{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:37:21Z","timestamp":1792615041672,"version":"4.5.0"},"reference-count":97,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"DOI":"10.1007\/s00432-026-06508-7","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:14:56Z","timestamp":1779707696000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular mechanisms of 5-FU resistance in colorectal cancer: the regulatory role of lncRNAs"],"prefix":"10.1007","volume":"152","author":[{"given":"Bing","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changmiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"issue":"2","key":"6508_CR1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/em.22477","volume":"63","author":"E Abdi","year":"2022","unstructured":"Abdi E, Latifi-Navid S, Latifi-Navid H (2022) Long noncoding RNA polymorphisms and colorectal cancer risk: progression and future perspectives. Environ Mol Mutagen 63(2):98\u2013112","journal-title":"Environ Mol Mutagen"},{"issue":"2","key":"6508_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1021\/acschembio.8b00807","volume":"14","author":"F.A Abulwerdi","year":"2019","unstructured":"Abulwerdi F.A., Xu W, Ageeli AA, Yonkunas M.J., Arun G, Nam H, Schneekloth J.S., Jr., Dayie T.K., Spector D., Baird N., Le Grice S.F.J. (2019) Selective small-molecule targeting of a triple helix encoded by the long noncoding RNA, MALAT1. ACS Chem Biol 14(2):223\u2013235","journal-title":"ACS Chem Biol"},{"issue":"12","key":"6508_CR3","doi-asserted-by":"publisher","first-page":"11243","DOI":"10.1007\/s11033-022-07680-y","volume":"49","author":"S Ak Aksoy","year":"2022","unstructured":"Ak Aksoy S, Tunca B, Er\u00e7elik M, Tezcan G, Ozturk E, Cecener G, Ugras N, Yilmazlar T, Yerci O (2022) Early-stage colon cancer with high MALAT1 expression is associated with the 5-Fluorouracil resistance and future metastasis. Mol Biol Rep 49(12):11243\u201311253","journal-title":"Mol Biol Rep"},{"issue":"4","key":"6508_CR4","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.3390\/ijms21041398","volume":"21","author":"A Baassiri","year":"2020","unstructured":"Baassiri A, Nassar F, Mukherji D, Shamseddine A, Nasr R, Temraz S (2020) Exosomal Non coding RNA in LIQUID biopsies as a promising biomarker for colorectal cancer. Int J Mol Sci 21(4):1398","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6508_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12943-016-0530-6","volume":"15","author":"N Bartonicek","year":"2016","unstructured":"Bartonicek N, Maag JL, Dinger ME (2016) Long noncoding RNAs in cancer: mechanisms of action and technological advancements. Mol Cancer 15(1):43","journal-title":"Mol Cancer"},{"issue":"2","key":"6508_CR6","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ncrna.2022.02.004","volume":"7","author":"O Beylerli","year":"2022","unstructured":"Beylerli O, Gareev I, Sufianov A, Ilyasova T, Guang Y (2022) Long noncoding RNAs as promising biomarkers in cancer. Non-coding RNA Res 7(2):66\u201370","journal-title":"Non-coding RNA Res"},{"issue":"6","key":"6508_CR7","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/bph.13422","volume":"173","author":"B Bhattacharya","year":"2016","unstructured":"Bhattacharya B, Mohd Omar MF, Soong R (2016) The Warburg effect and drug resistance. Br J Pharmacol 173(6):970\u2013979","journal-title":"Br J Pharmacol"},{"key":"6508_CR8","doi-asserted-by":"publisher","first-page":"23892","DOI":"10.1038\/srep23892","volume":"6","author":"Z Bian","year":"2016","unstructured":"Bian Z, Jin L, Zhang J, Yin Y, Quan C, Hu Y, Feng Y, Liu H, Fei B, Mao Y, Zhou L, Qi X, Huang S, Hua D, Xing C, Huang Z (2016) LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. Sci Rep 6:23892","journal-title":"Sci Rep"},{"issue":"9","key":"6508_CR9","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.3390\/ijms21093233","volume":"21","author":"K Bukowski","year":"2020","unstructured":"Bukowski K, Kciuk M, Kontek R (2020) Mechanisms of multidrug resistance in cancer chemotherapy. Int J Mol Sci 21(9):3233","journal-title":"Int J Mol Sci"},{"issue":"6","key":"6508_CR10","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1053\/j.gastro.2020.08.018","volume":"159","author":"B Chen","year":"2020","unstructured":"Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, De Los Santos MC, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA (2020) The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling. Gastroenterology 159(6):2146\u20132162e33","journal-title":"Gastroenterology"},{"issue":"1","key":"6508_CR11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12943-020-01287-2","volume":"19","author":"S Chen","year":"2020","unstructured":"Chen S, Shen X (2020) Long noncoding RNAs: functions and mechanisms in colon cancer. Mol Cancer 19(1):167","journal-title":"Mol Cancer"},{"issue":"1","key":"6508_CR12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12943-022-01581-1","volume":"21","author":"J Chou","year":"2022","unstructured":"Chou J, Kaller M, Jaeckel S, Rokavec M, Hermeking H (2022) AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1\/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG\/miR-22-3p. Mol Cancer 21(1):120","journal-title":"Mol Cancer"},{"issue":"5","key":"6508_CR13","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1101\/gr.131037.111","volume":"22","author":"MB Clark","year":"2012","unstructured":"Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME, Mattick JS (2012) Genome-wide analysis of long noncoding RNA stability. Genome Res 22(5):885\u2013898","journal-title":"Genome Res"},{"key":"6508_CR14","doi-asserted-by":"crossref","unstructured":"Cui Z, