{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:05:34Z","timestamp":1787601934347,"version":"build-2736575974"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Key Technology Research and Developmental Program of China","award":["2022YFC2704400"],"award-info":[{"award-number":["2022YFC2704400"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-082"],"award-info":[{"award-number":["2022-PUMCH-B-082"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"DOI":"10.1007\/s00432-025-06369-6","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T16:32:54Z","timestamp":1762533174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fertility-sparing treatment for overweight patients with early-stage endometrial cancer or atypical endometrial hyperplasia under weight loss intervention"],"prefix":"10.1007","volume":"151","author":[{"given":"Mengdi","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninghai","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"6369_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19159059","author":"N Abdol Manap","year":"2022","unstructured":"Abdol Manap N, Ng BK, Phon SE, Abdul Karim AK, Lim PS, Fadhil M (2022) Endometrial cancer in pre-menopausal women and younger: risk factors and outcome. Int J Environ Res Public Health. https:\/\/doi.org\/10.3390\/ijerph19159059","journal-title":"Int J Environ Res Public Health"},{"issue":"11","key":"6369_CR2","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1158\/1940-6207.CAPR-21-0229","volume":"14","author":"CE Barr","year":"2021","unstructured":"Barr CE, Ryan NAJ, Derbyshire AE, Wan YL, MacKintosh ML, McVey RJ et al (2021) Weight loss during intrauterine progestin treatment for obesity-associated atypical hyperplasia and early-stage cancer of the endometrium. Cancer Prev Res Phila 14(11):1041\u20131050. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-21-0229","journal-title":"Cancer Prev Res Phila"},{"issue":"1","key":"6369_CR3","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ygyno.2015.02.028","volume":"138","author":"A Burleigh","year":"2015","unstructured":"Burleigh A, Talhouk A, Gilks CB, McAlpine JN (2015) Clinical and pathological characterization of endometrial cancer in young women: identification of a cohort without classical risk factors. Gynecol Oncol 138(1):141\u2013146. https:\/\/doi.org\/10.1016\/j.ygyno.2015.02.028","journal-title":"Gynecol Oncol"},{"issue":"17","key":"6369_CR4","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/NEJMoa021423","volume":"348","author":"EE Calle","year":"2003","unstructured":"Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348(17):1625\u20131638. https:\/\/doi.org\/10.1056\/NEJMoa021423","journal-title":"N Engl J Med"},{"key":"6369_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.738370","volume":"11","author":"J Chen","year":"2021","unstructured":"Chen J, Cao D, Yang J, Yu M, Zhou H, Cheng N et al (2021a) Management of recurrent endometrial cancer or atypical endometrial hyperplasia patients after primary fertility-sparing therapy. Front Oncol 11:738370. https:\/\/doi.org\/10.3389\/fonc.2021.738370","journal-title":"Front Oncol"},{"issue":"8","key":"6369_CR6","first-page":"561","volume":"56","author":"JY Chen","year":"2021","unstructured":"Chen JY, Cao DY, Zhou HM, Yu M, Yang JX, Wang JH et al (2021) GnRH-a combined fertility-sparing re-treatment in women with endometrial carcinoma or atypical endomertial hyperplasia who failed to oral progestin therapy. Zhonghua Fu Chan Ke Za Zhi. 56(8):561\u20138","journal-title":"Zhonghua Fu Chan Ke Za Zhi."