{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:10:20Z","timestamp":1793398220324,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903394"],"award-info":[{"award-number":["81903394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572071"],"award-info":[{"award-number":["81572071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s00432-023-05434-2","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:02:40Z","timestamp":1696921360000},"page":"17285-17296","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Alteration of serum bile acids in non-small cell lung cancer identified by a validated LC\u2013MS\/MS method"],"prefix":"10.1007","volume":"149","author":[{"given":"Tongxin","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiankun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"5434_CR1","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1136\/gutjnl-2021-325021","volume":"71","author":"X Bai","year":"2022","unstructured":"Bai X, Wei H, Liu W, Coker OO, Gou H, Liu C, Zhao L, Li C, Zhou Y, Wang G, Kang W, Ng EK, Yu J (2022) Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites. Gut 71:2439\u20132450","journal-title":"Gut"},{"key":"5434_CR2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/toxsci\/kfu227","volume":"143","author":"SP Bathena","year":"2015","unstructured":"Bathena SP, Thakare R, Gautam N, Mukherjee S, Olivera M, Meza J, Alnouti Y (2015) Urinary bile acids as biomarkers for liver diseases I. Stability of the baseline profile in healthy subjects. Toxicol Sci 143:296\u2013307","journal-title":"Toxicol Sci"},{"key":"5434_CR3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13293-022-00473-9","volume":"13","author":"Y Cai","year":"2022","unstructured":"Cai Y, Shen X, Lu L, Yan H, Huang H, Gaule P, Muca E, Theriot CM, Rattray Z, Rattray NJW, Lu J, Ahuja N, Zhang Y, Paty PB, Khan SA, Johnson CH (2022) Bile acid distributions, sex-specificity, and prognosis in colorectal cancer. Biol Sex Differ 13:61","journal-title":"Biol Sex Differ"},{"key":"5434_CR4","doi-asserted-by":"crossref","first-page":"G322","DOI":"10.1152\/ajpgi.00263.2012","volume":"304","author":"W Cao","year":"2013","unstructured":"Cao W, Tian W, Hong J, Li D, Tavares R, Noble L, Moss SF, Resnick MB (2013) Expression of bile acid receptor TGR5 in gastric adenocarcinoma. Am J Physiol Gastrointest Liver Physiol 304:G322\u2013G327","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5434_CR5","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1053\/j.gastro.2017.01.055","volume":"152","author":"O Ch\u00e1vez-Talavera","year":"2017","unstructured":"Ch\u00e1vez-Talavera O, Tailleux A, Lefebvre P, Staels B (2017) Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease. Gastroenterology 152:1679\u201394.e3","journal-title":"Gastroenterology"},{"key":"5434_CR6","doi-asserted-by":"crossref","first-page":"s4","DOI":"10.5604\/01.3001.0010.5493","volume":"16","author":"A Di Ciaula","year":"2017","unstructured":"Di Ciaula A, Garruti G, Lunardi Baccetto R, Molina-Molina E, Bonfrate L, Wang DQ, Portincasa P (2017) Bile acid physiology. Ann Hepatol 16:s4\u2013s14","journal-title":"Ann Hepatol"},{"key":"5434_CR7","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/hep4.2003","volume":"6","author":"Z Farhat","year":"2022","unstructured":"Farhat Z, Freedman ND, Sampson JN, Falk RT, Koshiol J, Weinstein SJ, Albanes D, Sinha R, Loftfield E (2022) A prospective investigation of serum bile acids with risk of liver cancer, fatal liver disease, and biliary tract cancer. Hepatol Commun 6:2391\u20132399","journal-title":"Hepatol Commun"},{"key":"5434_CR8","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/jcsm.12798","volume":"12","author":"L Feng","year":"2021","unstructured":"Feng L, Zhang W, Shen Q, Miao C, Chen L, Li Y, Gu X, Fan M, Ma Y, Wang H, Liu X, Zhang X (2021) Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome. J