"Dvo\u0159\u00e1nkov\u00e1 B, Szabo P, Kodet O et al (2017) Intercellular crosstalk in human malignant melanoma. Protoplasma 254:1143\u20131150. https:\/\/doi.org\/10.1007\/s00709-016-1038-z","journal-title":"Protoplasma"},{"key":"4680_CR13","first-page":"852","volume":"1","author":"MS Emmett","year":"2011","unstructured":"Emmett MS, Dewing D, Pritchard-Jones RO (2011a) Angiogenesis and melanoma - from basic science to clinical trials. Am J Cancer Res 1:852\u2013868","journal-title":"Am J Cancer Res"},{"key":"4680_CR14","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1056\/nejm197111182852108","volume":"285","author":"J Folkman","year":"1971","unstructured":"Folkman J (1971) Tumor angiogenesis therapeutic implications. N Engl J Med 285:1182\u20131186. https:\/\/doi.org\/10.1056\/nejm197111182852108","journal-title":"N Engl J Med"},{"key":"4680_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1053\/sonc.2002.37263","volume":"29","author":"J Folkman","year":"2002","unstructured":"Folkman J (2002) Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29:15\u201318. https:\/\/doi.org\/10.1053\/sonc.2002.37263","journal-title":"Semin Oncol"},{"key":"4680_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv381","author":"JE Gershenwald","year":"2016","unstructured":"Gershenwald JE, Guy GP Jr (2016) Stemming the rising incidence of melanoma calling prevention to action. J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/djv381","journal-title":"J Natl Cancer Inst"},{"key":"4680_CR17","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/cmr.0000000000000571","volume":"29","author":"HZ Gong","year":"2019","unstructured":"Gong HZ, Zheng HY, Li J (2019b) Amelanotic melanoma. Melanoma Res 29:221\u2013230. https:\/\/doi.org\/10.1097\/cmr.0000000000000571","journal-title":"Melanoma Res"},{"key":"4680_CR18","doi-asserted-by":"publisher","first-page":"4186","DOI":"10.1038\/s41467-019-12160-2","volume":"10","author":"J Griss","year":"2019","unstructured":"Griss J, Bauer W, Wagner C et al (2019) B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. Nat Commun 10:4186. https:\/\/doi.org\/10.1038\/s41467-019-12160-2","journal-title":"Nat Commun"},{"key":"4680_CR19","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13046-018-0763-x","volume":"37","author":"R Huang","year":"2018","unstructured":"Huang R, Rofstad EK (2018) Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma. J Exp Clin Cancer Res 37:92. https:\/\/doi.org\/10.1186\/s13046-018-0763-x","journal-title":"J Exp Clin Cancer Res"},{"key":"4680_CR20","doi-asserted-by":"publisher","first-page":"6966","DOI":"10.18632\/aging.103054","volume":"12","author":"R Huang","year":"2020","unstructured":"Huang R, Mao M, Lu Y et al (2020) A novel immune-related genes prognosis biomarker for melanoma associated with tumor microenvironment. Aging (albany NY) 12:6966\u20136980. https:\/\/doi.org\/10.18632\/aging.103054","journal-title":"Aging (albany NY)"},{"key":"4680_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210399","volume":"14","author":"E Hugdahl","year":"2019","unstructured":"Hugdahl E, Bachmann IM, Schuster C et al (2019) Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma. PLoS ONE 14:e0210399. https:\/\/doi.org\/10.1371\/journal.pone.0210399","journal-title":"PLoS ONE"},{"key":"4680_CR22","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1136\/jclinpath-2015-203482","volume":"69","author":"G Jour","year":"2016","unstructured":"Jour G, Ivan D, Aung PP (2016) Angiogenesis in melanoma an update with a focus on current targeted therapies. J Clin Pathol 69:472\u2013483. https:\/\/doi.org\/10.1136\/jclinpath-2015-203482","journal-title":"J Clin Pathol"},{"key":"4680_CR23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s12272-022-01389-z","volume":"45","author":"HJ Kim","year":"2022","unstructured":"Kim HJ, Ji YR, Lee YM (2022) Crosstalk between angiogenesis