{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:04:03Z","timestamp":1740107043389,"version":"3.37.3"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273449"],"award-info":[{"award-number":["82273449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1039"],"award-info":[{"award-number":["2024KY1039"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Small round cell tumor (SRCT) is a group of malignancy with similar optical microscopic morphology. Despite its low incidence, SRCT has a high malignant degree and poor prognosis. Besides, atypical clinical symptoms make it difficult in preoperative diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case report<\/jats:title>\n                <jats:p>A 67-year-old man was presented to the outpatient service with dysuria and weak urine stream lasting for 3\u00a0months. After oral treatment with tamsulosin and finasteride for 2\u00a0months, the symptoms worsen. Transurethral prostate holmium laser enucleation was operated and postoperative pathology result revealed small blue round cell malignant tumor. Further immunohistochemistry and fluorescence in situ hybridization examination indicated Ewing-like SRCT. So a Da Vinci Robotic prostatectomy was performed further and whole-genome sequencing was conducted. Several gene mutations including <jats:italic>RAF1, ARID1A, SMARCA4,<\/jats:italic> and <jats:italic>BCL2L11<\/jats:italic> were found but no FDA-approved drug could treat specifically. Then the patient received Ewing-type therapeutic regimens treatment and has been followed up to date (over 24\u00a0months).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Because of its non-elevated serum PSA level, prostate SRCT is often ignored as a possibility of malignant tumor and regarded as benign prostatic hyperplasia (BPH). The possibility of prostate SRCT need to be considered if dysuria symptoms could not alleviate significantly after a period of oral treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00432-023-05585-2","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T16:02:47Z","timestamp":1709308967000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare Ewing-like small round cell tumor in prostate: a case report and literature review"],"prefix":"10.1007","volume":"150","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"issue":"1","key":"5585_CR1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/his.12281","volume":"64","author":"C Antonescu","year":"2014","unstructured":"Antonescu C (2014) Round cell sarcomas beyond Ewing: emerging entities. Histopathology 64(1):26\u201337","journal-title":"Histopathology"},{"issue":"3","key":"5585_CR2","first-page":"1161","volume":"9","author":"JM Davis","year":"2003","unstructured":"Davis JM, Navolanic PM, Weinstein-Oppenheimer CR et al (2003) Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance. Clin Cancer Res off J Am Assoc Cancer Res 9(3):1161\u20131170","journal-title":"Clin Cancer Res off J Am Assoc Cancer Res"},{"issue":"4","key":"5585_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/sj.onc.1201198","volume":"15","author":"D El-Ashry","year":"1997","unstructured":"El-Ashry D, Miller DL, Kharbanda S, Lippman ME, Kern FG (1997) Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis. Oncogene 15(4):423\u2013435","journal-title":"Oncogene"},{"issue":"7546","key":"5585_CR4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nature14122","volume":"520","author":"CM Fillmore","year":"2015","unstructured":"Fillmore CM, Xu C, Desai PT et al (2015) EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature 520(7546):239\u2013242","journal-title":"Nature"},{"issue":"7","key":"5585_CR5","first-page":"983","volume":"27","author":"HN Huang","year":"2014","unstructured":"Huang HN, Lin MC, Huang WC, Chiang YC, Kuo KT (2014) Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma. Modern Pathol off J U S Can Acad Pathol. 27(7):983\u2013990","journal-title":"Modern Pathol off J U S Can Acad Pathol."},{"issue":"33","key":"5585_CR6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001263","volume":"94","author":"WF Huang","year":"2015","unstructured":"Huang WF, Liu AH, Zhao HJ, Dong HM, Liu LY, Cai SX (2015) BIM gene polymorphism lowers the efficacy of EGFR-TKIs in advanced nonsmall cell lung cancer with sensitive EGFR mutations: a systematic review and meta-analysis. Medicine 94(33):e1263","journal-title":"Medicine"},{"issue":"26","key":"5585_CR7","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1056\/NEJMoa1500596","volume":"372","author":"DT Le","year":"2015","unstructured":"Le DT, Uram JN, Wang H et al (2015) PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 372(26):2509\u20132520","journal-title":"N Engl J Med"},{"issue":"11","key":"5585_CR8","first-page":"1169","volume":"31","author":"I Machado","year":"2016","unstructured":"Machado I, Navarro S, Llombart-Bosch A (2016) Ewing sarcoma and the new emerging Ewing-like sarcomas: (CIC and BCOR-rearranged-sarcomas). A systematic review. Histol Histopathol 31(11):1169\u20131181","journal-title":"Histol Histopathol"},{"key":"5585_CR9","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.biocel.2014.04.022","volume":"53","author":"A Marino-Enriquez","year":"2014","unstructured":"Marino-Enriquez A, Fletcher CD (2014) Round cell sarcomas - biologically important refinements in subclassification. Int J Biochem Cell Biol 53:493\u2013504","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"5585_CR10","first-page":"213","volume":"13","author":"JM Meis-Kindblom","year":"1996","unstructured":"Meis-Kindblom JM, Stenman G, Kindblom LG (1996) Differential diagnosis of small round cell tumors. Semin Diagn Pathol 13(3):213\u2013241","journal-title":"Semin Diagn Pathol"},{"issue":"28","key":"5585_CR11","doi-asserted-by":"publisher","first-page":"25696","DOI":"10.18632\/oncotarget.4678","volume":"6","author":"W Nie","year":"2015","unstructured":"Nie W, Tao X, Wei H, Chen WS, Li