{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:28:18Z","timestamp":1793834898495,"version":"4.6.1"},"reference-count":248,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NV19-03-00179"],"award-info":[{"award-number":["NV19-03-00179"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019563","name":"Mikrobiologick\u00fd \u00dastav, Akademie V\u011bd \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["LQ200202105"],"award-info":[{"award-number":["LQ200202105"]}],"id":[{"id":"10.13039\/501100019563","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since the composition of this ecosystem depends on a variety of internal and external factors, each individual harbors a unique set of microbes. These differences in microbiota composition make individuals either more or less susceptible to various diseases, including cancer. Specific microbes are associated with cancer etiology and pathogenesis and several mechanisms of how they drive the typical hallmarks of cancer were recently identified. Although most microbes reside in the distal gut, they can influence cancer initiation and progression in distant tissues, as well as modulate the outcomes of established cancer therapies. Here, we describe the mechanisms by which microbes influence carcinogenesis and discuss their current and potential future applications in cancer diagnostics and management.<\/jats:p>","DOI":"10.1007\/s00432-023-05244-6","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T11:02:31Z","timestamp":1691578951000},"page":"14429-14450","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Microbiota as the unifying factor behind the hallmarks of cancer"],"prefix":"10.1007","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-4214","authenticated-orcid":false,"given":"Iva","family":"Bene\u0161ov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-7363","authenticated-orcid":false,"given":"\u013dudmila","family":"K\u0159\u00ed\u017eov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1335-5252","authenticated-orcid":false,"given":"Miloslav","family":"Kverka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"5244_CR1","first-page":"355","volume":"12","author":"GD Abrams","year":"1963","unstructured":"Abrams GD, Bauer H, Sprinz H (1963) Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice. Lab Invest 12:355\u2013364","journal-title":"Lab Invest"},{"issue":"4","key":"5244_CR2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jhep.2010.01.003","volume":"52","author":"Y Akazawa","year":"2010","unstructured":"Akazawa Y, Cazanave S, Mott JL et al (2010) Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis. J Hepatol 52(4):586\u2013593","journal-title":"J Hepatol"},{"issue":"6","key":"5244_CR3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrgastro.2017.20","volume":"14","author":"JL Alexander","year":"2017","unstructured":"Alexander JL, Wilson ID, Teare J et al (2017) Gut microbiota modulation of chemotherapy efficacy and toxicity. Nat Rev Gastroenterol Hepatol 14(6):356\u2013365","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"10","key":"5244_CR4","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.4049\/jimmunol.2000731","volume":"205","author":"E Alpdundar Bulut","year":"2020","unstructured":"Alpdundar Bulut E, Bayyurt Kocabas B, Yazar V et al (2020) Human gut commensal membrane vesicles modulate inflammation by generating M2-like macrophages and myeloid-derived suppressor cells. J Immunol 205(10):2707\u20132718","journal-title":"J Immunol"},{"issue":"9","key":"5244_CR5","first-page":"1814","volume":"91","author":"R Al-Sabbagh","year":"1996","unstructured":"Al-Sabbagh R, Sinicrope FA, Sellin JH et al (1996) Evaluation of short-chain fatty acid enemas: treatment of radiation proctitis. Am J Gastroenterol 91(9):1814\u20131816","journal-title":"Am J Gastroenterol"},{"issue":"7480","key":"5244_CR6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","volume":"504","author":"N Arpaia","year":"2013","unstructured":"Arpaia N, Campbell C, Fan X et al (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504(7480):451\u2013455","journal-title":"Nature"},{"key":"5244_CR7","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00092-18","author":"TA Auchtung","year":"2018","unstructured":"Auchtung TA, Fofanova TY, Stewart CJ et al (2018) Investigating colonization of the healthy adult gastrointestinal tract by fungi. mSphere. https:\/\/doi.org\/10.1128\/mSphere.00092-18","journal-title":"mSphere"},{"issue":"12","key":"5244_CR8","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1111\/bph.13428","volume":"174","author":"G Aviello","year":"2017","unstructured":"Aviello G, Knaus UG (2017) ROS in gastrointestinal inflammation: rescue or sabotage? Br J Pharmacol 174(12):1704\u20131718","journal-title":"Br J Pharmacol"},{"issue":"2","key":"5244_CR9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1158\/1078-0432.CCR-05-1886","volume":"12","author":"C Badoual","year":"2006","unstructured":"Badoual C, Hans S, Rodriguez J et al (2006) Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin Cancer Res 12(2):465\u2013472","journal-title":"Clin Cancer Res"},{"issue":"25","key":"5244_CR10","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.3748\/wjg.v23.i25.4548","volume":"23","author":"L Bajer","year":"2017","unstructured":"Bajer L, Kverka M, Kostovcik M et al (2017) Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol 23(25):4548\u20134558","journal-title":"World J Gastroenterol"},{"issue":"7681","key":"5244_CR11","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature24462","volume":"551","author":"VP Balachandran","year":"2017","unstructured":"Balachandran VP, Luksza M, Zhao JN et al (2017) Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer. Nature 551(7681):512\u2013516","journal-title":"Nature"},{"issue":"3","key":"5244_CR12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cmet.2020.07.004","volume":"32","author":"ML Balmer","year":"2020","unstructured":"Balmer ML, Ma EH, Thompson AJ et al (2020) Memory CD8(+) T cells balance pro- and anti-inflammatory activity by reprogramming cellular acetate handling at sites of infection. Cell Metab 32(3):457-467 e455","journal-title":"Cell Metab"},{"issue":"6529","key":"5244_CR13","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1126\/science.abb5920","volume":"371","author":"EN Baruch","year":"2021","unstructured":"Baruch EN, Youngster I, Ben-Betzalel G et al (2021) Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Science 371(6529):602\u2013609","journal-title":"Science"},{"issue":"26","key":"5244_CR14","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1182\/bloodadvances.2017011221","volume":"1","author":"D Bayik","year":"2017","unstructured":"Bayik D, Tross D, Haile LA et al (2017) Regulation of the maturation of human monocytes into immunosuppressive macrophages. Blood Adv 1(26):2510\u20132519","journal-title":"Blood Adv"},{"issue":"6","key":"5244_CR15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.it.2013.03.003","volume":"34","author":"Y Belkaid","year":"2013","unstructured":"Belkaid Y, Bouladoux N, Hand TW (2013) Effector and memory T cell responses to commensal bacteria. Trends Immunol 34(6):299\u2013306","journal-title":"Trends Immunol"},{"issue":"2","key":"5244_CR16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1128\/iai.23.2.403-411.1979","volume":"23","author":"RD Berg","year":"1979","unstructured":"Berg RD, Garlington AW (1979) Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 23(2):403\u2013411","journal-title":"Infect Immun"},{"issue":"3","key":"5244_CR17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.chom.2012.01.013","volume":"11","author":"J Bergounioux","year":"2012","unstructured":"Bergounioux J, Elisee R, Prunier AL et al (2012) Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium\u2019s epithelial niche. Cell Host Microbe 11(3):240\u2013252","journal-title":"Cell Host Microbe"},{"issue":"5","key":"5244_CR18","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ccell.2021.03.004","volume":"39","author":"A Bertocchi","year":"2021","unstructured":"Bertocchi A, Carloni S, Ravenda PS et al (2021) Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver. Cancer Cell 39(5):708\u2013724","journal-title":"Cancer Cell"},{"issue":"3","key":"5244_CR19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41416-021-01365-2","volume":"125","author":"M Boesch","year":"2021","unstructured":"Boesch M, Baty F, Rothschild SI et al (2021) Tumour neoantigen mimicry by microbial species in cancer immunotherapy. Br J Cancer 125(3):313\u2013323","journal-title":"Br J Cancer"},{"issue":"3","key":"5244_CR20","doi-asserted-by":"crossref","first-page":"e01117","DOI":"10.1128\/mBio.01117-14","volume":"5","author":"NA Broderick","year":"2014","unstructured":"Broderick NA, Buchon N, Lemaitre B (2014) Microbiota-induced changes in drosophila melanogaster host gene expression and gut morphology. Mbio 5(3):e01117-e11114","journal-title":"Mbio"},{"issue":"14","key":"5244_CR21","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1158\/0008-5472.CAN-18-3464","volume":"79","author":"C Buchta Rosean","year":"2019","unstructured":"Buchta Rosean C, Bostic RR, Ferey JCM et al (2019) Preexisting commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer. Cancer Res 79(14):3662\u20133675","journal-title":"Cancer Res"},{"issue":"4","key":"5244_CR22","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.cell.2021.01.029","volume":"184","author":"LF Camarillo-Guerrero","year":"2021","unstructured":"Camarillo-Guerrero LF, Almeida A, Rangel-Pineros G et al (2021) Massive expansion of human gut bacteriophage diversity. Cell 184(4):1098-1109 e1099","journal-title":"Cell"},{"issue":"11","key":"5244_CR23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41575-018-0025-6","volume":"15","author":"PD Cani","year":"2018","unstructured":"Cani PD, Jordan BF (2018) Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer. Nat Rev Gastroenterol Hepatol 15(11):671\u2013682","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"5244_CR24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1101\/gr.126516.111","volume":"22","author":"M Castellarin","year":"2012","unstructured":"Castellarin M, Warren RL, Freeman JD et al (2012) Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res 22(2):299\u2013306","journal-title":"Genome Res"},{"issue":"6","key":"5244_CR25","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/annonc\/mdx108","volume":"28","author":"N Chaput","year":"2017","unstructured":"Chaput N, Lepage P, Coutzac C et al (2017) Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab. Ann Oncol 28(6):1368\u20131379","journal-title":"Ann Oncol"},{"issue":"12","key":"5244_CR26","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","volume":"198","author":"W Chen","year":"2003","unstructured":"Chen