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Clinical and pathological variables were reviewed, and relevant gene alterations were extracted from cBioPortal. Overall survival (OS) and disease-free survival (DFS) were estimated using Kaplan\u2013Meier curves and compared by the log-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty patients were analyzed (median follow-up, 36\u00a0months; range, 4\u2013130). The cohort comprised 10 men and 20 women (mean age 51\u00a0years). Hoarseness (36.7%) was the most frequent symptom and correlated with poorer OS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033). Locoregional recurrence occurred in 5 patients (16.7%), and distant metastases in 15 (50%). OS rates at 3, 5, and 10\u00a0years were 95.5%, 76.4%, and 38.2%; DFS rates were 79.2%, 49.4%, and 10.3%. Survival rates were estimated using the Kaplan\u2013Meier method, with 9 censored patients who had follow-up shorter than 3 or 5\u00a0years without tumor progression or death. Higher Ki-67 index (&gt;\u200915%) predicted an unfavorable DFS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.041). Gene fusions (4 MYB\u2013NFIB, 1 CTNNA3\u2013NFIB) were detected in 50% of tested cases, highlighting molecular features of LHACC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hoarseness and Ki-67 may help identify high-risk LHACC patients. Surgical resection remains the cornerstone of therapy, but individualized management and long-term follow-up are essential. Frequent MYB\u2013NFIB fusions underscore the molecular basis of LHACC and may inform future prognostic assessment and therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00432-026-06449-1","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:45:15Z","timestamp":1775663115000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological features and prognostic analysis of 30 patients with laryngeal and hypopharyngeal adenoid cystic carcinoma: a single-center retrospective study"],"prefix":"10.1007","volume":"152","author":[{"given":"Mingzhu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3981-981X","authenticated-orcid":false,"given":"Tingyao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-2647","authenticated-orcid":false,"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"issue":"2","key":"6449_CR1","first-page":"79","volume":"15","author":"HE Aliabadi","year":"2022","unstructured":"Aliabadi HE, Dabiri S, Motamed S (2022) Laryngeal adenoid cystic carcinoma: a rare case report. 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