{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:20:59Z","timestamp":1790630459694,"version":"4.1.0"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s00432-023-04694-2","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T17:03:24Z","timestamp":1679504604000},"page":"8027-8038","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Parasites as potential targets for cancer immunotherapy"],"prefix":"10.1007","volume":"149","author":[{"given":"Morteza","family":"Yousefi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadesmail","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboubeh","family":"hadipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azar Balouti","family":"Dehkordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Farahbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein Yousofi","family":"Darani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"4694_CR1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1186\/s12885-016-2764-5","volume":"16","author":"P Abello-C\u00e1ceres","year":"2016","unstructured":"Abello-C\u00e1ceres P, Pizarro-Bauerle J, Rosas C, Maldonado I, Aguilar-Guzm\u00e1n L, Gonz\u00e1lez C, Ram\u00edrez G, Ferreira J, Ferreira A (2016) Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection? BMC Cancer 16:731","journal-title":"BMC Cancer"},{"key":"4694_CR2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12964-019-0342-6","volume":"17","author":"D Adah","year":"2019","unstructured":"Adah D, Yang Y, Liu Q, Gadidasu K, Tao Z, Yu S, Dai L, Li X, Zhao S, Qin L (2019) Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model. Cell Commun Signal 17:32","journal-title":"Cell Commun Signal"},{"key":"4694_CR3","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/cncr.11752","volume":"98","author":"H Akg\u00fcl","year":"2003","unstructured":"Akg\u00fcl H, Tez M, \u00dcnal AE, Ke\u015fkek M, Sayek \u0130, \u00d6z\u00e7elik T (2003) Echinococcus against cancer: why not? Cancer 98:1998\u20131999","journal-title":"Cancer"},{"key":"4694_CR4","first-page":"227","volume":"55","author":"DM Alejandra","year":"2014","unstructured":"Alejandra DM, Elena BG, Sulbar\u00e1n AL, Ibarra A, Alvarez C, Victoria MC, Bonfante-Cabarcas R (2014) Trypanosoma cruzi infection decreases malignant melanoma development and increases survival in C57BL\/6 mice. Invest Clin 55:227\u2013237","journal-title":"Invest Clin"},{"key":"4694_CR5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/1471-2334-11-189","volume":"11","author":"A Alemu","year":"2011","unstructured":"Alemu A, Atnafu A, Addis Z, Shiferaw Y, Teklu T, Mathewos B, Birhan W, Gebretsadik S, Gelaw B (2011) Soil transmitted helminths and Schistosoma mansoni infections among school children in Zarima town, northwest Ethiopia. BMC Infect Dis 11:189","journal-title":"BMC Infect Dis"},{"key":"4694_CR6","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1128\/iai.62.4.1298-1303.1994","volume":"62","author":"H Alizadeh","year":"1994","unstructured":"Alizadeh H, Pidherney MS, McCulley JP, Niederkorn JY (1994) Apoptosis as a mechanism of cytolysis of tumor cells by a pathogenic free-living amoeba. Infect Immun 62:1298\u20131303","journal-title":"Infect Immun"},{"key":"4694_CR7","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.7314\/APJCP.2015.16.4.1391","volume":"16","author":"A Altun","year":"2015","unstructured":"Altun A, Saraydin SU, Soylu S, Inan DS, Yasti C, Ozdenkaya Y, Koksal B, Duger C, Isbir C, Turan M (2015) Chemopreventive effects of hydatid disease on experimental breast cancer. Asian Pac J Cancer Prev 16:1391\u20131395","journal-title":"Asian Pac J Cancer Prev"},{"key":"4694_CR8","first-page":"223","volume":"48","author":"V Apanasevich","year":"2002","unstructured":"Apanasevich V, Britov V (2002) Anti-tumor cross-resistance of trichinosis. Voprosy Onkol 48:223\u2013226","journal-title":"Voprosy Onkol"},{"key":"4694_CR9","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","volume":"66","author":"M Arnold","year":"2017","unstructured":"Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F (2017) Global patterns and trends in colorectal cancer incidence and mortality. Gut 