{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:43:54Z","timestamp":1780670634821,"version":"3.54.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"DOI":"10.1007\/s00432-025-06370-z","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T17:11:01Z","timestamp":1763485861000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Constructing a novel MPT-driven necrosis-associated gene set for predicting prognosis and immune status in skin cutaneous melanoma"],"prefix":"10.1007","volume":"151","author":[{"given":"Yang","family":"Wenxian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Shuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"issue":"2","key":"6370_CR1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran D, Looney AP, Liu L et al (2019) Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol 20(2):163\u2013172. https:\/\/doi.org\/10.1038\/s41590-018-0276-y","journal-title":"Nat Immunol"},{"key":"6370_CR2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/978-1-4020-6191-2_18","volume":"45","author":"P Bernardi","year":"2007","unstructured":"Bernardi P, Rasola A (2007) Calcium and cell death: the mitochondrial connection. Subcell Biochem 45:481\u2013506. https:\/\/doi.org\/10.1007\/978-1-4020-6191-2_18","journal-title":"Subcell Biochem"},{"key":"6370_CR3","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","volume":"30","author":"P Bernardi","year":"2023","unstructured":"Bernardi P, Gerle C, Halestrap AP et al (2023) Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions. Cell Death Differ 30:1869\u20131885. https:\/\/doi.org\/10.1038\/s41418-023-01187-0","journal-title":"Cell Death Differ"},{"issue":"7","key":"6370_CR4","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3390\/biom10070998","volume":"10","author":"M Bonora","year":"2020","unstructured":"Bonora M, Patergnani S, Ramaccini D et al (2020) Physiopathology of the permeability transition pore: molecular mechanisms in human pathology. Biomolecules 10(7):998. https:\/\/doi.org\/10.3390\/biom10070998","journal-title":"Biomolecules"},{"issue":"5","key":"6370_CR5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41422-025-01107-6","volume":"35","author":"P Broz","year":"2025","unstructured":"Broz P (2025) Pyroptosis: molecular mechanisms and roles in disease. Cell Res 35(5):334\u2013344. https:\/\/doi.org\/10.1038\/s41422-025-01107-6","journal-title":"Cell Res"},{"key":"6370_CR6","doi-asserted-by":"publisher","first-page":"1002297","DOI":"10.37349\/etat.2025.1002297","volume":"6","author":"L Cabez\u00f3n-Guti\u00e9rrez","year":"2025","unstructured":"Cabez\u00f3n-Guti\u00e9rrez L, Palka-Kotlowska M, Custodio-Cabello S, Chac\u00f3n-Ovejero B, Pacheco-Barcia V (2025) Metabolic mechanisms of immunotherapy resistance. Exploration Target Anti-Tumor Therapy 6:1002297. https:\/\/doi.org\/10.37349\/etat.2025.1002297","journal-title":"Exploration Target Anti-Tumor Therapy"},{"issue":"7","key":"6370_CR7","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.3390\/cancers14071671","volume":"14","author":"P Cetraro","year":"2022","unstructured":"Cetraro P, Plaza-Diaz J, MacKenzie A, Abad\u00eda-Molina F (2022) A review of the current impact of inhibitors of apoptosis proteins and their repression in cancer. Cancers (Basel) 14(7):1671. https:\/\/doi.org\/10.3390\/cancers14071671","journal-title":"Cancers (Basel)"},{"issue":"1","key":"6370_CR8","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","volume":"18","author":"P Charoentong","year":"2017","unstructured":"Charoentong P, Finotello F, Angelova M et al (2017) Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep 18(1):248\u2013262. https:\/\/doi.org\/10.1016\/j.celrep.2016.12.019","journal-title":"Cell Rep"},{"issue":"7637","key":"6370_CR9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nature21349","volume":"541","author":"DS