},{"key":"6369_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.812346","volume":"12","author":"J Chen","year":"2022","unstructured":"Chen J, Cao D, Yang J, Yu M, Zhou H, Cheng N et al (2022) Fertility-sparing treatment for endometrial cancer or atypical endometrial hyperplasia patients with obesity. Front Oncol 12:812346. https:\/\/doi.org\/10.3389\/fonc.2022.812346","journal-title":"Front Oncol"},{"key":"6369_CR8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ygyno.2024.02.017","volume":"185","author":"Y Chen","year":"2024","unstructured":"Chen Y, Yang J, Wan Y, Li Q, Yang D, Wang Y et al (2024) DEAR model in overweight endometrial cancer patients undergoing fertility-sparing treatment: a randomized controlled trial. Gynecol Oncol 185:148\u2013155. https:\/\/doi.org\/10.1016\/j.ygyno.2024.02.017","journal-title":"Gynecol Oncol"},{"issue":"2","key":"6369_CR9","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.ygyno.2015.12.010","volume":"140","author":"D Cholakian","year":"2016","unstructured":"Cholakian D, Hacker K, Fader AN, Gehrig PA, Tanner EJ 3rd (2016) Effect of oral versus intrauterine progestins on weight in women undergoing fertility preserving therapy for complex atypical hyperplasia or endometrial cancer. Gynecol Oncol 140(2):234\u2013238. https:\/\/doi.org\/10.1016\/j.ygyno.2015.12.010","journal-title":"Gynecol Oncol"},{"issue":"10333","key":"6369_CR10","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/S0140-6736(22)00323-3","volume":"399","author":"EJ Crosbie","year":"2022","unstructured":"Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME, Singh N (2022) Endometrial cancer. Lancet 399(10333):1412\u20131428. https:\/\/doi.org\/10.1016\/S0140-6736(22)00323-3","journal-title":"Lancet"},{"issue":"2","key":"6369_CR11","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/ijc.25050","volume":"127","author":"L Dossus","year":"2010","unstructured":"Dossus L, Allen N, Kaaks R, Bakken K, Lund E, Tjonneland A et al (2010) Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 127(2):442\u201351. https:\/\/doi.org\/10.1002\/ijc.25050","journal-title":"Int J Cancer"},{"issue":"3","key":"6369_CR12","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000493132","volume":"84","author":"J Feinberg","year":"2019","unstructured":"Feinberg J, Albright B, Black J, Lu L, Passarelli R, Gysler S et al (2019) Ten-year comparison study of type 1 and 2 endometrial cancers: risk factors and outcomes. Gynecol Obstet Invest 84(3):290\u2013297. https:\/\/doi.org\/10.1159\/000493132","journal-title":"Gynecol Obstet Invest"},{"issue":"2","key":"6369_CR13","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/13645706.2023.2294993","volume":"33","author":"A Gallo","year":"2024","unstructured":"Gallo A, D\u2019Alisa R, Di Spiezio SA, Guerra S, Berardi G, Vitale SG et al (2024) Hysteroscopy and weight loss in treatment of endometrial cancer: case report and literature review. Minim Invasive Ther Allied Technol. 33(2):109\u201319. https:\/\/doi.org\/10.1080\/13645706.2023.2294993","journal-title":"Minim Invasive Ther Allied Technol."},{"issue":"3","key":"6369_CR14","doi-asserted-by":"publisher","first-page":"335","DOI":"10.5858\/arpa.2012-0654-RA","volume":"138","author":"K Garg","year":"2014","unstructured":"Garg K, Soslow RA (2014) Endometrial carcinoma in women aged 40 years and younger. Arch Pathol Lab Med 138(3):335\u2013342. https:\/\/doi.org\/10.5858\/arpa.2012-0654-RA","journal-title":"Arch Pathol Lab Med"},{"issue":"10","key":"6369_CR15","doi-asserted-by":"publisher","first-page":"4791","DOI":"10.22034\/apjcp.2016.17.10.4791","volume":"17","author":"M Ghanbari Andarieh","year":"2016","unstructured":"Ghanbari Andarieh M, Agajani Delavar M, Moslemi D, Esmaeilzadeh S (2016) Risk factors for endometrial cancer: results from a hospital-based case-control study. Asian Pac J Cancer Prev 17(10):4791\u20134796. https:\/\/doi.org\/10.22034\/apjcp.2016.17.10.4791","journal-title":"Asian Pac