{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:09:04Z","timestamp":1758845344480,"version":"3.44.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012940","name":"Universit\u00e4tsklinikum T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012940","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction and objectives<\/jats:title>\n            <jats:p>High socioeconomic status (SES) is associated with improved oncological outcomes across various cancer types, including prostate cancer. However, limited evidence exists regarding the impact of SES and lifestyle factors on patient-reported outcomes (PROs), including quality of life (QoL), health status (HS), and functional recovery following radical prostatectomy (RP).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods<\/jats:title>\n            <jats:p>We conducted a retrospective single-center analysis of 327 patients undergoing RP (177 open, 150 robotic-assisted) assessing pre- and postoperative functional outcomes (QoL, HS, erectile function, continence). PROs were evaluated 24 months postoperatively. Correlations with sociodemographic, socioeconomic (ISEI-based SES, marital status, occupational status, hometown size), and lifestyle factors (physical activity, BMI, mental stress) were analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Pathological features of locally advanced tumors correlated negatively with QoL and HS. Higher SES was significantly associated with improved continence, but not with QoL, HS, or erectile function. Pre-existing mental stress negatively affected both continence and HS. Regular physical activity correlated positively with QoL and HS. Multivariable regression confirmed these findings and identified mental stress, SES, partnership and physical activity as independent predictors of PROs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Beyond adverse tumor pathology, mental stress adversely impacts functional recovery and subjective health. In contrast, physical activity and a stable partnership correlate with better PROs. These findings may inform personalized patient counseling to increase postoperative satisfaction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00432-025-06287-7","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T03:08:50Z","timestamp":1757387330000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of sociodemographic and socioeconomic factors on functional and health-related quality of life outcomes 24 months after radical prostatectomy"],"prefix":"10.1007","volume":"151","author":[{"given":"M.","family":"Maas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Funk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"St\u00fchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Walz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Bahlburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hennenlotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bedke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Aufderklamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stenzl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Tsaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Rausch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"issue":"Suppl 1","key":"6287_CR1","first-page":"112","volume":"16","author":"A Aky\u00fcz \u00d6zdemir","year":"2018","unstructured":"Aky\u00fcz \u00d6zdemir A, Say\u0131n CB, Erdal R, \u00d6zcan C, Haberal M (2018) Influence of social, economic, familial, marital status, and disease adaptation on the physical and mental health dimensions of patients who are candidates for renal transplant. Exp Clin TranspU7 16(Suppl 1):112\u2013116","journal-title":"Exp Clin TranspU7"},{"issue":"5","key":"6287_CR2","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0022-3999(94)90100-7","volume":"38","author":"A Ayres","year":"1994","unstructured":"Ayres A, Hoon PW, Franzoni JB, Matheny KB, Cotanch PH, Takayanagi S (1994) Influence of mood and adjustment to cancer on compliance with chemotherapy among breast cancer patients. J Psychosom Res 38(5):393\u2013402","journal-title":"J Psychosom Res"},{"issue":"1","key":"6287_CR3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0022-5347(06)00589-1","volume":"176","author":"CG Bacon","year":"2006","unstructured":"Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB (2006) A prospective study of risk factors for erectile dysfunction. J Urol 176(1):217\u2013221","journal-title":"J Urol"},{"issue":"5","key":"6287_CR4","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.eururo.2013.09.040","volume":"65","author":"L Bourke","year":"2014","unstructured":"Bourke L, Gilbert S, Hooper R, Steed LA, Joshi M, Catto JW et al (2014) Lifestyle changes for improving disease-specific quality of life in sedentary men on long-term androgen-deprivation therapy for advanced prostate cancer: a randomised controlled trial. Eur Urol 65(5):865\u2013872","journal-title":"Eur Urol"},{"issue":"3","key":"6287_CR5","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.eururo.2015.04.023","volume":"68","author":"L Bourke","year":"2015","unstructured":"Bourke L, Boorjian SA, Briganti A, Klotz L, Mucci L, Resnick MJ et al (2015) Survivorship and improving quality of life in men with prostate cancer. Eur Urol 68(3):374\u2013383","journal-title":"Eur Urol"},{"issue":"5","key":"6287_CR6","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.urology.2009.09.075","volume":"75","author":"S Carlsson","year":"2010","unstructured":"Carlsson S, Nilsson AE, Schumacher MC, Jonsson