66:683\u2013691","journal-title":"Gut"},{"key":"4694_CR10","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0968-0004(86)90087-3","volume":"11","author":"F Ashall","year":"1986","unstructured":"Ashall F (1986) Cancer cells and parasites: two of a kind. Trends Biochem Sci 11:518\u2013520","journal-title":"Trends Biochem Sci"},{"key":"4694_CR11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/CMR.0b013e3282feeaab","volume":"18","author":"VD Atayde","year":"2008","unstructured":"Atayde VD, Jasiulionis MG, Cortez M, Yoshida N (2008) A recombinant protein based on Trypanosoma cruzi surface molecule gp82 induces apoptotic cell death in melanoma cells. Melanoma Res 18:172\u2013183","journal-title":"Melanoma Res"},{"key":"4694_CR12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4049\/jimmunol.1201209","volume":"190","author":"JR Baird","year":"2013","unstructured":"Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M (2013a) Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge. J Immunol 190:469\u2013478","journal-title":"J Immunol"},{"key":"4694_CR13","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1158\/0008-5472.CAN-12-1974","volume":"73","author":"JR Baird","year":"2013","unstructured":"Baird JR, Fox BA, Sanders KL, Lizotte PH, Cubillos-Ruiz JR, Scarlett UK, Rutkowski MR, Conejo-Garcia JR, Fiering S, Bzik DJ (2013b) Avirulent Toxoplasma gondii generates therapeutic anti-tumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Can Res 73:3842\u20133851","journal-title":"Can Res"},{"key":"4694_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/vaccines1010001","volume":"1","author":"A Bartnik","year":"2013","unstructured":"Bartnik A, Nirmal AJ, Yang S-Y (2013) Peptide vaccine therapy in colorectal cancer. Vaccines 1:1","journal-title":"Vaccines"},{"key":"4694_CR15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s10517-006-0395-6","volume":"142","author":"Z Batmonkh","year":"2006","unstructured":"Batmonkh Z, Kallinikova V, Pakhorukova L, Kravtsov E, Karpenko L, Dalin M (2006) In vivo anticancer activity of lysates from Trypanosoma cruzi of different genetic groups. Bull Exp Biol Med 142:470\u2013473","journal-title":"Bull Exp Biol Med"},{"key":"4694_CR16","doi-asserted-by":"crossref","unstructured":"Berriel E, Russo S, Monin L, Festari MF, Berois N, Fern\u00e1ndez G, Freire T, Osinaga E (2013) Anti-tumor activity of human hydatid cyst fluid in a murine model of colon cancer. Sci World J","DOI":"10.1155\/2013\/230176"},{"key":"4694_CR17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394\u2013424","journal-title":"CA Cancer J Clin"},{"key":"4694_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1054\/mehy.1998.0808","volume":"54","author":"H Cabral","year":"2000","unstructured":"Cabral H (2000) The tumoricidal effect of Trypanosoma cruzi: its intracellular cycle and the immune response of the host. Med Hypothes 54:1\u20136","journal-title":"Med Hypothes"},{"key":"4694_CR19","volume":"6","author":"L Chen","year":"2011","unstructured":"Chen L, He Z, Qin L, Li Q, Shi X, Zhao S, Chen L, Zhong N, Chen X (2011) Anti-tumor effect of malaria parasite infection in a murine Lewis lung cancer model through induction of innate and adaptive immunity. PLoS ONE 6:e24407","journal-title":"PLoS ONE"},{"key":"4694_CR20","first-page":"129","volume":"37","author":"JD Choo","year":"2005","unstructured":"Choo JD, Lee JS, Kang JS, Lee HS, Yeom JY, Lee YH (2005) Inhibitory effects of toxoplasma antigen on proliferation and invasion of human glioma cells. J Korean Neurosurg Soc 37:129\u2013136","journal-title":"J Korean Neurosurg Soc"},{"key":"4694_CR21","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1007\/s12639-015-0643-7","volume":"40","author":"MB Chookami","year":"2016","unstructured":"Chookami MB, Sharafi SM, Sefiddashti RR, Jafari R, Bahadoran M, Pestechian N, Darani HY (2016) Effect of two hydatid cyst antigens on the growth of melanoma cancer in C57\/black mice. J Parasit Dis 40:1170\u20131173","journal-title":"J Parasit Dis"},{"key":"4694_CR22","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI31202","volume":"117","author":"TJ Curiel","year":"2007","unstructured":"Curiel