J Cancer Prev"},{"issue":"3","key":"6369_CR16","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/ijgo.12882","volume":"146","author":"S Guillon","year":"2019","unstructured":"Guillon S, Popescu N, Phelippeau J, Koskas M (2019) A systematic review and meta-analysis of prognostic factors for remission in fertility-sparing management of endometrial atypical hyperplasia and adenocarcinoma. Int J Gynaecol Obstet 146(3):277\u2013288. https:\/\/doi.org\/10.1002\/ijgo.12882","journal-title":"Int J Gynaecol Obstet"},{"issue":"2","key":"6369_CR17","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.ygyno.2012.01.003","volume":"125","author":"CC Gunderson","year":"2012","unstructured":"Gunderson CC, Fader AN, Carson KA, Bristow RE (2012) Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review. Gynecol Oncol 125(2):477\u2013482. https:\/\/doi.org\/10.1016\/j.ygyno.2012.01.003","journal-title":"Gynecol Oncol"},{"issue":"6","key":"6369_CR18","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1056\/NEJMc2035378","volume":"384","author":"SI Kim","year":"2021","unstructured":"Kim SI, Kim JW (2021) Endometrial Cancer. N Engl J Med. 384(6):586. https:\/\/doi.org\/10.1056\/NEJMc2035378","journal-title":"N Engl J Med."},{"issue":"9","key":"6369_CR19","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s00384-018-3065-z","volume":"33","author":"KH Lee","year":"2018","unstructured":"Lee KH, Kang BK, Ahn BK (2018) Higher visceral fat area\/subcutaneous fat area ratio measured by computed tomography is associated with recurrence and poor survival in patients with mid and low rectal cancers. Int J Colorectal Dis 33(9):1303\u20131307. https:\/\/doi.org\/10.1007\/s00384-018-3065-z","journal-title":"Int J Colorectal Dis"},{"key":"6369_CR20","doi-asserted-by":"publisher","first-page":"4005","DOI":"10.2147\/CMAR.S194607","volume":"11","author":"M Li","year":"2019","unstructured":"Li M, Guo T, Cui R, Feng Y, Bai H, Zhang Z (2019) Weight control is vital for patients with early-stage endometrial cancer or complex atypical hyperplasia who have received progestin therapy to spare fertility: a systematic review and meta-analysis. Cancer Manag Res 11:4005\u20134021. https:\/\/doi.org\/10.2147\/CMAR.S194607","journal-title":"Cancer Manag Res"},{"issue":"1","key":"6369_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-17275-2","volume":"23","author":"X Li","year":"2023","unstructured":"Li X, Lian Y, Ping W, Wang K, Jiang L, Li S (2023) Abdominal obesity and digestive system cancer: a systematic review and meta-analysis of prospective studies. BMC Public Health 23(1):2343. https:\/\/doi.org\/10.1186\/s12889-023-17275-2","journal-title":"BMC Public Health"},{"issue":"1","key":"6369_CR22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ygyno.2017.05.002","volume":"146","author":"JY Park","year":"2017","unstructured":"Park JY, Seong SJ, Kim TJ, Kim JW, Bae DS, Nam JH (2017) Significance of body weight change during fertility-sparing progestin therapy in young women with early endometrial cancer. Gynecol Oncol. 146(1):39\u201343. https:\/\/doi.org\/10.1016\/j.ygyno.2017.05.002","journal-title":"Gynecol Oncol."},{"issue":"3","key":"6369_CR23","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/1471-0528.14385","volume":"124","author":"ME Pennant","year":"2017","unstructured":"Pennant ME, Mehta R, Moody P, Hackett G, Prentice A, Sharp SJ et al (2017) Premenopausal abnormal uterine bleeding and risk of endometrial cancer. BJOG 124(3):404\u2013411. https:\/\/doi.org\/10.1111\/1471-0528.14385","journal-title":"BJOG"},{"issue":"2","key":"6369_CR24","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.ygyno.2021.02.030","volume":"161","author":"A Raffone","year":"2021","unstructured":"Raffone A, Travaglino A, Raimondo