{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:10:08Z","timestamp":1792026608931,"version":"4.4.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Ningbo Health Science and Technology Project Fund","award":["2023Y04"],"award-info":[{"award-number":["2023Y04"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"DOI":"10.1007\/s00432-025-06218-6","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T11:07:52Z","timestamp":1746788872000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thoracoscopy-guided thoracic paravertebral block using dexmedetomidine in combination with ropivacaine for postoperative analgesia after thoracoscopic radical resection of lung cancer: a randomized controlled trial"],"prefix":"10.1007","volume":"151","author":[{"given":"Ke-wei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-yu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"6218_CR1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_81_18","author":"M Anindya","year":"2018","unstructured":"Anindya M, Anjan D, Nairita M, Chiranjib B, Hirak B, Tapobrata M, Sandip RS, Kumar M (2018) Comparative evaluation of analgesic sparing efficacy between dexmedetomidine and clonidine used as adjuvant to ropivacaine in thoracic paravertebral block for patients undergoing breast cancer surgery: a prospective, randomized, double-blind study. Saudi J Anaesth. https:\/\/doi.org\/10.4103\/sja.SJA_81_18","journal-title":"Saudi J Anaesth"},{"key":"6218_CR2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7804584","author":"Z Baoli","year":"2022","unstructured":"Baoli Z, Yong Y, Shengchi S (2022) Effects of different doses of dexmedetomidine combined with thoracic paravertebral nerve block anesthesia on agitation and hemodynamics in patients undergoing thoracotomy during recovery. Evid Based Complement Alternat Med. https:\/\/doi.org\/10.1155\/2022\/7804584","journal-title":"Evid Based Complement Alternat Med"},{"key":"6218_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-024-02762-3","author":"Y Dan","year":"2024","unstructured":"Dan Y, Xi Z (2024) Enhanced recovery after surgery program focusing on chest tube management improves surgical recovery after video-assisted thoracoscopic surgery. J Cardiothorac Surg. https:\/\/doi.org\/10.1186\/s13019-024-02762-3","journal-title":"J Cardiothorac Surg"},{"key":"6218_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/srep21514","author":"G Dong-Jian","year":"2016","unstructured":"Dong-Jian G, Bin Q, Gang T, Jin-Yu L (2016) Intraoperative dexmedetomidine promotes postoperative analgesia and recovery in patients after abdominal hysterectomy: a double-blind, randomized clinical trial. Sci Rep. https:\/\/doi.org\/10.1038\/srep21514","journal-title":"Sci Rep"},{"key":"6218_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287296","author":"L Fangzhou","year":"2023","unstructured":"Fangzhou L, Liang G, Zijin H, Fei L, Linghui P (2023) Effects of dexmedetomidine as an adjuvant to ropivacaine or ropivacaine alone on duration of postoperative analgesia: a systematic review and meta-analysis of randomized controlled trials. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0287296","journal-title":"PLoS ONE"},{"key":"6218_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2021.02.018","author":"S Indu Mohini","year":"2021","unstructured":"Indu Mohini S, Prashanth K, Nidhi B, Nitika G, Lileswar K (2021) Paravertebral block using levobupivacaine or dexmedetomidine-levobupivacaine for analgesia after cholecystectomy: a randomized double-blind trial. Braz J Anesthesiol. https:\/\/doi.org\/10.1016\/j.bjane.2021.02.018","journal-title":"Braz J Anesthesiol"},{"key":"6218_CR7","doi-asserted-by":"publisher","DOI":"10.48095\/ccko2021S35","author":"V Jedli\u010dka","year":"2021","unstructured":"Jedli\u010dka V (2021) Surgical treatment of lung cancer. Klin Onkol. https:\/\/doi.org\/10.48095\/ccko2021S35","journal-title":"Klin Onkol"},{"key":"6218_CR8","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.06.023","author":"X Jianghui","year":"2017","unstructured":"Jianghui X, Xiaoyu Y, Xiaobing H, Xiaofeng C, Jun Z, Yingwei W (2017) Multilevel thoracic paravertebral block using ropivacaine with\/without dexmedetomidine in video-assisted thoracoscopic surgery. J Cardiothorac Vasc Anesth. https:\/\/doi.org\/10.1053\/j.jvca.2017.06.023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"6218_CR9","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S366428","author":"Y Jing","year":"2022","unstructured":"Jing Y, Min Z, Xiao-Rui Z, Xiao-Rui W, Zhi-Hao W, Xiao-Yue F, Ya-Juan L, Jian-Wen Z (2022) Ropivacaine with