{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:02:52Z","timestamp":1785528172449,"version":"3.56.0"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":62,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of this review is to summarize transcriptomic studies using single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq to investigate leukemic stem cells (LSCs) population in acute myeloid leukemia (AML).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature for inclusion was identified through a PubMed search. Twenty-seven studies were analyzed, covering various aspects of LSCs biology, including epigenetic, transcriptional, and translational gene regulation, metabolic reprogramming or cellular differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The reviewed studies highlight the complexity of LSCs, including their quiescent state, state-to-state cellular plasticity, and metabolic reprogramming from glycolysis to lipogenesis. Comparative analyses of matched diagnostic and post-treatment samples provide insights into the dynamic behavior of LSCs during therapy. The findings also identify potential therapeutic targets and strategies to selectively eradicate LSCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Single-cell RNA sequencing technologies offer unprecedented resolution for studying LSCs in AML, revealing cellular heterogeneity and dynamic evolution within these critical populations. Despite these advances, standardized criteria for LSCs identification are still needed, and longitudinal studies at clinically relevant time points are essential to fully understand their role in disease progression and therapy resistance. Such approaches may ultimately uncover novel therapeutic vulnerabilities and improve clinical management of AML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00432-026-06500-1","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:05:52Z","timestamp":1780052752000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diving into the transcriptional landscape of leukemic stem cells in acute myeloid leukemia at single-cell resolution"],"prefix":"10.1007","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8417-8915","authenticated-orcid":false,"given":"Zuzanna","family":"Rzetelska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-3637","authenticated-orcid":false,"given":"Lidia","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4320-9253","authenticated-orcid":false,"given":"Francesco","family":"Buccisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0855-6591","authenticated-orcid":false,"given":"Dominik","family":"Dytfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"6500_CR1","doi-asserted-by":"publisher","unstructured":"Ahmed F, Zhong J (2024) Advances in DNA\/RNA sequencing and their applications in acute myeloid leukemia (AML). Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26010071","DOI":"10.3390\/ijms26010071"},{"issue":"12","key":"6500_CR2","doi-asserted-by":"publisher","first-page":"3742","DOI":"10.3390\/cancers12123742","volume":"12","author":"M Arnone","year":"2020","unstructured":"Arnone M, Konantz M, Hanns P, Paczulla Stanger AM, Bertels S, Godavarthy PS, Christopeit M, Lengerke C (2020) Acute myeloid leukemia stem cells: the challenges of phenotypic heterogeneity. Cancers (Basel) 12(12):3742. https:\/\/doi.org\/10.3390\/cancers12123742","journal-title":"Cancers (Basel)"},{"key":"6500_CR3","doi-asserted-by":"publisher","first-page":"1445173","DOI":"10.3389\/fonc.2024.1445173","volume":"14","author":"M Bakhtiari","year":"2024","unstructured":"Bakhtiari M, Jordan SC, Mumme HL, Sharma R, Shanmugam M, Bhasin SS, Bhasin M (2024) ARMH1 is a novel marker associated with poor pediatric AML outcomes that affect the fatty acid synthesis and cell cycle pathways. Front Oncol 14:1445173. https:\/\/doi.org\/10.3389\/fonc.2024.1445173","journal-title":"Front Oncol"},{"key":"6500_CR4","doi-asserted-by":"publisher","unstructured":"Barreto IV, Pessoa FMC, de Machado P, Pantoja CB, Ribeiro L da, Lopes RM, Amaral de Moraes GS, de Moraes Filho ME, de Souza MO, Burbano LEB, Khayat RMR, Moreira-Nunes AS CA (2022) Leukemic stem cell: a mini-review on clinical perspectives. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2022.931050","DOI":"10.3389\/fonc.2022.931050"},{"issue":"5","key":"6500_CR5","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.stem.2023.04.001","volume":"30","author":"S Beneyto-Calabuig","year":"2023","unstructured":"Beneyto-Calabuig S, Merbach AK, Kniffka J-A, Antes M, Szu-Tu C, Rohde C, Waclawiczek A, Stelmach P, Gr\u00e4\u00dfle S, Pervan P, Janssen M, Landry JJM, Benes V, Jauch A, Brough M, Bauer M, Besenbeck B, Felden J, B\u00e4umer S, Hundemer M, Sauer T, Pabst C, Wickenhauser C, Angenendt L, Schliemann C, Trumpp A, Haas S, Scherer M, Raffel S, M\u00fcller-Tidow C, Velten L (2023) Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia. Cell Stem Cell 30(5):706\u2013721e8. https:\/\/doi.org\/10.1016\/j.stem.2023.04.001","journal-title":"Cell Stem Cell"},{"issue":"9","key":"6500_CR7","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1038\/s41375-019-0429-5","volume":"33","author":"M Bill","year":"2019","unstructured":"Bill M, Papaioannou D, Karunasiri M, Kohlschmidt J, Pepe F, Walker CJ, Walker AE, Brannan Z, Pathmanathan A, Zhang X, Mr\u00f3zek K, LaRocco A, Volinia S, Bloomfield CD, Garzon R, Dorrance AM (2019) Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells. Leukemia 33(9):2169\u20132182. https:\/\/doi.org\/10.1038\/s41375-019-0429-5","journal-title":"Leukemia"},{"issue":"3","key":"6500_CR6","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3324\/haematol.2019.225003","volume":"105","author":"M Bill","year":"2020","unstructured":"Bill M, Nicolet D, Kohlschmidt J, Walker CJ, Mr\u00f3zek K, Eisfeld A-K, Papaioannou D, Rong-Mullins X, Brannan Z, Kolitz JE, Powell BL, Archer KJ, Dorrance AM, Carroll AJ, Stone RM, Byrd JC, Garzon R, Bloomfield CD (2020) Mutations associated with a 17-gene leukemia stem cell score and the score\u2019s prognostic relevance in the context of the European LeukemiaNet classification of acute myeloid leukemia. Haematologica 105(3):721\u2013729. https:\/\/doi.org\/10.3324\/haematol.2019.225003","journal-title":"Haematologica"},{"issue":"7","key":"6500_CR8","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/nm0797-730","volume":"3","author":"D Bonnet","year":"1997","unstructured":"Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3(7):730\u2013737. https:\/\/doi.org\/10.1038\/nm0797-730","journal-title":"Nat Med"},{"issue":"6","key":"6500_CR9","doi-asserted-by":"publisher","first-page":"114260","DOI":"10.1016\/j.celrep.2024.114260","volume":"43","author":"M-E Bordeleau","year":"2024","unstructured":"Bordeleau M-E, Audemard \u00c9, M\u00e9tois A, Theret L, Lisi V, Farah A, Spinella J-F, Chagraoui J, Moujaber O, Aubert L, Khakipoor B, Mallinger L, Boivin I, Mayotte N, Hajmirza A, Bonneil \u00c9, B\u00e9liveau F, Pfammatter S, Feghaly A, Boucher G, Gendron P, Thibault P, Barab\u00e9 F, Lemieux S, Richard-Carpentier G, H\u00e9bert J, Lavall\u00e9e V-P, Roux PP, Sauvageau G (2024) Immunotherapeutic targeting of surfaceome heterogeneity in AML. Cell Rep 43(6):114260. https:\/\/doi.org\/10.1016\/j.celrep.2024.114260","journal-title":"Cell Rep"},{"key":"6500_CR10","doi-asserted-by":"publisher","unstructured":"Bordenave J, Gajda D, Michonneau D, Vallet N, Chevalier M, Clappier E, Lemaire P, Mathis S, Robin M, Xhaard A, Sicre de Fontbrune F, Corneau A, Caillat-Zucman S, de Peffault R, Curis E, Soci\u00e9 G (2024) Deciphering bone marrow engraftment after allogeneic stem cell transplantation in humans using single-cell analyses. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI180331","DOI":"10.1172\/JCI180331"},{"issue":"7","key":"6500_CR11","doi-asserted-by":"publisher","first-page":"101108","DOI":"10.1016\/j.xcrm.2023.101108","volume":"4","author":"AL Boyd","year":"2023","unstructured":"Boyd AL, Lu J, Hollands CG, Alsostovar L, Murali S, Reid JC, Ye W, Vandersluis S, Johnson P, ElRafie A, Porras DP, Xenocostas D, Leber A, Leber B, Foley R, Trus M, Berg T, Kawata E, Xenocostas A, Bhatia M (2023) Leukemic progenitor compartment serves as a prognostic measure of cancer stemness in patients with acute myeloid leukemia. Cell Rep Med 4(7):101108. https:\/\/doi.org\/10.1016\/j.xcrm.2023.101108","journal-title":"Cell Rep Med"},{"key":"6500_CR12","doi-asserted-by":"publisher","first-page":"796477","DOI":"10.3389\/fonc.2021.796477","volume":"11","author":"C Caprioli","year":"2021","unstructured":"Caprioli C, Nazari I, Milovanovic S, Pelicci PG (2021) Single-cell technologies to decipher the immune microenvironment in myeloid neoplasms: perspectives and opportunities. Front Oncol 11:796477. https:\/\/doi.org\/10.3389\/fonc.2021.796477","journal-title":"Front Oncol"},{"issue":"1","key":"6500_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13046-024-03267-6","volume":"44","author":"JL Carter","year":"2025","unstructured":"Carter JL, Su Y, Al-Antary ET, Zhao J, Qiao X, Wang G, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Buck SA, H\u00fcttemann M, Allen JE, Prabhu VV, Yang J, Taub JW, Ge Y (2025) ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress. J Exp Clin Cancer Res 44(1):10. https:\/\/doi.org\/10.1186\/s13046-024-03267-6","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"6500_CR15","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1186\/s12967-024-05779-3","volume":"22","author":"Y Chen","year":"2024","unstructured":"Chen Y (2024) Dissecting L-glutamine metabolism in acute myeloid leukemia: single-cell insights and therapeutic implications. J Transl Med 22(1):1002. https:\/\/doi.org\/10.1186\/s12967-024-05779-3","journal-title":"J Translational Med"},{"issue":"24","key":"6500_CR14","doi-asserted-by":"publisher","first-page":"e70306","DOI":"10.1111\/jcmm.70306","volume":"28","author":"C-H Chen","year":"2024","unstructured":"Chen C-H, Chen T-C, Wu T-S, Hsiao T-H, Chen J-MM, Huang C-YF, Cheng P-L, Tsai J-R, Teng C-LJ (2024) Myeloperoxidase and thyrotropin-releasing hormone within leukaemia stem cells increased chemosensitivity in acute myeloid leukaemia. J Cell Mol Med 28(24):e70306. https:\/\/doi.org\/10.1111\/jcmm.70306","journal-title":"J Cell Mol Med"},{"key":"6500_CR16","doi-asserted-by":"publisher","unstructured":"Cl J, Bm S, Ja AD, R C-H R, C TNSPNKBAHYAKDR, Da SJD, Ct P J (2018) Inhibition of amino acid metabolism selectively targets human leukemia stem cells. Cancer Cell. https:\/\/doi.org\/10.1016\/j.ccell.2018.10.005","DOI":"10.1016\/j.ccell.2018.10.005"},{"issue":"7","key":"6500_CR17","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1056\/NEJMoa2012971","volume":"383","author":"CD DiNardo","year":"2020","unstructured":"DiNardo CD, Jonas BA, Pullarkat V, Thirman MJ, Garcia JS, Wei AH, Konopleva M, D\u00f6hner H, Letai A, Fenaux P, Koller E, Havelange V, Leber B, Esteve J, Wang J, Pejsa V, H\u00e1jek R, Porkka K, Ill\u00e9s \u00c1, Lavie D, Lemoli RM, Yamamoto K, Yoon S-S, Jang J-H, Yeh S-P, Turgut M, Hong W-J, Zhou Y, Potluri J, Pratz KW (2020) Azacitidine and venetoclax in previously untreated acute myeloid leukemia. N Engl J Med 383(7):617\u2013629. https:\/\/doi.org\/10.1056\/NEJMoa2012971","journal-title":"N Engl J Med"},{"issue":"7382","key":"6500_CR18","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature10738","volume":"481","author":"L Ding","year":"2012","unstructured":"Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling DJ, Fulton RS, Fulton LL, Chen K, Schmidt H, Kalicki-Veizer J, Magrini VJ, Cook L, McGrath SD, Vickery TL, Wendl MC, Heath S, Watson MA, Link DC, Tomasson MH, Shannon WD, Payton JE, Kulkarni S, Westervelt P, Walter MJ, Graubert TA, Mardis ER, Wilson RK, DiPersio JF (2012) Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 481(7382):506\u2013510. https:\/\/doi.org\/10.1038\/nature10738","journal-title":"Nature"},{"issue":"12","key":"6500_CR19","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1182\/blood.2022016867","volume":"140","author":"H D\u00f6hner","year":"2022","unstructured":"D\u00f6hner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, R\u00f6llig C, Sierra J, Stein EM, Tallman MS, Tien H-F, Wang J, Wierzbowska A, L\u00f6wenberg B (2022) Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood 140(12):1345\u20131377. https:\/\/doi.org\/10.1182\/blood.2022016867","journal-title":"Blood"},{"key":"6500_CR20","doi-asserted-by":"publisher","unstructured":"Domingues AF, Kulkarni R, Giotopoulos G, Gupta S, Vinnenberg L, Arede L, Foerner E, Khalili M, Adao RR, Johns A, Tan S, Zeka K, Huntly BJ, Prabakaran S, Pina C (2020) Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells. Elife. https:\/\/doi.org\/10.7554\/eLife.51754","DOI":"10.7554\/eLife.51754"},{"issue":"4","key":"6500_CR21","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1111\/bjh.70019","volume":"207","author":"A Dreyzin","year":"2025","unstructured":"Dreyzin A, Holtzman NG, Bonifant CL (2025) CD123-targeting immunotherapeutic approaches in acute myeloid leukaemia. Br J Haematol 207(4):1178\u20131191. https:\/\/doi.org\/10.1111\/bjh.70019","journal-title":"Br J Haematol"},{"issue":"6","key":"6500_CR22","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1158\/2159-8290.CD-20-1375","volume":"11","author":"C Duy","year":"2021","unstructured":"Duy C, Li M, Teater M, Meydan C, Garrett-Bakelman FE, Lee TC, Chin CR, Durmaz C, Kawabata KC, Dhimolea E, Mitsiades CS, Doehner H, D\u2019Andrea RJ, Becker MW, Paietta EM, Mason CE, Carroll M, Melnick