W, Jin W, Hardegen N et al (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198(12):1875\u20131886","journal-title":"J Exp Med"},{"issue":"3","key":"5244_CR27","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/19490976.2019.1695494","volume":"11","author":"S Chen","year":"2020","unstructured":"Chen S, Su T, Zhang Y et al (2020a) Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating KRT7-AS\/KRT7. Gut Microbes 11(3):511\u2013525","journal-title":"Gut Microbes"},{"issue":"1","key":"5244_CR28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1186\/s12879-020-05324-9","volume":"20","author":"Y Chen","year":"2020","unstructured":"Chen Y, Qiu X, Wang W et al (2020b) Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort. BMC Infect Dis 20(1):629","journal-title":"BMC Infect Dis"},{"issue":"21","key":"5244_CR29","doi-asserted-by":"crossref","first-page":"11436","DOI":"10.3390\/ijms222111436","volume":"22","author":"Z Chen","year":"2021","unstructured":"Chen Z, Wang B, Dong J et al (2021) Gut microbiota-derived l-histidine\/imidazole propionate axis fights against the radiation-induced cardiopulmonary injury. Int J Mol Sci 22(21):11436","journal-title":"Int J Mol Sci"},{"issue":"46","key":"5244_CR30","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1038\/s41388-020-01509-3","volume":"39","author":"A Chronopoulos","year":"2020","unstructured":"Chronopoulos A, Kalluri R (2020) Emerging role of bacterial extracellular vesicles in cancer. Oncogene 39(46):6951\u20136960","journal-title":"Oncogene"},{"issue":"10","key":"5244_CR31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108482","volume":"33","author":"NM Clark","year":"2020","unstructured":"Clark NM, Martinez LM, Murdock S et al (2020) Regulatory T cells support breast cancer progression by opposing IFN-gamma-dependent functional reprogramming of myeloid cells. Cell Rep 33(10):108482","journal-title":"Cell Rep"},{"issue":"7","key":"5244_CR32","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2014.11.020","volume":"159","author":"SA Comerford","year":"2014","unstructured":"Comerford SA, Huang Z, Du X et al (2014) Acetate dependence of tumors. Cell 159(7):1591\u20131602","journal-title":"Cell"},{"issue":"1","key":"5244_CR33","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1038\/s41598-019-40145-0","volume":"9","author":"A Copland","year":"2019","unstructured":"Copland A, Sparrow A, Hart P et al (2019) Bacillus Calmette-Guerin induces PD-L1 expression on antigen-presenting cells via autocrine and paracrine interleukin-STAT3 circuits. Sci Rep 9(1):3655","journal-title":"Sci Rep"},{"issue":"1","key":"5244_CR34","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1038\/s41467-020-16079-x","volume":"11","author":"C Coutzac","year":"2020","unstructured":"Coutzac C, Jouniaux JM, Paci A et al (2020) Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer. Nat Commun 11(1):2168","journal-title":"Nat Commun"},{"issue":"9","key":"5244_CR35","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nm1093","volume":"10","author":"TJ Curiel","year":"2004","unstructured":"Curiel TJ, Coukos G, Zou L et al (2004) Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10(9):942\u2013949","journal-title":"Nat Med"},{"issue":"7402","key":"5244_CR36","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","volume":"486","author":"H Curtis","year":"2012","unstructured":"Curtis H et al (2012) Human microbiome project C: structure, function and diversity of the healthy human microbiome. Nature 486(7402):207\u2013214","journal-title":"Nature"},{"issue":"1","key":"5244_CR37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40168-018-0451-2","volume":"6","author":"Z Dai","year":"2018","unstructured":"Dai Z, Coker OO, Nakatsu G et al (2018) Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers. Microbiome 6(1):70","journal-title":"Microbiome"},{"issue":"5","key":"5244_CR38","doi-asserted-by":"crossref","first-page":"675","DOI":"10.4161\/19490976.2014.969989","volume":"5","author":"G Dalmasso","year":"2014","unstructured":"Dalmasso G, Cougnoux A, Delmas J et al (2014) The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment. Gut Microbes 5(5):675\u2013680","journal-title":"Gut Microbes"},{"issue":"6529","key":"5244_CR39","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1126\/science.abf3363","volume":"371","author":"D Davar","year":"2021","unstructured":"Davar D, Dzutsev AK, McCulloch JA et al (2021) Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients. Science 371(6529):595\u2013602","journal-title":"Science"},{"issue":"7484","key":"5244_CR40","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","volume":"505","author":"LA David","year":"2014","unstructured":"David LA, Maurice CF, Carmody RN et al (2014) Diet rapidly and reproducibly alters the human gut microbiome. Nature 505(7484):559\u2013563","journal-title":"Nature"},{"issue":"1","key":"5244_CR41","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1186\/s12885-019-6473-8","volume":"19","author":"JM Deleemans","year":"2019","unstructured":"Deleemans JM, Chleilat F, Reimer RA et al (2019) The chemo-gut study: investigating the long-term effects of chemotherapy on gut microbiota, metabolic, immune, psychological and cognitive parameters in young adult Cancer survivors; study protocol. BMC Cancer 19(1):1243","journal-title":"BMC Cancer"},{"issue":"2","key":"5244_CR42","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.bjc.6600360","volume":"87","author":"AS Denton","year":"2002","unstructured":"Denton AS, Andreyev HJ, Forbes A et al (2002) Systematic review for non-surgical interventions for the management of late radiation proctitis. Br J Cancer 87(2):134\u2013143","journal-title":"Br J Cancer"},{"issue":"6","key":"5244_CR43","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/annonc\/mdy103","volume":"29","author":"L Derosa","year":"2018","unstructured":"Derosa L, Hellmann MD, Spaziano M et al (2018) Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer. Ann Oncol 29(6):1437\u20131444","journal-title":"Ann Oncol"},{"issue":"2","key":"5244_CR44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41591-021-01655-5","volume":"28","author":"L Derosa","year":"2022","unstructured":"Derosa L, Routy B, Thomas AM et al (2022) Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer. Nat Med 28(2):315\u2013324","journal-title":"Nat Med"},{"key":"5244_CR45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.radonc.2020.01.011","volume":"143","author":"X Ding","year":"2020","unstructured":"Ding X, Li Q, Li P et al (2020) Fecal microbiota transplantation: a promising treatment for radiation enteritis? Radiother Oncol 143:12\u201318","journal-title":"Radiother Oncol"},{"issue":"6","key":"5244_CR46","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/jnci\/66.6.1192","volume":"66","author":"R Doll","year":"1981","unstructured":"Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66(6):1191\u20131308","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"5244_CR47","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.molcel.2012.08.033","volume":"48","author":"DR Donohoe","year":"2012","unstructured":"Donohoe DR, Collins LB, Wali A et al (2012) The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol Cell 48(4):612\u2013626","journal-title":"Mol Cell"},{"key":"5244_CR48","doi-asserted-by":"crossref","first-page":"10391","DOI":"10.1038\/ncomms10391","volume":"7","author":"K Dubin","year":"2016","unstructured":"Dubin K, Callahan MK, Ren B et al (2016) Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat Commun 7:10391","journal-title":"Nat Commun"},{"issue":"7","key":"5244_CR49","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41591-020-0908-2","volume":"26","author":"PJ Dziubanska-Kusibab","year":"2020","unstructured":"Dziubanska-Kusibab PJ, Berger H, Battistini F et al (2020) Colibactin DNA-damage signature indicates mutational impact in colorectal cancer. Nat Med 26(7):1063\u20131069","journal-title":"Nat Med"},{"issue":"10","key":"5244_CR50","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/annonc\/mdz206","volume":"30","author":"A Elkrief","year":"2019","unstructured":"Elkrief A, Derosa L, Kroemer G et al (2019) The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor? Ann Oncol 30(10):1572\u20131579","journal-title":"Ann Oncol"},{"key":"5244_CR51","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab032","author":"M Ellingjord-Dale","year":"2021","unstructured":"Ellingjord-Dale M, Christakoudi S, Weiderpass E et al (2021) Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Int J Epidemiol. https:\/\/doi.org\/10.1093\/ije\/dyab032","journal-title":"Int J Epidemiol"},{"issue":"5","key":"5244_CR52","doi-asserted-by":"crossref","first-page":"G1025","DOI":"10.1152\/ajpgi.90227.2008","volume":"295","author":"JB Ewaschuk","year":"2008","unstructured":"Ewaschuk JB, Diaz H, Meddings L et al (2008) Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function. Am J Physiol Gastrointest Liver Physiol 295(5):G1025-1034","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5244_CR53","first-page":"705","volume":"7","author":"MJ Fabrega","year":"2016","unstructured":"Fabrega MJ, Aguilera L, Gimenez R et al (2016) Activation of immune and defense responses in the intestinal mucosa by outer membrane vesicles of commensal and probiotic Escherichia coli strains. Front Microbiol 7:705","journal-title":"Front Microbiol"},{"issue":"5","key":"5244_CR54","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.ijrobp.2021.07.1713","volume":"111","author":"MR Ferreira","year":"2021","unstructured":"Ferreira MR, Sands CJ, Li JV et al (2021) Impact of pelvic radiation therapy for prostate cancer on global metabolic profiles and microbiota-driven gastrointestinal late side effects: a longitudinal observational study. Int J Radiat Oncol Biol Phys 111(5):1204\u20131213","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"5244_CR55","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s10096-014-2081-3","volume":"33","author":"L Flanagan","year":"2014","unstructured":"Flanagan L, Schmid J, Ebert M et al (2014) Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome. Eur J Clin Microbiol Infect Dis 33(8):1381\u20131390","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"5","key":"5244_CR56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127909","volume":"10","author":"R Flores","year":"2015","unstructured":"Flores R, Zhong G (2015) The chlamydia pneumoniae inclusion membrane protein Cpn1027 interacts with host cell Wnt signaling pathway regulator cytoplasmic activation\/proliferation-associated protein 2 (Caprin2). PLoS ONE 10(5):e0127909","journal-title":"PLoS ONE"},{"key":"5244_CR57","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1479-5876-10-253","volume":"10","author":"R Flores","year":"2012","unstructured":"Flores