{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:26:52Z","timestamp":1788190012552,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272411"],"award-info":[{"award-number":["82272411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272411"],"award-info":[{"award-number":["82272411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272411"],"award-info":[{"award-number":["82272411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272411"],"award-info":[{"award-number":["82272411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Circular RNA (circRNA), which has been demonstrated in studies to be abundantly prevalent in tumor cells and bodily fluids and to play a significant role in tumors, has the potential for biological markers to be used to assist tumor diagnosis. This study mainly discusses the potential of circBRIP1 as a biomarker for diagnosing non-small-cell lung cancer (NSCLC).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>First, high-throughput sequencing screened the differentially expressed circBRIP1, and real-time fluorescence quantitative PCR (qRT-PCR) verified its expression in NSCLC. Next, sanger sequencing, agarose gel electrophoresis, RNase R assay, and fluorescence in situ hybridization (FISH) were used to verify its molecular characteristics. The diagnostic value was analyzed by the subject operating characteristic curve (ROC), and the cardinality test was analyzed for correlation with clinicopathological parameters. Finally, we tentatively predicted the downstream miRNA- or RNA-binding protein that may bind to circBRIP1.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>CircBRIP1 is highly expressed in NSCLC tissues, cells and plasma with good specificity and stability. CircBRIP1 not only can well-distinguish NSCLC patients from benign pulmonary diseases (BPD) patients, healthy individuals and small cell lung cancer (SCLC) patients, but it also has some potential for dynamic monitoring. Combined with the analysis of clinicopathological data, the high level of circRNA expression was related to the degree of tumor differentiation, TNM stage, T stage, lymph node metastasis and distal metastasis in NSCLC patients. In addition, circBRIP1 has a high diagnostic value.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Plasma circBRIP1 is significantly overexpressed in NSCLC patients. It can be used as a sensitive biomarker with unique value for early diagnosis, tumor development and prognosis detection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-023-05558-5","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T10:02:17Z","timestamp":1707386537000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["CircBRIP1: a plasma diagnostic marker for non-small-cell lung cancer"],"prefix":"10.1007","volume":"150","author":[{"given":"Xinfeng","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqing","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"issue":"10","key":"5558_CR1","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1136\/gut.14.10.794","volume":"14","author":"SN Booth","year":"1973","unstructured":"Booth SN et al (1973) Serum carcinoembryonic antigen in clinical disorders. Gut 14(10):794\u2013799. https:\/\/doi.org\/10.1136\/gut.14.10.794","journal-title":"Gut"},{"issue":"12","key":"5558_CR2","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1111\/jcmm.12431","volume":"18","author":"J Chen","year":"2014","unstructured":"Chen J et al (2014a) Long non-coding RNAs in non-small cell lung cancer as biomarkers and therapeutic targets. J Cell Mol Med 18(12):2425\u20132436. https:\/\/doi.org\/10.1111\/jcmm.12431","journal-title":"J Cell Mol Med"},{"issue":"8","key":"5558_CR3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nrc3775","volume":"14","author":"Z Chen","year":"2014","unstructured":"Chen Z et al (2014b) Non-small-cell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer 14(8):535\u2013546. https:\/\/doi.org\/10.1038\/nrc3775","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"5558_CR4","doi-asserted-by":"publisher","first-page":"4695","DOI":"10.1038\/s41467-019-12651-2","volume":"10","author":"RX