AM (2021) Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence. Cancer Discov 11(6):1542\u20131561. https:\/\/doi.org\/10.1158\/2159-8290.CD-20-1375","journal-title":"Cancer Discov"},{"issue":"3","key":"6500_CR23","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/s41375-019-0604-8","volume":"34","author":"AH Elsayed","year":"2020","unstructured":"Elsayed AH, Rafiee R, Cao X, Raimondi S, Downing JR, Ribeiro R, Fan Y, Gruber TA, Baker S, Klco J, Rubnitz JE, Pounds S, Lamba JK (2020) A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia. Leukemia 34(3):735\u2013745. https:\/\/doi.org\/10.1038\/s41375-019-0604-8","journal-title":"Leukemia"},{"issue":"9","key":"6500_CR24","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/nm.2415","volume":"17","author":"K Eppert","year":"2011","unstructured":"Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, van Galen P, Metzeler KH, Poeppl A, Ling V, Beyene J, Canty AJ, Danska JS, Bohlander SK, Buske C, Minden MD, Golub TR, Jurisica I, Ebert BL, Dick JE (2011) Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med 17(9):1086\u20131093. https:\/\/doi.org\/10.1038\/nm.2415","journal-title":"Nat Med"},{"issue":"7","key":"6500_CR25","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1158\/2159-8290.CD-16-0441","volume":"7","author":"T Farge","year":"2017","unstructured":"Farge T, Saland E, de Toni F, Aroua N, Hosseini M, Perry R, Bosc C, Sugita M, Stuani L, Fraisse M, Scotland S, Larrue C, Boutzen H, F\u00e9liu V, Nicolau-Travers M-L, Cassant-Sourdy S, Broin N, David M, Serhan N, Sarry A, Tavitian S, Kaoma T, Vallar L, Iacovoni J, Linares LK, Montersino C, Castellano R, Griessinger E, Collette Y, Duchamp O, Barreira Y, Hirsch P, Palama T, Gales L, Delhommeau F, Garmy-Susini B, Portais J-C, Vergez F, Selak MA, Danet-Desnoyers G, Carroll M, R\u00e9cher C, Sarry J-E (2017) Chemotherapy resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism. Cancer Discov 7(7):716\u2013735. https:\/\/doi.org\/10.1158\/2159-8290.CD-16-0441","journal-title":"Cancer Discov"},{"issue":"24","key":"6500_CR26","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1001\/jama.2010.1862","volume":"304","author":"AJ Gentles","year":"2010","unstructured":"Gentles AJ, Plevritis SK, Majeti R, Alizadeh AA (2010) Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA 304(24):2706\u20132715. https:\/\/doi.org\/10.1001\/jama.2010.1862","journal-title":"JAMA"},{"issue":"23","key":"6500_CR27","doi-asserted-by":"publisher","first-page":"5826","DOI":"10.3390\/ijms20235826","volume":"20","author":"T Gluexam","year":"2019","unstructured":"Gluexam T, Grandits AM, Schlerka A, Nguyen CH, Etzler J, Finkes T, Fuchs M, Scheid C, Heller G, Hackl H, Harrer N, Sill H, Koller E, Stoiber D, Sommergruber W, Wieser R (2019) CGRP signaling via CALCRL increases chemotherapy resistance and stem cell properties in acute myeloid leukemia. Int J Mol Sci 20(23):5826. https:\/\/doi.org\/10.3390\/ijms20235826","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6500_CR28","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ymthe.2018.10.001","volume":"27","author":"D Gomes-Silva","year":"2019","unstructured":"Gomes-Silva D, Atilla E, Atilla PA, Mo F, Tashiro H, Srinivasan M, Lulla P, Rouce RH, Cabral JMS, Ramos CA, Brenner MK, Mamonkin M (2019) CD7 CAR T cells for the therapy of acute myeloid leukemia. Mol Ther 27(1):272\u2013280. https:\/\/doi.org\/10.1016\/j.ymthe.2018.10.001","journal-title":"Mol Ther"},{"key":"6500_CR29","doi-asserted-by":"publisher","unstructured":"Guerrero-Rodr\u00edguez SL, Mata-Cruz C, P\u00e9rez-Tapia SM, Velasco-Vel\u00e1zquez MA (2022) Role of CD36 in cancer progression, stemness, and targeting. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2022.1079076","DOI":"10.3389\/fcell.2022.1079076"},{"issue":"1","key":"6500_CR30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1365-2362.2007.01746.x","volume":"37","author":"AW Hauswirth","year":"2007","unstructured":"Hauswirth AW, Florian S, Printz D, Sotlar K, Krauth M-T, Fritsch G, Schernthaner G-H, Wacheck V, Selzer E, Sperr WR, Valent P (2007) Expression of the target receptor CD33 in CD34+\/CD38-\/CD123\u2009+\u2009AML stem cells. Eur J Clin Invest 37(1):73\u201382. https:\/\/doi.org\/10.1111\/j.1365-2362.2007.01746.x","journal-title":"Eur J Clin Invest"},{"issue":"20","key":"6500_CR31","doi-asserted-by":"publisher","first-page":"5118","DOI":"10.1182\/bloodadvances.2020001742","volume":"4","author":"H Herrmann","year":"2020","unstructured":"Herrmann H, Sadovnik I, Eisenwort G, R\u00fclicke T, Blatt K, Herndlhofer S, Willmann M, Stefanzl G, Baumgartner S, Greiner G, Schulenburg A, Mueller N, Rabitsch W, Bilban M, Hoermann G, Streubel B, Vallera DA, Sperr WR, Valent P (2020) Delineation of target expression profiles in CD34+\/CD38\u2009\u2013\u2009and CD34+\/CD38\u2009+\u2009stem and progenitor cells in AML and CML. Blood Adv 4(20):5118\u20135132. https:\/\/doi.org\/10.1182\/bloodadvances.2020001742","journal-title":"Blood Adv"},{"key":"6500_CR32","doi-asserted-by":"publisher","unstructured":"Horibata S, Gui G, Lack J, DeStefano CB, Gottesman MM, Hourigan CS (2019) Heterogeneity in refractory acute myeloid leukemia. Proc Natl Acad Sci 116(21):10494\u201310503. https:\/\/doi.org\/10.1073\/pnas.1902375116","DOI":"10.1073\/pnas.1902375116"},{"issue":"26","key":"6500_CR33","doi-asserted-by":"publisher","first-page":"11008","DOI":"10.1073\/pnas.0704271104","volume":"104","author":"N Hosen","year":"2007","unstructured":"Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, Krensky AM, Weissman IL (2007) CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proc Natl Acad Sci U S A 104(26):11008\u201311013. https:\/\/doi.org\/10.1073\/pnas.0704271104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6500_CR57","doi-asserted-by":"publisher","unstructured":"Hp PMSTRSRH P, R S, M M (2021) Proportion of CD34\u2009+\u2009CD38-CD123\u2009+\u2009leukemia stem cells at diagnosis varies in ELN risk groups and an emerging novel marker for prognosticating the intermediate risk patients of acute myeloid leukemia: a prospective study. Indian J Hematol Blood Transfusion Off J Indian Soc Hematol Blood Transfus. https:\/\/doi.org\/10.1007\/s12288-020-01383-9","DOI":"10.1007\/s12288-020-01383-9"},{"issue":"10","key":"6500_CR34","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s00277-012-1501-7","volume":"91","author":"K Hwang","year":"2012","unstructured":"Hwang K, Park C-J, Jang S, Chi H-S, Kim D-Y, Lee J-H, Lee JH, Lee KH, Im H-J, Seo J-J (2012) Flow cytometric quantification and immunophenotyping of leukemic stem cells in acute myeloid leukemia. Ann Hematol 91(10):1541\u20131546. https:\/\/doi.org\/10.1007\/s00277-012-1501-7","journal-title":"Ann