R, Shi J, Fuhrman B et al (2012) Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study. J Transl Med 10:253","journal-title":"J Transl Med"},{"issue":"2","key":"5244_CR58","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.cell.2015.08.030","volume":"163","author":"DM Fonseca","year":"2015","unstructured":"Fonseca DM, Hand TW, Han SJ et al (2015) Microbiota-dependent sequelae of acute infection compromise tissue-specific immunity. Cell 163(2):354\u2013366","journal-title":"Cell"},{"issue":"10","key":"5244_CR59","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.neo.2017.08.004","volume":"19","author":"AE Frankel","year":"2017","unstructured":"Frankel AE, Coughlin LA, Kim J et al (2017) Metagenomic shotgun sequencing and unbiased metabolomic profiling identify specific human gut microbiota and metabolites associated with immune checkpoint therapy efficacy in melanoma patients. Neoplasia 19(10):848\u2013855","journal-title":"Neoplasia"},{"issue":"3","key":"5244_CR60","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.immuni.2016.02.019","volume":"44","author":"TC Fung","year":"2016","unstructured":"Fung TC, Bessman NJ, Hepworth MR et al (2016) Lymphoid-tissue-resident commensal bacteria promote members of the IL-10 cytokine family to establish mutualism. Immunity 44(3):634\u2013646","journal-title":"Immunity"},{"issue":"7480","key":"5244_CR61","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","volume":"504","author":"Y Furusawa","year":"2013","unstructured":"Furusawa Y, Obata Y, Fukuda S et al (2013) Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504(7480):446\u2013450","journal-title":"Nature"},{"issue":"3","key":"5244_CR62","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","volume":"9","author":"DI Gabrilovich","year":"2009","unstructured":"Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9(3):162\u2013174","journal-title":"Nat Rev Immunol"},{"key":"5244_CR63","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.oraloncology.2015.11.013","volume":"53","author":"LV Galvao-Moreira","year":"2016","unstructured":"Galvao-Moreira LV, da Cruz MC (2016) Oral microbiome, periodontitis and risk of head and neck cancer. Oral Oncol 53:17\u201319","journal-title":"Oral Oncol"},{"key":"5244_CR64","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fcimb.2017.00057","volume":"7","author":"F Geng","year":"2017","unstructured":"Geng F, Liu J, Guo Y et al (2017) Persistent exposure to porphyromonas gingivalis promotes proliferative and invasion capabilities, and tumorigenic properties of human immortalized oral epithelial cells. Front Cell Infect Microbiol 7:57","journal-title":"Front Cell Infect Microbiol"},{"key":"5244_CR65","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv147","author":"JJ Goedert","year":"2015","unstructured":"Goedert JJ, Jones G, Hua X et al (2015) Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case-control pilot study. J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/djv147","journal-title":"J Natl Cancer Inst"},{"issue":"6371","key":"5244_CR66","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.aan4236","volume":"359","author":"V Gopalakrishnan","year":"2018","unstructured":"Gopalakrishnan V, Spencer CN, Nezi L et al (2018) Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359(6371):97\u2013103","journal-title":"Science"},{"issue":"6558","key":"5244_CR67","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1126\/science.abc9113","volume":"373","author":"ME Griffin","year":"2021","unstructured":"Griffin ME, Espinosa J, Becker JL et al (2021) Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy. Science 373(6558):1040\u20131046","journal-title":"Science"},{"key":"5244_CR68","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321187","author":"S Guo","year":"2020","unstructured":"Guo S, Chen J, Chen F et al (2020) Exosomes derived from Fusobacterium nucleatum-infected colorectal cancer cells facilitate tumour metastasis by selectively carrying miR-1246\/92b-3p\/27a-3p and CXCL16. Gut. https:\/\/doi.org\/10.1136\/gutjnl-2020-321187","journal-title":"Gut"},{"key":"5244_CR69","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3389\/fmicb.2017.01162","volume":"8","author":"VK Gupta","year":"2017","unstructured":"Gupta VK, Paul S, Dutta C (2017) Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity. Front Microbiol 8:1162","journal-title":"Front Microbiol"},{"issue":"2","key":"5244_CR70","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","volume":"42","author":"C Gur","year":"2015","unstructured":"Gur C, Ibrahim Y, Isaacson B et al (2015) Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity 42(2):344\u2013355","journal-title":"Immunity"},{"issue":"6","key":"5244_CR71","volume":"8","author":"C Gur","year":"2019","unstructured":"Gur C, Maalouf N, Shhadeh A et al (2019) Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1. Oncoimmunology 8(6):e1581531","journal-title":"Oncoimmunology"},{"issue":"1","key":"5244_CR72","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1186\/s12885-019-6115-1","volume":"19","author":"F Haghi","year":"2019","unstructured":"Haghi F, Goli E, Mirzaei B et al (2019) The association between fecal enterotoxigenic B. fragilis with colorectal cancer. BMC Cancer 19(1):879","journal-title":"BMC Cancer"},{"key":"5244_CR73","volume":"12","author":"T Han","year":"2021","unstructured":"Han T, Hu X, Li K et al (2021) Bifidobacterium infantis maintains genome stability in ulcerative colitis via regulating anaphase-promoting complex subunit 7. Front Microbiol 12:761113","journal-title":"Front Microbiol"},{"issue":"1","key":"5244_CR74","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D (2022) Hallmarks of cancer: new dimensions. Cancer Discov 12(1):31\u201346","journal-title":"Cancer Discov"},{"issue":"5","key":"5244_CR75","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674","journal-title":"Cell"},{"issue":"3","key":"5244_CR76","volume":"7","author":"CH Hansen","year":"2012","unstructured":"Hansen CH, Nielsen DS, Kverka M et al (2012) Patterns of early gut colonization shape future immune responses of the host. PLoS ONE 7(3):e34043","journal-title":"PLoS ONE"},{"issue":"5986","key":"5244_CR77","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1126\/science.1188454","volume":"328","author":"S Hapfelmeier","year":"2010","unstructured":"Hapfelmeier S, Lawson MA, Slack E et al (2010) Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science 328(5986):1705\u20131709","journal-title":"Science"},{"issue":"4","key":"5244_CR78","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1158\/2326-6066.CIR-18-0444","volume":"7","author":"A Harusato","year":"2019","unstructured":"Harusato A, Viennois E, Etienne-Mesmin L et al (2019) Early-life microbiota exposure restricts myeloid-derived suppressor cell-driven colonic tumorigenesis. Cancer Immunol Res 7(4):544\u2013551","journal-title":"Cancer Immunol Res"},{"issue":"3","key":"5244_CR79","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0002-9610(49)90165-8","volume":"77","author":"MA Hayes","year":"1949","unstructured":"Hayes MA (1949) Chronic ulcerative colitis and associated carcinoma. Am J Surg 77(3):363\u2013370","journal-title":"Am J Surg"},{"issue":"2","key":"5244_CR80","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/gutjnl-2018-317200","volume":"68","author":"Z He","year":"2019","unstructured":"He Z, Gharaibeh RZ, Newsome RC et al (2019) Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin. Gut 68(2):289\u2013300","journal-title":"Gut"},{"issue":"5","key":"5244_CR81","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cmet.2021.03.002","volume":"33","author":"Y He","year":"2021","unstructured":"He Y, Fu L, Li Y et al (2021) Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8(+) T cell immunity. Cell Metab 33(5):988-1000 e1007","journal-title":"Cell Metab"},{"issue":"5","key":"5244_CR82","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1053\/j.gastro.2017.07.047","volume":"153","author":"AN Hegazy","year":"2017","unstructured":"Hegazy AN, West NR, Stubbington MJT et al (2017) Circulating and tissue-resident CD4(+) T cells with reactivity to intestinal microbiota are abundant in healthy individuals and function is altered during inflammation. Gastroenterology 153(5):1320-1337 e1316","journal-title":"Gastroenterology"},{"key":"5244_CR83","doi-asserted-by":"crossref","first-page":"30751","DOI":"10.1038\/srep30751","volume":"6","author":"TJ Hieken","year":"2016","unstructured":"Hieken TJ, Chen J, Hoskin TL et al (2016) The microbiome of aseptically collected human breast tissue in benign and malignant disease. Sci Rep 6:30751","journal-title":"Sci Rep"},{"issue":"3","key":"5244_CR84","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","volume":"33","author":"T Hirano","year":"2021","unstructured":"Hirano T (2021) IL-6 in inflammation, autoimmunity and cancer. Int Immunol 33(3):127\u2013148","journal-title":"Int Immunol"},{"issue":"6","key":"5244_CR85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066019","volume":"8","author":"C Hoffmann","year":"2013","unstructured":"Hoffmann C, Dollive S, Grunberg S et al (2013) Archaea and fungi of the human gut microbiome: correlations with diet and bacterial residents. PLoS ONE 8(6):e66019","journal-title":"PLoS ONE"},{"issue":"5","key":"5244_CR86","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1074\/jbc.M117.801480","volume":"293","author":"AT Holdbrooks","year":"2018","unstructured":"Holdbrooks AT, Britain CM, Bellis SL (2018) ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor. J Biol Chem 293(5):1610\u20131622","journal-title":"J Biol Chem"},{"issue":"1","key":"5244_CR87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007468","volume":"15","author":"L Holokai","year":"2019","unstructured":"Holokai L, Chakrabarti J, Broda T et al (2019) Increased programmed death-ligand 1 is an early epithelial cell response to helicobacter pylori infection. PLoS Pathog 15(1):e1007468","journal-title":"PLoS Pathog"},{"issue":"24","key":"5244_CR88","doi-asserted-by":"crossref","first-page":"9862","DOI":"10.1073\/pnas.1307575110","volume":"110","author":"B Hu","year":"2013","unstructured":"Hu B, Elinav E, Huber S et al (2013) Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc Natl Acad Sci USA 110(24):9862\u20139867","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"5244_CR89","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1258\/ebm.2011.011297","volume":"237","author":"Y Huang","year":"2012","unstructured":"Huang Y, Yang W, Liu H et al (2012) Effect of high-dose methotrexate chemotherapy on intestinal Bifidobacteria, Lactobacillus and Escherichia coli in children with acute lymphoblastic leukemia. Exp Biol Med (maywood) 237(3):305\u2013311","journal-title":"Exp Biol Med (maywood)"},{"issue":"5","key":"5244_CR90","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41564-019-0381-1","volume":"4","author":"Z Huang","year":"2019","unstructured":"Huang Z, Wang J, Xu X et al (2019) Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity. Nat Microbiol 4(5):766\u2013773","journal-title":"Nat Microbiol"},{"key":"5244_CR91","volume-title":"IARC: biological agents, vol 100","author":"IARC","year":"2012","unstructured":"IARC (2012) IARC: biological agents, vol 100. International Agency for Research on Cancer, Lyon"},{"key":"5244_CR92","volume-title":"IARC: RED meat and processed meat, vol 114","author":"IARC","year":"2018","unstructured":"IARC (2018) IARC: RED meat and processed meat, vol 114. International Agency for Research on Cancer, Lyon"},{"issue":"1\u20132","key":"5244_CR93","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10555-019-09787-4","volume":"38","author":"A Ibrahim-Hashim","year":"2019","unstructured":"Ibrahim-Hashim A, Estrella V (2019) Acidosis and cancer: from mechanism to neutralization. Cancer Metastasis Rev 38(1\u20132):149\u2013155","journal-title":"Cancer Metastasis Rev"},{"issue":"6161","key":"5244_CR94","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1240527","volume":"342","author":"N Iida","year":"2013","unstructured":"Iida N, Dzutsev A, Stewart CA et al (2013) Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 342(6161):967\u2013970","journal-title":"Science"},{"issue":"1","key":"5244_CR95","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/cmi.12211","volume":"16","author":"H Inaba","year":"2014","unstructured":"Inaba H, Sugita H, Kuboniwa M et al (2014) Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation. Cell Microbiol 16(1):131\u2013145","journal-title":"Cell Microbiol"},{"issue":"3","key":"5244_CR96","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/19490976.2019.1592421","volume":"11","author":"DN Jackson","year":"2020","unstructured":"Jackson DN, Theiss AL (2020) Gut bacteria signaling to mitochondria in intestinal inflammation and cancer. Gut Microbes 11(3):285\u2013304","journal-title":"Gut Microbes"},{"key":"5244_CR97","doi-asserted-by":"crossref","first-page":"9895721","DOI":"10.1155\/2016\/9895721","volume":"2016","author":"K Jakubowska","year":"2016","unstructured":"Jakubowska K, Pryczynicz A, Januszewska J et al (2016) Expressions of matrix metalloproteinases 2, 7, and 9 in carcinogenesis of pancreatic ductal adenocarcinoma. Dis Markers 2016:9895721","journal-title":"Dis Markers"},{"issue":"4","key":"5244_CR98","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ijrobp.2020.04.015","volume":"107","author":"BS Jang","year":"2020","unstructured":"Jang BS, Chang JH, Chie EK et al (2020) Gut microbiome composition is associated with a pathologic response after preoperative chemoradiation in patients with rectal cancer. Int J Radiat Oncol Biol Phys 107(4):736\u2013746","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"5244_CR99","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/hep.30852","volume":"71","author":"X Jia","year":"2020","unstructured":"Jia X, Lu S, Zeng Z et al (2020) Characterization of gut microbiota, bile acid metabolism, and cytokines in intrahepatic cholangiocarcinoma. Hepatology 71(3):893\u2013906","journal-title":"Hepatology"},{"issue":"8","key":"5244_CR100","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jtho.2019.04.007","volume":"14","author":"Y Jin","year":"2019","unstructured":"Jin Y, Dong H, Xia L et al (2019) The diversity of gut microbiome is associated with favorable responses to anti-programmed death 1 immunotherapy in Chinese patients with NSCLC. J Thorac Oncol 14(8):1378\u20131389","journal-title":"J Thorac Oncol"},{"issue":"7827","key":"5244_CR101","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-020-2541-0","volume":"586","author":"E Kadosh","year":"2020","unstructured":"Kadosh E, Snir-Alkalay I, Venkatachalam A et al (2020) The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic. Nature 586(7827):133\u2013138","journal-title":"Nature"},{"issue":"1","key":"5244_CR102","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12866-021-02146-w","volume":"21","author":"R Kalkeri","year":"2021","unstructured":"Kalkeri R, Walters K, Van Der Pol W et al (2021) Changes in the gut microbiome community of nonhuman primates following radiation injury. BMC Microbiol 21(1):93","journal-title":"BMC Microbiol"},{"issue":"6","key":"5244_CR103","doi-asserted-by":"crossref","first-page":"847","DOI":"10.21037\/tlcr.2019.10.23","volume":"8","author":"Y Katayama","year":"2019","unstructured":"Katayama Y, Yamada T, Shimamoto T et al (2019) The role of the gut microbiome on the efficacy of immune checkpoint inhibitors in Japanese responder patients with advanced non-small cell lung cancer. Transl Lung Cancer Res 8(6):847\u2013853","journal-title":"Transl Lung Cancer Res"},{"key":"5244_CR104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anaerobe.2015.01.004","volume":"33","author":"YS Kim","year":"2015","unstructured":"Kim YS, Kim J, Park SJ (2015) High-throughput 16S rRNA gene sequencing reveals alterations of mouse intestinal microbiota after radiotherapy. Anaerobe 33:1\u20137","journal-title":"Anaerobe"},{"issue":"4","key":"5244_CR105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3393\/ac.2017.33.4.139","volume":"33","author":"IY Kim","year":"2017","unstructured":"Kim IY, Kwon HY, Park KH et al (2017a) Anaphase-promoting complex 7 is a prognostic factor in human colorectal cancer. Ann Coloproctol 33(4):139\u2013145","journal-title":"Ann Coloproctol"},{"issue":"1","key":"5244_CR106","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41467-017-00729-8","volume":"8","author":"OY Kim","year":"2017","unstructured":"Kim OY, Park HT, Dinh NTH et al (2017b) Bacterial outer membrane vesicles suppress tumor by interferon-gamma-mediated antitumor response. Nat Commun 8(1):626","journal-title":"Nat Commun"},{"issue":"1","key":"5244_CR107","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s40168-020-00894-x","volume":"8","author":"JY Kim","year":"2020","unstructured":"Kim JY, Whon TW, Lim MY et al (2020) The human gut archaeome: identification of diverse haloarchaea in Korean subjects. Microbiome 8(1):114","journal-title":"Microbiome"},{"issue":"1","key":"5244_CR108","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1038\/s41467-018-05767-4","volume":"9","author":"A Kindt","year":"2018","unstructured":"Kindt A, Liebisch G, Clavel T et al (2018) The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice. Nat Commun 9(1):3760","journal-title":"Nat Commun"},{"issue":"6","key":"5244_CR109","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1097\/MIB.0b013e318281330a","volume":"19","author":"K Klimesova","year":"2013","unstructured":"Klimesova K, Kverka M, Zakostelska Z et al (2013) Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice. Inflamm Bowel Dis 19(6):1266\u20131277","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"5244_CR110","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10549-019-05472-w","volume":"179","author":"AS Komorowski","year":"2020","unstructured":"Komorowski AS, Pezo RC (2020) Untapped \u201c-omics\u201d: the microbial metagenome, estrobolome, and their influence on the development of breast cancer and response to treatment. Breast Cancer Res Treat 179(2):287\u2013300","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"5244_CR111","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chom.2013.07.007","volume":"14","author":"AD Kostic","year":"2013","unstructured":"Kostic AD, Chun E, Robertson L et al (2013) Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 14(2):207\u2013215","journal-title":"Cell Host Microbe"},{"issue":"3","key":"5244_CR112","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cellsig.2013.11.032","volume":"26","author":"M Krausova","year":"2014","unstructured":"Krausova M, Korinek V (2014) Wnt signaling in adult intestinal stem cells and cancer. Cell Signal 26(3):570\u2013579","journal-title":"Cell Signal"},{"issue":"1","key":"5244_CR113","volume":"20","author":"DS Kuen","year":"2020","unstructured":"Kuen DS, Kim BS, Chung Y (2020) IL-17-producing cells in tumor immunity: friends or foes? Immune Netw 20(1):e6","journal-title":"Immune Netw"},{"issue":"5","key":"5244_CR114","doi-asserted-by":"crossref","DOI":"10.1136\/esmoopen-2020-000803","volume":"5","author":"AA Kulkarni","year":"2020","unstructured":"Kulkarni AA, Ebadi M, Zhang S et al (2020) Comparative analysis of antibiotic exposure association with clinical outcomes of chemotherapy versus immunotherapy across three tumour types. ESMO Open 5(5):e000803","journal-title":"ESMO Open"},{"issue":"1\u20132","key":"5244_CR115","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000449095","volume":"35","author":"M Kverka","year":"2017","unstructured":"Kverka M, Tlaskalova-Hogenova H (2017) Intestinal microbiota: facts and fiction. Dig Dis 35(1\u20132):139\u2013147","journal-title":"Dig Dis"},{"key":"5244_CR116","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324489","author":"SK Kwon","year":"2021","unstructured":"Kwon SK, Park JC, Kim KH et al (2021) Human gastric microbiota transplantation recapitulates premalignant lesions in germ-free mice. Gut. https:\/\/doi.org\/10.1136\/gutjnl-2021-324489","journal-title":"Gut"},{"issue":"5","key":"5244_CR117","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4161\/onci.20068","volume":"1","author":"T Lanca","year":"2012","unstructured":"Lanca T, Silva-Santos B (2012) The split nature of tumor-infiltrating leukocytes: Implications for cancer surveillance and immunotherapy. Oncoimmunology 1(5):717\u2013725","journal-title":"Oncoimmunology"},{"issue":"4","key":"5244_CR118","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41585-020-0286-z","volume":"17","author":"P Laniewski","year":"2020","unstructured":"Laniewski P, Ilhan ZE, Herbst-Kralovetz MM (2020) The microbiome and gynaecological cancer development, prevention and therapy. Nat Rev Urol 17(4):232\u2013250","journal-title":"Nat Rev Urol"},{"key":"5244_CR119","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.3389\/fimmu.2018.01830","volume":"9","author":"V Lazar","year":"1830","unstructured":"Lazar V, Ditu LM, Pircalabioru GG et al (1830) Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer. Front Immunol 9:1830","journal-title":"Front Immunol"},{"issue":"9","key":"5244_CR120","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1128\/IAI.00222-07","volume":"75","author":"HS Lee","year":"2007","unstructured":"Lee HS, Boulton IC, Reddin K et al (2007) Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function. Infect Immun 75(9):4449\u20134455","journal-title":"Infect Immun"},{"issue":"4","key":"5244_CR121","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nri.2017.7","volume":"17","author":"M