Chen","year":"2019","unstructured":"Chen RX et al (2019) N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Nat Commun 10(1):4695. https:\/\/doi.org\/10.1038\/s41467-019-12651-2","journal-title":"Nat Commun"},{"key":"5558_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.canlet.2021.02.004","volume":"505","author":"L Chen","year":"2021","unstructured":"Chen L, Shan G (2021) CircRNA in cancer: fundamental mechanism and clinical potential. Cancer Lett 505:49\u201357. https:\/\/doi.org\/10.1016\/j.canlet.2021.02.004","journal-title":"Cancer Lett"},{"key":"5558_CR6","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2021.4","volume":"23","author":"X Dai","year":"2021","unstructured":"Dai X et al (2021) Methylation multiplicity and its clinical values in cancer. Expert Rev Mol Med 23:e2. https:\/\/doi.org\/10.1017\/erm.2021.4","journal-title":"Expert Rev Mol Med"},{"issue":"6225","key":"5558_CR7","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.1261417","volume":"347","author":"S Geula","year":"2015","unstructured":"Geula S et al (2015) Stem cells. m6A mRNA methylation facilitates resolution of na\u00efve pluripotency toward differentiation. Science 347(6225):1002\u20131006. https:\/\/doi.org\/10.1126\/science.1261417","journal-title":"Science"},{"issue":"4","key":"5558_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.21873\/cgp.20128","volume":"16","author":"C Goebel","year":"2019","unstructured":"Goebel C et al (2019) Diagnosis of non-small cell lung cancer for early stage asymptomatic patients. Cancer Genom Proteom 16(4):229\u2013244. https:\/\/doi.org\/10.21873\/cgp.20128","journal-title":"Cancer Genom Proteom"},{"issue":"2","key":"5558_CR9","doi-asserted-by":"publisher","first-page":"12447","DOI":"10.1080\/21655979.2021.2005875","volume":"12","author":"X Gong","year":"2021","unstructured":"Gong X et al (2021) Serum hsa_circ_0087776 as a new oncologic marker for the joint diagnosis of multiple myeloma. Bioengineered 12(2):12447\u201312459. https:\/\/doi.org\/10.1080\/21655979.2021.2005875","journal-title":"Bioengineered"},{"issue":"8","key":"5558_CR10","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1097\/JTO.0b013e318180270b","volume":"3","author":"R Govindan","year":"2008","unstructured":"Govindan R, Bogart J, Vokes EE (2008) Locally advanced non-small cell lung cancer: the past, present, and future. J Thorac Oncol 3(8):917\u2013928. https:\/\/doi.org\/10.1097\/JTO.0b013e318180270b","journal-title":"J Thorac Oncol"},{"key":"5558_CR11","doi-asserted-by":"publisher","first-page":"15009","DOI":"10.1038\/nrdp.2015.9","volume":"1","author":"C Gridelli","year":"2015","unstructured":"Gridelli C et al (2015) Non-small-cell lung cancer. Nat Rev Dis Prim 1:15009. https:\/\/doi.org\/10.1038\/nrdp.2015.9","journal-title":"Nat Rev Dis Prim"},{"issue":"1","key":"5558_CR12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12943-019-1036-9","volume":"18","author":"J Han","year":"2019","unstructured":"Han J et al (2019) METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221\/222 maturation in m6A-dependent manner. Mol Cancer 18(1):110. https:\/\/doi.org\/10.1186\/s12943-019-1036-9","journal-title":"Mol Cancer"},{"key":"5558_CR13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/bs.pmbts.2018.12.011","volume":"162","author":"C Hao","year":"2019","unstructured":"Hao C, Zhang G, Zhang L (2019) Serum CEA levels in 49 different types of cancer and noncancer diseases. Prog Mol Biol Transl Sci 162:213\u2013227. https:\/\/doi.org\/10.1016\/bs.pmbts.2018.12.011","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"1","key":"5558_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13046-018-0990-1","volume":"38","author":"Q He","year":"2019","unstructured":"He Q et al (2019) MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p\/miR-382-5p mediated ZIC4 expression change. J Exp Clin Cancer Res 38(1):9. https:\/\/doi.org\/10.1186\/s13046-018-0990-1","journal-title":"J Exp Clin Cancer Res"},{"issue":"3","key":"5558_CR15","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020105977","volume":"40","author":"PC