Hematol"},{"issue":"2","key":"6500_CR35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/s42255-019-0032-0","volume":"1","author":"AM Intlekofer","year":"2019","unstructured":"Intlekofer AM, Finley LWS (2019) Metabolic signatures of cancer cells and stem cells. Nat Metab 1(2):177\u2013188. https:\/\/doi.org\/10.1038\/s42255-019-0032-0","journal-title":"Nat Metab"},{"issue":"9","key":"6500_CR36","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1182\/bloodadvances.2018026054","volume":"3","author":"J Izaguirre-Carbonell","year":"2019","unstructured":"Izaguirre-Carbonell J, Christiansen L, Burns R, Schmitz J, Li C, Mokry RL, Bluemn T, Zheng Y, Shen J, Carlson K-S, Rao S, Wang D, Zhu N (2019) Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia. Blood Adv 3(9):1499\u20131511. https:\/\/doi.org\/10.1182\/bloodadvances.2018026054","journal-title":"Blood Adv"},{"issue":"4","key":"6500_CR37","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1002\/ajh.24663","volume":"92","author":"M Jentzsch","year":"2017","unstructured":"Jentzsch M, Bill M, Nicolet D, Leiblein S, Schubert K, Pless M, Bergmann U, Wildenberger K, Schuhmann L, Cross M, P\u00f6nisch W, Franke G-N, Vucinic V, Lange T, Behre G, Mr\u00f3zek K, Bloomfield CD, Niederwieser D, Schwind S (2017) Prognostic impact of the CD34+\/CD38- cell burden in patients with acute myeloid leukemia receiving allogeneic stem cell transplantation. Am J Hematol 92(4):388\u2013396. https:\/\/doi.org\/10.1002\/ajh.24663","journal-title":"Am J Hematol"},{"issue":"22","key":"6500_CR38","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1002\/cncr.34481","volume":"128","author":"R Jia","year":"2022","unstructured":"Jia R, Ji M, Li G, Xia Y, Guo S, Li P, Sun Y, Lu F, Zhang J, Zang S, Yan S, Ye J, Xue F, Ma D, Sun T, Ji C (2022) Subclones of bone marrow CD34(+) cells in acute myeloid leukemia at diagnosis confer responses of patients to induction chemotherapy. Cancer 128(22):3929\u20133942. https:\/\/doi.org\/10.1002\/cncr.34481","journal-title":"Cancer"},{"key":"6500_CR39","doi-asserted-by":"publisher","first-page":"117265","DOI":"10.1016\/j.biopha.2024.117265","volume":"179","author":"S Kadam","year":"2024","unstructured":"Kadam S, Ali A, Pospiech M, Onyemaechi S, Meng Y, Dhuri K, MacKay JA, Alachkar H (2024) Enhanced T cell activation and cytotoxicity against AML via targeted anti-CD99 nanoparticle treatment. Biomed Pharmacother 179:117265. https:\/\/doi.org\/10.1016\/j.biopha.2024.117265","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"6500_CR40","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1007\/s12013-025-01666-w","volume":"83","author":"S Kevat","year":"2025","unstructured":"Kevat S, Mistry A, Oza N, Majmudar M, Patel N, Shah R, Ramachandran AV, Chauhan R, Haque S, Parashar NC, Tuli HS, Parashar G (2025) Cancer stem cell regulation as a target of therapeutic intervention: insights into breast, cervical and lung cancer. Cell Biochem Biophys 83(2):1521\u20131535. https:\/\/doi.org\/10.1007\/s12013-025-01666-w","journal-title":"Cell Biochem Biophys"},{"issue":"1","key":"6500_CR41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s40164-024-00534-2","volume":"13","author":"P Klaihmon","year":"2024","unstructured":"Klaihmon P, Samart P, Rojanasakul Y, Issaragrisil S, Luanpitpong S (2024) Anti-TIM3 chimeric antigen receptor-natural killer cells preferentially target primitive acute myeloid leukemia cells with minimal fratricide and exhaustion. Exp Hematol Oncol 13(1):67. https:\/\/doi.org\/10.1186\/s40164-024-00534-2","journal-title":"Exp Hematol Oncol"},{"issue":"3","key":"6500_CR42","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1182\/blood-2013-08-523548","volume":"123","author":"C Krupka","year":"2014","unstructured":"Krupka C, Kufer P, Kischel R, Zugmaier G, B\u00f6geholz J, K\u00f6hnke T, Lichtenegger FS, Schneider S, Metzeler KH, Fiegl M, Spiekermann K, Baeuerle PA, Hiddemann W, Riethm\u00fcller G, Subklewe M (2014) CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell\u2013engaging antibody AMG 330. Blood 123(3):356\u2013365. https:\/\/doi.org\/10.1182\/blood-2013-08-523548","journal-title":"Blood"},{"key":"6500_CR43","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.exphem.2017.06.007","volume":"54","author":"AA Laing","year":"2017","unstructured":"Laing AA, Harrison CJ, Gibson BES, Keeshan K (2017) Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia. Exp Hematol 54:40\u201350. https:\/\/doi.org\/10.1016\/j.exphem.2017.06.007","journal-title":"Exp Hematol"},{"issue":"12","key":"6500_CR44","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1016\/j.ccell.2023.10.008","volume":"41","author":"S Lambo","year":"2023","unstructured":"Lambo S, Trinh DL, Ries RE, Jin D, Setiadi A, Ng M, Leblanc VG, Loken MR, Brodersen LE, Dai F, Pardo LM, Ma X, Vercauteren SM, Meshinchi S, Marra MA (2023) A longitudinal single-cell atlas of treatment response in pediatric AML. Cancer Cell 41(12):2117\u20132135e12. https:\/\/doi.org\/10.1016\/j.ccell.2023.10.008","journal-title":"Cancer Cell"},{"issue":"2","key":"6500_CR45","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41375-022-01789-6","volume":"37","author":"K Li","year":"2023","unstructured":"Li K, Du Y, Cai Y, Liu W, Lv Y, Huang B, Zhang L, Wang Z, Liu P, Sun Q, Li N, Zhu M, Bosco B, Li L, Wu W, Wu L, Li J, Wang Q, Hong M, Qian S (2023) Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed\/refractory acute myeloid leukemia. Leukemia 37(2):308\u2013325. https:\/\/doi.org\/10.1038\/s41375-022-01789-6","journal-title":"Leukemia"},{"issue":"5","key":"6500_CR46","doi-asserted-by":"publisher","first-page":"884","DOI":"10.3390\/cancers16050884","volume":"16","author":"LF Lincz","year":"2024","unstructured":"Lincz LF, Theron DZ, Barry DL, Scorgie FE, Sillar J, Sefhore O, Enjeti AK, Skelding KA (2024) High expression of ENO1 and low levels of circulating anti-ENO1 autoantibodies in patients with myelodysplastic neoplasms and acute myeloid leukaemia. Cancers (Basel) 16(5):884. https:\/\/doi.org\/10.3390\/cancers16050884","journal-title":"Cancers (Basel)"},{"issue":"14","key":"6500_CR47","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1182\/blood.2024027207","volume":"145","author":"J Lyu","year":"2025","unstructured":"Lyu J, Liu Y, Liu N, Vu HS, Cai F, Cao H, Kaphle P, Wu Z, Botten GA, Zhang Y, Wang J, Achyutuni S, Gao X, Iacobucci I, Mullighan CG, Chung SS, Ni M, DeBerardinis RJ, Xu J (2025) CD44-mediated metabolic rewiring is a targetable dependency of IDH-mutant leukemia. Blood 145(14):1553\u20131567. https:\/\/doi.org\/10.1182\/blood.2024027207","journal-title":"Blood"},{"issue":"2","key":"6500_CR48","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.cell.2009.05.045","volume":"138","author":"R Majeti","year":"2009","unstructured":"Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD, van