{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:43:37Z","timestamp":1783748617922,"version":"3.55.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"2024 Hubei Provincial Key Research and Development Program","award":["2024BCB032"],"award-info":[{"award-number":["2024BCB032"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"DOI":"10.1007\/s00432-025-06283-x","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:52:07Z","timestamp":1755078727000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combined small-cell lung cancer with adenocarcinoma: a rare case and literatures review"],"prefix":"10.1007","volume":"151","author":[{"given":"Xiao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingkun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"issue":"2","key":"6283_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.cllc.2012.07.002","volume":"14","author":"S Babakoohi","year":"2013","unstructured":"Babakoohi S, Fu P, Yang M, Linden PA, Dowlati A (2013) Combined SCLC clinical and pathologic characteristics. Clin Lung Cancer 14(2):113\u2013119","journal-title":"Clin Lung Cancer"},{"issue":"4","key":"6283_CR2","first-page":"011917","volume":"4","author":"H Barnes","year":"2017","unstructured":"Barnes H, See K, Barnett S, Manser R (2017) Surgery for limited-stage small-cell lung cancer. Cochrane Database Syst Rev 4(4):011917","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"6283_CR3","volume":"11","author":"J Bitran","year":"2019","unstructured":"Bitran J (2019) The abscopal effect exists in non-small cell lung cancer: a case report and review of the literature. Cureus 11(2):e4118","journal-title":"Cureus"},{"issue":"15","key":"6283_CR4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025180","volume":"100","author":"J Chen","year":"2021","unstructured":"Chen J, Wang J, Xu H (2021) Comparison of atezolizumab, durvalumab, pembrolizumab, and nivolumab as first-line treatment in patients with extensive-stage small cell lung cancer: a systematic review and network meta-analysis. Medicine 100(15):e25180","journal-title":"Medicine"},{"key":"6283_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.831698","volume":"13","author":"Y Dong","year":"2022","unstructured":"Dong Y, Li Q, Li D, Fang Y, Wang C (2022) Whole-process treatment of combined small cell lung cancer initially diagnosed as lung squamous cell carcinoma: a case report and review of the literature. Front Immunol 13:831698","journal-title":"Front Immunol"},{"issue":"12","key":"6283_CR6","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nrc.2017.87","volume":"17","author":"AF Gazdar","year":"2017","unstructured":"Gazdar AF, Bunn PA, Minna JD (2017) Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer 17(12):725\u2013737","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"6283_CR7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/S1607-551X(09)70322-5","volume":"22","author":"HH Hsiao","year":"2006","unstructured":"Hsiao HH, Tsai HJ, Liu YC et al (2006) A rare case of combined small-cell lung cancer with unusual soft tissue metastasis. Kaohsiung J Med Sci 22(7):352\u2013356","journal-title":"Kaohsiung J Med Sci"},{"issue":"5","key":"6283_CR8","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.annonc.2021.01.075","volume":"32","author":"KD Lach","year":"2021","unstructured":"Lach KD, Sorin M, Huynh C et al (2021) Combined small-cell lung carcinoma revealed to be an intratumoural metastasis by genetic analysis. Ann Oncol: off J Europ Soc Med Oncol 32(5):679\u2013681","journal-title":"Ann Oncol: off J Europ Soc Med Oncol"},{"issue":"15","key":"6283_CR9","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1111\/1759-7714.14559","volume":"13","author":"T Morimoto","year":"2022","unstructured":"Morimoto T, Yamasaki K, Shingu T et al (2022) Autopsy case of a patient with rapidly progressive combined small-cell lung carcinoma with spindle-shaped cell tumor. Thoracic Cancer 13(15):2279\u20132282","journal-title":"Thoracic Cancer"},{"issue":"9","key":"6283_CR10","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1097\/00000478-200209000-00009","volume":"26","author":"SA Nicholson","year":"2002","unstructured":"Nicholson SA, Beasley MB, Brambilla E et al (2002) Small cell lung carcinoma (SCLC): a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol 26(9):1184\u20131197","journal-title":"Am J Surg Pathol"},{"issue":"10212","key":"6283_CR11","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/S0140-6736(19)32222-6","volume":"394","author":"L Paz-Ares","year":"2019","unstructured":"Paz-Ares L, Dvorkin M, Chen Y et al (2019) Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial. Lancet (London, England) 394(10212):1929\u20131939","journal-title":"Lancet (London, England)"},{"issue":"Suppl 4","key":"6283_CR12","doi-asserted-by":"publisher","first-page":"iv192","DOI":"10.1093\/annonc\/mdy275","volume":"29","author":"D