Cachexia Sarcopenia Muscle 12:1553\u20131569","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"5434_CR9","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1002\/jcp.27411","volume":"234","author":"N Hashemi Goradel","year":"2019","unstructured":"Hashemi Goradel N, Najafi M, Salehi E, Farhood B, Mortezaee K (2019) Cyclooxygenase-2 in cancer: a review. J Cell Physiol 234:5683\u20135699","journal-title":"J Cell Physiol"},{"key":"5434_CR10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1164\/rccm.202112-2758OC","volume":"207","author":"H He","year":"2023","unstructured":"He H, He MM, Wang H, Qiu W, Liu L, Long L, Shen Q, Zhang S, Qin S, Lu Z, Cai Y, Zhang M, Niu S, Li J, Shen N, Zhu Y, Tian J, Chang J, Miao X, Zhong R (2023) In utero and childhood\/adolescence exposure to tobacco smoke, genetic risk, and lung cancer incidence and mortality in adulthood. Am J Respir Crit Care Med 207:173\u2013182","journal-title":"Am J Respir Crit Care Med"},{"key":"5434_CR11","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature25183","volume":"553","author":"RS Herbst","year":"2018","unstructured":"Herbst RS, Morgensztern D, Boshoff C (2018) The biology and management of non-small cell lung cancer. Nature 553:446\u2013454","journal-title":"Nature"},{"key":"5434_CR12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","volume":"15","author":"W Jia","year":"2018","unstructured":"Jia W, Xie G, Jia W (2018) Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat Rev Gastroenterol Hepatol 15:111\u2013128","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"5434_CR13","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1074\/jbc.M209706200","volume":"278","author":"Y Kawamata","year":"2003","unstructured":"Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M (2003) A G protein-coupled receptor responsive to bile acids. J Biol Chem 278:9435\u20139440","journal-title":"J Biol Chem"},{"key":"5434_CR14","first-page":"3632","volume":"38","author":"YJ Kim","year":"2017","unstructured":"Kim YJ, Jeong SH, Kim EK, Kim EJ, Cho JH (2017) Ursodeoxycholic acid suppresses epithelial-mesenchymal transition and cancer stem cell formation by reducing the levels of peroxiredoxin II and reactive oxygen species in pancreatic cancer cells. Oncol Rep 38:3632\u20133638","journal-title":"Oncol Rep"},{"key":"5434_CR15","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/jnci\/djz166","volume":"112","author":"T K\u00fchn","year":"2020","unstructured":"K\u00fchn T, Stepien M, L\u00f3pez-Nogueroles M, Damms-Machado A, Sookthai D, Johnson T, Roca M, H\u00fcsing A, Maldonado SG, Cross AJ, Murphy N, Freisling H, Rinaldi S, Scalbert A, Fedirko V, Severi G, Boutron-Ruault MC, Mancini FR, Sowah SA, Boeing H, Jakszyn P, S\u00e1nchez MJ, Merino S, Colorado-Yohar S, Barricarte A, Khaw KT, Schmidt JA, Perez-Cornago A, Trichopoulou A, Karakatsani A, Thriskos P, Palli D, Agnoli C, Tumino R, Sacerdote C, Panico S, Bueno-de-Mesquita B, van Gils CH, Heath AK, Gunter MJ, Riboli E, Lahoz A, Jenab M, Kaaks R (2020) Prediagnostic plasma bile acid levels and colon cancer risk: a prospective study. J Natl Cancer Inst 112:516\u2013524","journal-title":"J Natl Cancer Inst"},{"key":"5434_CR16","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/pr.113.008201","volume":"66","author":"T Li","year":"2014","unstructured":"Li T, Chiang JY (2014) Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev 66:948\u2013983","journal-title":"Pharmacol Rev"},{"key":"5434_CR17","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/cas.15629","volume":"114","author":"J Li","year":"2022","unstructured":"Li J, Liu K, Ji Z, Wang Y, Yin T, Long T, Shen Y, Cheng L (2022) Serum untargeted metabolomics reveal metabolic alteration of non-small cell lung cancer and refine disease detection. Cancer Sci 114:680\u2013689","journal-title":"Cancer