Rooijen N, Weissman IL (2009) CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138(2):286\u2013299. https:\/\/doi.org\/10.1016\/j.cell.2009.05.045","journal-title":"Cell"},{"issue":"5","key":"6500_CR49","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/pin.12798","volume":"69","author":"S Mii","year":"2019","unstructured":"Mii S, Enomoto A, Shiraki Y, Taki T, Murakumo Y, Takahashi M (2019) CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis. Pathol Int 69(5):249\u2013259. https:\/\/doi.org\/10.1111\/pin.12798","journal-title":"Pathol Int"},{"issue":"10","key":"6500_CR50","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1007\/s00726-014-1827-7","volume":"46","author":"AK Nagel","year":"2014","unstructured":"Nagel AK, Ball LE (2014) O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity. Amino Acids 46(10):2305\u20132316. https:\/\/doi.org\/10.1007\/s00726-014-1827-7","journal-title":"Amino Acids"},{"issue":"1","key":"6500_CR51","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/s41467-023-36969-0","volume":"14","author":"MM Naldini","year":"2023","unstructured":"Naldini MM, Casirati G, Barcella M, Rancoita PMV, Cosentino A, Caserta C, Pavesi F, Zonari E, Desantis G, Gilioli D, Carrabba MG, Vago L, Bernardi M, Di Micco R, Di Serio C, Merelli I, Volpin M, Montini E, Ciceri F, Gentner B (2023) Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia. Nat Commun 14(1):1285. https:\/\/doi.org\/10.1038\/s41467-023-36969-0","journal-title":"Nat Commun"},{"issue":"7633","key":"6500_CR52","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature20598","volume":"540","author":"SWK Ng","year":"2016","unstructured":"Ng SWK, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, G\u00f6rlich D, B\u00fcchner T, Hiddemann W, Berdel WE, W\u00f6rmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, L\u00f6wenberg B, Valk PJM, Zandstra PW, Minden MD, Dick JE, Wang JCY (2016) A 17-gene stemness score for rapid determination of risk in acute leukaemia. Nature 540(7633):433\u2013437. https:\/\/doi.org\/10.1038\/nature20598","journal-title":"Nature"},{"issue":"26","key":"6500_CR54","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1182\/blood.2020007651","volume":"137","author":"X Niu","year":"2021","unstructured":"Niu X, Rothe K, Chen M, Grasedieck S, Li R, Nam S-E, Zhang X, Novakovskiy GE, Ahn Y-H, Maksakova I, Lai S, Zhang H, Yan J, Liu H, Zhao Y, Wu D, Ge Y, Wasserman WW, Rouhi A, Kuchenbauer F, Yip CK, Zhang Z, Jiang X (2021) Targeting AXL kinase sensitizes leukemic stem and progenitor cells to venetoclax treatment in acute myeloid leukemia. Blood 137(26):3641\u20133655. https:\/\/doi.org\/10.1182\/blood.2020007651","journal-title":"Blood"},{"key":"6500_CR53","doi-asserted-by":"publisher","unstructured":"Niu J, Peng D, Liu L (2022) Drug resistance mechanisms of acute myeloid leukemia stem cells. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2022.896426","DOI":"10.3389\/fonc.2022.896426"},{"key":"6500_CR55","doi-asserted-by":"crossref","unstructured":"Okoniewski M, Lugo JG, Lin TL (2025) Moving away from standard induction in newly diagnosed acute myeloid leukemia. American Society of Clinical Oncology Educational Book","DOI":"10.1200\/EDBK-25-473646"},{"issue":"6","key":"6500_CR56","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1111\/bjh.19472","volume":"204","author":"CA Ortiz Rojas","year":"2024","unstructured":"Ortiz Rojas CA, Pereira-Martins DA, Bellido More CC, Sternadt D, Weinh\u00e4user I, Hilberink JR, Coelho-Silva JL, Thom\u00e9 CH, Ferreira GA, Ammatuna E, Huls G, Valk PJ, Schuringa JJ, Rego EM (2024) A 4-gene prognostic index for enhancing acute myeloid leukaemia survival prediction. Br J Haematol 204(6):2287\u20132300. https:\/\/doi.org\/10.1111\/bjh.19472","journal-title":"Br J Haematol"},{"issue":"3","key":"6500_CR58","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3109\/10428194.2014.927453","volume":"56","author":"A Plesa","year":"2015","unstructured":"Plesa A, Elhamri M, Clapisson G, Mattei E, Gazzo S, Hequet O, Tigaud I, Michallet M, Dumontet C, Thomas X (2015) Higher percentage of CD34\u2009+\u2009CD38- cells detected by multiparameter flow cytometry from leukapheresis products predicts unsustained complete remission in acute myeloid leukemia. Leuk Lymphoma 56(3):622\u2013629. https:\/\/doi.org\/10.3109\/10428194.2014.927453","journal-title":"Leuk Lymphoma"},{"issue":"12","key":"6500_CR59","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1038\/s41591-018-0233-1","volume":"24","author":"DA Pollyea","year":"2018","unstructured":"Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, D\u2019Alessandro A, Culp-Hill R, Riemondy KA, Gillen AE, Hesselberth JR, Abbott D, Schatz D, Gutman JA, Purev E, Smith C, Jordan CT (2018) Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in acute myeloid leukemia patients. Nat Med 24(12):1859\u20131866. https:\/\/doi.org\/10.1038\/s41591-018-0233-1","journal-title":"Nat Med"},{"key":"6500_CR60","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ebiom.2019.05.025","volume":"44","author":"PP Ruvolo","year":"2019","unstructured":"Ruvolo PP, Hu CW, Qiu Y, Ruvolo VR, Go RL, Hubner SE, Coombes KR, Andreeff M, Qutub AA, Kornblau SM (2019) LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML. EBioMedicine 44:126\u2013137. https:\/\/doi.org\/10.1016\/j.ebiom.2019.05.025","journal-title":"EBioMedicine"},{"issue":"3","key":"6500_CR61","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1158\/0008-5472.CAN-18-2932","volume":"80","author":"K Sachs","year":"2020","unstructured":"Sachs K, Sarver AL, Noble-Orcutt KE, LaRue RS, Antony ML, Chang D, Lee Y, Navis CM, Hillesheim AL, Nykaza IR, Ha NA, Hansen CJ, Karadag FK, Bergerson RJ, Verneris MR, Meredith MM, Schomaker ML, Linden MA, Myers CL, Largaespada DA, Sachs Z (2020) Single-cell gene expression analyses reveal distinct self-renewing and proliferating subsets in the leukemia stem cell compartment in acute myeloid leukemia. Cancer Res 80(3):458\u2013470. https:\/\/doi.org\/10.1158\/0008-5472.CAN-18-2932","journal-title":"Cancer Res"},{"key":"6500_CR62","doi-asserted-by":"publisher","first-page":"692","DOI":"10.3389\/fonc.2019.00692","volume":"9","author":"S Saha","year":"2019","unstructured":"Saha S, Murmu KC, Biswas M, Chakraborty S, Basu J, Madhulika S, Kolapalli SP, Chauhan S, Sengupta A, Prasad P (2019) Transcriptomic analysis identifies RNA binding proteins as putative regulators of myelopoiesis and leukemia. Front Oncol 9:692. https:\/\/doi.org\/10.3389\/fonc.2019.00692","journal-title":"Front Oncol"},{"key":"6500_CR63","doi-asserted-by":"publisher","unstructured":"Sauzay C, Voutetakis K, Chatziioannou A, Chevet E, Avril T (2019) CD90\/Thy-1, a cancer-associated cell surface signaling molecule. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2019.00066","DOI":"10.3389\/fcell.2019.00066"},{"key":"6500_CR64","doi-asserted-by":"publisher","first-page":"1327405","DOI":"10.3389\/fimmu.2024.1327405","volume":"15","author":"R Schauner","year":"2024","unstructured":"Schauner R, Cress J, Hong C, Wald D, Ramakrishnan P (2024) Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells. Front Immunol 15:1327405. https:\/\/doi.org\/10.3389\/fimmu.2024.1327405","journal-title":"Front Immunol"},{"issue":"10","key":"6500_CR65","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1158\/2159-8290.CD-23-1145","volume":"14","author":"AI Sheth","year":"2024","unstructured":"Sheth AI, Althoff MJ, Tolison H, Engel K, Amaya ML, Krug AE, Young TN, Minhajuddin M, Pei S, Patel SB, Winters A, Miller R, Shelton IT, St-Germain J, Ling T, Jones CL, Raught B, Gillen AE, Ransom M, Staggs S, Smith CA, Pollyea DA, Stevens BM, Jordan CT (2024) Targeting acute myeloid leukemia stem cells through perturbation of mitochondrial calcium. Cancer Discov 14(10):1922\u20131939. https:\/\/doi.org\/10.1158\/2159-8290.CD-23-1145","journal-title":"Cancer Discov"},{"issue":"5","key":"6500_CR66","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.bj.2021.04.012","volume":"44","author":"AK Singh","year":"2021","unstructured":"Singh AK, Lin H-H (2021) The role of GPR56\/ADGRG1 in health and disease. Biomed J 44(5):534\u2013547. https:\/\/doi.org\/10.1016\/j.bj.2021.04.012","journal-title":"Biomed J"},{"issue":"11","key":"6500_CR67","doi-asserted-by":"publisher","first-page":"114864","DOI":"10.1016\/j.celrep.2024.114864","volume":"43","author":"D Sj\u00f6vall","year":"2024","unstructured":"Sj\u00f6vall D, Ghosh S, Fernandez-Fuentes N, Velasco-Hernandez T, Hogmalm A, Menendez P, Hansson J, Guibentif C, Jaako P (2024) Defective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia. Cell Rep 43(11):114864. https:\/\/doi.org\/10.1016\/j.celrep.2024.114864","journal-title":"Cell Rep"},{"issue":"9","key":"6500_CR68","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1002\/cac2.12189","volume":"41","author":"J Song","year":"2021","unstructured":"Song J, Du L, Liu P, Wang F, Zhang B, Xie Y, Lu J, Jin Y, Zhou Y, Lv G, Zhang J, Chen S, Chen Z, Sun X, Zhang Y, Huang Q (2021) Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2(-\/-) acute myeloid leukemia. Cancer Commun (Lond) 41(9):867\u2013888. https:\/\/doi.org\/10.1002\/cac2.12189","journal-title":"Cancer Commun (Lond)"},{"issue":"2","key":"6500_CR69","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3324\/haematol.2022.280800","volume":"108","author":"P Stelmach","year":"2023","unstructured":"Stelmach P, Trumpp A (2023) Leukemic stem cells and therapy resistance in acute myeloid leukemia. Haematologica 108(2):353\u2013366. https:\/\/doi.org\/10.3324\/haematol.2022.280800","journal-title":"Haematologica"},{"issue":"10","key":"6500_CR70","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1038\/s41375-021-01338-7","volume":"35","author":"LC Stetson","year":"2021","unstructured":"Stetson LC, Balasubramanian D, Ribeiro SP, Stefan T, Gupta K, Xu X, Fourati S, Roe A, Jackson Z, Schauner R, Sharma A, Tamilselvan B, Li S, de Lima M, Hwang TH, Balderas R, Saunthararajah Y, Maciejewski J, LaFramboise T, Barnholtz-Sloan JS, Sekaly R-P, Wald DN (2021) Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression. Leukemia 35(10):2799\u20132812. https:\/\/doi.org\/10.1038\/s41375-021-01338-7","journal-title":"Leukemia"},{"issue":"1","key":"6500_CR71","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41597-024-03399-6","volume":"11","author":"EY Su","year":"2024","unstructured":"Su EY, Fread K, Goggin S, Zunder ER, Cahan P (2024) Direct comparison of mass cytometry and single-cell RNA sequencing of human peripheral blood mononuclear cells. Sci Data 11(1):559. https:\/\/doi.org\/10.1038\/s41597-024-03399-6","journal-title":"Sci Data"},{"issue":"9","key":"6500_CR72","doi-asserted-by":"publisher","first-page":"e107587","DOI":"10.1371\/journal.pone.0107587","volume":"9","author":"M Terwijn","year":"2014","unstructured":"Terwijn M, Zeijlemaker W, Kelder A, Rutten AP, Snel AN, Scholten WJ, Pabst T, Verhoef G, L\u00f6wenberg B, Zweegman S, Ossenkoppele GJ, Schuurhuis GJ (2014) Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia. PLoS ONE 9(9):e107587. https:\/\/doi.org\/10.1371\/journal.pone.0107587","journal-title":"PLoS ONE"},{"key":"6500_CR73","doi-asserted-by":"publisher","first-page":"944760","DOI":"10.3389\/fcell.2022.944760","volume":"10","author":"S Tesanovic","year":"2022","unstructured":"Tesanovic S, Krenn PW, Aberger F (2022) Hedgehog\/GLI signaling in hematopoietic development and acute myeloid leukemia-from bench to bedside. Front Cell Dev Biol 10:944760. https:\/\/doi.org\/10.3389\/fcell.2022.944760","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"6500_CR74","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s00277-022-05021-4","volume":"102","author":"D Thakral","year":"2023","unstructured":"Thakral D, Singh VK, Gupta R, Jha N, Khan A, Kaur G, Rai S, Kumar V, Supriya M, Bakhshi S, Seth R (2023) Integrated single-cell transcriptome analysis of CD34\u2009+\u2009enriched leukemic stem cells revealed intra- and inter-patient transcriptional heterogeneity in pediatric acute myeloid leukemia. Ann Hematol 102(1):73\u201387. https:\/\/doi.org\/10.1007\/s00277-022-05021-4","journal-title":"Ann Hematol"},{"issue":"1","key":"6500_CR75","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1186\/s13287-024-03969-w","volume":"15","author":"Y Tian","year":"2024","unstructured":"Tian Y, Guo J, Mao L, Chen Z, Zhang X, Li Y, Zhang Y, Zha X, Luo OJ (2024) Single-cell dissection reveals promotive role of ENO1 in leukemia stem cell self-renewal and chemoresistance in acute myeloid leukemia. Stem Cell Res Ther 15(1):347. https:\/\/doi.org\/10.1186\/s13287-024-03969-w","journal-title":"Stem Cell Res Ther"},{"key":"6500_CR76","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ebiom.2019.01.022","volume":"40","author":"C-H Tsai","year":"2019","unstructured":"Tsai C-H, Yao C-Y, Tien F-M, Tang J-L, Kuo Y-Y, Chiu Y-C, Lin C-C, Tseng M-H, Peng Y-L, Liu M-C, Liu C-W, Yao M, Lin L-I, Chou W-C, Chen C-Y, Hou H-A, Tien H-F (2019) Incorporation of long non-coding RNA expression profile in the 2017 ELN risk classification can improve prognostic prediction of acute myeloid leukemia patients. eBioMedicine 40:240\u2013250. https:\/\/doi.org\/10.1016\/j.ebiom.2019.01.022","journal-title":"eBioMedicine"},{"issue":"6","key":"6500_CR77","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.cell.2019.01.031","volume":"176","author":"P van Galen","year":"2019","unstructured":"van Galen P, Hovestadt V, Wadsworth Ii MH, Hughes TK, Griffin GK, Battaglia S, Verga JA, Stephansky J, Pastika TJ, Lombardi Story J, Pinkus