He","year":"2021","unstructured":"He PC, He C (2021) m(6) A RNA methylation: from mechanisms to therapeutic potential. Embo J 40(3):e105977. https:\/\/doi.org\/10.15252\/embj.2020105977","journal-title":"Embo J"},{"issue":"5\u20136","key":"5558_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ygeno.2017.06.005","volume":"109","author":"S Huang","year":"2017","unstructured":"Huang S et al (2017) The emerging role of circular RNAs in transcriptome regulation. Genomics 109(5\u20136):401\u2013407. https:\/\/doi.org\/10.1016\/j.ygeno.2017.06.005","journal-title":"Genomics"},{"issue":"5","key":"5558_CR17","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nbt.2890","volume":"32","author":"WR Jeck","year":"2014","unstructured":"Jeck WR, Sharpless NE (2014) Detecting and characterizing circular RNAs. Nat Biotechnol 32(5):453\u2013461. https:\/\/doi.org\/10.1038\/nbt.2890","journal-title":"Nat Biotechnol"},{"issue":"13","key":"5558_CR18","doi-asserted-by":"publisher","first-page":"2003376","DOI":"10.1002\/advs.202003376","volume":"8","author":"L Jia","year":"2021","unstructured":"Jia L, Wang Y, Wang CY (2021) circFAT1 promotes cancer stemness and immune evasion by promoting STAT3 activation. Adv Sci (Weinh) 8(13):2003376. https:\/\/doi.org\/10.1002\/advs.202003376","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"5558_CR19","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12943-021-01406-7","volume":"20","author":"W Jiang","year":"2021","unstructured":"Jiang W et al (2021) The role of lncRNAs and circRNAs in the PD-1\/PD-L1 pathway in cancer immunotherapy. Mol Cancer 20(1):116. https:\/\/doi.org\/10.1186\/s12943-021-01406-7","journal-title":"Mol Cancer"},{"issue":"11","key":"5558_CR20","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","volume":"20","author":"LS Kristensen","year":"2019","unstructured":"Kristensen LS et al (2019) The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet 20(11):675\u2013691. https:\/\/doi.org\/10.1038\/s41576-019-0158-7","journal-title":"Nat Rev Genet"},{"issue":"3","key":"5558_CR21","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41571-021-00585-y","volume":"19","author":"LS Kristensen","year":"2022","unstructured":"Kristensen LS et al (2022) The emerging roles of circRNAs in cancer and oncology. Nat Rev Clin Oncol 19(3):188\u2013206. https:\/\/doi.org\/10.1038\/s41571-021-00585-y","journal-title":"Nat Rev Clin Oncol"},{"issue":"5","key":"5558_CR22","doi-asserted-by":"publisher","first-page":"500","DOI":"10.4149\/neo_2012_064","volume":"59","author":"X Li","year":"2012","unstructured":"Li X et al (2012) Biomarkers in the lung cancer diagnosis: a clinical perspective. Neoplasma 59(5):500\u2013507. https:\/\/doi.org\/10.4149\/neo_2012_064","journal-title":"Neoplasma"},{"issue":"11","key":"5558_CR23","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s00109-017-1582-9","volume":"95","author":"PG Maass","year":"2017","unstructured":"Maass PG et al (2017) A map of human circular RNAs in clinically relevant tissues. J Mol Med (berl) 95(11):1179\u20131189. https:\/\/doi.org\/10.1007\/s00109-017-1582-9","journal-title":"J Mol Med (berl)"},{"issue":"1","key":"5558_CR24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1556-0864(15)31514-8","volume":"1","author":"AM McWilliams","year":"2006","unstructured":"McWilliams AM et al (2006) Lung cancer screening using multi-slice thin-section computed tomography and autofluorescence bronchoscopy. J Thorac Oncol 1(1):61\u201368","journal-title":"J Thorac Oncol"},{"issue":"2","key":"5558_CR25","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0169-5002(95)00485-8","volume":"13","author":"D Moro","year":"1995","unstructured":"Moro D et al (1995) CEA, CYFRA21-1 and SCC in non-small cell lung cancer. Lung Cancer 13(2):169\u2013176. https:\/\/doi.org\/10.1016\/0169-5002(95)00485-8","journal-title":"Lung Cancer"},{"issue":"5","key":"5558_CR26","first-page":"279","volume":"39","author":"J Nikli\u0144ski","year":"1992","unstructured":"Nikli\u0144ski J et al (1992) Evaluation of squamous cell carcinoma antigen (SCC-Ag) in the