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Serum anti-M\u00fcllerian hormone (AMH), follicle stimulating hormone (FSH), inhibin B, antral follicle count (AFC), and self-reported (first) pregnancy outcomes were evaluated in female childhood HL survivors and controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>84 HL survivors and 798 controls were included, aged 29.6 and 32.7\u00a0years old at time of assessment. Median age at HL diagnosis was 13.4\u00a0years. Cyclophosphamide equivalent dose (CED-score) exceeded 6000\u00a0mg\/m<jats:sup>2<\/jats:sup> in 56 women and 14 survivors received pelvic irradiation.<\/jats:p>\n                <jats:p>All clinical markers were significantly deteriorated in survivors (odds-ratio for low AMH (&lt;\u2009p10) 10.1 [95% CI 4.9; 20.6]; low AFC (&lt;\u2009p10) 4.6 [95% CI 2.1; 9.9]; elevated FSH (&gt;\u200910\u00a0IU\/l) 15.3 [95% CI 5.7; 41.1], low Inhibin B (&lt;\u200920\u00a0ng\/l) 3.6 [ 95% CI 1.7; 7.7], p\u2009&lt;\u20090.001). Pregnancy outcomes were comparable between survivors and controls (\u00b1\u200980% live birth,\u2009\u00b1\u200920% miscarriage). However, survivors were significantly younger at first pregnancy (27.0\u00a0years vs 29.0 years, P\u2009=\u20090.04). Adjusted odds-ratio for time to pregnancy\u2009&gt;\u200912\u00a0months was 2.5 [95% CI 1.1; 5.6] in survivors, p\u2009=\u20090.031. Adverse outcomes were specifically present after treatment with procarbazine and higher CED-score.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>HL survivors appear to have an impaired ovarian reserve. However, chance to achieve pregnancy seems reassuring at a young age. Additional follow-up studies are needed to assess fertile life span and reproductive potential of HL survivors, in particular for current HL treatments that are hypothesized to be less gonadotoxic.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-023-05035-z","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T09:01:56Z","timestamp":1690794116000},"page":"13677-13695","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and self-reported markers of reproductive function in female survivors of childhood Hodgkin lymphoma"],"prefix":"10.1007","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9879-4678","authenticated-orcid":false,"given":"K. C. 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Cancer 46(10):2123\u20132125. https:\/\/doi.org\/10.1002\/1097-0142(19801115)46:10%3c2123::AID-CNCR2820461002%3e3.0.CO;2-R","journal-title":"Cancer"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05035-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-023-05035-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05035-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T13:04:31Z","timestamp":1697893471000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-023-05035-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":79,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["5035"],"URL":"https:\/\/doi.org\/10.1007\/s00432-023-05035-z","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,31]]},"assertion":[{"value":"22 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors are involved in the ongoing fertility add-on study, nested within the EuroNET-PHL-C2 study (Clinicaltrials NCT02684708; EudraCT number 2012\u2013004053-88). This prospective study evaluates gonadal function and fertility in children with newly diagnosed Hodgkin lymphoma, treated according to the EuroNET-PHL-C2 protocol.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Medical Ethics Review Committee of the VU University Medical Center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}