Sci"},{"key":"5434_CR18","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/hep.27085","volume":"60","author":"R Liu","year":"2014","unstructured":"Liu R, Zhao R, Zhou X, Liang X, Campbell DJ, Zhang X, Zhang L, Shi R, Wang G, Pandak WM, Sirica AE, Hylemon PB, Zhou H (2014) Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2. Hepatology 60:908\u2013918","journal-title":"Hepatology"},{"key":"5434_CR19","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.ajpath.2018.05.015","volume":"188","author":"R Liu","year":"2018","unstructured":"Liu R, Li X, Hylemon PB, Zhou H (2018a) Conjugated bile acids promote invasive growth of esophageal adenocarcinoma cells and cancer stem cell expansion via sphingosine 1-phosphate receptor 2-mediated yes-associated protein activation. Am J Pathol 188:2042\u20132058","journal-title":"Am J Pathol"},{"key":"5434_CR20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.canlet.2017.10.017","volume":"412","author":"X Liu","year":"2018","unstructured":"Liu X, Chen B, You W, Xue S, Qin H, Jiang H (2018b) The membrane bile acid receptor TGR5 drives cell growth and migration via activation of the JAK2\/STAT3 signaling pathway in non-small cell lung cancer. Cancer Lett 412:194\u2013207","journal-title":"Cancer Lett"},{"key":"5434_CR21","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbabio.2018.04.002","volume":"1859","author":"E Mik\u00f3","year":"2018","unstructured":"Mik\u00f3 E, Vida A, Kov\u00e1cs T, Ujlaki G, Trencs\u00e9nyi G, M\u00e1rton J, S\u00e1ri Z, Kov\u00e1cs P, Boratk\u00f3 A, Hujber Z, Csonka T, Antal-Szalm\u00e1s P, Watanabe M, Gombos I, Csoka B, Kiss B, V\u00edgh L, Szab\u00f3 J, M\u00e9hes G, Sebesty\u00e9n A, Goedert JJ, Bai P (2018) Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness. Biochim Biophys Acta Bioenerg 1859:958\u2013974","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"5434_CR22","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1038\/s41467-021-26685-y","volume":"12","author":"M Nie","year":"2021","unstructured":"Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z (2021) Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma. Nat Commun 12:6479","journal-title":"Nat Commun"},{"key":"5434_CR23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.semcancer.2020.10.003","volume":"73","author":"S Ocvirk","year":"2021","unstructured":"Ocvirk S, O\u2019Keefe SJD (2021) Dietary fat, bile acid metabolism and colorectal cancer. Semin Cancer Biol 73:347\u2013355","journal-title":"Semin Cancer Biol"},{"key":"5434_CR24","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1158\/1078-0432.CCR-19-2184","volume":"26","author":"K Pocha","year":"2020","unstructured":"Pocha K, Mock A, Rapp C, Dettling S, Warta R, Geisenberger C, Jungk C, Martins LR, Grabe N, Reuss D, Debus J, von Deimling A, Abdollahi A, Unterberg A, Herold-Mende CC (2020) Surfactant expression defines an inflamed subtype of lung adenocarcinoma brain metastases that correlates with prolonged survival. Clin Cancer Res 26:2231\u20132243","journal-title":"Clin Cancer Res"},{"key":"5434_CR25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1388-1981(02)00190-7","volume":"1583","author":"D Qiao","year":"2002","unstructured":"Qiao D, Im E, Qi W, Martinez JD (2002) Activator protein-1 and CCAAT\/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis. Biochim Biophys Acta 1583:108\u2013116","journal-title":"Biochim Biophys Acta"},{"key":"5434_CR26","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.molmed.2019.04.012","volume":"25","author":"V Relli","year":"2019","unstructured":"Relli V, Trerotola M, Guerra E, Alberti S (2019) Abandoning the notion of non-small cell lung cancer. Trends Mol Med 25:585\u2013594","journal-title":"Trends Mol Med"},{"key":"5434_CR27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00018-022-04278-2","volume":"79","author":"T