TJ (2007) Tregs and rethinking cancer immunotherapy. J Clin Investig 117:1167\u20131174","journal-title":"J Clin Investig"},{"key":"4694_CR23","doi-asserted-by":"crossref","unstructured":"Daneshpour S, Bahadoran M, Hejazi SH, Eskandarian AA, Mahmoudzadeh M, Darani HY (2016) Common antigens between hydatid cyst and cancers. Adv Biomed Res 5","DOI":"10.4103\/2277-9175.175242"},{"key":"4694_CR24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/abr.abr_220_18","volume":"8","author":"S Daneshpour","year":"2019","unstructured":"Daneshpour S, Kefayat AH, Mofid MR, Rad SR, Darani HY (2019) Effect of hydatid cyst fluid antigens on induction of apoptosis on breast cancer cells. Adv Biomed Res 8:27","journal-title":"Adv Biomed Res"},{"key":"4694_CR25","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.2217\/fon.12.155","volume":"8","author":"HY Darani","year":"2012","unstructured":"Darani HY, Yousefi M (2012) Parasites and cancers: parasite antigens as possible targets for cancer immunotherapy. Future Oncol 8:1529\u20131535","journal-title":"Future Oncol"},{"key":"4694_CR26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3347\/kjp.2009.47.2.175","volume":"47","author":"HY Darani","year":"2009","unstructured":"Darani HY, Shirzad H, Mansoori F, Zabardast N, Mahmoodzadeh M (2009) Effects of Toxoplasma gondii and Toxocara canis antigens on WEHI-164 fibrosarcoma growth in a mouse model. Korean J Parasitol 47:175","journal-title":"Korean J Parasitol"},{"key":"4694_CR27","first-page":"978","volume":"9","author":"X Deng","year":"2016","unstructured":"Deng X, Dong Z, Quanxing L, Yan D, Xu W, Qian C (2016) Anti-tumor effect of intravenous immunization with malaria genetically attenuated sporozoites through induction of innate and adaptive immunity. Int J Clin Exp Pathol 9:978\u2013986","journal-title":"Int J Clin Exp Pathol"},{"key":"4694_CR28","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.2217\/fon.14.65","volume":"10","author":"Z Dorosti","year":"2014","unstructured":"Dorosti Z, Yousefi M, Sharafi SM, Darani HY (2014) Mutual action of anticancer and anti-parasitic drugs: are there any shared targets? Future Oncol 10:2529\u20132539","journal-title":"Future Oncol"},{"key":"4694_CR29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.vetpar.2013.01.051","volume":"194","author":"L Duan","year":"2013","unstructured":"Duan L, Li J, Cheng B, Lv Q, Gong P-T, Su L-B, Cai Y, Zhang X (2013) Identification of a novel gene product expressed by Trichinella spiralis that binds antiserum to Sp2\/0 myeloma cells. Vet Parasitol 194:183\u2013185","journal-title":"Vet Parasitol"},{"key":"4694_CR30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10637-018-0609-6","volume":"37","author":"MM Eissa","year":"2019","unstructured":"Eissa MM, Ismail CA, El-Azzouni MZ, Ghazy AA, Hadi MA (2019) Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer. Invest New Drugs 37:47\u201356","journal-title":"Invest New Drugs"},{"key":"4694_CR31","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/415926a","volume":"415","author":"BA Fox","year":"2002","unstructured":"Fox BA, Bzik DJ (2002) De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Nature 415:926","journal-title":"Nature"},{"key":"4694_CR32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.pt.2013.07.001","volume":"29","author":"BA Fox","year":"2013","unstructured":"Fox BA, Sanders KL, Chen S, Bzik DJ (2013) Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines. Trends Parasitol 29:431\u2013437","journal-title":"Trends Parasitol"},{"key":"4694_CR33","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.4049\/jimmunol.182.2.1069","volume":"182","author":"JP Gigley","year":"2009","unstructured":"Gigley JP, Fox BA, Bzik DJ (2009) Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication. J Immunol 182:1069\u20131078","journal-title":"J Immunol"},{"key":"4694_CR34","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.exppara.2010.12.001","volume":"127","author":"P Gong","year":"2011","unstructured":"Gong P, Zhang J, Cao L, Nan Z, Li J, Yang J, Fang H, Jiao H, Jiang T, Su L (2011) Identification and characterization of myeloma-associated