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However, its role in gastric cancer (GC) is still unclear. This study aims to elucidate the potential regulatory role of <jats:italic>PPP2R1A<\/jats:italic> in the biological functions of GC.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The mutation status and expression levels of <jats:italic>PPP2R1A<\/jats:italic> in GC were assessed through bioinformatics analysis, the correlation between <jats:italic>PPP2R1A<\/jats:italic> levels and patient survival rates was examined, and its potential functional network was analyzed. Stable AGS and MGC803 cell lines were set up for overexpressing and silencing <jats:italic>PPP2R1A<\/jats:italic>. The effects on cell proliferation, migration, invasion, and apoptosis were assessed through CCK-8 assays, scratch assays, Transwell assays, and flow cytometry.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The expression of <jats:italic>PPP2R1A<\/jats:italic> is significantly elevated in GC samples (<jats:italic>P<\/jats:italic> &lt; 0.001) and is not caused by mutations in <jats:italic>PPP2R1A<\/jats:italic> (<jats:italic>P<\/jats:italic> &gt; 0.05). Patients with high levels of <jats:italic>PPP2R1A<\/jats:italic> have a poorer 5-year survival rate (<jats:italic>P<\/jats:italic> &lt; 0.001). Silencing <jats:italic>PPP2R1A<\/jats:italic> significantly inhibits the proliferation, migration, and invasion of GC cells while promoting apoptosis (<jats:italic>P<\/jats:italic> &lt; 0.01). In contrast, overexpression of <jats:italic>PPP2R1A<\/jats:italic> does not have a significant impact on these cellular functions (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>\n              <jats:italic>PPP2R1A<\/jats:italic> has potential oncogenic properties in the progression of GC, and knocking down the expression of <jats:italic>PPP2R1A<\/jats:italic> can inhibit the tumor progression of GC cells. This suggests that <jats:italic>PPP2R1A<\/jats:italic> may serve as a potential prognostic marker and therapeutic target for GC.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00432-025-06177-y","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T19:22:12Z","timestamp":1745004132000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Silencing PPP2R1A inhibits the progression of gastric cancer cells"],"prefix":"10.1007","volume":"151","author":[{"given":"Gengming","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laibijiang","family":"Wusiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingding","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"issue":"3","key":"6177_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. 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