Levy","year":"2017","unstructured":"Levy M, Kolodziejczyk AA, Thaiss CA et al (2017) Dysbiosis and the immune system. Nat Rev Immunol 17(4):219\u2013232","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"5244_CR122","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1158\/0008-5472.CAN-08-1565","volume":"69","author":"B Li","year":"2009","unstructured":"Li B, Vincent A, Cates J et al (2009) Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res 69(1):338\u2013348","journal-title":"Cancer Res"},{"issue":"23","key":"5244_CR123","doi-asserted-by":"crossref","first-page":"34599","DOI":"10.18632\/oncotarget.8963","volume":"7","author":"X Li","year":"2016","unstructured":"Li X, Chen Y, Qi H et al (2016) Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling. Oncotarget 7(23):34599\u201334616","journal-title":"Oncotarget"},{"issue":"11","key":"5244_CR124","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.14309\/ajg.0000000000001393","volume":"116","author":"H Li","year":"2021","unstructured":"Li H, Boakye D, Chen X et al (2021) Association of body mass index with risk of early-onset colorectal cancer: systematic review and meta-analysis. Am J Gastroenterol 116(11):2173\u20132183","journal-title":"Am J Gastroenterol"},{"key":"5244_CR125","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140940","author":"A Limeta","year":"2020","unstructured":"Limeta A, Ji B, Levin M et al (2020) Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.140940","journal-title":"JCI Insight"},{"issue":"46","key":"5244_CR126","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1038\/onc.2016.131","volume":"35","author":"LY Lin","year":"2016","unstructured":"Lin LY, Du LM, Cao K et al (2016) Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities. Oncogene 35(46):6038\u20136042","journal-title":"Oncogene"},{"issue":"7","key":"5244_CR127","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1002\/jcp.26356","volume":"233","author":"S Lin","year":"2018","unstructured":"Lin S, Li Y, Zamyatnin AA Jr et al (2018) Reactive oxygen species and colorectal cancer. J Cell Physiol 233(7):5119\u20135132","journal-title":"J Cell Physiol"},{"issue":"4","key":"5244_CR128","volume":"6","author":"J Liu","year":"2011","unstructured":"Liu J, Zhang N, Li Q et al (2011) Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice. PLoS ONE 6(4):e19495","journal-title":"PLoS ONE"},{"issue":"2","key":"5244_CR129","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.immuni.2019.06.017","volume":"51","author":"C Liu","year":"2019","unstructured":"Liu C, Chikina M, Deshpande R et al (2019a) Treg cells promote the SREBP1-dependent metabolic fitness of tumor-promoting macrophages via repression of CD8(+) T cell-derived interferon-gamma. Immunity 51(2):381-397 e386","journal-title":"Immunity"},{"issue":"11","key":"5244_CR130","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.7150\/ijbs.35980","volume":"15","author":"F Liu","year":"2019","unstructured":"Liu F, Li J, Guan Y et al (2019b) Dysbiosis of the gut microbiome is associated with tumor biomarkers in lung cancer. Int J Biol Sci 15(11):2381\u20132392","journal-title":"Int J Biol Sci"},{"issue":"1","key":"5244_CR131","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13014-020-01735-9","volume":"16","author":"J Liu","year":"2021","unstructured":"Liu J, Liu C, Yue J (2021) Radiotherapy and the gut microbiome: facts and fiction. Radiat Oncol 16(1):9","journal-title":"Radiat Oncol"},{"issue":"6","key":"5244_CR132","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.4049\/jimmunol.178.6.3731","volume":"178","author":"E Lombardo","year":"2007","unstructured":"Lombardo E, Alvarez-Barrientos A, Maroto B et al (2007) TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-alpha autocrine signalling. J Immunol 178(6):3731\u20133739","journal-title":"J Immunol"},{"issue":"16\u201317","key":"5244_CR133","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1007\/s00253-021-11491-9","volume":"105","author":"H Lu","year":"2021","unstructured":"Lu H, Wang Q, Liu W et al (2021) Precision strategies for cancer treatment by modifying the tumor-related bacteria. Appl Microbiol Biotechnol 105(16\u201317):6183\u20136197","journal-title":"Appl Microbiol Biotechnol"},{"key":"5244_CR134","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan5931","author":"C Ma","year":"2018","unstructured":"Ma C, Han M, Heinrich B et al (2018) Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science. https:\/\/doi.org\/10.1126\/science.aan5931","journal-title":"Science"},{"issue":"5664","key":"5244_CR135","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1091334","volume":"303","author":"AJ Macpherson","year":"2004","unstructured":"Macpherson AJ, Uhr T (2004) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303(5664):1662\u20131665","journal-title":"Science"},{"issue":"6510","key":"5244_CR136","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.abc3421","volume":"369","author":"LF Mager","year":"2020","unstructured":"Mager LF, Burkhard R, Pett N et al (2020) Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy. Science 369(6510):1481\u20131489","journal-title":"Science"},{"issue":"4","key":"5244_CR137","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108677","volume":"34","author":"C Maisonneuve","year":"2021","unstructured":"Maisonneuve C, Tsang DKL, Foerster EG et al (2021) Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells. Cell Rep 34(4):108677","journal-title":"Cell Rep"},{"key":"5244_CR138","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.25","volume":"4","author":"F Marques-Fernandez","year":"2013","unstructured":"Marques-Fernandez F, Planells-Ferrer L, Gozzelino R et al (2013) TNFalpha induces survival through the FLIP-L-dependent activation of the MAPK\/ERK pathway. Cell Death Dis 4:e493","journal-title":"Cell Death Dis"},{"issue":"8390","key":"5244_CR139","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","volume":"1","author":"BJ Marshall","year":"1984","unstructured":"Marshall BJ, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1(8390):1311\u20131315","journal-title":"Lancet"},{"issue":"52","key":"5244_CR140","doi-asserted-by":"crossref","first-page":"20852","DOI":"10.1073\/pnas.0810958105","volume":"105","author":"M Marzec","year":"2008","unstructured":"Marzec M, Zhang Q, Goradia A et al (2008) Oncogenic kinase NPM\/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7\u2013H1). Proc Natl Acad Sci USA 105(52):20852\u201320857","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"5244_CR141","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109220","volume":"35","author":"SL Mathiasen","year":"2021","unstructured":"Mathiasen SL, Gall-Mas L, Pateras IS et al (2021) Bacterial genotoxins induce T cell senescence. Cell Rep 35(10):109220","journal-title":"Cell Rep"},{"issue":"6371","key":"5244_CR142","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.aao3290","volume":"359","author":"V Matson","year":"2018","unstructured":"Matson V, Fessler J, Bao R et al (2018) The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science 359(6371):104\u2013108","journal-title":"Science"},{"issue":"6","key":"5244_CR143","first-page":"3163","volume":"11","author":"H Matsukawa","year":"2021","unstructured":"Matsukawa H, Iida N, Kitamura K et al (2021) Dysbiotic gut microbiota in pancreatic cancer patients form correlation networks with the oral microbiota and prognostic factors. Am J Cancer Res 11(6):3163\u20133175","journal-title":"Am J Cancer Res"},{"issue":"1","key":"5244_CR144","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227707","volume":"15","author":"R Miao","year":"2020","unstructured":"Miao R, Badger TC, Groesch K et al (2020) Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer. PLoS ONE 15(1):e0227707","journal-title":"PLoS ONE"},{"issue":"8","key":"5244_CR145","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/jnci\/djx278","volume":"110","author":"DS Michaud","year":"2018","unstructured":"Michaud DS, Lu J, Peacock-Villada AY et al (2018) Periodontal disease assessed using clinical dental measurements and cancer risk in the ARIC study. J Natl Cancer Inst 110(8):843\u2013854","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"5244_CR146","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ijc.20662","volume":"114","author":"KB Michels","year":"2005","unstructured":"Michels KB (2005) The role of nutrition in cancer development and prevention. Int J Cancer 114(2):163\u2013165","journal-title":"Int J Cancer"},{"issue":"5","key":"5244_CR147","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1001\/jamaoncol.2015.1377","volume":"1","author":"K Mima","year":"2015","unstructured":"Mima K, Sukawa Y, Nishihara R et al (2015) Fusobacterium nucleatum and T cells in colorectal carcinoma. JAMA Oncol 1(5):653\u2013661","journal-title":"JAMA Oncol"},{"issue":"12","key":"5244_CR148","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1136\/gutjnl-2015-310101","volume":"65","author":"K Mima","year":"2016","unstructured":"Mima K, Nishihara R, Qian ZR et al (2016) Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut 65(12):1973\u20131980","journal-title":"Gut"},{"issue":"2","key":"5244_CR149","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00535-014-0963-x","volume":"50","author":"L Mira-Pascual","year":"2015","unstructured":"Mira-Pascual L, Cabrera-Rubio R, Ocon S et al (2015) Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers. J Gastroenterol 50(2):167\u2013179","journal-title":"J Gastroenterol"},{"key":"5244_CR150","doi-asserted-by":"crossref","first-page":"16865","DOI":"10.1038\/srep16865","volume":"5","author":"A Mitra","year":"2015","unstructured":"Mitra A, MacIntyre DA, Lee YS et al (2015) Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity. Sci Rep 5:16865","journal-title":"Sci Rep"},{"issue":"1","key":"5244_CR151","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/s41467-020-15856-y","volume":"11","author":"A Mitra","year":"2020","unstructured":"Mitra A, MacIntyre DA, Ntritsos G et al (2020) The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nat Commun 11(1):1999","journal-title":"Nat Commun"},{"issue":"5","key":"5244_CR152","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/apt.13302","volume":"42","author":"E Montassier","year":"2015","unstructured":"Montassier E, Gastinne T, Vangay P et al (2015) Chemotherapy-driven dysbiosis in the intestinal microbiome. Aliment Pharmacol Ther 42(5):515\u2013528","journal-title":"Aliment Pharmacol Ther"},{"issue":"7","key":"5244_CR153","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neo.2018.05.002","volume":"20","author":"F Morgillo","year":"2018","unstructured":"Morgillo F, Dallio M, Della Corte CM et al (2018) Carcinogenesis as a result of multiple inflammatory and oxidative hits: a comprehensive