diagnosis and follow-up of patients with non-small cell lung carcinoma. Neoplasma 39(5):279\u2013282","journal-title":"Neoplasma"},{"issue":"1","key":"5558_CR27","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.path.2019.11.002","volume":"13","author":"R Ruiz-Cordero","year":"2020","unstructured":"Ruiz-Cordero R, Devine WP (2020) Targeted therapy and checkpoint immunotherapy in lung cancer. Surg Pathol Clin 13(1):17\u201333. https:\/\/doi.org\/10.1016\/j.path.2019.11.002","journal-title":"Surg Pathol Clin"},{"issue":"9","key":"5558_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003777","volume":"9","author":"J Salzman","year":"2013","unstructured":"Salzman J et al (2013) Cell-type specific features of circular RNA expression. PLoS Genet 9(9):e1003777. https:\/\/doi.org\/10.1371\/journal.pgen.1003777","journal-title":"PLoS Genet"},{"key":"5558_CR29","doi-asserted-by":"publisher","first-page":"1027758","DOI":"10.3389\/fmed.2022.1027758","volume":"9","author":"MA Shadbad","year":"2022","unstructured":"Shadbad MA et al (2022) A scoping review on the significance of programmed death-ligand 1-inhibiting microRNAs in non-small cell lung treatment: a single-cell RNA sequencing-based study. Front Med (lausanne) 9:1027758. https:\/\/doi.org\/10.3389\/fmed.2022.1027758","journal-title":"Front Med (lausanne)"},{"issue":"1","key":"5558_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1136\/thx.41.1.17","volume":"41","author":"RA Stockley","year":"1986","unstructured":"Stockley RA et al (1986) Effect of cigarette smoking, pulmonary inflammation, and lung disease on concentrations of carcinoembryonic antigen in serum and secretions. Thorax 41(1):17\u201324. https:\/\/doi.org\/10.1136\/thx.41.1.17","journal-title":"Thorax"},{"issue":"3","key":"5558_CR31","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"5558_CR32","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nrg.2016.114","volume":"17","author":"L Szabo","year":"2016","unstructured":"Szabo L, Salzman J (2016) Detecting circular RNAs: bioinformatic and experimental challenges. Nat Rev Genet 17(11):679\u2013692. https:\/\/doi.org\/10.1038\/nrg.2016.114","journal-title":"Nat Rev Genet"},{"issue":"9","key":"5558_CR33","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/s1470-2045(07)70246-2","volume":"8","author":"A Verdecchia","year":"2007","unstructured":"Verdecchia A et al (2007) Recent cancer survival in Europe: a 2000\u201302 period analysis of EUROCARE-4 data. Lancet Oncol 8(9):784\u2013796. https:\/\/doi.org\/10.1016\/s1470-2045(07)70246-2","journal-title":"Lancet Oncol"},{"issue":"18","key":"5558_CR34","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.7150\/jca.25902","volume":"9","author":"G Wang","year":"2018","unstructured":"Wang G et al (2018a) The effect of Hsa_circ_0001451 in clear cell renal cell carcinoma cells and its relationship with clinicopathological features. J Cancer 9(18):3269\u20133277. https:\/\/doi.org\/10.7150\/jca.25902","journal-title":"J Cancer"},{"issue":"3","key":"5558_CR35","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/s41419-018-0338-y","volume":"9","author":"M Wang","year":"2018","unstructured":"Wang M et al (2018b) AGO1 may influence the prognosis of hepatocellular carcinoma through TGF-\u03b2 pathway. Cell Death Dis 9(3):324. https:\/\/doi.org\/10.1038\/s41419-018-0338-y","journal-title":"Cell Death Dis"},{"issue":"8","key":"5558_CR36","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/s41591-021-01450-2","volume":"27","author":"M Wang","year":"2021","unstructured":"Wang M, Herbst RS, Boshoff C (2021) Toward personalized treatment approaches for non-small-cell lung cancer. Nat Med 27(8):1345\u20131356. https:\/\/doi.org\/10.1038\/s41591-021-01450-2","journal-title":"Nat Med"},{"issue":"6","key":"5558_CR37","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1093\/bib\/bbw081","volume":"18","author":"S Xia","year":"2017","unstructured":"Xia S et al (2017) Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Brief Bioinform 18(6):984\u2013992. https:\/\/doi.org\/10.1093\/bib\/bbw081","journal-title":"Brief