Chen","year":"2017","unstructured":"Chen DS, Mellman I (2017) Elements of cancer immunity and the cancer-immune set point. Nature 541(7637):321\u2013330. https:\/\/doi.org\/10.1038\/nature21349","journal-title":"Nature"},{"key":"6370_CR10","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","volume":"8","author":"Z Chen","year":"2023","unstructured":"Chen Z, Han F, Du Y et al (2023) Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions. Sig Transduct Target Ther 8:70. https:\/\/doi.org\/10.1038\/s41392-023-01332-8","journal-title":"Sig Transduct Target Ther"},{"key":"6370_CR11","doi-asserted-by":"publisher","first-page":"e69916","DOI":"10.7554\/eLife.69916","volume":"11","author":"S Dahal","year":"2022","unstructured":"Dahal S, Siddiqua H, Sharma S et al (2022) Unleashing a novel function of Endonuclease G in mitochondrial genome instability. Elife 11:e69916. https:\/\/doi.org\/10.7554\/eLife.69916","journal-title":"Elife"},{"issue":"4","key":"6370_CR12","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1093\/nar\/gkg205","volume":"31","author":"AM Davies","year":"2003","unstructured":"Davies AM, Hershman S, Stabley GJ, Hoek JB, Peterson J, Cahill A (2003) A Ca2+-induced mitochondrial permeability transition causes complete release of rat liver endonuclease G activity from its exclusive location within the mitochondrial intermembrane space. Identification of a novel endo-exonuclease activity residing within the mitochondrial matrix. Nucleic Acids Res 31(4):1364\u20131373. https:\/\/doi.org\/10.1093\/nar\/gkg205","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"6370_CR13","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/s12276-025-01470-9","volume":"57","author":"SH Dho","year":"2025","unstructured":"Dho SH, Cho M, Woo W, Jeong S, Kim LK (2025) Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond. Exp Mol Med 57(6):1121\u20131132. https:\/\/doi.org\/10.1038\/s12276-025-01470-9","journal-title":"Exp Mol Med"},{"issue":"1","key":"6370_CR14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13578-020-00521-0","volume":"11","author":"R Frazzi","year":"2021","unstructured":"Frazzi R (2021) BIRC3 and BIRC5: multi-faceted inhibitors in cancer. Cell Biosci 11(1):8. https:\/\/doi.org\/10.1186\/s13578-020-00521-0","journal-title":"Cell Biosci"},{"issue":"12","key":"6370_CR15","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/nrm3479","volume":"13","author":"L Galluzzi","year":"2012","unstructured":"Galluzzi L, Kepp O, Kroemer G (2012) Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol 13(12):780\u2013788. https:\/\/doi.org\/10.1038\/nrm3479","journal-title":"Nat Rev Mol Cell Biol"},{"key":"6370_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1146\/annurev-pathol-052016-100247","volume":"12","author":"L Galluzzi","year":"2017","unstructured":"Galluzzi L, Kepp O, Chan FK, Kroemer G (2017) Necroptosis: mechanisms and relevance to disease. Annu Rev Pathol 12:103\u2013130. https:\/\/doi.org\/10.1146\/annurev-pathol-052016-100247","journal-title":"Annu Rev Pathol"},{"issue":"3","key":"6370_CR17","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L Galluzzi","year":"2018","unstructured":"Galluzzi L, Vitale I, Aaronson SA et al (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 25(3):486\u2013541. https:\/\/doi.org\/10.1038\/s41418-017-0012-4","journal-title":"Cell Death Differ"},{"key":"6370_CR18","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","volume":"7","author":"W Gao","year":"2022","unstructured":"Gao W, Wang X, Zhou Y et al (2022) Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy. Signal Transduct Target Ther 