dexmedetomidine or dexamethasone in a thoracic paravertebral nerve block combined with an erector spinae plane block for thoracoscopic lobectomy analgesia: a randomized controlled trial. Drug des Devel Ther. https:\/\/doi.org\/10.2147\/DDDT.S366428","journal-title":"Drug des Devel Ther"},{"key":"6218_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00582-7","author":"F Julio Jr","year":"2022","unstructured":"Julio F Jr, Charbel F, Marc-Aurele E, Philip C, Uyen N, Ghadeer D, Fateme O, Araz R, Alexa K, Tara D, Alexandre L, Amy A, Agnihotram B, Marc VR, Lawrence M, Gabriele LB, Liane SF (2022) Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials. Lancet. https:\/\/doi.org\/10.1016\/S0140-6736(22)00582-7","journal-title":"Lancet"},{"key":"6218_CR11","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2024.2327143","author":"CLP Killian","year":"2024","unstructured":"Killian CLP, Oliver K, Guido K, Lucillia B (2024) Trial watch: dexmedetomidine in cancer therapy. Oncoimmunology. https:\/\/doi.org\/10.1080\/2162402X.2024.2327143","journal-title":"Oncoimmunology"},{"key":"6218_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2020.03.001","author":"M Kyle","year":"2020","unstructured":"Kyle M, Keleigh M (2020) Pain management in thoracic surgery. Thorac Surg Clin. https:\/\/doi.org\/10.1016\/j.thorsurg.2020.03.001","journal-title":"Thorac Surg Clin"},{"key":"6218_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-020-00231-y","author":"H Lihong","year":"2021","unstructured":"Lihong H, Xia X, Hui T, Jinxian H (2021a) Effect of single-injection thoracic paravertebral block via the intrathoracic approach for analgesia after single-port video-assisted thoracoscopic lung wedge resection: a randomized controlled trial. Pain Ther. https:\/\/doi.org\/10.1007\/s40122-020-00231-y","journal-title":"Pain Ther"},{"key":"6218_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-020-00807-9","author":"H Lihong","year":"2021","unstructured":"Lihong H, Xia X, Weiyu S, Jinxian H (2021b) Feasibility and effectiveness of multi-injection thoracic paravertebral block via the intrathoracic approach for analgesia after thoracoscopic-laparoscopic esophagectomy. Esophagus. https:\/\/doi.org\/10.1007\/s10388-020-00807-9","journal-title":"Esophagus"},{"key":"6218_CR15","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.120787","author":"A Mahzad","year":"2022","unstructured":"Mahzad A, Farnad I, Poupak RS, Hamid Reza F, Leila B, Arthur CH (2022) Adding dexmedetomidine to bupivacaine in ultrasound-guided thoracic paravertebral block for pain management after upper abdominal surgery: a double-blind randomized controlled trial. Anesth Pain Med. https:\/\/doi.org\/10.5812\/aapm.120787","journal-title":"Anesth Pain Med"},{"key":"6218_CR16","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.12.83","author":"U Marzia","year":"2018","unstructured":"Marzia U, Stefano F, Matteo S, Michele Z, Marco C, Lucia C, Francesco P, Stefano L, Umberto L (2018) Anesthesia and fast-track in video-assisted thoracic surgery (VATS): from evidence to practice. J Thorac Dis. https:\/\/doi.org\/10.21037\/jtd.2017.12.83","journal-title":"J Thorac Dis"},{"key":"6218_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/IMI.0000000000000382","author":"F Matthew","year":"2017","unstructured":"Matthew F, Mohamad B, Amer H, David S, Mariano D, Hazim E, Callum H, Maxwell K, Michael JS (2017) Video-assisted thoracoscopic versus robotic-assisted thoracoscopic thymectomy: systematic review and meta-analysis. Innovations (Phila). https:\/\/doi.org\/10.1097\/IMI.0000000000000382","journal-title":"Innovations (Phila)"},{"key":"6218_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-015-2123-8","author":"M Medha","year":"2015","unstructured":"Medha M, Bhumika K, Ashok KS, Navneet K (2015) Efficacy of dexmedetomidine as an adjuvant in paravertebral block in breast cancer surgery. J Anesth. https:\/\/doi.org\/10.1007\/s00540-015-2123-8","journal-title":"J Anesth"},{"key":"6218_CR19","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-020-02309-7","author":"A Nagalingeswaran","year":"2021","unstructured":"Nagalingeswaran A, Rajendran DK, Hem Anand N, Omprakash S, Vaibhavi KR, Vishakha M (2021) Ropivacaine: a novel\u00a0local anaesthetic drug to use in otorhinolaryngology\u00a0practice. Indian J Otolaryngol Head Neck Surg. https:\/\/doi.org\/10.1007\/s12070-020-02309-7","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"3","key":"6218_CR20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s40140-019-00328-x","volume":"9","author":"A Pawa","year":"2019","unstructured":"Pawa A, Wojcikiewicz