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The aim of our study was to detect laboratory parameters following HSCT that can predict the occurrence of SOS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective study included 182 children, adolescents, and young adults who underwent allogeneic or autologous HSCT for the first time (median age 7.2\u00a0years). The diagnosis of SOS was based on the pediatric criteria of European Society for Blood and Marrow Transplantation (EBMT). We investigated 15 laboratory parameters after HSCT before the onset of SOS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The overall incidence of SOS was 14.8%. SOS developed in 24 of 126 allogeneic (19.1%) and in 3 of 56 autologous (5.4%) HSCT patients at a median time of 13\u00a0days after HSCT. We observed a low SOS mortality rate of 11.1% within 100\u00a0days after HSCT. International normalized ratio (INR)\u2009\u2265\u20091.3, activated partial thromboplastin time (aPTT)\u2009\u2265\u200940\u00a0s, reptilase time\u2009\u2265\u200918.3\u00a0s, factor VIII\u2009\u2264\u200980%, antithrombin III\u2009\u2264\u200975%, protein C\u2009\u2264\u200948%, D-dimer\u2009\u2265\u2009315\u00a0\u00b5g\/L, bilirubin\u2009\u2265\u20099\u00a0\u00b5mol\/L, and ferritin\u2009\u2265\u20093100\u00a0\u00b5g\/L showed significant associations with the onset of SOS in the univariate analyses. In the multivariate analysis, INR\u2009\u2265\u20091.3 [odds ratio (OR)\u2009=\u20098.104, <jats:italic>p<\/jats:italic>\u2009=\u20090.006], aPTT\u2009\u2265\u200940\u00a0s (OR\u2009=\u200910.174, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), protein C\u2009\u2264\u200948% (OR\u2009=\u20095.215, <jats:italic>p<\/jats:italic>\u2009=\u20090.014), and ferritin\u2009\u2265\u20093100\u00a0\u00b5g\/L (OR\u2009=\u20097.472, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) could be confirmed as independent risk factors after HSCT before SOS. If three of the four significant cut-off values were present, the probability of developing SOS was more than 70%. The probability of SOS was 96%, if all four laboratory parameters were changed according to the cut-off values. The values of factor XIII, von Willebrand factor (vWF), von Willebrand factor activity (vWF activity), protein S, fibrinogen, and alanine aminotransferase (ALT) were not relevant for the occurrence of SOS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In summary, the laboratory parameters INR, aPTT, protein C, and ferritin were very useful to predict the occurrence of SOS. In addition, this is the first report on a significant association between SOS and high values of INR and aPTT after HSCT before SOS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-023-05561-w","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:02:22Z","timestamp":1704988942000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of laboratory parameters before the occurrence of hepatic sinusoidal obstruction syndrome in children, adolescents, and young adults after hematopoietic stem cell transplantation"],"prefix":"10.1007","volume":"150","author":[{"given":"Lorena","family":"Johann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Gruhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"issue":"6","key":"5561_CR1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/ajh.23188","volume":"87","author":"P Armand","year":"2012","unstructured":"Armand P, Sainvil MM, Kim HT, Rhodes J, Cutler C, Ho VT, Koreth J, Alyea EP, Neufeld EJ, Kwong RY, Soiffer RJ, Antin JH (2012) Does iron overload really matter in stem cell transplantation? 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