Bioinform"},{"issue":"11","key":"5558_CR38","doi-asserted-by":"publisher","first-page":"10983","DOI":"10.18632\/aging.103311","volume":"12","author":"L Xing","year":"2020","unstructured":"Xing L et al (2020) The circRNA circIFI30 promotes progression of triple-negative breast cancer and correlates with prognosis. Aging (albany NY) 12(11):10983\u201311003. https:\/\/doi.org\/10.18632\/aging.103311","journal-title":"Aging (albany NY)"},{"issue":"1","key":"5558_CR39","first-page":"13","volume":"50","author":"C Yang","year":"2019","unstructured":"Yang C, Deng SP (2019) Mechanism of hsa-miR-302a-3p-targeted VEGFA in the inhibition of proliferation of gastric cancer cell. Sichuan Da Xue Xue Bao Yi Xue Ban 50(1):13\u201319","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"issue":"6","key":"5558_CR40","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.jhep.2018.01.012","volume":"68","author":"J Yu","year":"2018","unstructured":"Yu J et al (2018) Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. J Hepatol 68(6):1214\u20131227. https:\/\/doi.org\/10.1016\/j.jhep.2018.01.012","journal-title":"J Hepatol"},{"issue":"1","key":"5558_CR41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13045-019-0776-8","volume":"12","author":"T Yu","year":"2019","unstructured":"Yu T et al (2019) CircRNAs in cancer metabolism: a review. J Hematol Oncol 12(1):90. https:\/\/doi.org\/10.1186\/s13045-019-0776-8","journal-title":"J Hematol Oncol"},{"issue":"1","key":"5558_CR42","doi-asserted-by":"publisher","first-page":"4936","DOI":"10.1080\/21655979.2021.1960769","volume":"12","author":"G Yuan","year":"2021","unstructured":"Yuan G et al (2021) Upregulated circRNA_102231 promotes gastric cancer progression and its clinical significance. Bioengineered 12(1):4936\u20134945. https:\/\/doi.org\/10.1080\/21655979.2021.1960769","journal-title":"Bioengineered"},{"issue":"3","key":"5558_CR43","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s13105-019-00690-8","volume":"75","author":"J Zhang","year":"2019","unstructured":"Zhang J et al (2019) ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1. J Physiol Biochem 75(3):379\u2013389. https:\/\/doi.org\/10.1007\/s13105-019-00690-8","journal-title":"J Physiol Biochem"},{"issue":"4","key":"5558_CR44","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1007\/s00216-012-6117-1","volume":"404","author":"A Zhang","year":"2012","unstructured":"Zhang A, Sun H, Wang X (2012) Serum metabolomics as a novel diagnostic approach for disease: a systematic review. Anal Bioanal Chem 404(4):1239\u20131245. https:\/\/doi.org\/10.1007\/s00216-012-6117-1","journal-title":"Anal Bioanal Chem"},{"key":"5558_CR45","doi-asserted-by":"publisher","unstructured":"(2021) Cancer of the lung. Jama 325(10):1010. https:\/\/doi.org\/10.1001\/jama.2020.17834","DOI":"10.1001\/jama.2020.17834"},{"key":"5558_CR46","doi-asserted-by":"publisher","unstructured":"Ettinger DS et al (2013) Non-small cell lung cancer, version 2.2013. J Natl Compr Canc Netw 11(6):645\u2013653. https:\/\/doi.org\/10.6004\/jnccn.2013.0084(quiz 653)","DOI":"10.6004\/jnccn.2013.0084"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05558-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-023-05558-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05558-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T22:03:59Z","timestamp":1711145039000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-023-05558-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,8]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["5558"],"URL":"https:\/\/doi.org\/10.1007\/s00432-023-05558-5","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,8]]},"assertion":[{"value":"9 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors claim to have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the ethics committee of the Affiliated Hospital of Nantong University (ethics review report number: 2018-L055). The participants provided their written informed consent to participate in this study. This study did not involve any animal studies.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"83"}}