Planchard","year":"2018","unstructured":"Planchard D, Popat S, Kerr K et al (2018) Metastatic non-small cell lung cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol: off J Europ Soc Med Oncol 29(Suppl 4):iv192\u2013iv237","journal-title":"Ann Oncol: off J Europ Soc Med Oncol"},{"key":"6283_CR13","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.2147\/OTT.S159057","volume":"11","author":"J Qin","year":"2018","unstructured":"Qin J, Lu H (2018) Combined small-cell lung carcinoma. Onco Targets Ther 11:3505\u20133511","journal-title":"Onco Targets Ther"},{"issue":"2","key":"6283_CR14","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jtho.2018.10.003","volume":"14","author":"N Ready","year":"2019","unstructured":"Ready N, Farago AF, de Braud F et al (2019) Third-line nivolumab monotherapy in recurrent SCLC: CHECKMATE 032. J Thoracic Oncol\u202f: off Publicat Int Associat Study Lung Cancer 14(2):237\u2013244","journal-title":"J Thoracic Oncol : off Publicat Int Associat Study Lung Cancer"},{"issue":"3","key":"6283_CR15","first-page":"230136","volume":"44","author":"T Sasaki","year":"2021","unstructured":"Sasaki T, Kuno H, Hiyama T et al (2021) WHO classification of lung cancer molecular biology research and radiologic-pathologic correlation. Radiogr Rev Publicat Radiol Soc North Am 44(3):230136","journal-title":"Radiogr Rev Publicat Radiol Soc North Am"},{"issue":"1","key":"6283_CR16","first-page":"7","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics. CA Cancer J Clin 72(1):7\u201333","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"6283_CR17","first-page":"17","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics 2023. CA: Cancer J Clin 73(1):17\u201348","journal-title":"CA: Cancer J Clin"},{"issue":"5","key":"6283_CR18","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S2213-2600(20)30391-X","volume":"9","author":"W Theelen","year":"2021","unstructured":"Theelen W, Chen D, Verma V et al (2021) Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials. Lancet Respir Med 9(5):467\u2013475","journal-title":"Lancet Respir Med"},{"issue":"1","key":"6283_CR19","first-page":"18","volume":"25","author":"WD Travis","year":"2012","unstructured":"Travis WD (2012) Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas. Canad Acad Pathol, Inc 25(1):18\u201330","journal-title":"Canad Acad Pathol, Inc"},{"issue":"Suppl 2","key":"6283_CR20","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s00292-014-1974-3","volume":"35","author":"WD Travis","year":"2014","unstructured":"Travis WD (2014) The 2015 WHO classification of lung tumors. Pathologe 35(Suppl 2):188","journal-title":"Pathologe"},{"issue":"12","key":"6283_CR21","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1158\/2326-6066.CIR-18-0793","volume":"7","author":"JW Welsh","year":"2019","unstructured":"Welsh JW, Tang C, de Groot P et al (2019) Phase II trial of ipilimumab with stereotactic radiation therapy for metastatic disease: outcomes, toxicities, and low-dose radiation-related abscopal responses. Cancer Immunol Res 7(12):1903\u20131909","journal-title":"Cancer Immunol Res"},{"issue":"2","key":"6283_CR22","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jtho.2017.10.010","volume":"13","author":"X Zhao","year":"2018","unstructured":"Zhao X, McCutcheon JN, Kallakury B et al (2018) Combined small cell carcinoma of the lung: is it a single entity? J Thoracic Oncol\u202f: off Publicat Int Associat Study Lung Cancer 13(2):237\u2013245","journal-title":"J Thoracic Oncol : off Publicat Int Associat Study Lung Cancer"},{"key":"6283_CR23","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.humpath.2023.08.003","volume":"141","author":"Y Zhu","year":"2023","unstructured":"Zhu Y, Li S, Wang H et al (2023) Molecular subtype expression and genomic profiling differ between surgically resected pure and combined small cell lung carcinoma. Hum Pathol 141:118\u2013129","journal-title":"Hum Pathol"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06283-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-025-06283-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06283-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T04:35:25Z","timestamp":1757478925000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-025-06283-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":23,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["6283"],"URL":"https:\/\/doi.org\/10.1007\/s00432-025-06283-x","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"assertion":[{"value":"5 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors state that they have obtained verbal and written informed consent from the patient for the inclusion of their medical and treatment history within this case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"230"}}