MN, Volz DS, Steineck G et al (2010) Surgery-related complications in 1253 robot-assisted and 485 open retropubic radical prostatectomies at the Karolinska University Hospital, Sweden. Urology 75(5):1092\u20131097","journal-title":"Urology"},{"issue":"6b","key":"6287_CR7","doi-asserted-by":"publisher","first-page":"E36","DOI":"10.1111\/bju.13179","volume":"117","author":"S Carlsson","year":"2016","unstructured":"Carlsson S, Drevin L, Loeb S, Widmark A, Lissbrant IF, Robinson D et al (2016) Population-based study of long-term functional outcomes after prostate cancer treatment. BJU Int 117(6b):E36-45","journal-title":"BJU Int"},{"issue":"8","key":"6287_CR8","first-page":"1431","volume":"20","author":"I Cheng","year":"2009","unstructured":"Cheng I, Witte JS, McClure LA, Shema SJ, Cockburn MG, John EM et al (2009) Socioeconomic status and prostate cancer incidence and mortality rates among the diverse population of California. Cancer Causes Control 20(8):1431\u20131440","journal-title":"Cancer Causes Control"},{"issue":"2","key":"6287_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.prnil.2019.08.001","volume":"8","author":"SS Coughlin","year":"2020","unstructured":"Coughlin SS (2020) A review of social determinants of prostate cancer risk, stage, and survival. Prostate Int 8(2):49\u201354","journal-title":"Prostate Int"},{"issue":"10","key":"6287_CR10","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1002\/pon.4888","volume":"27","author":"F Crawford-Williams","year":"2018","unstructured":"Crawford-Williams F, March S, Goodwin BC, Ralph N, Galv\u00e3o DA, Newton RU et al (2018) Interventions for prostate cancer survivorship: a systematic review of reviews. Psychooncology 27(10):2339\u20132348","journal-title":"Psychooncology"},{"issue":"1","key":"6287_CR11","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/SPC.0000000000000195","volume":"10","author":"JC Emanu","year":"2016","unstructured":"Emanu JC, Avildsen IK, Nelson CJ (2016) Erectile dysfunction after radical prostatectomy: prevalence, medical treatments, and psychosocial interventions. Curr Opin Support Palliat Care 10(1):102\u2013107","journal-title":"Curr Opin Support Palliat Care"},{"issue":"5","key":"6287_CR12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-042212","volume":"11","author":"H Foster","year":"2021","unstructured":"Foster H, Polz P, Mair F, Gill J, O\u2019Donnell CA (2021) Understanding the influence of socioeconomic status on the association between combinations of lifestyle factors and adverse health outcomes: a systematic review protocol. BMJ Open 11(5):e042212","journal-title":"BMJ Open"},{"issue":"1","key":"6287_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/0033-2909.134.1.1","volume":"134","author":"M Hagedoorn","year":"2008","unstructured":"Hagedoorn M, Sanderman R, Bolks HN, Tuinstra J, Coyne JC (2008) Distress in couples coping with cancer: a meta-analysis and critical review of role and gender effects. Psychol Bull 134(1):1\u201330","journal-title":"Psychol Bull"},{"issue":"7","key":"6287_CR14","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1093\/aje\/kwm154","volume":"166","author":"J He","year":"2007","unstructured":"He J, Reynolds K, Chen J, Chen CS, Wu X, Duan X et al (2007) Cigarette smoking and erectile dysfunction among Chinese men without clinical vascular disease. Am J Epidemiol 166(7):803\u2013809","journal-title":"Am J Epidemiol"},{"issue":"7","key":"6287_CR15","first-page":"5577","volume":"30","author":"C James","year":"2022","unstructured":"James C, Brunckhorst O, Eymech O, Stewart R, Dasgupta P, Ahmed K (2022) Fear of cancer recurrence and PSA anxiety in patients with prostate cancer: a systematic review. Support Care Cancer 30(7):5577\u20135589","journal-title":"Support Care Cancer"},{"issue":"4","key":"6287_CR16","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/j.1743-6109.2007.00741.x","volume":"5","author":"PI Karakiewicz","year":"2008","unstructured":"Karakiewicz PI, Bhojani N, Neugut A, Shariat SF, Jeldres C, Graefen M et al (2008) The effect of comorbidity and socioeconomic status on sexual and urinary function and on general health-related quality of life in men treated with radical prostatectomy for localized prostate cancer. J Sex Med 5(4):919\u2013927","journal-title":"J Sex Med"},{"key":"6287_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1135024","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu Y, Hu X, Xiong M, Li J, Jiang X, Wan Y et al (2023) Association of BMI with erectile dysfunction: a cross-sectional study of men from an andrology clinic. Front Endocrinol (Lausanne) 14:1135024","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"6287_CR18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ypmed.2012.06.017","volume":"55","author":"M Loef","year":"2012","unstructured":"Loef M, Walach H (2012) The combined effects of healthy lifestyle behaviors on all cause mortality: a systematic review and meta-analysis. Prev Med 55(3):163\u2013170","journal-title":"Prev Med"},{"issue":"23","key":"6287_CR19","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1056\/NEJMsa0707519","volume":"358","author":"JP Mackenbach","year":"2008","unstructured":"Mackenbach JP, Stirbu I, Roskam AJ, Schaap MM, Menvielle G, Leinsalu M et al (2008) Socioeconomic inequalities in health in 22 European countries. N Engl J Med 358(23):2468\u20132481","journal-title":"N Engl J Med"},{"issue":"3","key":"6287_CR20","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/pcan.2014.23","volume":"17","author":"BA