antigens in Trichinella spiralis. Exp Parasitol 127:784\u2013788","journal-title":"Exp Parasitol"},{"key":"4694_CR35","doi-asserted-by":"crossref","first-page":"765","DOI":"10.4049\/jimmunol.123.2.765","volume":"123","author":"M Hansson","year":"1979","unstructured":"Hansson M, K\u00e4rre K, Kiessling R, Roder J, Andersson B, H\u00e4yry P (1979) Natural NK-cell targets in the mouse thymus: characteristics of the sensitive cell population. J Immunol 123:765\u2013771","journal-title":"J Immunol"},{"key":"4694_CR36","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1200\/JCO.2005.06.081","volume":"23","author":"DJ Hicklin","year":"2005","unstructured":"Hicklin DJ, Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23:1011\u20131027","journal-title":"J Clin Oncol"},{"key":"4694_CR37","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.4049\/jimmunol.166.10.5878","volume":"166","author":"CA Hunter","year":"2001","unstructured":"Hunter CA, Yu D, Gee M, Ngo CV, Sevignani C, Goldschmidt M, Golovkina TV, Evans S, Lee WF, Thomas-Tikhonenko A (2001) Cutting edge: systemic inhibition of angiogenesis underlies resistance to tumors during acute toxoplasmosis. J Immunol 166:5878\u20135881","journal-title":"J Immunol"},{"key":"4694_CR38","first-page":"301","volume":"23","author":"Y Jiao","year":"2011","unstructured":"Jiao Y, Zhang L, Ge Y, Liang Y, Yong W (2011) Effects of excreted\/secreted antigens of Toxoplasma gondii on CD4+ CD25+ Foxp3+ T cells and NK cells of melanoma-bearing mice. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi Chin J Schistosomiasis Control 23:301\u2013306","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi Chin J Schistosomiasis Control"},{"key":"4694_CR39","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1023\/A:1016636419597","volume":"28","author":"V Kallinikova","year":"2001","unstructured":"Kallinikova V, Matekin P, Ogloblina T, Leikina M, Kononenko A, Sokolova N, Pogodina L (2001) Anticancer properties of flagellate protozoan Trypanosoma cruzi Chagas, 1909. Biol Bull Russ Acad Sci 28:244\u2013255","journal-title":"Biol Bull Russ Acad Sci"},{"key":"4694_CR40","first-page":"9","volume":"4","author":"V Kallinikova","year":"2006","unstructured":"Kallinikova V, Borisova E, Pakhorukova L, Ogloblina T, Batmonkh T, Kravtsov E, Karpenko L, Dalin M (2006) Immunization against Trypanosoma cruzi and tumor growth in mice. Med Parazitol Parazit Bolezn 4:9\u201312","journal-title":"Med Parazitol Parazit Bolezn"},{"key":"4694_CR41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.vetpar.2013.02.021","volume":"196","author":"Y-J Kang","year":"2013","unstructured":"Kang Y-J, Jo J-O, Cho M-K, Yu H-S, Leem S-H, Song KS, Ock MS, Cha H-J (2013) Trichinella spiralis infection reduces tumor growth and metastasis of B16\u2013F10 melanoma cells. Vet Parasitol 196:106\u2013113","journal-title":"Vet Parasitol"},{"key":"4694_CR42","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1007\/s11033-013-2565-8","volume":"40","author":"S Karadayi","year":"2013","unstructured":"Karadayi S, Arslan S, Sumer Z, Turan M, Sumer H, Karadayi K (2013) Does hydatid disease have protective effects against lung cancer? Mol Biol Rep 40:4701\u20134704","journal-title":"Mol Biol Rep"},{"key":"4694_CR43","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.4049\/jimmunol.179.5.2832","volume":"179","author":"SN Karagiannis","year":"2007","unstructured":"Karagiannis SN, Bracher MG, Hunt J, McCloskey N, Beavil RL, Beavil AJ, Fear DJ, Thompson RG, East N, Burke F (2007) IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells. J Immunol 179:2832\u20132843","journal-title":"J Immunol"},{"key":"4694_CR44","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.3346\/jkms.2007.22.S.S38","volume":"22","author":"J-O Kim","year":"2007","unstructured":"Kim J-O, Jung S-S, Kim S-Y, Kim TY, Shin D-W, Lee J-H, Lee Y-H (2007) Inhibition of Lewis lung carcinoma growth by Toxoplasma gondii through induction of Th1 immune responses and inhibition of angiogenesis. J Korean Med Sci 22:S38\u2013S46","journal-title":"J Korean Med Sci"},{"key":"4694_CR45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1590\/S0104-59702009000500005","volume":"16","author":"N