D, Boccellino MP, Maletta M, Borghese G et al (2021) Tumor-infiltrating lymphocytes and POLE mutation in endometrial carcinoma. Gynecol Oncol 161(2):621\u2013628. https:\/\/doi.org\/10.1016\/j.ygyno.2021.02.030","journal-title":"Gynecol Oncol"},{"issue":"7","key":"6369_CR25","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1002\/ijc.31961","volume":"145","author":"O Raglan","year":"2019","unstructured":"Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J et al (2019) Risk factors for endometrial cancer: an umbrella review of the literature. Int J Cancer 145(7):1719\u20131730. https:\/\/doi.org\/10.1002\/ijc.31961","journal-title":"Int J Cancer"},{"issue":"5","key":"6369_CR26","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/CCO.0000000000001075","volume":"36","author":"D Raimondo","year":"2024","unstructured":"Raimondo D, Raffone A, Aguzzi A, Bertoldo L, Seracchioli R (2024) Role of sentinel lymph node biopsy with indocyanine green and site of injection in endometrial cancer. Curr Opin Oncol 36(5):383\u2013390. https:\/\/doi.org\/10.1097\/CCO.0000000000001075","journal-title":"Curr Opin Oncol"},{"issue":"1","key":"6369_CR27","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac057","volume":"2023","author":"A Rodolakis","year":"2023","unstructured":"Rodolakis A, Scambia G, Planchamp F, Acien M, Di Spiezio Sardo A, Farrugia M et al (2023) ESGO\/ESHRE\/ESGE guidelines for the fertility-sparing treatment of patients with endometrial carcinoma(). Hum Reprod Open 2023(1):hoac057. https:\/\/doi.org\/10.1093\/hropen\/hoac057","journal-title":"Hum Reprod Open"},{"issue":"2","key":"6369_CR28","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.ygyno.2013.06.032","volume":"131","author":"MN Shafiee","year":"2013","unstructured":"Shafiee MN, Chapman C, Barrett D, Abu J, Atiomo W (2013) Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS): time for paradigm shift? Gynecol Oncol 131(2):489\u2013492. https:\/\/doi.org\/10.1016\/j.ygyno.2013.06.032","journal-title":"Gynecol Oncol"},{"key":"6369_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.749881","volume":"11","author":"Y Shan","year":"2021","unstructured":"Shan Y, Qin M, Yin J, Cai Y, Li Y, Gu Y et al (2021) Effect and management of excess weight in the context of fertility-sparing treatments in patients with atypical endometrial hyperplasia and endometrial cancer: eight-year experience of 227 cases. Front Oncol 11:749881. https:\/\/doi.org\/10.3389\/fonc.2021.749881","journal-title":"Front Oncol"},{"issue":"2 Suppl","key":"6369_CR30","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.xfre.2022.11.009","volume":"4","author":"ES Surrey","year":"2023","unstructured":"Surrey ES (2023) GnRH agonists in the treatment of symptomatic endometriosis: a review. F S Rep 4(2 Suppl):40\u20135. https:\/\/doi.org\/10.1016\/j.xfre.2022.11.009","journal-title":"F S Rep"},{"issue":"2","key":"6369_CR31","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00404-021-06385-0","volume":"306","author":"A Travaglino","year":"2022","unstructured":"Travaglino A, Raffone A, Raimondo D, Reppuccia S, Ruggiero A, Arena A et al (2022) Prognostic significance of CTNNB1 mutation in early stage endometrial carcinoma: a systematic review and meta-analysis. Arch Gynecol Obstet 306(2):423\u2013431. https:\/\/doi.org\/10.1007\/s00404-021-06385-0","journal-title":"Arch Gynecol Obstet"},{"issue":"3","key":"6369_CR32","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1056\/NEJMc2207023","volume":"387","author":"PL Valenzuela","year":"2022","unstructured":"Valenzuela PL, Castillo-Garcia A, Lucia A (2022) Calorie restriction with or without time-restricted eating in weight loss. N Engl J Med 387(3):280\u2013281. https:\/\/doi.org\/10.1056\/NEJMc2207023","journal-title":"N