7:196. https:\/\/doi.org\/10.1038\/s41392-022-01046-3","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"6370_CR19","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3322\/caac.21409","volume":"67","author":"JE Gershenwald","year":"2017","unstructured":"Gershenwald JE, Scolyer RA, Hess KR et al (2017) Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin 67(6):472\u2013492. https:\/\/doi.org\/10.3322\/caac.21409","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"6370_CR20","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1158\/1535-7163.MCT-23-0123","volume":"22","author":"MQ Glasheen","year":"2023","unstructured":"Glasheen MQ, Caksa S, Young AG et al (2023) Targeting upregulated cIAP2 in SOX10-deficient drug tolerant melanoma. Mol Cancer Ther 22(9):1087\u20131099. https:\/\/doi.org\/10.1158\/1535-7163.MCT-23-0123","journal-title":"Mol Cancer Ther"},{"key":"6370_CR21","doi-asserted-by":"publisher","first-page":"832","DOI":"10.3389\/fimmu.2018.00832","volume":"9","author":"S Grazioli","year":"2018","unstructured":"Grazioli S, Pugin J (2018) Mitochondrial damage-associated molecular patterns: from inflammatory signaling to human diseases. Front Immunol 9:832. https:\/\/doi.org\/10.3389\/fimmu.2018.00832","journal-title":"Front Immunol"},{"issue":"1","key":"6370_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo Q, Jin Y, Chen X et al (2024) NF-\u03baB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther 9(1):53. https:\/\/doi.org\/10.1038\/s41392-024-01757-9","journal-title":"Signal Transduct Target Ther"},{"key":"6370_CR23","doi-asserted-by":"publisher","first-page":"1428802","DOI":"10.3389\/fonc.2024.1428802","volume":"14","author":"Z Gurel","year":"2024","unstructured":"Gurel Z, Luy MS, Luo Q et al (2024) Metabolic modulation of melanoma enhances the therapeutic potential of immune checkpoint inhibitors. Front Oncol 14:1428802. https:\/\/doi.org\/10.3389\/fonc.2024.1428802","journal-title":"Front Oncol"},{"issue":"1","key":"6370_CR24","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D (2022) Hallmarks of cancer: new dimensions. Cancer Discov 12(1):31\u201346. https:\/\/doi.org\/10.1158\/2159-8290.CD-21-1059","journal-title":"Cancer Discov"},{"issue":"5","key":"6370_CR25","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674. https:\/\/doi.org\/10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"key":"6370_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann S, Castelo R, Guinney J (2013) GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform 14:7. https:\/\/doi.org\/10.1186\/1471-2105-14-7","journal-title":"BMC Bioinform"},{"issue":"11","key":"6370_CR27","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.3390\/cells11111855","volume":"11","author":"L Haslem","year":"2022","unstructured":"Haslem L, Hays JM, Hays FA (2022) p66Shc in cardiovascular pathology. Cells 11(11):1855. https:\/\/doi.org\/10.3390\/cells11111855","journal-title":"Cells"},{"key":"6370_CR28","doi-asserted-by":"publisher","first-page":"709077","DOI":"10.3389\/fonc.2021.709077","volume":"11","author":"A Ju","year":"2021","unstructured":"Ju A, Tang J, Chen S, Fu Y, Luo Y (2021) Pyroptosis-related gene signatures can robustly diagnose skin cutaneous melanoma and predict the prognosis. Front Oncol 11:709077. https:\/\/doi.org\/10.3389\/fonc.2021.709077","journal-title":"Front Oncol"},{"issue":"12","key":"6370_CR29","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky I, Millard N, Fan J et al (2019) Fast, sensitive and accurate integration of single-cell data with Harmony. Nat Methods 16(12):1289\u20131296. https:\/\/doi.org\/10.1038\/s41592-019-0619-0","journal-title":"Nat Methods"},{"key":"6370_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-78655-1_19","author":"WG Land","year":"2018","unstructured":"Land WG (2018) Regulated cell death. Damage-Assoc Mol Patterns Human