Krementsov","year":"2009","unstructured":"Krementsov N (2009) Trypanosoma cruzi, cancer and the Cold War. Hist Ci\u00eanc Sa\u00fade-Manguinhos 16:75\u201394","journal-title":"Hist Ci\u00eanc Sa\u00fade-Manguinhos"},{"key":"4694_CR46","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.4049\/jimmunol.1000446","volume":"185","author":"F Legrand","year":"2010","unstructured":"Legrand F, Driss V, Delbeke M, Loiseau S, Hermann E, Dombrowicz D, Capron M (2010) Human eosinophils exert TNF-\u03b1 and granzyme A-mediated tumoricidal activity toward colon carcinoma cells. J Immunol 185:7443\u20137451","journal-title":"J Immunol"},{"key":"4694_CR47","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.2174\/1871520617666171121115847","volume":"18","author":"C Liao","year":"2018","unstructured":"Liao C, Cheng X, Liu M, Wang X, Boireau P (2018) Trichinella spiralis and tumors: cause, coincidence or treatment? Anti-Cancer Agents Med Chem (formerly Current Medicinal Chemistry-Anti-Cancer Agents) 18:1091\u20131099","journal-title":"Anti-Cancer Agents Med Chem (formerly Current Medicinal Chemistry-Anti-Cancer Agents)"},{"key":"4694_CR48","doi-asserted-by":"crossref","first-page":"24785","DOI":"10.18632\/oncotarget.15806","volume":"8","author":"Q Liu","year":"2017","unstructured":"Liu Q, Yang Y, Tan X, Tao Z, Adah D, Yu S, Lu J, Zhao S, Qin L, Qin L (2017) Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector. Oncotarget 8:24785","journal-title":"Oncotarget"},{"key":"4694_CR49","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1002\/ijc.30028","volume":"138","author":"C Machicado","year":"2016","unstructured":"Machicado C, Marcos LA (2016) Carcinogenesis associated with parasites other than Schistosoma, Opisthorchis and Clonorchis: a systematic review. Int J Cancer 138:2915\u20132921","journal-title":"Int J Cancer"},{"key":"4694_CR50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1292\/jvms.54.7","volume":"54","author":"K Miyahara","year":"1992","unstructured":"Miyahara K, Honda U, Tose S, Sakurai H, Igarashi I, Saito A, Hirose T, Suzuki N (1992) Therapeutic effects of Toxoplasma lysate antigen on 20-methylcholanthrene-induced BALB\/c mouse tumors. J Vet Med Sci 54:7\u201312","journal-title":"J Vet Med Sci"},{"key":"4694_CR51","first-page":"183","volume":"10","author":"F Mohamadi","year":"2019","unstructured":"Mohamadi F, Shakibapour M, Sharafi SM, Andalib AR, Tolouei S, Yousofi Darani H (2019) Anti-Toxoplasma gondii antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes. Biomed Rep 10:183\u2013188","journal-title":"Biomed Rep"},{"key":"4694_CR52","first-page":"405","volume":"12","author":"SM Ngoi","year":"2011","unstructured":"Ngoi SM, Sylvester FA, Vella AT (2011) The role of microbial byproducts in protection against immunological disorders and the hygiene hypothesis. Discov Med 12:405\u2013412","journal-title":"Discov Med"},{"key":"4694_CR53","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3892\/ijo.2013.2000","volume":"43","author":"V Noya","year":"2013","unstructured":"Noya V, Bay S, Festari MF, Garc\u00eda EP, Rodriguez E, Chiale C, Ganneau C, Baleux F, Astrada S, Bollati-Fogol\u00edn M (2013) Mucin-like peptides from Echinococcus granulosus induce anti-tumor activity. Int J Oncol 43:775\u2013784","journal-title":"Int J Oncol"},{"key":"4694_CR54","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/carcin\/22.5.737","volume":"22","author":"E Oliveira","year":"2001","unstructured":"Oliveira E, Leite M, Miranda J, Andrade A, Garcia SB, Luquetti A, Moreira H (2001) Chronic Trypanosoma cruzi infection associated with low incidence of 1, 2-dimethylhydrazine-induced colon cancer in rats. Carcinogenesis 22:737\u2013740","journal-title":"Carcinogenesis"},{"key":"4694_CR55","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0304-3835(93)90016-3","volume":"72","author":"MS Pidherney","year":"1993","unstructured":"Pidherney MS, Alizadeh H, Stewart GL, McCulley JP, Niederkorn JY (1993) In vitro and in vivo tumoricidal properties of a pathogenic\/free-living amoeba. Cancer Lett 72:91\u201398","journal-title":"Cancer