GS, Pozdnyakova O, Galinsky I, Stone RM, Graubert TA, Shalek AK, Aster JC, Lane AA, Bernstein BE (2019a) Single-cell RNA-Seq reveals AML hierarchies relevant to disease progression and immunity. Cell 176(6):1265\u20131281e24. https:\/\/doi.org\/10.1016\/j.cell.2019.01.031","journal-title":"Cell"},{"issue":"6","key":"6500_CR78","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.cell.2019.01.031","volume":"176","author":"P van Galen","year":"2019","unstructured":"van Galen P, Hovestadt V, Wadsworth Ii MH, Hughes TK, Griffin GK, Battaglia S, Verga JA, Stephansky J, Pastika TJ, Lombardi Story J, Pinkus GS, Pozdnyakova O, Galinsky I, Stone RM, Graubert TA, Shalek AK, Aster JC, Lane AA, Bernstein BE (2019b) Single-cell RNA-Seq reveals AML hierarchies relevant to disease progression and immunity. Cell 176(6):1265\u20131281e24. https:\/\/doi.org\/10.1016\/j.cell.2019.01.031","journal-title":"Cell"},{"issue":"18","key":"6500_CR79","doi-asserted-by":"publisher","first-page":"6520","DOI":"10.1158\/1078-0432.CCR-05-0468","volume":"11","author":"A van Rhenen","year":"2005","unstructured":"van Rhenen A, Feller N, Kelder A, Westra AH, Rombouts E, Zweegman S, van der Pol MA, Waisfisz Q, Ossenkoppele GJ, Schuurhuis GJ (2005) High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival. Clin Cancer Res 11(18):6520\u20136527. https:\/\/doi.org\/10.1158\/1078-0432.CCR-05-0468","journal-title":"Clin Cancer Res"},{"issue":"7","key":"6500_CR80","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1182\/blood-2007-03-083048","volume":"110","author":"A van Rhenen","year":"2007","unstructured":"van Rhenen A, van Dongen GAMS, Kelder A, Rombouts EJ, Feller N, Moshaver B, Walsum MS, Zweegman S, Ossenkoppele GJ, Jan Schuurhuis G (2007) The novel AML stem cell\u2013associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. Blood 110(7):2659\u20132666. https:\/\/doi.org\/10.1182\/blood-2007-03-083048","journal-title":"Blood"},{"issue":"2","key":"6500_CR81","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1002\/hem3.45","volume":"8","author":"T Velasco-Hernandez","year":"2024","unstructured":"Velasco-Hernandez T, Trincado JL, Vinyoles M, Closa A, Mart\u00ednez-Moreno A, Guti\u00e9rrez-Ag\u00fcera F, Molina O, Rodr\u00edguez-Cortez VC, Ximeno-Parpal P, Fern\u00e1ndez-Fuentes N, Petazzi P, Beneyto-Calabuig S, Velten L, Romecin P, Casquero R, Abollo-Jim\u00e9nez F, de la Guardia RD, Lorden P, Bataller A, Lapillonne H, Stam RW, Vives S, Torrebadell M, Fuster JL, Bueno C, Sarry J-E, Eyras E, Heyn H, Men\u00e9ndez P (2024) Integrative single-cell expression and functional studies unravels a sensitization to cytarabine-based chemotherapy through HIF pathway inhibition in AML leukemia stem cells. HemaSphere 8(2):e45. https:\/\/doi.org\/10.1002\/hem3.45","journal-title":"HemaSphere"},{"issue":"1","key":"6500_CR82","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/s41467-021-21650-1","volume":"12","author":"L Velten","year":"2021","unstructured":"Velten L, Story BA, Hern\u00e1ndez-Malmierca P, Raffel S, Leonce DR, Milbank J, Paulsen M, Demir A, Szu-Tu C, Fr\u00f6mel R, Lutz C, Nowak D, Jann J-C, Pabst C, Boch T, Hofmann W-K, M\u00fcller-Tidow C, Trumpp A, Haas S, Steinmetz LM (2021) Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics. Nat Commun 12(1):1366. https:\/\/doi.org\/10.1038\/s41467-021-21650-1","journal-title":"Nat Commun"},{"issue":"7","key":"6500_CR83","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1182\/bloodadvances.2022007682","volume":"7","author":"S von Palffy","year":"2023","unstructured":"von Palffy S, Thorsson H, Pe\u00f1a-Mart\u00ednez P, Puente-Moncada N, Sand\u00e9n C, Blom AM, Henningsson R, Juliusson G, King B, Landberg N, Lazarevic V, Orsmark-Pietras C, Rissler M, Rissler V, \u00c5gerstam H, J\u00e4r\u00e5s M, Lilljebj\u00f6rn H, Fioretos T (2023) The complement receptor C3AR constitutes a novel therapeutic target in NPM1-mutated AML. Blood Adv 7(7):1204\u20131218. https:\/\/doi.org\/10.1182\/bloodadvances.2022007682","journal-title":"Blood Adv"},{"issue":"6","key":"6500_CR84","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1158\/2159-8290.CD-22-0939","volume":"13","author":"A Waclawiczek","year":"2023","unstructured":"Waclawiczek A, Lepp\u00e4 A-M, Renders S, Stumpf K, Reyneri C, Betz B, Janssen M, Shahswar R, Donato E, Karpova D, Thiel V, Unglaub JM, Grabowski S, Gryzik S, Vierbaum L, Schlenk RF, R\u00f6llig C, Hundemer M, Pabst C, Heuser M, Raffel S, M\u00fcller-Tidow C, Sauer T, Trumpp A (2023) Combinatorial BCL2 family expression in acute myeloid leukemia stem cells predicts clinical response to azacitidine\/venetoclax. Cancer Discov 13(6):1408\u20131427. https:\/\/doi.org\/10.1158\/2159-8290.CD-22-0939","journal-title":"Cancer Discov"},{"issue":"1","key":"6500_CR85","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41467-023-43843-6","volume":"15","author":"H Wang","year":"2024","unstructured":"Wang H, Sica RA, Kaur G, Galbo PM, Jing Z, Nishimura CD, Ren X, Tanwar A, Etemad-Gilbertson B, Will B, Zheng D, Fooksman D, Zang X (2024) TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells. Nat Commun 15(1):11. https:\/\/doi.org\/10.1038\/s41467-023-43843-6","journal-title":"Nat Commun"},{"issue":"9","key":"6500_CR86","doi-asserted-by":"publisher","first-page":"107688","DOI":"10.1016\/j.celrep.2020.107688","volume":"31","author":"J Wesely","year":"2020","unstructured":"Wesely J, Kotini AG, Izzo F, Luo H, Yuan H, Sun J, Georgomanoli M, Zviran A, Deslauriers AG, Dusaj N, Nimer SD, Leslie C, Landau DA, Kharas MG, Papapetrou EP (2020) Acute myeloid leukemia iPSCs reveal a role for RUNX1 in the maintenance of human leukemia stem cells. Cell Rep 31(9):107688. https:\/\/doi.org\/10.1016\/j.celrep.2020.107688","journal-title":"Cell Rep"},{"issue":"2","key":"6500_CR87","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/08880018.2010.528171","volume":"28","author":"K-E Witte","year":"2011","unstructured":"Witte K-E, Ahlers J, Sch\u00e4fer I, Andr\u00e9 M, Kerst G, Scheel-Walter H-G, Schwarze CP, Pfeiffer M, Lang P, Handgretinger R, Ebinger M (2011) High proportion of leukemic stem cells at diagnosis is correlated with unfavorable prognosis in childhood acute myeloid leukemia. Pediatr Hematol Oncol 28(2):91\u201399. https:\/\/doi.org\/10.3109\/08880018.2010.528171","journal-title":"Pediatr Hematol Oncol"},{"issue":"5","key":"6500_CR88","doi-asserted-by":"publisher","first-page":"e3002088","DOI":"10.1371\/journal.pbio.3002088","volume":"21","author":"B Wu","year":"2023","unstructured":"Wu B, Chen X, Pan X, Deng X, Li S, Wang Z, Wang J, Liao D, Xu J, Chen M, Zhao C, Xue Z, Wang Y, Niu T, Lin J, Chen L, Liu Y, Chen C (2023a) Single-cell transcriptome analyses reveal critical roles of RNA splicing during leukemia progression. PLoS Biol 