Diseases. https:\/\/doi.org\/10.1007\/978-3-319-78655-1_19","journal-title":"Damage-Assoc Mol Patterns Human Diseases"},{"key":"6370_CR31","doi-asserted-by":"publisher","first-page":"3537471","DOI":"10.1155\/2018\/3537471","volume":"2018","author":"SY Lee","year":"2018","unstructured":"Lee SY, Ju MK, Jeon HM et al (2018) Regulation of tumor progression by programmed necrosis. Oxid Med Cell Longev 2018:3537471. https:\/\/doi.org\/10.1155\/2018\/3537471","journal-title":"Oxid Med Cell Longev"},{"key":"6370_CR32","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/s41467-023-36979-y","volume":"14","author":"SY Lim","year":"2023","unstructured":"Lim SY, Shklovskaya E, Lee JH et al (2023) The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma. Nat Commun 14:1516. https:\/\/doi.org\/10.1038\/s41467-023-36979-y","journal-title":"Nat Commun"},{"key":"6370_CR33","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12920-022-01194-z","volume":"15","author":"C Liu","year":"2022","unstructured":"Liu C, Liu Y, Yu Y et al (2022) Comprehensive analysis of ferroptosis-related genes and prognosis of cutaneous melanoma. BMC Med Genomics 15:39. https:\/\/doi.org\/10.1186\/s12920-022-01194-z","journal-title":"BMC Med Genomics"},{"issue":"6","key":"6370_CR34","doi-asserted-by":"publisher","first-page":"e8746","DOI":"10.15252\/msb.20188746","volume":"15","author":"MD Luecken","year":"2019","unstructured":"Luecken MD, Theis FJ (2019) Current best practices in single-cell RNA-seq analysis: a tutorial. Mol Syst Biol 15(6):e8746. https:\/\/doi.org\/10.15252\/msb.20188746","journal-title":"Mol Syst Biol"},{"issue":"8","key":"6370_CR35","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrclinonc.2017.43","volume":"14","author":"JJ Luke","year":"2017","unstructured":"Luke JJ, Flaherty KT, Ribas A, Long GV (2017) Targeted agents and immunotherapies: optimizing outcomes in melanoma. Nat Rev Clin Oncol 14(8):463\u2013482. https:\/\/doi.org\/10.1038\/nrclinonc.2017.43","journal-title":"Nat Rev Clin Oncol"},{"issue":"21","key":"6370_CR36","doi-asserted-by":"publisher","first-page":"4987","DOI":"10.1158\/1078-0432.CCR-23-3775","volume":"30","author":"KL Ma","year":"2024","unstructured":"Ma KL, Mitchell TC, Dougher M et al (2024) Tumor-infiltrating lymphocytes in necrotic tumors after melanoma neoadjuvant anti-PD-1 therapy correlate with pathologic response and recurrence-free survival. Clin Cancer Res 30(21):4987\u20134994. https:\/\/doi.org\/10.1158\/1078-0432.CCR-23-3775","journal-title":"Clin Cancer Res"},{"issue":"6","key":"6370_CR37","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.jid.2024.11.007","volume":"145","author":"Y Meng","year":"2025","unstructured":"Meng Y, Zhou Q, Dian Y, Zeng F, Deng G, Chen X (2025) Ferroptosis: a targetable vulnerability for melanoma treatment. J Invest Dermatol 145(6):1323\u20131344. https:\/\/doi.org\/10.1016\/j.jid.2024.11.007","journal-title":"J Invest Dermatol"},{"key":"6370_CR38","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1038\/s12276-023-01046-5","volume":"55","author":"TT Nguyen","year":"2023","unstructured":"Nguyen TT, Wei S, Nguyen TH et al (2023) Mitochondria-associated programmed cell death as a therapeutic target for age-related disease. Exp Mol Med 55:1595\u20131619. https:\/\/doi.org\/10.1038\/s12276-023-01046-5","journal-title":"Exp Mol Med"},{"issue":"6","key":"6370_CR39","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","volume":"148","author":"J Nunnari","year":"2012","unstructured":"Nunnari J, Suomalainen A (2012) Mitochondria: in sickness and in health. Cell 148(6):1145\u20131159. https:\/\/doi.org\/10.1016\/j.cell.2012.02.035","journal-title":"Cell"},{"issue":"2","key":"6370_CR40","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.bbcan.2019.01.006","volume":"1871","author":"X