and immune regulation in the tumor microenvironment. Arch Pharm Res 45:401\u2013416. https:\/\/doi.org\/10.1007\/s12272-022-01389-z","journal-title":"Arch Pharm Res"},{"key":"4680_CR24","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10456-020-09754-6","volume":"24","author":"M Kobayashi","year":"2021","unstructured":"Kobayashi M, Wakabayashi I, Suzuki Y et al (2021) Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors. Angiogenesis 24:159\u2013176. https:\/\/doi.org\/10.1007\/s10456-020-09754-6","journal-title":"Angiogenesis"},{"key":"4680_CR25","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1093\/jnci\/djr077","volume":"103","author":"BA Kohler","year":"2011","unstructured":"Kohler BA, Ward E, McCarthy BJ et al (2011) Annual report to the nation on the status of cancer, 1975\u20132007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 103:714\u2013736. https:\/\/doi.org\/10.1093\/jnci\/djr077","journal-title":"J Natl Cancer Inst"},{"key":"4680_CR26","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1097\/SLA.0b013e31822a72dc","volume":"254","author":"ZJ Liu","year":"2011","unstructured":"Liu ZJ, Tian R, Li Y et al (2011) Inhibition of tumor angiogenesis and melanoma growth by targeting vascular E-selectin. Ann Surg 254:450\u2013456. https:\/\/doi.org\/10.1097\/SLA.0b013e31822a72dc","journal-title":"Ann Surg"},{"key":"4680_CR27","doi-asserted-by":"publisher","first-page":"20493","DOI":"10.1038\/s41598-020-77568-z","volume":"10","author":"H Liu","year":"2020","unstructured":"Liu H, Qiu Y, Pei X et al (2020) Endothelial specific YY1 deletion restricts tumor angiogenesis and tumor growth. Sci Rep 10:20493. https:\/\/doi.org\/10.1038\/s41598-020-77568-z","journal-title":"Sci Rep"},{"key":"4680_CR28","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1089\/ten.TEB.2009.0085","volume":"15","author":"M Lovett","year":"2009","unstructured":"Lovett M, Lee K, Edwards A et al (2009) Vascularization strategies for tissue engineering. Tissue Eng Part B Rev 15:353\u2013370. https:\/\/doi.org\/10.1089\/ten.TEB.2009.0085","journal-title":"Tissue Eng Part B Rev"},{"key":"4680_CR29","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.hoc.2009.03.007","volume":"23","author":"AG Marneros","year":"2009","unstructured":"Marneros AG (2009) Tumor angiogenesis in melanoma. Hematol Oncol Clin North Am 23:431\u2013446. https:\/\/doi.org\/10.1016\/j.hoc.2009.03.007","journal-title":"Hematol Oncol Clin North Am"},{"key":"4680_CR30","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/j.ccell.2021.11.010","volume":"39","author":"DY Oh","year":"2021","unstructured":"Oh DY, Fong L, Newell EW et al (2021) Toward a better understanding of T cells in cancer. Cancer Cell 39:1549\u20131552. https:\/\/doi.org\/10.1016\/j.ccell.2021.11.010","journal-title":"Cancer Cell"},{"key":"4680_CR31","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1001\/jamadermatol.2020.0470","volume":"156","author":"CM Olsen","year":"2020","unstructured":"Olsen CM, Thompson JF, Pandeya N et al (2020) Evaluation of sex-specific incidence of melanoma. JAMA Dermatol 156:553\u2013560. https:\/\/doi.org\/10.1001\/jamadermatol.2020.0470","journal-title":"JAMA Dermatol"},{"key":"4680_CR32","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s10456-021-09829-y","volume":"25","author":"Y Onetti","year":"2022","unstructured":"Onetti Y, K\u00e4lin RE, Pitter B et al (2022) Deletion of endothelial \u03b1-parvin inhibits tumour angiogenesis, reduces tumour growth and induces tumour cell apoptosis. Angiogenesis 25:155\u2013158. https:\/\/doi.org\/10.1007\/s10456-021-09829-y","journal-title":"Angiogenesis"},{"key":"4680_CR33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3389\/fphys.2013.00159","volume":"4","author":"JL Owen","year":"2013","unstructured":"Owen JL, Mohamadzadeh M (2013) Macrophages and chemokines as mediators of angiogenesis. Front