{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:40:58Z","timestamp":1792597258025,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002957","name":"Technische Universit\u00e4t Dresden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002957","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We assessed factors that affect the utilization of sperm cryopreservation before 2021, when patients covered expenses, and the influence on quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 2011 and 2021, testicular cancer survivors (TCS) at our clinic completed a questionnaire, including EORTC QLQ-TC26, covering sperm cryopreservation, sociodemographic details, post-treatment births, and artificial insemination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 5.7\u2009\u00b1\u20093.0 years, 279 participants (64%) responded to the questionnaire. Among them, 33% (91\/279) of testicular cancer survivors chose sperm cryopreservation prior to treatment, with 11% (10\/91) using it for insemination. Conversely, 2% (3\/188) without cryopreservation reported unfulfilled desire to have children. Univariate analysis showed TCS with cryopreservation were younger (30.6\u2009\u00b1\u20097.1 (35 (21\u201359)) vs. 42.4\u2009\u00b1\u200910.9 (48 (22\u201381)) years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), had a lower BMI (24.2\u2009\u00b1\u20093.3 vs. 26.6\u2009\u00b1\u20094.6 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and a lower Charlson Score (&gt;\u20093: 36% vs. 60%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariate analysis revealed older age (\u2265\u200937 years: OR 13.1 (5.5\u201331.2),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and lower education (middle school or less: OR 3.3 (1.6\u20136.9),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) as independent factors associated with not undergoing cryopreservation. Regarding quality of life, multivariate analysis identified a lower infertility anxiety score (OR 4.3 (2.0\u20139.0),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and higher age (\u2265\u200944 years: OR 5.4 (2.6\u201311.3);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) as predictors for the absence of prior cryopreservation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Age and education seem to impact the choice of undergoing paid sperm cryopreservation. Urologists should inform testicular cancer patients about costs and coverage. Importantly, the occurrence of unmet desires for parenthood is minimal among those who forego cryopreservation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00432-024-05725-2","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T02:02:23Z","timestamp":1713319343000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Utilization of sperm cryopreservation in patients with testicular cancer"],"prefix":"10.1007","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3153-6775","authenticated-orcid":false,"given":"Viktoria","family":"Menzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Helke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn Thorben","family":"B\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger H. 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