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Nonetheless, limited information is available regarding Fc\u03b3RIIa levels in most cancer types. This study aimed to detect serum Fc\u03b3RIIa in 333 patients with non-small cell lung cancer (NSCLC) and 100 healthy individuals, and to explore the relationship between serum Fc\u03b3RIIa levels and clinical outcomes in patients with NSCLC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples from 333 patients with stage I\u2013IV NSCLC and 100 healthy volunteers were analyzed using ELISA. The clinical and laboratory data underwent statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Circulating Fc\u03b3RIIa levels were markedly increased in patients with NSCLC, especially in advanced pathologic stages.ROC curve analysis yielded an AUC of 0.7713 (95% CI: 0.7132\u20130.8264), with an optimal cutoff value of 2115.88\u00a0pg\/mL based on the Youden index (sensitivity: 60.06%, specificity: 86.00%). Notably, 13% of healthy controls showed Fc\u03b3RIIa levels above the cutoff, suggesting that elevated Fc\u03b3RIIa may partially reflect systemic inflammatory status. Survival analysis in 333 patients with NSCLC showed markedly shorter overall survival in Fc\u03b3RIIa-positive cases. Serum Fc\u03b3RIIa levels were further identified to be significantly associated with metastatic status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that circulating Fc\u03b3RIIa levels rise along with tumor progression and may serve as a potential complementary prognostic indicator in metastatic NSCLC, though these findings require validation in prospective cohorts with comprehensive adjustment for inflammatory markers and treatment regimens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00432-026-06505-w","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T15:03:37Z","timestamp":1779635017000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical significance of circulating Fc\u03b3RIIa in the prognosis of patients with metastatic non-small cell lung cancer"],"prefix":"10.1007","volume":"152","author":[{"given":"Xiaojie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"6505_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.657393","volume":"12","author":"OR Alem\u00e1n","year":"2021","unstructured":"Alem\u00e1n OR, Mora N, Rosales C (2021) The antibody receptor Fc Gamma Receptor IIIb induces calcium entry via Transient Receptor Potential Melastatin 2 in human neutrophils. 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