review from tumor microenvironment to gut microbiota. Neoplasia 20(7):721\u2013733","journal-title":"Neoplasia"},{"key":"5244_CR154","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.146083","volume":"811","author":"A Morikawa","year":"2022","unstructured":"Morikawa A, Kawabata A, Shirahige K et al (2022) Altered cervicovaginal microbiota in premenopausal ovarian cancer patients. Gene 811:146083","journal-title":"Gene"},{"issue":"18","key":"5244_CR155","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1073\/pnas.1405634111","volume":"111","author":"AM Morton","year":"2014","unstructured":"Morton AM, Sefik E, Upadhyay R et al (2014) Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proc Natl Acad Sci USA 111(18):6696\u20136701","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6032","key":"5244_CR156","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.1198719","volume":"332","author":"BD Muegge","year":"2011","unstructured":"Muegge BD, Kuczynski J, Knights D et al (2011) Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science 332(6032):970\u2013974","journal-title":"Science"},{"issue":"12","key":"5244_CR157","volume":"8","author":"YD Nam","year":"2013","unstructured":"Nam YD, Kim HJ, Seo JG et al (2013) Impact of pelvic radiotherapy on gut microbiota of gynecological cancer patients revealed by massive pyrosequencing. PLoS ONE 8(12):e82659","journal-title":"PLoS ONE"},{"issue":"6494","key":"5244_CR158","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.aay9189","volume":"368","author":"D Nejman","year":"2020","unstructured":"Nejman D, Livyatan I, Fuks G et al (2020) The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 368(6494):973\u2013980","journal-title":"Science"},{"key":"5244_CR159","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejca.2020.02.047","volume":"131","author":"P Nenclares","year":"2020","unstructured":"Nenclares P, Bhide SA, Sandoval-Insausti H et al (2020) Impact of antibiotic use during curative treatment of locally advanced head and neck cancers with chemotherapy and radiotherapy. Eur J Cancer 131:9\u201315","journal-title":"Eur J Cancer"},{"issue":"8","key":"5244_CR160","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S1470-2045(19)30340-7","volume":"20","author":"NR Nene","year":"2019","unstructured":"Nene NR, Reisel D, Leimbach A et al (2019) Association between the cervicovaginal microbiome, BRCA1 mutation status, and risk of ovarian cancer: a case-control study. Lancet Oncol 20(8):1171\u20131182","journal-title":"Lancet Oncol"},{"issue":"6","key":"5244_CR161","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.chom.2014.05.003","volume":"15","author":"G Nigro","year":"2014","unstructured":"Nigro G, Rossi R, Commere PH et al (2014) The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe 15(6):792\u2013798","journal-title":"Cell Host Microbe"},{"issue":"2","key":"5244_CR162","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/1471-0528.15854","volume":"127","author":"J Norenhag","year":"2020","unstructured":"Norenhag J, Du J, Olovsson M et al (2020) The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis. BJOG 127(2):171\u2013180","journal-title":"BJOG"},{"issue":"7","key":"5244_CR163","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1182\/blood-2002-05-1461","volume":"101","author":"M Numasaki","year":"2003","unstructured":"Numasaki M, Fukushi J, Ono M et al (2003) Interleukin-17 promotes angiogenesis and tumor growth. Blood 101(7):2620\u20132627","journal-title":"Blood"},{"key":"5244_CR164","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1038\/ncomms7505","volume":"6","author":"AJ Obregon-Tito","year":"2015","unstructured":"Obregon-Tito AJ, Tito RY, Metcalf J et al (2015) Subsistence strategies in traditional societies distinguish gut microbiomes. Nat Commun 6:6505","journal-title":"Nat Commun"},{"issue":"7","key":"5244_CR165","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/cas.14069","volume":"110","author":"Y Ohue","year":"2019","unstructured":"Ohue Y, Nishikawa H (2019) Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target? Cancer Sci 110(7):2080\u20132089","journal-title":"Cancer Sci"},{"key":"5244_CR166","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13099-020-00384-3","volume":"12","author":"Y Okita","year":"2020","unstructured":"Okita Y, Koi M, Takeda K et al (2020) Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage. Gut Pathog 12:46","journal-title":"Gut Pathog"},{"issue":"9","key":"5244_CR167","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.celrep.2015.02.024","volume":"10","author":"J Park","year":"2015","unstructured":"Park J, Lee SE, Hur J et al (2015) M-CSF from cancer cells induces fatty acid synthase and PPARbeta\/delta activation in tumor myeloid cells leading to tumor progression. Cell Rep 10(9):1614\u20131625","journal-title":"Cell Rep"},{"issue":"4","key":"5244_CR168","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.4049\/jimmunol.158.4.1582","volume":"158","author":"SL Pender","year":"1997","unstructured":"Pender SL, Tickle SP, Docherty AJ et al (1997) A major role for matrix metalloproteinases in T cell injury in the gut. J Immunol 158(4):1582\u20131590","journal-title":"J Immunol"},{"issue":"3","key":"5244_CR169","doi-asserted-by":"crossref","first-page":"e724","DOI":"10.1542\/peds.2006-1649","volume":"119","author":"PF Perez","year":"2007","unstructured":"Perez PF, Dore J, Leclerc M et al (2007) Bacterial imprinting of the neonatal immune system: lessons from maternal cells? Pediatrics 119(3):e724-732","journal-title":"Pediatrics"},{"issue":"6564","key":"5244_CR170","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.abf8403","volume":"374","author":"N Pernigoni","year":"2021","unstructured":"Pernigoni N, Zagato E, Calcinotto A et al (2021) Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis. Science 374(6564):216\u2013224","journal-title":"Science"},{"key":"5244_CR171","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2021.103404","volume":"164","author":"F Perrone","year":"2021","unstructured":"Perrone F, Belluomini L, Mazzotta M et al (2021) Exploring the role of respiratory microbiome in lung cancer: a systematic review. Crit Rev Oncol Hematol 164:103404","journal-title":"Crit Rev Oncol Hematol"},{"issue":"2","key":"5244_CR172","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/lam.13486","volume":"73","author":"RA Pomares Bascunana","year":"2021","unstructured":"Pomares Bascunana RA, Veses V, Sheth CC (2021) Effectiveness of fecal microbiota transplant for the treatment of Clostridioides difficile diarrhea: a systematic review and meta-analysis. Lett Appl Microbiol 73(2):149\u2013158","journal-title":"Lett Appl Microbiol"},{"issue":"1","key":"5244_CR173","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/hep.30036","volume":"69","author":"FR Ponziani","year":"2019","unstructured":"Ponziani FR, Bhoori S, Castelli C et al (2019) Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease. Hepatology 69(1):107\u2013120","journal-title":"Hepatology"},{"issue":"1","key":"5244_CR174","first-page":"1","volume":"13","author":"X Qi","year":"2021","unstructured":"Qi X, Yun C, Pang Y et al (2021) The impact of the gut microbiota on the reproductive and metabolic endocrine system. Gut Microbes 13(1):1\u201321","journal-title":"Gut Microbes"},{"issue":"7285","key":"5244_CR175","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","volume":"464","author":"J Qin","year":"2010","unstructured":"Qin J, Li R, Raes J et al (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464(7285):59\u201365","journal-title":"Nature"},{"issue":"11","key":"5244_CR176","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.7150\/jca.15480","volume":"7","author":"D Ray","year":"2016","unstructured":"Ray D, Kidane D (2016) Gut microbiota imbalance and base excision repair dynamics in colon cancer. J Cancer 7(11):1421\u20131430","journal-title":"J Cancer"},{"issue":"7","key":"5244_CR177","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3390\/cancers12071791","volume":"12","author":"C Rebe","year":"2020","unstructured":"Rebe C, Ghiringhelli F (2020) Interleukin-1beta and cancer. Cancers (basel) 12(7):1791","journal-title":"Cancers (basel)"},{"issue":"2","key":"5244_CR178","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.clnu.2006.10.006","volume":"26","author":"BS Reddy","year":"2007","unstructured":"Reddy BS, MacFie J, Gatt M et al (2007) Commensal bacteria do translocate across the intestinal barrier in surgical patients. Clin Nutr 26(2):208\u2013215","journal-title":"Clin Nutr"},{"issue":"4","key":"5244_CR179","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/86373","volume":"2","author":"M Rescigno","year":"2001","unstructured":"Rescigno M, Urbano M, Valzasina B et al (2001) Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2(4):361\u2013367","journal-title":"Nat Immunol"},{"issue":"4","key":"5244_CR180","volume":"16","author":"C Rey","year":"2020","unstructured":"Rey C, Chang YY, Latour-Lambert P et al (2020) Transcytosis subversion by M cell-to-enterocyte spread promotes Shigella flexneri and Listeria monocytogenes intracellular bacterial dissemination. PLoS Pathog 16(4):e1008446","journal-title":"PLoS Pathog"},{"issue":"3","key":"5244_CR181","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/19490976.2016.1150414","volume":"7","author":"JM Ridlon","year":"2016","unstructured":"Ridlon JM, Wolf PG, Gaskins HR (2016) Taurocholic acid metabolism by gut microbes and colon cancer. Gut Microbes 7(3):201\u2013215","journal-title":"Gut Microbes"},{"key":"5244_CR182","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fmicb.2016.00185","volume":"7","author":"D Rios-Covian","year":"2016","unstructured":"Rios-Covian D, Ruas-Madiedo P, Margolles A et al (2016) Intestinal short chain fatty acids and their link with diet and human health. Front Microbiol 7:185","journal-title":"Front Microbiol"},{"key":"5244_CR183","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.3389\/fimmu.2019.02390","volume":"10","author":"MR Rogan","year":"2019","unstructured":"Rogan MR, Patterson LL, Wang JY et al (2019) Bacterial manipulation of Wnt signaling: a host-pathogen Tug-of-Wnt. Front Immunol 10:2390","journal-title":"Front Immunol"},{"issue":"6","key":"5244_CR184","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/s41590-020-0673-x","volume":"21","author":"A Roquilly","year":"2020","unstructured":"Roquilly A, Jacqueline C, Davieau M et al (2020) Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis. Nat Immunol 21(6):636\u2013648","journal-title":"Nat Immunol"},{"issue":"5","key":"5244_CR185","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","volume":"9","author":"JL Round","year":"2009","unstructured":"Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9(5):313\u2013323","journal-title":"Nat