Physiol 4:159. https:\/\/doi.org\/10.3389\/fphys.2013.00159","journal-title":"Front Physiol"},{"key":"4680_CR34","first-page":"1005","volume":"28","author":"M Rastrelli","year":"2014","unstructured":"Rastrelli M, Tropea S, Rossi CR et al (2014) Melanoma epidemiology, risk factors, pathogenesis, diagnosis and classification. In Vivo 28:1005\u20131011","journal-title":"In Vivo"},{"key":"4680_CR35","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/185687","volume":"2010","author":"R Ria","year":"2010","unstructured":"Ria R, Reale A, Castrovilli A et al (2010) Angiogenesis and progression in human melanoma. Dermatol Res Pract 2010:185687. https:\/\/doi.org\/10.1155\/2010\/185687","journal-title":"Dermatol Res Pract"},{"key":"4680_CR36","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/sj.neo.7900038","volume":"1","author":"D Ribatti","year":"1999","unstructured":"Ribatti D, Vacca A, Dammacco F (1999) The role of the vascular phase in solid tumor growth a historical review. Neoplasia 1:293\u2013302. https:\/\/doi.org\/10.1038\/sj.neo.7900038","journal-title":"Neoplasia"},{"key":"4680_CR37","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aak9670","author":"M Schmittnaegel","year":"2017","unstructured":"Schmittnaegel M, Rigamonti N, Kadioglu E et al (2017) Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.aak9670","journal-title":"Sci Transl Med"},{"key":"4680_CR38","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13073-019-0647-5","volume":"11","author":"SR Selitsky","year":"2019","unstructured":"Selitsky SR, Mose LE, Smith CC et al (2019) Prognostic value of B cells in cutaneous melanoma. Genome Med 11:36. https:\/\/doi.org\/10.1186\/s13073-019-0647-5","journal-title":"Genome Med"},{"key":"4680_CR39","doi-asserted-by":"publisher","first-page":"107327481878936","DOI":"10.1177\/1073274818789361","volume":"25","author":"K Suyama","year":"2018","unstructured":"Suyama K, Iwase H (2018) Lenvatinib A promising molecular targeted agent for multiple cancers. Cancer Control 25:1073274818789361. https:\/\/doi.org\/10.1177\/1073274818789361","journal-title":"Cancer Control"},{"key":"4680_CR40","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10456-017-9562-9","volume":"20","author":"C Viallard","year":"2017","unstructured":"Viallard C, Larriv\u00e9e B (2017) Tumor angiogenesis and vascular normalization alternative therapeutic targets. Angiogenesis 20:409\u2013426. https:\/\/doi.org\/10.1007\/s10456-017-9562-9","journal-title":"Angiogenesis"},{"key":"4680_CR41","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s10585-007-9093-7","volume":"24","author":"P Vihinen","year":"2007","unstructured":"Vihinen P, Kallioinen M, Vuoristo MS et al (2007) Serum angiogenin levels predict treatment response in patients with stage IV melanoma. Clin Exp Metastasis 24:567\u2013574. https:\/\/doi.org\/10.1007\/s10585-007-9093-7","journal-title":"Clin Exp Metastasis"},{"key":"4680_CR42","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.3889\/oamjms.2019.781","volume":"7","author":"A Vojvodic","year":"2019","unstructured":"Vojvodic A, Vojvodic P, Vlaskovic-Jovicevic T et al (2019) Beta blockers and melanoma. Open Access Maced J Med Sci. 7:3110\u20133112. https:\/\/doi.org\/10.3889\/oamjms.2019.781","journal-title":"Open Access Maced J Med Sci."},{"key":"4680_CR43","first-page":"464","volume":"15","author":"BA Warren","year":"1966","unstructured":"Warren BA, Shubik P (1966) The growth of the blood supply to melanoma transplants in the hamster cheek pouch. Lab Invest 15:464\u2013478","journal-title":"Lab Invest"},{"key":"4680_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11071238","author":"F Werner","year":"2021","unstructured":"Werner F, Wagner C, Simon M et al (2021) Loss of lymphotoxin alpha-expressing memory B cells correlates with metastasis of human primary melanoma. Diagnostics (basel). https:\/\/doi.org\/10.3390\/diagnostics11071238","journal-title":"Diagnostics (basel)"},{"key":"4680_CR45","doi-asserted-by":"publisher","first-page":"8562","DOI":"10.1002\/cam4.3318","volume":"9","author":"Y Xiao","year":"2020","unstructured":"Xiao Y, Peng S, Hu Y et al (2020) Development and validation of prognostic nomogram in patients with nonmetastatic malignant melanoma a SEER population-based study. Cancer Med 9:8562\u20138570. https:\/\/doi.org\/10.1002\/cam4.3318","journal-title":"Cancer Med"},{"key":"4680_CR46","doi-asserted-by":"publisher","first-page":"5091","DOI":"10.3892\/ol.2018.9247","volume":"16","author":"Z Xu","year":"2018","unstructured":"Xu Z, Shi P, Yibulayin F et al (2018a) Spindle cell melanoma incidence and survival, 1973\u20132017. Oncol Lett 16:5091\u20135099. https:\/\/doi.org\/10.3892\/ol.2018.9247","journal-title":"Oncol Lett"},{"key":"4680_CR47","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000011563","volume":"97","author":"Z Xu","year":"2018","unstructured":"Xu Z, Yibulayin F, Shi P et al (2018b) Desmoplastic melanoma versus spindle cell melanoma Incidence and survival, 1973 to 2017. Medicine (baltimore) 97:e11563. https:\/\/doi.org\/10.1097\/md.0000000000011563","journal-title":"Medicine (baltimore)"},{"key":"4680_CR48","doi-asserted-by":"publisher","first-page":"641","DOI":"10.21037\/atm.2019.10.77","volume":"7","author":"C Yu","year":"2019","unstructured":"Yu C, Zhang Y (2019) Development and validation of prognostic nomogram for young patients with gastric cancer. Ann Transl Med 7:641. https:\/\/doi.org\/10.21037\/atm.2019.10.77","journal-title":"Ann Transl Med"},{"key":"4680_CR49","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1634\/theoncologist.2014-0465","volume":"20","author":"Y Zhao","year":"2015","unstructured":"Zhao Y, Adjei AA (2015) Targeting angiogenesis in cancer therapy moving beyond vascular endothelial growth factor. Oncologist 20:660\u2013673. https:\/\/doi.org\/10.1634\/theoncologist.2014-0465","journal-title":"Oncologist"},{"key":"4680_CR50","doi-asserted-by":"publisher","first-page":"7876","DOI":"10.3390\/ijms16047876","volume":"16","author":"V Zidlik","year":"2015","unstructured":"Zidlik V, Brychtova S, Uvirova M et al (2015) The changes of angiogenesis and immune cell infiltration in the intra- and peri-tumoral melanoma microenvironment. Int J Mol Sci 16:7876\u20137889. https:\/\/doi.org\/10.3390\/ijms16047876","journal-title":"Int J Mol Sci"},{"key":"4680_CR51","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.18632\/aging.203895","volume":"14","author":"S Zou","year":"2022","unstructured":"Zou S, Zhang Y, Zhang L et al (2022) Construction and validation of a prognostic risk model of angiogenesis factors in skin cutaneous melanoma. Aging (albany NY). 14:1529\u20131548. https:\/\/doi.org\/10.18632\/aging.203895","journal-title":"Aging (albany NY)."}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-04680-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-023-04680-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-04680-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T17:28:08Z","timestamp":1690478888000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-023-04680-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["4680"],"URL":"https:\/\/doi.org\/10.1007\/s00432-023-04680-8","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"type":"print","value":"0171-5216"},{"type":"electronic","value":"1432-1335"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"assertion":[{"value":"31 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This is an observational study. The Research Ethics Committee of Sichuan Academy of Chinese Medicine Sciences has confirmed that no ethical approval is required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Our manuscript does not contain any individual data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}