{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:09:23Z","timestamp":1792804163689,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"17","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Luzern"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Mesonephric-like adenocarcinomas (MLA) of the female genital tract represent a rare and relatively recently described neoplasm exhibiting characteristic morphologic and immunohistochemical findings commonly associated with a\n                      <jats:italic>KRAS<\/jats:italic>\n                      -mutation. Most cases display an aggressive clinical behavior, but knowledge about treatment approaches is limited, especially for targeting\n                      <jats:italic>KRAS<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We report a series of eight cases with a detailed molecular analysis for\n                      <jats:italic>KRAS<\/jats:italic>\n                      . These cases as well as the data of previously published cases with detailed information regarding\n                      <jats:italic>KRAS<\/jats:italic>\n                      -mutational events were reviewed for a potential targeted approach and its prognostic impact.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both the uterine and ovarian MLA harbor a somatic\n                      <jats:italic>KRAS-mutation<\/jats:italic>\n                      in about 85% of the reported cases, affecting the hotspot codons 12 and 13. 15.7% of the endometrial and 15.6% of ovarian MLA are wild type for\n                      <jats:italic>KRAS<\/jats:italic>\n                      . A p.G12A-alteration was seen in 5.6% (5\/89) of the endometrial and in 6.2% (2\/32) of the ovarian tumors, for p.G12C in 7.9% and 6.2%, for p.G12D in 32.6% and 34.5% and for p.G12V in 36% and 37.5%, respectively. Very limited data are available regarding the prognostic impact of different mutational sites within the\n                      <jats:italic>KRAS-gene<\/jats:italic>\n                      without significant prognostic impact.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Because of a specific p.G12C-\n                      <jats:italic>KRAS<\/jats:italic>\n                      somatic mutation, only the minority of MLA (7.9% with uterine and 6.2% with ovarian primary) are potentially targetable by sotarasib in that rare but aggressive subtype of adenocarcinoma of the female genital tract. Until now, the different location of a somatic\n                      <jats:italic>KRAS<\/jats:italic>\n                      -mutation is of no prognostic impact.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00432-023-05306-9","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T08:02:27Z","timestamp":1693900947000},"page":"15727-15736","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment\u2014detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations"],"prefix":"10.1007","volume":"149","author":[{"given":"Christine E.","family":"Brambs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-Christian","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Hiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Kr\u00fccken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Christmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Monecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Kathrin","family":"H\u00f6hn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"issue":"2","key":"5306_CR1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/PGP.0000000000000781","volume":"41","author":"S Al Nabhani","year":"2022","unstructured":"Al Nabhani S, Doyle A, Kennedy S, McVey R, Crown J, Gibbons D (2022) Endometrial mesonephric-like adenocarcinoma presenting as an ocular lesion: a case report. 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