Re\u017een","year":"2022","unstructured":"Re\u017een T, Rozman D, Kov\u00e1cs T, Kov\u00e1cs P, Sipos A, Bai P, Mik\u00f3 E (2022) The role of bile acids in carcinogenesis. Cell Mol Life Sci 79:243","journal-title":"Cell Mol Life Sci"},{"key":"5434_CR28","volume":"36","author":"Y Shen","year":"2022","unstructured":"Shen Y, Liu K, Luo X, Guan Q, Cheng L (2022) A simple and reliable bile acid assay in human serum by LC\u2013MS\/MS. J Clin Lab Anal 36:e24279","journal-title":"J Clin Lab Anal"},{"key":"5434_CR29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/path.4983","volume":"243","author":"L Sheng","year":"2017","unstructured":"Sheng L, Jena PK, Hu Y, Liu HX, Nagar N, Kalanetra KM, French SW, French SW, Mills DA, Wan YY (2017) Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation. J Pathol 243:431\u2013441","journal-title":"J Pathol"},{"key":"5434_CR30","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s12010-013-0417-6","volume":"171","author":"W Song","year":"2013","unstructured":"Song W, Yang HB, Chen P, Wang SM, Zhao LP, Xu WH, Fan HF, Gu X, Chen LY (2013) Apoptosis of human gastric carcinoma SGC-7901 induced by deoxycholic acid via the mitochondrial-dependent pathway. Appl Biochem Biotechnol 171:1061\u20131071","journal-title":"Appl Biochem Biotechnol"},{"key":"5434_CR31","volume":"8","author":"WS Song","year":"2018","unstructured":"Song WS, Park HM, Ha JM, Shin SG, Park HG, Kim J, Zhang T, Ahn DH, Kim SM, Yang YH, Jeong JH, Theberge AB, Kim BG, Lee JK, Kim YG (2018) Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma. Sci Rep 8:11088","journal-title":"Sci Rep"},{"key":"5434_CR32","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/ijc.33885","volume":"150","author":"M Stepien","year":"2022","unstructured":"Stepien M, Lopez-Nogueroles M, Lahoz A, K\u00fchn T, Perlemuter G, Voican C, Ciocan D, Boutron-Ruault MC, Jansen E, Viallon V, Leitzmann M, Tj\u00f8nneland A, Severi G, Mancini FR, Dong C, Kaaks R, Fortner RT, Bergmann MM, Boeing H, Trichopoulou A, Karakatsani A, Peppa E, Palli D, Krogh V, Tumino R, Sacerdote C, Panico S, Bueno-de-Mesquita HB, Skeie G, Merino S, Ros RZ, S\u00e1nchez MJ, Amiano P, Huerta JM, Barricarte A, Sj\u00f6berg K, Ohlsson B, Nystr\u00f6m H, Werner M, Perez-Cornago A, Schmidt JA, Freisling H, Scalbert A, Weiderpass E, Christakoudi S, Gunter MJ, Jenab M (2022) Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma. Int J Cancer 150:1255\u20131268","journal-title":"Int J Cancer"},{"key":"5434_CR33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jhep.2022.02.030","volume":"77","author":"R Sun","year":"2022","unstructured":"Sun R, Zhang Z, Bao R, Guo X, Gu Y, Yang W, Wei J, Chen X, Tong L, Meng J, Zhong C, Zhang C, Zhang J, Sun Y, Ling C, Tong X, Yu FX, Yu H, Qu W, Zhao B, Guo W, Qian M, Saiyin H, Liu Y, Liu RH, Xie C, Liu W, Xiong Y, Guan KL, Shi Y, Wang P, Ye D (2022) Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis. J Hepatol 77:453\u2013466","journal-title":"J Hepatol"},{"key":"5434_CR34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209\u2013249","journal-title":"CA Cancer J Clin"},{"key":"5434_CR35","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000196584","volume":"63","author":"H Takahashi","year":"1996","unstructured":"Takahashi H, Kuroki Y, Honda Y, Shijubo N, Hirasawa M, Fujishima T, Akino T, Abe S (1996) Lipid analysis and surfactant-associated protein expression in lung adenocarcinoma cells from pleural effusion. Respiration 63:390\u2013396","journal-title":"Respiration"},{"key":"5434_CR36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/carcin\/bgh010","volume":"25","author":"ON Tucker","year":"2004","unstructured":"Tucker ON, Dannenberg AJ, Yang EK, Fahey TJ 3rd (2004) Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines. Carcinogenesis 25:419\u2013423","journal-title":"Carcinogenesis"},{"key":"5434_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2017.07.001","volume":"56","author":"DH