Rev Immunol"},{"issue":"6371","key":"5244_CR186","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.aan3706","volume":"359","author":"B Routy","year":"2018","unstructured":"Routy B, Le Chatelier E, Derosa L et al (2018) Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 359(6371):91\u201397","journal-title":"Science"},{"issue":"1","key":"5244_CR187","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ccell.2014.11.009","volume":"27","author":"MR Rutkowski","year":"2015","unstructured":"Rutkowski MR, Stephen TL, Svoronos N et al (2015) Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation. Cancer Cell 27(1):27\u201340","journal-title":"Cancer Cell"},{"issue":"4","key":"5244_CR188","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.eururo.2020.07.011","volume":"78","author":"NJ Salgia","year":"2020","unstructured":"Salgia NJ, Bergerot PG, Maia MC et al (2020) Stool microbiome profiling of patients with metastatic renal cell carcinoma receiving anti-PD-1 immune checkpoint inhibitors. Eur Urol 78(4):498\u2013502","journal-title":"Eur Urol"},{"issue":"3","key":"5244_CR189","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1053\/j.gastro.2012.11.005","volume":"144","author":"A Schirbel","year":"2013","unstructured":"Schirbel A, Kessler S, Rieder F et al (2013) Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis. Gastroenterology 144(3):613-623 e619","journal-title":"Gastroenterology"},{"issue":"11","key":"5244_CR190","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/nrc3610","volume":"13","author":"RF Schwabe","year":"2013","unstructured":"Schwabe RF, Jobin C (2013) The microbiome and cancer. Nat Rev Cancer 13(11):800\u2013812","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"5244_CR191","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cell.2017.03.040","volume":"169","author":"TA Scott","year":"2017","unstructured":"Scott TA, Quintaneiro LM, Norvaisas P et al (2017) Host-microbe co-metabolism dictates cancer drug efficacy in C. elegans. Cell 169(3):442-456 e418","journal-title":"Cell"},{"key":"5244_CR192","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3389\/fimmu.2018.01170","volume":"9","author":"Y Sheng","year":"2018","unstructured":"Sheng Y, Li F, Qin Z (2018) TNF receptor 2 makes tumor necrosis factor a friend of tumors. Front Immunol 9:1170","journal-title":"Front Immunol"},{"issue":"3","key":"5244_CR193","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","volume":"122","author":"A Sica","year":"2012","unstructured":"Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122(3):787\u2013795","journal-title":"J Clin Invest"},{"issue":"6","key":"5244_CR194","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.ejca.2006.01.003","volume":"42","author":"A Sica","year":"2006","unstructured":"Sica A, Schioppa T, Mantovani A et al (2006) Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 42(6):717\u2013727","journal-title":"Eur J Cancer"},{"issue":"1","key":"5244_CR195","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s42003-021-01741-x","volume":"4","author":"TT Sims","year":"2021","unstructured":"Sims TT, El Alam MB, Karpinets TV et al (2021) Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation. Commun Biol 4(1):237","journal-title":"Commun Biol"},{"issue":"6264","key":"5244_CR196","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.aac4255","volume":"350","author":"A Sivan","year":"2015","unstructured":"Sivan A, Corrales L, Hubert N et al (2015) Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350(6264):1084\u20131089","journal-title":"Science"},{"issue":"6","key":"5244_CR197","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1600-051X.1986.tb00849.x","volume":"13","author":"J Slots","year":"1986","unstructured":"Slots J, Bragd L, Wikstrom M et al (1986) The occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius in destructive periodontal disease in adults. J Clin Periodontol 13(6):570\u2013577","journal-title":"J Clin Periodontol"},{"issue":"4","key":"5244_CR198","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.niox.2005.08.002","volume":"13","author":"T Sobko","year":"2005","unstructured":"Sobko T, Reinders CI, Jansson E et al (2005) Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite. Nitric Oxide 13(4):272\u2013278","journal-title":"Nitric Oxide"},{"key":"5244_CR199","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13059-015-0614-4","volume":"16","author":"F Sommer","year":"2015","unstructured":"Sommer F, Nookaew I, Sommer N et al (2015) Site-specific programming of the host epithelial transcriptome by the gut microbiota. Genome Biol 16:62","journal-title":"Genome Biol"},{"issue":"1","key":"5244_CR200","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.immuni.2013.11.018","volume":"40","author":"X Song","year":"2014","unstructured":"Song X, Gao H, Lin Y et al (2014) Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity 40(1):140\u2013152","journal-title":"Immunity"},{"issue":"34","key":"5244_CR201","doi-asserted-by":"crossref","first-page":"35579","DOI":"10.18632\/oncotarget.5758","volume":"6","author":"X Song","year":"2015","unstructured":"Song X, Xin N, Wang W et al (2015) Wnt\/beta-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis. Oncotarget 6(34):35579\u201335588","journal-title":"Oncotarget"},{"issue":"6","key":"5244_CR202","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/1759-7714.13442","volume":"11","author":"P Song","year":"2020","unstructured":"Song P, Yang D, Wang H et al (2020) Relationship between intestinal flora structure and metabolite analysis and immunotherapy efficacy in Chinese NSCLC patients. Thorac Cancer 11(6):1621\u20131632","journal-title":"Thorac Cancer"},{"issue":"1","key":"5244_CR203","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41385-018-0053-0","volume":"12","author":"MT Sorbara","year":"2019","unstructured":"Sorbara MT, Pamer EG (2019) Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them. Mucosal Immunol 12(1):1\u20139","journal-title":"Mucosal Immunol"},{"issue":"6575","key":"5244_CR204","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.aaz7015","volume":"374","author":"CN Spencer","year":"2021","unstructured":"Spencer CN, McQuade JL, Gopalakrishnan V et al (2021) Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science 374(6575):1632\u20131640","journal-title":"Science"},{"issue":"24","key":"5244_CR205","doi-asserted-by":"crossref","first-page":"15451","DOI":"10.1073\/pnas.202604299","volume":"99","author":"TS Stappenbeck","year":"2002","unstructured":"Stappenbeck TS, Hooper LV, Gordon JI (2002) Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci USA 99(24):15451\u201315455","journal-title":"Proc Natl Acad Sci USA"},{"key":"5244_CR206","volume":"10","author":"L Sun","year":"2020","unstructured":"Sun L, Yang S, Deng Q et al (2020) Salmonella effector SpvB disrupts intestinal epithelial barrier integrity for bacterial translocation. Front Cell Infect Microbiol 10:606541","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"5244_CR207","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2017.1373208","volume":"5","author":"T Takiishi","year":"2017","unstructured":"Takiishi T, Fenero CIM, Camara NOS (2017) Intestinal barrier and gut microbiota: shaping our immune responses throughout life. Tissue Barriers 5(4):e1373208","journal-title":"Tissue Barriers"},{"issue":"7741","key":"5244_CR208","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-019-0878-z","volume":"565","author":"T Tanoue","year":"2019","unstructured":"Tanoue T, Morita S, Plichta DR et al (2019) A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature 565(7741):600\u2013605","journal-title":"Nature"},{"issue":"2","key":"5244_CR209","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/15384101.2019.1706903","volume":"19","author":"G Tchakarska","year":"2020","unstructured":"Tchakarska G, Sola B (2020) The double dealing of cyclin D1. Cell Cycle 19(2):163\u2013178","journal-title":"Cell Cycle"},{"issue":"9","key":"5244_CR210","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1158\/1055-9965.EPI-09-0334","volume":"18","author":"M Tezal","year":"2009","unstructured":"Tezal M, Sullivan MA, Hyland A et al (2009) Chronic periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 18(9):2406\u20132412","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"5244_CR211","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.cell.2014.09.048","volume":"159","author":"CA Thaiss","year":"2014","unstructured":"Thaiss CA, Zeevi D, Levy M et al (2014) Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell 159(3):514\u2013529","journal-title":"Cell"},{"issue":"5","key":"5244_CR212","doi-asserted-by":"crossref","first-page":"G602","DOI":"10.1152\/ajpgi.00230.2019","volume":"317","author":"CR Tiffany","year":"2019","unstructured":"Tiffany CR, Baumler AJ (2019) Dysbiosis: from fiction to function. Am J Physiol Gastrointest Liver Physiol 317(5):G602\u2013G608","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5244_CR213","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2217\/fmb-2018-0317","volume":"14","author":"A Togo","year":"2019","unstructured":"Togo A, Dufour JC, Lagier JC et al (2019) Repertoire of human breast and milk microbiota: a systematic review. Future Microbiol 14:623\u2013641","journal-title":"Future Microbiol"},{"key":"5244_CR214","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2020.10.033","volume":"156","author":"M Tonneau","year":"2021","unstructured":"Tonneau M, Elkrief A, Pasquier D et al (2021) The role of the gut microbiome on radiation therapy efficacy and gastrointestinal complications: a systematic review. Radiother Oncol 156:1\u20139","journal-title":"Radiother Oncol"},{"key":"5244_CR215","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.656795","volume":"9","author":"W Tremblay","year":"2021","unstructured":"Tremblay W, Mompart F, Lopez E et al (2021) Cytolethal distending toxin promotes replicative stress leading to genetic instability transmitted to daughter cells. Front Cell Dev Biol 9:656795","journal-title":"Front Cell Dev Biol"},{"issue":"16","key":"5244_CR216","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1128\/AEM.01235-16","volume":"82","author":"C Urbaniak","year":"2016","unstructured":"Urbaniak C, Gloor GB, Brackstone M et al (2016) The microbiota of breast tissue and its association with breast cancer. Appl Environ Microbiol 82(16):5039\u20135048","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"5244_CR217","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1172\/JCI124332","volume":"130","author":"M Uribe-Herranz","year":"2020","unstructured":"Uribe-Herranz M, Rafail S, Beghi S et al (2020) Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response. J Clin Invest 130(1):466\u2013479","journal-title":"J Clin