Mahal","year":"2014","unstructured":"Mahal BA, Aizer AA, Ziehr DR, Hyatt AS, Lago-Hernandez C, Chen YW et al (2014) The association between insurance status and prostate cancer outcomes: implications for the Affordable Care Act. Prostate Cancer Prostatic Dis 17(3):273\u2013279","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"6287_CR21","unstructured":"Mottet NPC, van den Bergh RCN, Briers E (2023) EAU - EANM- ESTRO - ESUR - ISUP - SIOG Guidelines on Prostate Cancer 6. European Association of Urology: European Association of Urology"},{"issue":"5","key":"6287_CR22","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.genhosppsych.2006.05.006","volume":"28","author":"AA Onitilo","year":"2006","unstructured":"Onitilo AA, Nietert PJ, Egede LE (2006) Effect of depression on all-cause mortality in adults with cancer and differential effects by cancer site. Gen Hosp Psychiatry 28(5):396\u2013402","journal-title":"Gen Hosp Psychiatry"},{"issue":"4","key":"6287_CR23","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s11154-020-09541-0","volume":"21","author":"D Pizzol","year":"2020","unstructured":"Pizzol D, Smith L, Fontana L, Caruso MG, Bertoldo A, Demurtas J et al (2020) Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and meta-analysis. Rev Endocr Metab Disord 21(4):657\u2013666","journal-title":"Rev Endocr Metab Disord"},{"issue":"4","key":"6287_CR24","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.eururo.2014.08.074","volume":"68","author":"S Punnen","year":"2015","unstructured":"Punnen S, Cowan JE, Chan JM, Carroll PR, Cooperberg MR (2015) Long-term health-related quality of life after primary treatment for localized prostate cancer: results from the CaPSURE registry. Eur Urol 68(4):600\u2013608","journal-title":"Eur Urol"},{"issue":"23","key":"6287_CR25","doi-asserted-by":"publisher","first-page":"5556","DOI":"10.1002\/cncr.24607","volume":"115","author":"E Rapiti","year":"2009","unstructured":"Rapiti E, Fioretta G, Schaffar R, Neyroud-Caspar I, Verkooijen HM, Schmidlin F et al (2009) Impact of socioeconomic status on prostate cancer diagnosis, treatment, and prognosis. Cancer 115(23):5556\u20135565","journal-title":"Cancer"},{"issue":"12","key":"6287_CR26","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1056\/NEJMoa074311","volume":"358","author":"MG Sanda","year":"2008","unstructured":"Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L et al (2008) Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med 358(12):1250\u20131261","journal-title":"N Engl J Med"},{"key":"6287_CR27","unstructured":"SEER d. Tumor statistics prostate cancer 2023 [Available from: https:\/\/seer.cancer.gov\/statistics-network\/explorer\/application.html?site=66&data_type=1&graph_type=2&compareBy=stage&chk_stage_104=104&chk_stage_105=105&chk_stage_106=106&chk_stage_107=107&hdn_rate_type=1&hdn_sex=2&race=1&age_range=1&advopt_precision=1&advopt_show_ci=on&hdn_view=0&advopt_show_apc=on&advopt_display=1."},{"issue":"1","key":"6287_CR28","first-page":"17","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA Cancer J Clin 73(1):17\u201348","journal-title":"CA Cancer J Clin"},{"issue":"10075","key":"6287_CR29","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/S0140-6736(16)32380-7","volume":"389","author":"S Stringhini","year":"2017","unstructured":"Stringhini S, Carmeli C, Jokela M, Avenda\u00f1o M, Muennig P, Guida F et al (2017) Socioeconomic status and the 25\u2008\u00d7\u200825 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1\u00b77 million men and women. Lancet 389(10075):1229\u20131237","journal-title":"Lancet"},{"issue":"10049","key":"6287_CR30","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/S0140-6736(16)30592-X","volume":"388","author":"JW Yaxley","year":"2016","unstructured":"Yaxley JW, Coughlin GD, Chambers SK, Occhipinti S, Samaratunga H, Zajdlewicz L et al (2016) Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: early outcomes from a randomised controlled phase 3 study. Lancet 388(10049):1057\u20131066","journal-title":"Lancet"},{"issue":"4","key":"6287_CR31","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1159\/000499242","volume":"14","author":"KG Yiannopoulou","year":"2020","unstructured":"Yiannopoulou KG, Anastasiou AI, Kontoangelos K, Papageorgiou C, Anastasiou IP (2020) Cognitive and psychological impacts of different treatment options for prostate cancer: a critical analysis. Curr Urol 14(4):169\u2013177","journal-title":"Curr Urol"},{"issue":"1","key":"6287_CR32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00125-019-04985-9","volume":"63","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Pan XF, Chen J, Xia L, Cao A, Zhang Y et al (2020) Combined lifestyle factors and risk of incident type 2 diabetes and prognosis among individuals with type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Diabetologia 63(1):21\u201333","journal-title":"Diabetologia"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06287-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-025-06287-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06287-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:01:50Z","timestamp":1758787310000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-025-06287-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["6287"],"URL":"https:\/\/doi.org\/10.1007\/s00432-025-06287-7","relation":{},"ISSN":["1432-1335"],"issn-type":[{"type":"electronic","value":"1432-1335"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"10 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"245"}}