Lett"},{"key":"4694_CR56","doi-asserted-by":"crossref","unstructured":"Plumelle Y, Gonin C, Edouard A, Bucher BJ, Thomas L, Brebion A, Panelatti G (1997) Effect of Strongyloides stercoralis infection and eosinophilia on age at onset and prognosis of adult T-cell leukemia. Am J Clin Pathol 107:81\u201387","DOI":"10.1093\/ajcp\/107.1.81"},{"key":"4694_CR57","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1017\/S0031182000052768","volume":"84","author":"D Pocock","year":"1982","unstructured":"Pocock D, Meerovitch E (1982) The anti-neoplastic effect of trichinellosis in a syngeneic murine model. Parasitology 84:463\u2013473","journal-title":"Parasitology"},{"key":"4694_CR58","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1756-3305-7-37","volume":"7","author":"RL Pullan","year":"2014","unstructured":"Pullan RL, Smith JL, Jasrasaria R, Brooker SJ (2014) Global numbers of infection and disease burden of soil transmitted helminth infections in 2010. Parasit Vectors 7:37","journal-title":"Parasit Vectors"},{"key":"4694_CR59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13027-017-0117-x","volume":"12","author":"L Qin","year":"2017","unstructured":"Qin L, Chen C, Chen L, Xue R, Ou-Yang M, Zhou C, Zhao S, He Z, Xia Y, He J (2017) Worldwide malaria incidence and cancer mortality are inversely associated. Infect Agents Cancer 12:14","journal-title":"Infect Agents Cancer"},{"key":"4694_CR60","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molimm.2012.05.006","volume":"52","author":"G Ram\u00edrez","year":"2012","unstructured":"Ram\u00edrez G, Valck C, Aguilar L, Kemmerling U, L\u00f3pez-Mu\u00f1oz R, Cabrera G, Morello A, Ferreira J, Maya JD, Galanti N (2012) Roles of Trypanosoma cruzi calreticulin in parasite\u2013host interactions and in tumor growth. Mol Immunol 52:133\u2013140","journal-title":"Mol Immunol"},{"key":"4694_CR61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004268","volume":"9","author":"SL Ranasinghe","year":"2015","unstructured":"Ranasinghe SL, Fischer K, Zhang W, Gobert GN, McManus DP (2015) Cloning and characterization of two potent Kunitz type protease inhibitors from Echinococcus granulosus. PLoS Negl Trop Dis 9:e0004268","journal-title":"PLoS Negl Trop Dis"},{"key":"4694_CR62","doi-asserted-by":"crossref","unstructured":"Ranasinghe SL, Boyle GM, Fischer K, Potriquet J, Mulvenna JP, Mcmanus DP (2018) Kunitz type protease inhibitor EgKI-1 from the canine tapeworm Echinococcus granulosus as a promising anti-cancer therapeutic. BioRxiv 357590","DOI":"10.1101\/357590"},{"key":"4694_CR63","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/ije\/dym219","volume":"37","author":"T Rastogi","year":"2007","unstructured":"Rastogi T, Devesa S, Mangtani P, Mathew A, Cooper N, Kao R, Sinha R (2007) Cancer incidence rates among South Asians in four geographic regions: India, Singapore, UK and US. Int J Epidemiol 37:147\u2013160","journal-title":"Int J Epidemiol"},{"key":"4694_CR64","unstructured":"Restifo NP (2007) Adoptive immunotherapy for cancer: building on success. AACR"},{"key":"4694_CR65","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-065X.2010.00987.x","volume":"240","author":"GA Rook","year":"2011","unstructured":"Rook GA, Dalgleish A (2011) Infection, immunoregulation, and cancer. Immunol Rev 240:141\u2013159","journal-title":"Immunol Rev"},{"key":"4694_CR66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14715\/cmb\/2018.64.12.1","volume":"64","author":"SR Rostami","year":"2018","unstructured":"Rostami SR, Daneshpour S, Mofid M, Andalib A, Eskandariyan A, Yousofi HD (2018) Effect of hydatid cyst antigens on inhibition of melanoma cancer growth in mouse model. Cell Mol Biol (noisy-Le-Grand, France) 64:1\u20135","journal-title":"Cell Mol Biol (noisy-Le-Grand, France)"},{"key":"4694_CR67","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ccell.2015.09.003","volume":"28","author":"A Salanti","year":"2015","unstructured":"Salanti A, Clausen TM, Agerb\u00e6k M\u00d8, AlNakouzi N, Dahlb\u00e4ck M, Oo HZ, Lee S, Gustavsson T, Rich JR, Hedberg BJ (2015) Targeting human cancer by a glycosaminoglycan binding malaria protein. Cancer