Qin","year":"2019","unstructured":"Qin X, Ma D, Tan YX, Wang HY, Cai Z (2019) The role of necroptosis in cancer: a double-edged sword? Biochim Biophys Acta Rev Cancer 1871(2):259\u2013266. https:\/\/doi.org\/10.1016\/j.bbcan.2019.01.006","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"6370_CR41","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yjmcc.2022.11.003","volume":"174","author":"DJ Robichaux","year":"2023","unstructured":"Robichaux DJ, Harata M, Murphy E, Karch J (2023) Mitochondrial permeability transition pore-dependent necrosis. J Mol Cell Cardiol 174:47\u201355. https:\/\/doi.org\/10.1016\/j.yjmcc.2022.11.003","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"6370_CR42","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1158\/2159-8290.CD-20-0805","volume":"11","author":"SR Rosenbaum","year":"2021","unstructured":"Rosenbaum SR, Wilski NA, Aplin AE (2021) Fueling the fire: inflammatory forms of cell death and implications for cancer immunotherapy. Cancer Discov 11(2):266\u2013281. https:\/\/doi.org\/10.1158\/2159-8290.CD-20-0805","journal-title":"Cancer Discov"},{"issue":"12","key":"6370_CR43","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.3390\/biomedicines10123209","volume":"10","author":"S Salmi","year":"2022","unstructured":"Salmi S, H\u00e4linen K, Lin A et al (2022) The association of CD8+ cytotoxic T cells and granzyme B+ lymphocytes with immunosuppressive factors, tumor stage and prognosis in cutaneous melanoma. Biomedicines 10(12):3209. https:\/\/doi.org\/10.3390\/biomedicines10123209","journal-title":"Biomedicines"},{"issue":"10151","key":"6370_CR44","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/S0140-6736(18)31559-9","volume":"392","author":"D Schadendorf","year":"2018","unstructured":"Schadendorf D, van Akkooi ACJ, Berking C et al (2018) Melanoma [published correction appears in Lancet. Lancet 392(10151):971\u2013984. https:\/\/doi.org\/10.1016\/S0140-6736(18)31559-9","journal-title":"Lancet"},{"issue":"7","key":"6370_CR45","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.medj.2024.03.015","volume":"5","author":"R Schlenker","year":"2024","unstructured":"Schlenker R, Schwalie PC, Dettling S et al (2024) Myeloid-T cell interplay and cell state transitions associated with checkpoint inhibitor response in melanoma. Med 5(7):759-779.e7. https:\/\/doi.org\/10.1016\/j.medj.2024.03.015","journal-title":"Med"},{"issue":"15","key":"6370_CR46","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","volume":"378","author":"R Schmitz","year":"2018","unstructured":"Schmitz R, Wright GW, Huang DW et al (2018) Genetics and pathogenesis of diffuse large B-cell lymphoma. N Engl J Med 378(15):1396\u20131407. https:\/\/doi.org\/10.1056\/NEJMoa1801445","journal-title":"N Engl J Med"},{"issue":"22","key":"6370_CR47","doi-asserted-by":"publisher","first-page":"e113614","DOI":"10.15252\/embj.2023113614","volume":"42","author":"F Schorn","year":"2023","unstructured":"Schorn F, Werthenbach JP, Hoffmann M et al (2023) cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J 42(22):e113614. https:\/\/doi.org\/10.15252\/embj.2023113614","journal-title":"EMBO J"},{"issue":"5","key":"6370_CR48","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1111\/bjd.18425","volume":"182","author":"YS Sheen","year":"2020","unstructured":"Sheen YS, Tan KT, Tse KP et al (2020) Genetic alterations in primary melanoma in Taiwan. Br J Dermatol 182(5):1205\u20131213. https:\/\/doi.org\/10.1111\/bjd.18425","journal-title":"Br J Dermatol"},{"issue":"1","key":"6370_CR49","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41420-025-02617-3","volume":"11","author":"D Shen","year":"2025","unstructured":"Shen D, Zhang L, Li S, Tang L (2025) Metabolic reprogramming