B (2015) The BIM deletion polymorphism is a prognostic biomarker of EGFR-TKIs response in NSCLC: a systematic review and meta-analysis. Oncotarget 6(28):25696\u201325700","journal-title":"Oncotarget"},{"issue":"2","key":"5585_CR12","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1200\/JCO.2017.74.7402","volume":"36","author":"AS Pappo","year":"2018","unstructured":"Pappo AS, Dirksen U (2018) Rhabdomyosarcoma, Ewing sarcoma, and other round cell sarcomas. J Clin Oncol off J Am Soc Clin Oncol 36(2):168\u2013179","journal-title":"J Clin Oncol off J Am Soc Clin Oncol"},{"issue":"4","key":"5585_CR13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/ng.1107","volume":"44","author":"G Pierron","year":"2012","unstructured":"Pierron G, Tirode F, Lucchesi C et al (2012) A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion. Nat Genet 44(4):461\u2013466","journal-title":"Nat Genet"},{"issue":"6502","key":"5585_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/372143a0","volume":"372","author":"TH Rabbitts","year":"1994","unstructured":"Rabbitts TH (1994) Chromosomal translocations in human cancer. Nature 372(6502):143\u2013149","journal-title":"Nature"},{"issue":"1","key":"5585_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/0970-9371.54861","volume":"26","author":"A Rajwanshi","year":"2009","unstructured":"Rajwanshi A, Srinivas R, Upasana G (2009) Malignant small round cell tumors. J Cytol 26(1):1\u201310","journal-title":"J Cytol"},{"issue":"6230","key":"5585_CR16","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1126\/science.aaa1348","volume":"348","author":"NA Rizvi","year":"2015","unstructured":"Rizvi NA, Hellmann MD, Snyder A et al (2015) Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science (New York, NY) 348(6230):124\u2013128","journal-title":"Science (New York, NY)"},{"issue":"10031","key":"5585_CR17","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/S0140-6736(16)00561-4","volume":"387","author":"JE Rosenberg","year":"2016","unstructured":"Rosenberg JE, Hoffman-Censits J, Powles T et al (2016) Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet (London, England) 387(10031):1909\u20131920","journal-title":"Lancet (London, England)"},{"issue":"14","key":"5585_CR18","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.18632\/oncotarget.2092","volume":"5","author":"EP Samartzis","year":"2014","unstructured":"Samartzis EP, Gutsche K, Dedes KJ, Fink D, Stucki M, Imesch P (2014) Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition. Oncotarget 5(14):5295\u20135303","journal-title":"Oncotarget"},{"issue":"1","key":"5585_CR19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00428-019-02720-8","volume":"476","author":"M Sbaraglia","year":"2020","unstructured":"Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP (2020) Ewing sarcoma and Ewing-like tumors. Virchows Archiv Int J Pathol 476(1):109\u2013119","journal-title":"Virchows Archiv Int J Pathol"},{"issue":"3","key":"5585_CR20","doi-asserted-by":"publisher","first-page":"349","DOI":"10.4103\/ijmpo.ijmpo_84_16","volume":"38","author":"S Sharma","year":"2017","unstructured":"Sharma S, Kamala R, Nair D et al (2017) Round cell tumors: classification and Immunohistochemistry. Indian J Med Paediatr Oncol off J Indian Soc Med Paediatr Oncol 38(3):349\u2013353","journal-title":"Indian J Med Paediatr Oncol off J Indian Soc Med Paediatr Oncol"},{"issue":"7","key":"5585_CR21","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1158\/2159-8290.CD-14-0849","volume":"5","author":"J Shen","year":"2015","unstructured":"Shen J, Peng Y, Wei L et al (2015) ARID1A deficiency impairs the DNA damage checkpoint and sensitizes cells to PARP inhibitors. Cancer Discov 5(7):752\u2013767","journal-title":"Cancer Discov"},{"issue":"23","key":"5585_CR22","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1056\/NEJMoa1406498","volume":"371","author":"A Snyder","year":"2014","unstructured":"Snyder A, Makarov V, Merghoub T et al (2014) Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 371(23):2189\u20132199","journal-title":"N Engl J Med"},{"issue":"9","key":"5585_CR23","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1158\/0008-5472.CAN-13-3608","volume":"74","author":"R Watanabe","year":"2014","unstructured":"Watanabe R, Ui A, Kanno S et al (2014) SWI\/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability. Can Res 74(9):2465\u20132475","journal-title":"Can Res"},{"issue":"16","key":"5585_CR24","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1016\/j.ejca.2005.08.003","volume":"41","author":"SJ Xia","year":"2005","unstructured":"Xia SJ, Barr FG (2005) Chromosome translocations in sarcomas and the emergence of oncogenic transcription factors. Eur J Cancer (oxford, England: 1990). 41(16):2513\u20132527","journal-title":"Eur J Cancer (oxford, England: 1990)."}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05585-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-023-05585-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-023-05585-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T11:02:48Z","timestamp":1713006168000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-023-05585-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["5585"],"URL":"https:\/\/doi.org\/10.1007\/s00432-023-05585-2","relation":{},"ISSN":["1432-1335"],"issn-type":[{"type":"electronic","value":"1432-1335"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"8 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author reports no conflicts of interest in this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the ethics committee of the Second Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, People\u2019s Republic of China). All clinical investigations were conducted in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that the patient provided informed consent for publication of the clinical data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"110"}}