{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T05:56:01Z","timestamp":1777182961874,"version":"3.51.4"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the 2024 College Students\u2019 Innovative Entrepreneurial Training Plan Program","award":["Project No. C2024130171"],"award-info":[{"award-number":["Project No. C2024130171"]}]},{"name":"the 2024 College Students\u2019 Innovative Entrepreneurial Training Plan Program","award":["Project No. C2024130171"],"award-info":[{"award-number":["Project No. C2024130171"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82303773"],"award-info":[{"award-number":["No. 82303773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82303772"],"award-info":[{"award-number":["No. 82303772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82204490"],"award-info":[{"award-number":["No. 82204490"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82303694"],"award-info":[{"award-number":["No. 82303694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82303773"],"award-info":[{"award-number":["No. 82303773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82303772"],"award-info":[{"award-number":["No. 82303772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82204490"],"award-info":[{"award-number":["No. 82204490"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82303694"],"award-info":[{"award-number":["No. 82303694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["No. 2023NSFSC1885"],"award-info":[{"award-number":["No. 2023NSFSC1885"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["No. 2023NSFSC1885"],"award-info":[{"award-number":["No. 2023NSFSC1885"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["No. 2023YFS0306"],"award-info":[{"award-number":["No. 2023YFS0306"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["No. 2023YFS0306"],"award-info":[{"award-number":["No. 2023YFS0306"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Survivors after pediatric Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) are with lifetime risk for second primary malignancy (SPM).\u00a0This necessitates a thorough analysis to better understand the potential long-term health implications for these individuals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We used a US-wide population-based cancer registry data to quantify the SPM risk and identify its incidence patterns among pediatric lymphoma patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We observed 4.74-fold (95% CI 4.27\u20135.25) and 3.40-fold (95% CI 2.78\u20134.10) increased risks of SPM in survivors after pediatric HL and NHL, respectively. Through over 40\u00a0years\u2019 follow-up, the cumulative incidence of SPM for pediatric lymphoma was persistently increasing, and here we firstly report the high 40-year cumulative incidence rates of SPM, 22.2% for HL and 12.6% for NHL, suggesting that SPM accounts for a great proportion of deaths among survivors. Of 6805 pediatric lymphomas, 462 (6.36%) developed a SPM, especially second breast and thyroid cancer, followed by hematologic neoplasms including leukemia and NHL. The competing risk analysis demonstrated gender, lymphoma subtype and radiotherapy were significantly associated with SPM. Different risk patterns of SPM were identified between pediatric HL and NHL. Chemotherapy accelerated SPM development but did not increase its incidence risk.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Overall, patients after pediatric lymphoma can be with high lifetime risk of SPM, and more attention should be paid to SPM-related signs for early detection and intervention.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-023-05583-4","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T10:02:23Z","timestamp":1706349743000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lifetime risks of second primary malignancies after pediatric Hodgkin lymphoma and non-Hodgkin lymphoma"],"prefix":"10.1007","volume":"150","author":[{"given":"Laduona","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Niedermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"5583_CR1","doi-asserted-by":"publisher","first-page":"4014","DOI":"10.1182\/blood-2007-08-106021","volume":"111","author":"EC Bluhm","year":"2008","unstructured":"Bluhm EC et al (2008) Cause-specific mortality and second cancer incidence after non-Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. Blood 111:4014\u20134021. https:\/\/doi.org\/10.1182\/blood-2007-08-106021","journal-title":"Blood"},{"key":"5583_CR2","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1002\/ijc.32391","volume":"146","author":"S Chattopadhyay","year":"2020","unstructured":"Chattopadhyay S et al (2020) Second primary cancers in non-Hodgkin lymphoma: family history and survival. Int J Cancer 146:970\u2013976. https:\/\/doi.org\/10.1002\/ijc.32391","journal-title":"Int J Cancer"},{"key":"5583_CR3","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1007\/s00432-015-1979-1","volume":"141","author":"SH