21(5):e3002088. https:\/\/doi.org\/10.1371\/journal.pbio.3002088","journal-title":"PLoS Biol"},{"issue":"1","key":"6500_CR89","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s40164-023-00391-5","volume":"12","author":"W Wu","year":"2023","unstructured":"Wu W, Shi Z, Tang Z, Li H, Huang X, Liang X, Li J, Yao Y, Zhao W, Wu M, Luo J, Liu Z (2023b) Characterization of bone marrow heterogeneity in NK-AML (M4\/M5) based on single-cell RNA sequencing. Exp Hematol Oncol 12(1):25. https:\/\/doi.org\/10.1186\/s40164-023-00391-5","journal-title":"Exp Hematol Oncol"},{"issue":"3","key":"6500_CR90","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.3892\/ol.2017.5669","volume":"13","author":"B Yan","year":"2017","unstructured":"Yan B, Hu Y, Ban KHK, Tiang Z, Ng C, Lee J, Tan W, Chiu L, Tan TW, Seah E, Ng CH, Chng W-J, Foo R (2017) Single-cell genomic profiling of acute myeloid leukemia for clinical use: a pilot study. Oncol Lett 13(3):1625\u20131630. https:\/\/doi.org\/10.3892\/ol.2017.5669","journal-title":"Oncol Lett"},{"issue":"1","key":"6500_CR91","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40364-023-00456-x","volume":"11","author":"H Yang","year":"2023","unstructured":"Yang H, Xun Y, You H (2023a) The landscape overview of CD47-based immunotherapy for hematological malignancies. Biomark Res 11(1):15. https:\/\/doi.org\/10.1186\/s40364-023-00456-x","journal-title":"Biomark Res"},{"issue":"1","key":"6500_CR92","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s12964-023-01315-w","volume":"21","author":"Y Yang","year":"2023","unstructured":"Yang Y, Zhu G, Yang L, Yang Y (2023b) Targeting CD24 as a novel immunotherapy for solid cancers. Cell Commun Signal 21(1):312. https:\/\/doi.org\/10.1186\/s12964-023-01315-w","journal-title":"Cell Communication Signal"},{"issue":"12","key":"6500_CR93","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.3324\/haematol.2018.215269","volume":"104","author":"AL Young","year":"2019","unstructured":"Young AL, Tong RS, Birmann BM, Druley TE (2019) Clonal hematopoiesis and risk of acute myeloid leukemia. Haematologica 104(12):2410\u20132417. https:\/\/doi.org\/10.3324\/haematol.2018.215269","journal-title":"Haematologica"},{"issue":"75","key":"6500_CR94","doi-asserted-by":"publisher","first-page":"34056","DOI":"10.18632\/oncotarget.26118","volume":"9","author":"AM Zahran","year":"2018","unstructured":"Zahran AM, Aly SS, Rayan A, El-Badawy O, Fattah MA, Ali AM, ElBadre HM, Hetta HF (2018) Survival outcomes of CD34\u2009+\u2009CD38-LSCs and their expression of CD123 in adult AML patients. Oncotarget 9(75):34056\u201334065. https:\/\/doi.org\/10.18632\/oncotarget.26118","journal-title":"Oncotarget"},{"issue":"2","key":"6500_CR96","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/bjh.13572","volume":"171","author":"W Zeijlemaker","year":"2015","unstructured":"Zeijlemaker W, Kelder A, Wouters R, Valk PJM, Witte BI, Cloos J, Ossenkoppele GJ, Schuurhuis GJ (2015) Absence of leukaemic CD34\u2009+\u2009cells in acute myeloid leukaemia is of high prognostic value: a longstanding controversy deciphered. Br J Haematol 171(2):227\u2013238. https:\/\/doi.org\/10.1111\/bjh.13572","journal-title":"Br J Haematol"},{"issue":"5","key":"6500_CR95","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/s41375-018-0326-3","volume":"33","author":"W Zeijlemaker","year":"2019","unstructured":"Zeijlemaker W, Grob T, Meijer R, Hanekamp D, Kelder A, Carbaat-Ham JC, Oussoren-Brockhoff YJM, Snel AN, Veldhuizen D, Scholten WJ, Maertens J, Breems DA, Pabst T, Manz MG, van der Velden VHJ, Slomp J, Preijers F, Cloos J, van de Loosdrecht AA, L\u00f6wenberg B, Valk PJM, Jongen-Lavrencic M, Ossenkoppele GJ, Schuurhuis GJ (2019) CD34\u2009+\u2009CD38- leukemic stem cell frequency to predict outcome in acute myeloid leukemia. Leukemia 33(5):1102\u20131112. https:\/\/doi.org\/10.1038\/s41375-018-0326-3","journal-title":"Leukemia"},{"key":"6500_CR97","doi-asserted-by":"crossref","unstructured":"Zeng AGX, Iacobucci I, Shah S, Mitchell A, Wong G, Bansal S, Chen D, Gao Q, Kim H, Kennedy JA, Arruda A, Minden MD, Haferlach T, Mullighan CG, Dick JE (2024) Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML","DOI":"10.1101\/2023.12.26.573390"},{"issue":"1","key":"6500_CR98","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s12943-022-01635-4","volume":"21","author":"Y Zhai","year":"2022","unstructured":"Zhai Y, Singh P, Dolnik A, Brazda P, Atlasy N, Del Gaudio N, D\u00f6hner K, D\u00f6hner H, Minucci S, Martens J, Altucci L, Megchelenbrink W, Bullinger L, Stunnenberg HG (2022) Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia. Mol Cancer 21(1):166. https:\/\/doi.org\/10.1186\/s12943-022-01635-4","journal-title":"Mol Cancer"},{"issue":"1","key":"6500_CR99","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s13059-023-03031-7","volume":"24","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Jiang S, He F, Tian Y, Hu H, Gao L, Zhang L, Chen A, Hu Y, Fan L, Yang C, Zhou B, Liu D, Zhou Z, Su Y, Qin L, Wang Y, He H, Lu J, Xiao P, Hu S, Wang Q-F (2023) Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML. Genome Biol 24(1):199. https:\/\/doi.org\/10.1186\/s13059-023-03031-7","journal-title":"Genome Biol"},{"issue":"1","key":"6500_CR100","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13045-024-01586-x","volume":"17","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Park M, Ghoda LY, Zhao D, Valerio M, Nafie E, Gonzalez A, Ly K, Parcutela B, Choi H, Gong X, Chen F, Harada K, Chen Z, Nguyen LXT, Pichiorri F, Chen J, Song J, Forman SJ, Amanam I, Zhang B, Jin J, Williams JC, Marcucci G (2024) IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells. J Hematol Oncol 17(1):67. https:\/\/doi.org\/10.1186\/s13045-024-01586-x","journal-title":"J Hematol Oncol"},{"key":"6500_CR101","doi-asserted-by":"publisher","first-page":"1365330","DOI":"10.3389\/fonc.2024.1365330","volume":"14","author":"J Zhou","year":"2024","unstructured":"Zhou J, Chng W-J (2024) Unveiling novel insights in acute myeloid leukemia through single-cell RNA sequencing. Front Oncol 14:1365330. https:\/\/doi.org\/10.3389\/fonc.2024.1365330","journal-title":"Front Oncol"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-026-06500-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-026-06500-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-026-06500-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:19:13Z","timestamp":1785521953000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-026-06500-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":101,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["6500"],"URL":"https:\/\/doi.org\/10.1007\/s00432-026-06500-1","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"23 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"151"}}