Cell 28:500\u2013514","journal-title":"Cancer Cell"},{"key":"4694_CR68","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107955","volume":"99","author":"M Shakibapour","year":"2021","unstructured":"Shakibapour M, Kefayat A, Mofid MR, Shojaie B, Mohamadi F, Sharafi SM, Mahmoudzadeh M, Darani HY (2021) Anti-cancer immunoprotective effects of immunization with hydatid cyst wall antigens in a non-immunogenic and metastatic triple-negative murine mammary carcinoma model. Int Immunopharmacol 99:107955","journal-title":"Int Immunopharmacol"},{"key":"4694_CR69","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4103\/0973-1482.144638","volume":"11","author":"SM Sharafi","year":"2015","unstructured":"Sharafi SM, Salehi N, Mortazavi N, Pour D, Yousefi M, Yousofi Darani H (2015) Low titer of antibody against Toxoplasma gondii may be related to resistant to cancer. J Cancer Res Therap 11:305\u2013307","journal-title":"J Cancer Res Therap"},{"key":"4694_CR70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1023466517225","volume":"135","author":"L Sheklakova","year":"2003","unstructured":"Sheklakova L, Kallinikova V, Karpenko L (2003) Genetic heterogeneity of Trypanosoma cruzi and its direct anticancer effect in cultured human tumor cells. Bull Exp Biol Med 135:89\u201392","journal-title":"Bull Exp Biol Med"},{"key":"4694_CR71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4236\/wjv.2012.22014","volume":"2","author":"H Shirzad","year":"2012","unstructured":"Shirzad H, Khorami S, Soozangar N, Yousefi M, Darani HY (2012) Toxoplasma gondii but not Leishmania major or Trichomonas vaginalis decreases cell proliferation and increases cell death on fibrosarcoma cancer cells in culture medium. World J Vaccines 2:105","journal-title":"World J Vaccines"},{"key":"4694_CR72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/3273544","volume":"33","author":"NR Stoll","year":"1947","unstructured":"Stoll NR (1947) This wormy world. J Parasitol 33:1\u201318","journal-title":"J Parasitol"},{"key":"4694_CR73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002801","volume":"8","author":"S Sutcliffe","year":"2012","unstructured":"Sutcliffe S, Neace C, Magnuson NS, Reeves R, Alderete J (2012) Trichomonosis, a common curable STI, and prostate carcinogenesis\u2014a proposed molecular mechanism. PLoS Pathog 8:e1002801","journal-title":"PLoS Pathog"},{"key":"4694_CR74","first-page":"288","volume":"5","author":"Y Suzuki","year":"1986","unstructured":"Suzuki Y, Muto M, Kobayashi A (1986) Anti-tumor effect of formalin-fixed Toxoplasma gondii organisms on EL4 lymphoma in Toxoplasma-infected mice. J Biol Response Mod 5:288\u2013293","journal-title":"J Biol Response Mod"},{"key":"4694_CR75","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40249-018-0433-4","volume":"7","author":"Z-Z Tong","year":"2018","unstructured":"Tong Z-Z, Fang Z-M, Zhang Q, Zhan Y, Zhang Y, Jiang W-F, Hou X, Li Y-L, Wang T (2018) Plasmodium yoelii infection inhibits murine leukaemia WEHI-3 cell proliferation in vivo by promoting immune responses. Infect Dis Poverty 7:48","journal-title":"Infect Dis Poverty"},{"key":"4694_CR76","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/pim.12152","volume":"37","author":"N Turhan","year":"2015","unstructured":"Turhan N, Esendagli G, Ozkayar O, Tunali G, Sokmensuer C, Abbasoglu O (2015) Co-existence of Echinococcus granulosus infection and cancer metastasis in the liver correlates with reduced Th1 immune responses. Parasite Immunol 37:16\u201322","journal-title":"Parasite Immunol"},{"key":"4694_CR77","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/ijc.29910","volume":"138","author":"L Ubillos","year":"2016","unstructured":"Ubillos L, Freire T, Berriel E, Chiribao ML, Chiale C, Festari MF, Medeiros A, Mazal D, Rond\u00e1n M, Bollati-Fogol\u00edn M (2016) Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers. Int J Cancer 138:1719\u20131731","journal-title":"Int J Cancer"},{"key":"4694_CR78","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2013.07.011","volume":"39","author":"JG van den Boorn","year":"2013","unstructured":"van den Boorn JG, Hartmann G (2013) Turning tumors