Invest"},{"issue":"5","key":"5244_CR218","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1056\/NEJMoa1205037","volume":"368","author":"E van Nood","year":"2013","unstructured":"van Nood E, Vrieze A, Nieuwdorp M et al (2013) Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 368(5):407\u2013415","journal-title":"N Engl J Med"},{"issue":"2","key":"5244_CR219","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.37341","volume":"4","author":"SK Veettil","year":"2021","unstructured":"Veettil SK, Wong TY, Loo YS et al (2021) Role of diet in colorectal cancer incidence: umbrella review of meta-analyses of prospective observational studies. JAMA Netw Open 4(2):e2037341","journal-title":"JAMA Netw Open"},{"issue":"6264","key":"5244_CR220","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.aad1329","volume":"350","author":"M Vetizou","year":"2015","unstructured":"Vetizou M, Pitt JM, Daillere R et al (2015) Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350(6264):1079\u20131084","journal-title":"Science"},{"issue":"6161","key":"5244_CR221","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1240537","volume":"342","author":"S Viaud","year":"2013","unstructured":"Viaud S, Saccheri F, Mignot G et al (2013) The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 342(6161):971\u2013976","journal-title":"Science"},{"issue":"1","key":"5244_CR222","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1158\/0008-5472.CAN-16-1359","volume":"77","author":"E Viennois","year":"2017","unstructured":"Viennois E, Merlin D, Gewirtz AT et al (2017) Dietary emulsifier-induced low-grade inflammation promotes colon carcinogenesis. Cancer Res 77(1):27\u201340","journal-title":"Cancer Res"},{"issue":"1","key":"5244_CR223","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/bjd.20626","volume":"186","author":"F Vitali","year":"2022","unstructured":"Vitali F, Colucci R, Di Paola M et al (2022) Early melanoma invasivity correlates with gut fungal and bacterial profiles. Br J Dermatol 186(1):106\u2013116","journal-title":"Br J Dermatol"},{"issue":"6354","key":"5244_CR224","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1126\/science.aan0677","volume":"357","author":"Y Wang","year":"2017","unstructured":"Wang Y, Kuang Z, Yu X et al (2017) The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. Science 357(6354):912\u2013916","journal-title":"Science"},{"issue":"3","key":"5244_CR225","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.immuni.2018.08.018","volume":"49","author":"T Wang","year":"2018","unstructured":"Wang T, Fan C, Yao A et al (2018) The adaptor protein CARD9 protects against colon cancer by restricting mycobiota-mediated expansion of myeloid-derived suppressor cells. Immunity 49(3):504-514 e504","journal-title":"Immunity"},{"issue":"3191","key":"5244_CR226","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956) On the origin of cancer cells. Science 123(3191):309\u2013314","journal-title":"Science"},{"issue":"2","key":"5244_CR227","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4049\/jimmunol.161.2.957","volume":"161","author":"RW Watson","year":"1998","unstructured":"Watson RW, Rotstein OD, Parodo J et al (1998) The IL-1 beta-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-1 beta. J Immunol 161(2):957\u2013962","journal-title":"J Immunol"},{"issue":"41","key":"5244_CR228","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1038\/sj.onc.1204733","volume":"20","author":"LH Wei","year":"2001","unstructured":"Wei LH, Kuo ML, Chen CA et al (2001) The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K\/Akt pathway. Oncogene 20(41):5799\u20135809","journal-title":"Oncogene"},{"issue":"29","key":"5244_CR229","doi-asserted-by":"crossref","first-page":"46158","DOI":"10.18632\/oncotarget.10064","volume":"7","author":"Z Wei","year":"2016","unstructured":"Wei Z, Cao S, Liu S et al (2016) Could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients\u2019 survival? A pilot study on relevant mechanism. Oncotarget 7(29):46158\u201346172","journal-title":"Oncotarget"},{"issue":"10","key":"5244_CR230","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1073\/pnas.0812874106","volume":"106","author":"WR Wikoff","year":"2009","unstructured":"Wikoff WR, Anfora AT, Liu J et al (2009) Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci USA 106(10):3698\u20133703","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"5244_CR231","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1128\/IAI.01443-13","volume":"82","author":"J Winter","year":"2014","unstructured":"Winter J, Letley D, Rhead J et al (2014) Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells. Infect Immun 82(4):1372\u20131381","journal-title":"Infect Immun"},{"issue":"4","key":"5244_CR232","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1128\/CMR.00011-10","volume":"23","author":"LE Wroblewski","year":"2010","unstructured":"Wroblewski LE, Peek RM Jr, Wilson KT (2010) Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev 23(4):713\u2013739","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"5244_CR233","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1053\/gast.2003.50047","volume":"124","author":"S Wu","year":"2003","unstructured":"Wu S, Morin PJ, Maouyo D et al (2003) Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation. Gastroenterology 124(2):392\u2013400","journal-title":"Gastroenterology"},{"issue":"9","key":"5244_CR234","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nm.2015","volume":"15","author":"S Wu","year":"2009","unstructured":"Wu S, Rhee KJ, Albesiano E et al (2009) A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med 15(9):1016\u20131022","journal-title":"Nat Med"},{"issue":"6052","key":"5244_CR235","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","volume":"334","author":"GD Wu","year":"2011","unstructured":"Wu GD, Chen J, Hoffmann C et al (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334(6052):105\u2013108","journal-title":"Science"},{"issue":"15","key":"5244_CR236","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000019698","volume":"99","author":"L Xiao","year":"2020","unstructured":"Xiao L, Zhang Q, Peng Y et al (2020a) The effect of periodontal bacteria infection on incidence and prognosis of cancer: a systematic review and meta-analysis. Medicine (baltimore) 99(15):e19698","journal-title":"Medicine (baltimore)"},{"issue":"1","key":"5244_CR237","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40168-020-00845-6","volume":"8","author":"HW Xiao","year":"2020","unstructured":"Xiao HW, Cui M, Li Y et al (2020b) Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein. Microbiome 8(1):69","journal-title":"Microbiome"},{"issue":"3","key":"5244_CR238","first-page":"743","volume":"10","author":"J Xu","year":"2020","unstructured":"Xu J, Peng JJ, Yang W et al (2020) Vaginal microbiomes and ovarian cancer: a review. Am J Cancer Res 10(3):743\u2013756","journal-title":"Am J Cancer Res"},{"issue":"4","key":"5244_CR239","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/j.gastro.2016.11.018","volume":"152","author":"Y Yang","year":"2017","unstructured":"Yang Y, Weng W, Peng J et al (2017) Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 Signaling to nuclear factor-kappaB, and up-regulating expression of MicroRNA-21. Gastroenterology 152(4):851-866 e824","journal-title":"Gastroenterology"},{"issue":"7402","key":"5244_CR240","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","volume":"486","author":"T Yatsunenko","year":"2012","unstructured":"Yatsunenko T, Rey FE, Manary MJ et al (2012) Human gut microbiome viewed across age and geography. Nature 486(7402):222\u2013227","journal-title":"Nature"},{"issue":"10","key":"5244_CR241","volume":"10","author":"S Ying","year":"2015","unstructured":"Ying S, Zeng DN, Chi L et al (2015) The influence of age and gender on skin-associated microbial communities in urban and rural human populations. PLoS ONE 10(10):e0141842","journal-title":"PLoS ONE"},{"issue":"3","key":"5244_CR242","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","volume":"170","author":"T Yu","year":"2017","unstructured":"Yu T, Guo F, Yu Y et al (2017) Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell 170(3):548-563 e516","journal-title":"Cell"},{"issue":"5","key":"5244_CR243","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/onc.2016.240","volume":"36","author":"Q Zhang","year":"2017","unstructured":"Zhang Q, Liu S, Parajuli KR et al (2017) Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition. Oncogene 36(5):687\u2013699","journal-title":"Oncogene"},{"issue":"5","key":"5244_CR244","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1158\/2159-8290.CD-20-0304","volume":"11","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Ma C, Duan Y et al (2021) Gut microbiome directs hepatocytes to recruit MDSCs and promote cholangiocarcinoma. Cancer Discov 11(5):1248\u20131267","journal-title":"Cancer Discov"},{"issue":"6","key":"5244_CR245","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","volume":"30","author":"D Zheng","year":"2020","unstructured":"Zheng D, Liwinski T, Elinav E (2020a) Interaction between microbiota and immunity in health and disease. Cell Res 30(6):492\u2013506","journal-title":"Cell Res"},{"issue":"4","key":"5244_CR246","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1080\/19490976.2020.1737487","volume":"11","author":"Y Zheng","year":"2020","unstructured":"Zheng Y, Fang Z, Xue Y et al (2020b) Specific gut microbiome signature predicts the early-stage lung cancer. Gut Microbes 11(4):1030\u20131042","journal-title":"Gut Microbes"},{"issue":"1","key":"5244_CR247","doi-asserted-by":"crossref","first-page":"1788891","DOI":"10.1080\/19490976.2020.1788891","volume":"12","author":"Z Zhu","year":"2020","unstructured":"Zhu Z, Huang J, Li X et al (2020) Gut microbiota regulate tumor metastasis via circRNA\/miRNA networks. Gut Microbes 12(1):1788891","journal-title":"Gut Microbes"},{"issue":"4","key":"5244_CR248","first-page":"634","volume":"67","author":"T Zuo","year":"2018","unstructured":"Zuo T, Wong SH, Lam K et al (2018) Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome. Gut 67(4):634\u2013643","journal-title":"Gut"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05244-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-023-05244-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05244-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T13:11:47Z","timestamp":1697893907000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-023-05244-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":248,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["5244"],"URL":"https:\/\/doi.org\/10.1007\/s00432-023-05244-6","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]},"assertion":[{"value":"5 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}