in melanoma therapy. Cell Death Discov 11(1):308. https:\/\/doi.org\/10.1038\/s41420-025-02617-3","journal-title":"Cell Death Discov"},{"issue":"36","key":"6370_CR50","doi-asserted-by":"publisher","first-page":"e30564","DOI":"10.1097\/MD.0000000000030564","volume":"101","author":"Z Shi","year":"2022","unstructured":"Shi Z, Gu J, Yao Y, Wu Z (2022) Identification of a predictive gene signature related to pyroptosis for the prognosis of cutaneous melanoma. Medicine (Baltimore) 101(36):e30564. https:\/\/doi.org\/10.1097\/MD.0000000000030564","journal-title":"Medicine (Baltimore)"},{"key":"6370_CR51","doi-asserted-by":"publisher","first-page":"20374","DOI":"10.1038\/s41598-022-23475-4","volume":"12","author":"Y Tang","year":"2022","unstructured":"Tang Y, Feng H, Zhang L et al (2022) A novel prognostic model for cutaneous melanoma based on an immune-related gene signature and clinical variables. Sci Rep 12:20374. https:\/\/doi.org\/10.1038\/s41598-022-23475-4","journal-title":"Sci Rep"},{"key":"6370_CR52","doi-asserted-by":"publisher","first-page":"1392535","DOI":"10.3389\/fimmu.2024.1392535","volume":"15","author":"R Thompson","year":"2024","unstructured":"Thompson R, Cao X (2024) Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials. Front Immunol 15:1392535. https:\/\/doi.org\/10.3389\/fimmu.2024.1392535","journal-title":"Front Immunol"},{"issue":"2","key":"6370_CR53","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jdin.2020.07.004","volume":"1","author":"BM Tod","year":"2020","unstructured":"Tod BM, Schneider JW, Bowcock AM, Visser WI, Kotze MJ (2020) The tumor genetics of acral melanoma: what should a dermatologist know? JAAD Int 1(2):135\u2013147. https:\/\/doi.org\/10.1016\/j.jdin.2020.07.004","journal-title":"JAAD Int"},{"issue":"6","key":"6370_CR54","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.immuni.2018.04.031","volume":"48","author":"C Tsui","year":"2018","unstructured":"Tsui C, Martinez-Martin N, Gaya M et al (2018) Protein kinase C-\u03b2 dictates B cell fate by regulating mitochondrial remodeling, metabolic reprogramming, and heme biosynthesis. Immunity 48(6):1144-1159.e5. https:\/\/doi.org\/10.1016\/j.immuni.2018.04.031","journal-title":"Immunity"},{"key":"6370_CR55","doi-asserted-by":"publisher","first-page":"867098","DOI":"10.3389\/fimmu.2022.867098","volume":"13","author":"K Tuomela","year":"2022","unstructured":"Tuomela K, Ambrose AR, Davis DM (2022) Escaping death: how cancer cells and infected cells resist cell-mediated cytotoxicity. Front Immunol 13:867098. https:\/\/doi.org\/10.3389\/fimmu.2022.867098","journal-title":"Front Immunol"},{"issue":"3","key":"6370_CR56","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.bbrc.2016.11.088","volume":"482","author":"H Vakifahmetoglu-Norberg","year":"2017","unstructured":"Vakifahmetoglu-Norberg H, Ouchida AT, Norberg E (2017) The role of mitochondria in metabolism and cell death. Biochem Biophys Res Commun 482(3):426\u2013431. https:\/\/doi.org\/10.1016\/j.bbrc.2016.11.088","journal-title":"Biochem Biophys Res Commun"},{"key":"6370_CR57","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1472-6947-8-53","volume":"8","author":"AJ Vickers","year":"2008","unstructured":"Vickers AJ, Cronin AM, Elkin EB, Gonen M (2008) Extensions to decision curve analysis, a novel method for evaluating diagnostic tests, prediction models and molecular markers. BMC Med Inform Decis Mak 8:53. https:\/\/doi.org\/10.1186\/1472-6947-8-53","journal-title":"BMC Med Inform Decis Mak"},{"key":"6370_CR58","doi-asserted-by":"publisher","first-page":"e12304","DOI":"10.7717\/peerj.12304","volume":"9","author":"Z Wu","year":"2021","unstructured":"Wu Z, Chen L, Jin C et al (2021) A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma. PeerJ 