Engl J Med"},{"issue":"4","key":"6369_CR33","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/s41591-023-02248-0","volume":"29","author":"K Watanabe","year":"2023","unstructured":"Watanabe K, Wilmanski T, Diener C, Earls JC, Zimmer A, Lincoln B et al (2023) Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention. Nat Med 29(4):996\u20131008. https:\/\/doi.org\/10.1038\/s41591-023-02248-0. (this study. All other authors declare no competing interests)","journal-title":"Nat Med"},{"issue":"37","key":"6369_CR34","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008034","volume":"96","author":"J Wei","year":"2017","unstructured":"Wei J, Zhang W, Feng L, Gao W (2017) Comparison of fertility-sparing treatments in patients with early endometrial cancer and atypical complex hyperplasia: a meta-analysis and systematic review. Medicine (Baltimore) 96(37):e8034. https:\/\/doi.org\/10.1097\/MD.0000000000008034","journal-title":"Medicine (Baltimore)"},{"key":"6369_CR35","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8584130","volume":"2019","author":"Y Wu","year":"2019","unstructured":"Wu Y, Sun W, Liu H, Zhang D (2019) Age at menopause and risk of developing endometrial cancer: a meta-analysis. BioMed Res Int 2019:8584130. https:\/\/doi.org\/10.1155\/2019\/8584130","journal-title":"BioMed Res Int"},{"issue":"6","key":"6369_CR36","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1016\/j.fertnstert.2009.06.013","volume":"92","author":"M Yu","year":"2009","unstructured":"Yu M, Yang JX, Wu M, Lang JH, Huo Z, Shen K (2009) Fertility-preserving treatment in young women with well-differentiated endometrial carcinoma and severe atypical hyperplasia of endometrium. Fertil Steril 92(6):2122\u20132124. https:\/\/doi.org\/10.1016\/j.fertnstert.2009.06.013","journal-title":"Fertil Steril"},{"key":"6369_CR37","doi-asserted-by":"publisher","first-page":"5711","DOI":"10.2147\/CMAR.S316040","volume":"13","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Li D, Yan Q, Song X, Tian W, Wang Y et al (2021) Weight loss improves pregnancy and livebirth outcomes in young women with early-stage endometrial cancer and atypical hyperplasia. Cancer Manag Res 13:5711\u20135722. https:\/\/doi.org\/10.2147\/CMAR.S316040","journal-title":"Cancer Manag Res"},{"issue":"1","key":"6369_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-021-01452-9","volume":"21","author":"J Zhao","year":"2021","unstructured":"Zhao J, Hu Y, Zhao Y, Chen D, Fang T, Ding M (2021) Risk factors of endometrial cancer in patients with endometrial hyperplasia: implication for clinical treatments. BMC Womens Health 21(1):312. https:\/\/doi.org\/10.1186\/s12905-021-01452-9","journal-title":"BMC Womens Health"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06369-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-025-06369-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06369-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T19:38:58Z","timestamp":1765654738000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-025-06369-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6369"],"URL":"https:\/\/doi.org\/10.1007\/s00432-025-06369-6","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,7]]},"assertion":[{"value":"30 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report that there are no conflicts of interest. Completed disclosure of interest forms is available online as supporting information.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"The study was reviewed and approved by the institutional review board of Peking Union Medical College Hospital (I-24PJ0364, dated February 29, 2024). All patients provided written informed consent to participate in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"317"}}