Chien","year":"2015","unstructured":"Chien SH et al (2015) Development of second primary malignancy in patients with non-Hodgkin lymphoma: a nationwide population-based study. J Cancer Res Clin Oncol 141:1995\u20132004. https:\/\/doi.org\/10.1007\/s00432-015-1979-1","journal-title":"J Cancer Res Clin Oncol"},{"key":"5583_CR4","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1182\/blood.2020010497","volume":"138","author":"D Chihara","year":"2021","unstructured":"Chihara D, Dores GM, Flowers CR, Morton LM (2021) The bidirectional increased risk of B-cell lymphoma and T-cell lymphoma. Blood 138:785\u2013789. https:\/\/doi.org\/10.1182\/blood.2020010497","journal-title":"Blood"},{"key":"5583_CR5","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1002\/cncr.29231","volume":"121","author":"AK Chowdhry","year":"2015","unstructured":"Chowdhry AK et al (2015) Second primary head and neck cancer after Hodgkin lymphoma: a population-based study of 44,879 survivors of Hodgkin lymphoma. Cancer 121:1436\u20131445. https:\/\/doi.org\/10.1002\/cncr.29231","journal-title":"Cancer"},{"key":"5583_CR6","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1093\/jnci\/djq238","volume":"102","author":"DL Friedman","year":"2010","unstructured":"Friedman DL et al (2010) Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J Natl Cancer Inst 102:1083\u20131095. https:\/\/doi.org\/10.1093\/jnci\/djq238","journal-title":"J Natl Cancer Inst"},{"key":"5583_CR7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/s0959-8049(02)00595-6","volume":"39","author":"K Hemminki","year":"2003","unstructured":"Hemminki K, Jiang Y, Steineck G (2003) Skin cancer and non-Hodgkin\u2019s lymphoma as second malignancies. markers of impaired immune function? Eur J Cancer 39:223\u2013229. https:\/\/doi.org\/10.1016\/s0959-8049(02)00595-6","journal-title":"Eur J Cancer"},{"key":"5583_CR8","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1182\/bloodadvances.2021006369","volume":"6","author":"J Joelsson","year":"2022","unstructured":"Joelsson J et al (2022) Incidence and time trends of second primary malignancies after non-Hodgkin lymphoma: a Swedish population-based study. Blood Adv 6:2657\u20132666. https:\/\/doi.org\/10.1182\/bloodadvances.2021006369","journal-title":"Blood Adv"},{"key":"5583_CR9","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1002\/1097-0142(20011001)92:7<1959::aid-cncr1715>3.0.co;2-y","volume":"92","author":"W Leung","year":"2001","unstructured":"Leung W et al (2001) Second malignancy after treatment of childhood non-Hodgkin lymphoma. Cancer 92:1959\u20131966. https:\/\/doi.org\/10.1002\/1097-0142(20011001)92:7%3c1959::aid-cncr1715%3e3.0.co;2-y","journal-title":"Cancer"},{"key":"5583_CR10","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.1200\/jco.2010.29.1112","volume":"28","author":"LM Morton","year":"2010","unstructured":"Morton LM et al (2010) Second malignancy risks after non-Hodgkin\u2019s lymphoma and chronic lymphocytic leukemia: differences by lymphoma subtype. J Clin Oncol 28:4935\u20134944. https:\/\/doi.org\/10.1200\/jco.2010.29.1112","journal-title":"J Clin Oncol"},{"key":"5583_CR11","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3324\/haematol.2019.244780","volume":"106","author":"O Moser","year":"2021","unstructured":"Moser O et al (2021) Second malignancies after treatment of childhood non-Hodgkin lymphoma: a report of the Berlin-Frankfurt-Muenster study group. Haematologica 106:1390\u20131400. https:\/\/doi.org\/10.3324\/haematol.2019.244780","journal-title":"Haematologica"},{"key":"5583_CR12","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1200\/jco.2016.70.9709","volume":"35","author":"A Sud","year":"2017","unstructured":"Sud A, Thomsen H, Sundquist K, Houlston RS, Hemminki K (2017) Risk of second cancer in Hodgkin lymphoma survivors and influence of family history. J Clin Oncol 35:1584\u20131590. https:\/\/doi.org\/10.1200\/jco.2016.70.9709","journal-title":"J Clin Oncol"},{"key":"5583_CR13","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/s0140-6736(07)61602-x","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E et al (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453\u20131457. https:\/\/doi.org\/10.1016\/s0140-6736(07)61602-x","journal-title":"Lancet"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05583-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-023-05583-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05583-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T13:05:21Z","timestamp":1711112721000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-023-05583-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,27]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["5583"],"URL":"https:\/\/doi.org\/10.1007\/s00432-023-05583-4","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,27]]},"assertion":[{"value":"13 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"41"}}