{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:42:09Z","timestamp":1779108129328,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Poor pulmonary function and chronic obstructive pulmonary disease (COPD) are associated with poorer overall survival (OS) in non-small-cell lung cancer (NSCLC) patients. Few studies have investigated the association between pulmonary function and OS in small-cell lung cancer (SCLC) patients. We compared the clinical characteristics of extensive disease SCLC (ED-SCLC) with or without moderately impaired diffusion capacity for carbon monoxide (DLco) and investigated the factors associated with survival in ED-SCLC patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective single-center study was performed between January 2011 and December 2020. Of the 307 SCLC patients who received cancer therapy during the study, 142 with ED-SCLC were analyzed. The patients were divided into DLco\u2009&lt;\u200960% group and DLco\u2009\u2265\u200960% groups. OS and predictors of poor OS were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The median OS of the 142 ED-SCLC patients was 9.3\u00a0months and the median age was 68\u00a0years. In total, 129 (90.8%) patients had a history of smoking, and 60 (42.3%) had COPD. Thirty-five (24.6%) patients were assigned to the DLco\u2009&lt;\u200960% group. Multivariate analysis revealed that DLco\u2009&lt;\u200960% (odds ratio [OR], 1.609; 95% confidence interval [CI], 1.062\u20132.437; P\u2009=\u20090.025), number of metastases (OR, 1.488; 95% CI, 1.262\u20131.756; P\u2009&lt;\u20090.001), and\u2009&lt;\u20094 cycles of first-line chemotherapy (OR, 3.793; 95% CI, 2.530\u20135.686; P\u2009&lt;\u20090.001) were associated with poor OS. Forty (28.2%) patients received\u2009&lt;\u20094 cycles of first-line chemotherapy; the most common reason for this was death (n\u2009=\u200922, 55%) from grade 4 febrile neutropenia (n\u2009=\u200915), infection (n\u2009=\u20095), or massive hemoptysis (n\u2009=\u20092). The DLco\u2009&lt;\u200960% group had a shorter median OS than the DLco\u2009\u2265\u200960% group (10.6\u2009\u00b1\u20090.8 vs. 4.9\u2009\u00b1\u20090.9\u00a0months, P\u2009=\u20090.003).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In this study, approximately one quarter of the ED-SCLC patients had DLco\u2009&lt;\u200960%. Low DLco (but not forced expiratory volume in 1\u00a0s or forced vital capacity), a large number of metastases, and\u2009&lt;\u20094 cycles of first-line chemotherapy were independent risk factors for poor survival outcomes in patients with ED-SCLC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-023-04686-2","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T22:22:40Z","timestamp":1679869360000},"page":"7275-7283","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low diffusion capacity predicts poor prognosis in extensive stage small cell lung cancer: a single-center analysis of 10\u00a0years"],"prefix":"10.1007","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8170-1428","authenticated-orcid":false,"given":"Jee Seon","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9994-6028","authenticated-orcid":false,"given":"Eun Ji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8040-5363","authenticated-orcid":false,"given":"Jong Geol","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2931-6861","authenticated-orcid":false,"given":"Kyung Soo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-8325","authenticated-orcid":false,"given":"June Hong","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"4686_CR1","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1200\/JCO.1990.8.9.1563","volume":"8","author":"KS Albain","year":"1990","unstructured":"Albain KS, Crowley JJ, LeBlanc M, Livingston RB (1990) Determinants of improved outcome in small-cell lung cancer: an analysis of the 2,580-patient Southwest Oncology Group data base. 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