9:e12304. https:\/\/doi.org\/10.7717\/peerj.12304","journal-title":"PeerJ"},{"issue":"4","key":"6370_CR59","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.1002\/cam4.5178","volume":"12","author":"G Wu","year":"2023","unstructured":"Wu G, Chen B, Jiang J et al (2023) Identification of a pyroptosis-based model for predicting clinical outcomes from immunotherapy in patients with metastatic melanoma. Cancer Med 12(4):4921\u20134937. https:\/\/doi.org\/10.1002\/cam4.5178","journal-title":"Cancer Med"},{"key":"6370_CR60","doi-asserted-by":"publisher","first-page":"758981","DOI":"10.3389\/fgene.2021.758981","volume":"12","author":"Z Xu","year":"2021","unstructured":"Xu Z, Xie Y, Mao Y et al (2021) Ferroptosis-related gene signature predicts the prognosis of skin cutaneous melanoma and response to immunotherapy. Front Genet 12:758981. https:\/\/doi.org\/10.3389\/fgene.2021.758981","journal-title":"Front Genet"},{"key":"6370_CR61","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41419-023-05691-6","volume":"14","author":"K Ye","year":"2023","unstructured":"Ye K, Chen Z, Xu Y (2023) The double-edged functions of necroptosis. Cell Death Dis 14:163. https:\/\/doi.org\/10.1038\/s41419-023-05691-6","journal-title":"Cell Death Dis"},{"issue":"6","key":"6370_CR62","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.3390\/ijms24065278","volume":"24","author":"E Zapletal","year":"2023","unstructured":"Zapletal E, Vasiljevic T, Busson P, Matijevic GT (2023) Dialog beyond the grave: necrosis in the tumor microenvironment and its contribution to tumor growth. Int J Mol Sci 24(6):5278. https:\/\/doi.org\/10.3390\/ijms24065278","journal-title":"Int J Mol Sci"},{"issue":"9","key":"6370_CR63","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1016\/j.celrep.2019.04.111","volume":"27","author":"J Zhang","year":"2019","unstructured":"Zhang J, Webster JD, Dugger DL et al (2019) Ubiquitin ligases cIAP1 and cIAP2 limit cell death to prevent inflammation. Cell Rep 27(9):2679-2689.e3. https:\/\/doi.org\/10.1016\/j.celrep.2019.04.111","journal-title":"Cell Rep"},{"key":"6370_CR64","doi-asserted-by":"publisher","first-page":"1115272","DOI":"10.3389\/fimmu.2023.1115272","volume":"14","author":"P Zhang","year":"2023","unstructured":"Zhang P, Pei S, Gong Z et al (2023) By integrating single-cell RNA-seq and bulk RNA-seq in sphingolipid metabolism, CACYBP was identified as a potential therapeutic target in lung adenocarcinoma. Front Immunol 14:1115272. https:\/\/doi.org\/10.3389\/fimmu.2023.1115272","journal-title":"Front Immunol"},{"issue":"1","key":"6370_CR65","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s40257-024-00907-7","volume":"26","author":"DX Zheng","year":"2025","unstructured":"Zheng DX, Bozym DJ, Tarantino G, Sullivan RJ, Liu D, Jenkins RW (2025) Overcoming resistance mechanisms to melanoma immunotherapy. Am J Clin Dermatol 26(1):77\u201396. https:\/\/doi.org\/10.1007\/s40257-024-00907-7","journal-title":"Am J Clin Dermatol"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06370-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-025-06370-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-025-06370-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T19:39:06Z","timestamp":1765654746000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-025-06370-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":65,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6370"],"URL":"https:\/\/doi.org\/10.1007\/s00432-025-06370-z","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"5 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable since all data used is available in public databases.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agree to publish.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"323"}}