into vaccines: co-opting the innate immune system. Immunity 39:27\u201337","journal-title":"Immunity"},{"key":"4694_CR79","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.vetpar.2008.10.052","volume":"159","author":"X Wang","year":"2009","unstructured":"Wang X, Fu B, Yang S, Wu X, Cui G, Liu M, Zhao Y, Yu Y, Liu X, Deng H (2009) Trichinella spiralis\u2014a potential anti-tumor agent. Vet Parasitol 159:249\u2013252","journal-title":"Vet Parasitol"},{"key":"4694_CR80","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.vetpar.2013.01.052","volume":"194","author":"X Wang","year":"2013","unstructured":"Wang X, Liu M, Sun S, Liu X, Yu L, Wang X, Chu L, Rosenthal B, Shi H, Boireau P (2013) An anti-tumor protein produced by Trichinella spiralis induces apoptosis in human hepatoma H7402 cells. Vet Parasitol 194:186\u2013188","journal-title":"Vet Parasitol"},{"key":"4694_CR81","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s13071-015-0778-5","volume":"8","author":"L Wang","year":"2015","unstructured":"Wang L, He L-Y, Chen Z-W, Wen H, Fang G-S, Luo Q-L, Huang K-Q, Shen J-L (2015) Seroprevalence and genetic characterization of Toxoplasma gondii in cancer patients in Anhui Province, Eastern China. Parasites Vectors 8:162","journal-title":"Parasites Vectors"},{"key":"4694_CR82","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2334-10-4","volume":"10","author":"Y Xiao","year":"2010","unstructured":"Xiao Y, Yin J, Jiang N, Xiang M, Hao L, Lu H, Sang H, Liu X, Xu H, Ankarklev J (2010) Seroepidemiology of human Toxoplasma gondii infection in China. BMC Infect Dis 10:4","journal-title":"BMC Infect Dis"},{"key":"4694_CR83","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2017.52","volume":"6","author":"Y Yang","year":"2017","unstructured":"Yang Y, Liu Q, Lu J, Adah D, Yu S, Zhao S, Yao Y, Qin L, Chen X (2017) Exosomes from Plasmodium-infected hosts inhibit tumor angiogenesis in a murine Lewis lung cancer model. Oncogenesis 6:e351","journal-title":"Oncogenesis"},{"key":"4694_CR84","doi-asserted-by":"crossref","unstructured":"Yousofi Darani H, Soozangar N, Khorami S, Taji F, Yousofi M, Shirzad H (2012) Hydatid cyst protoscolices induce cell death in WEHI-164 fibrosarcoma cells and inhibit the proliferation of baby hamster kidney fibroblasts in vitro. J Parasitol Res","DOI":"10.1155\/2012\/304183"},{"key":"4694_CR85","doi-asserted-by":"crossref","first-page":"651","DOI":"10.7150\/ijbs.7.651","volume":"7","author":"BF Zamarron","year":"2011","unstructured":"Zamarron BF, Chen W (2011) Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci 7:651","journal-title":"Int J Biol Sci"},{"key":"4694_CR86","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s10517-008-0089-3","volume":"145","author":"A Zenina","year":"2008","unstructured":"Zenina A, Kravtsov E, Tsetsegsaikhan B, Yashina N, Dalin M, Karpenko L, Sheklakova L, Kallinikova V (2008) The study of immunological component in anti-tumor effect of Trypanosoma cruzi. Bull Exp Biol Med 145:352\u2013354","journal-title":"Bull Exp Biol Med"},{"key":"4694_CR87","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s10517-013-2050-3","volume":"154","author":"A Zhigunova","year":"2013","unstructured":"Zhigunova A, Kravtsov E, Yashina N, Dalin M, Karpenko L (2013) Effects of specific antibodies and immunocompetent cells on tumor growth in passive transfer experiment. Bull Exp Biol Med 154:6","journal-title":"Bull Exp Biol Med"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-04694-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-023-04694-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-04694-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T11:24:46Z","timestamp":1702121086000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-023-04694-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":87,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["4694"],"URL":"https:\/\/doi.org\/10.1007\/s00432-023-04694-2","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,22]]},"assertion":[{"value":"30 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors clarify that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}