Volle","year":"2017","unstructured":"Volle DH (2017) Bile acids, roles in integrative physiology and pathophysiology. Mol Aspects Med 56:1","journal-title":"Mol Aspects Med"},{"key":"5434_CR38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","volume":"24","author":"A Wahlstr\u00f6m","year":"2016","unstructured":"Wahlstr\u00f6m A, Sayin SI, Marschall HU, B\u00e4ckhed F (2016) Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab 24:41\u201350","journal-title":"Cell Metab"},{"key":"5434_CR39","volume":"4","author":"Y Wang","year":"2019","unstructured":"Wang Y, Gao X, Zhang X, Xiao Y, Huang J, Yu D, Li X, Hu H, Ge T, Li D, Zhang T (2019) Gut microbiota dysbiosis is associated with altered bile acid metabolism in infantile cholestasis. mSystems 4:e00463-19","journal-title":"mSystems"},{"key":"5434_CR40","volume":"55","author":"M Wei","year":"2020","unstructured":"Wei M, Huang F, Zhao L, Zhang Y, Yang W, Wang S, Li M, Han X, Ge K, Qu C, Rajani C, Xie G, Zheng X, Zhao A, Bian Z, Jia W (2020) A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility. EBioMedicine 55:102766","journal-title":"EBioMedicine"},{"key":"5434_CR41","doi-asserted-by":"crossref","first-page":"G549","DOI":"10.1152\/ajpgi.00152.2020","volume":"319","author":"Y Yang","year":"2020","unstructured":"Yang Y, Zhang J (2020) Bile acid metabolism and circadian rhythms. Am J Physiol Gastrointest Liver Physiol 319:G549\u2013G563","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5434_CR42","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152678","volume":"450","author":"Y Yang","year":"2021","unstructured":"Yang Y, Yang C, Lei Z, Rong H, Yu S, Wu H, Yang L, Lei Y, Liu W, Nie Y, Zhu J, Guo J (2021) Cigarette smoking exposure breaks the homeostasis of cholesterol and bile acid metabolism and induces gut microbiota dysbiosis in mice with different diets. Toxicology 450:152678","journal-title":"Toxicology"},{"key":"5434_CR43","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41598-017-00698-4","volume":"7","author":"W You","year":"2017","unstructured":"You W, Chen B, Liu X, Xue S, Qin H, Jiang H (2017) Farnesoid X receptor, a novel proto-oncogene in non-small cell lung cancer, promotes tumor growth via directly transactivating CCND1. Sci Rep 7:591","journal-title":"Sci Rep"},{"key":"5434_CR44","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.apsb.2021.07.011","volume":"12","author":"L Zhao","year":"2022","unstructured":"Zhao L, Zhang H, Liu X, Xue S, Chen D, Zou J, Jiang H (2022) TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization. Acta Pharm Sin B 12:787\u2013800","journal-title":"Acta Pharm Sin B"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05434-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-023-05434-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05434-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T17:04:38Z","timestamp":1700327078000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-023-05434-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,10]]},"references-count":44,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["5434"],"URL":"https:\/\/doi.org\/10.1007\/s00432-023-05434-2","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,10]]},"assertion":[{"value":"15 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The informed consents were taken from all the participants present in the study. This study protocol was reviewed and approved by the Institutional Review Committee of the Tongji Medical College, HUST, approval number [2016YFC1302702].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consents were taken from all the participants present in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have given consent to the publication of this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}