T, Barron A, El-Boghdadly K (2019) Paravertebral blocks: anatomical, practical, and future concepts. Curr Anesthesiol Rep (Philadelphia) 9(3):263\u2013270. https:\/\/doi.org\/10.1007\/s40140-019-00328-x","journal-title":"Curr Anesthesiol Rep (Philadelphia)"},{"key":"6218_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.952441","author":"T Rong","year":"2022","unstructured":"Rong T, Yu-Qian L, Hai-Lian Z, Fang W, Shi-Xiong G, Wei L, Wen-Sheng L, Ying-Bin W (2022) Evidence basis for using dexmedetomidine to enhance the quality of paravertebral block: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2022.952441","journal-title":"Front Pharmacol"},{"issue":"3","key":"6218_CR22","first-page":"271","volume":"22","author":"A Sayed Kaoud","year":"2019","unstructured":"Sayed Kaoud A, Fatma A, Emad Zarief K, Heba E, Essam Abd A, Hatem Hassan Mohamed M, Jehan Ahmed S, Mohamed Shaaban A, Hussein E, Ghada Shalaby Khalaf M (2019) Paravertebral dexmedetomidine in video-assisted thoracic surgeries for acute and chronic pain prevention. Pain Physician 22(3):271","journal-title":"Pain Physician"},{"key":"6218_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.09.095","author":"S Smita","year":"2015","unstructured":"Smita S, Andrzej SK, Henning AG, Cameron DW, Paul HS (2015) Minimally invasive versus open esophagectomy for esophageal cancer: a comparison of early surgical outcomes from the society of thoracic surgeons national database. Ann Thorac Surg. https:\/\/doi.org\/10.1016\/j.athoracsur.2015.09.095","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"6218_CR24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/AJP.0000000000000992","volume":"38","author":"Q Wang","year":"2021","unstructured":"Wang Q, Li H, Wei S, Zhang G, Ni C, Sun L, Zheng H (2021) Dexmedetomidine Added to ropivacaine for ultrasound-guided erector spinae plane block prolongs analgesia duration and reduces perioperative opioid consumption after thoracotomy: a randomized, controlled clinical study. Clin J Pain 38(1):8\u201314. https:\/\/doi.org\/10.1097\/AJP.0000000000000992","journal-title":"Clin J Pain"},{"key":"6218_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-024-00593-7","author":"X Xia","year":"2024","unstructured":"Xia X, Ying-Xin X, Meng Z, Jian-Hui D, Jin-Xian H, Li-Hong H (2024) Comparison of thoracoscopy-guided thoracic paravertebral block and ultrasound-guided thoracic paravertebral block in postoperative analgesia of thoracoscopic lung cancer radical surgery: a randomized controlled trial. Pain Ther. https:\/\/doi.org\/10.1007\/s40122-024-00593-7","journal-title":"Pain Ther"},{"key":"6218_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-023-02263-9","author":"D Xiaoyun","year":"2023","unstructured":"Xiaoyun D, Huijun Z, Huahua L (2023) Early ambulation and postoperative recovery of patients with lung cancer under thoracoscopic surgery-an observational study. J Cardiothorac Surg. https:\/\/doi.org\/10.1186\/s13019-023-02263-9","journal-title":"J Cardiothorac Surg"},{"key":"6218_CR27","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112152-20240119-00035","author":"RS Zheng","year":"2022","unstructured":"Zheng RS, Chen R, Han BF, Wang SM, Li L, Sun KX, Zeng HM, Wei WW, He J (2022) Cancer incidence and mortality in China. Zhonghua Zhong Liu Za Zhi. https:\/\/doi.org\/10.3760\/cma.j.cn112152-20240119-00035","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"6218_CR28","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S405294","author":"C Zheping","year":"2023","unstructured":"Zheping C, Zhenzhen L, Chang F, Yanwu J, Xin Z (2023) Dexmedetomidine as an adjuvant in peripheral nerve block. Drug des Devel Ther. https:\/\/doi.org\/10.2147\/DDDT.S405294","journal-title":"Drug des Devel Ther"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06218-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-025-06218-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06218-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T10:32:42Z","timestamp":1749551562000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-025-06218-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["6218"],"URL":"https:\/\/doi.org\/10.1007\/s00432-025-06218-6","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"assertion":[{"value":"8 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research project was approved by the Ethics Committee of the Lihuili Hospital, Affiliated to Ningbo University (Approval number: KY2023SL340-01). All participants included in the study signed their informed consents.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"158"}}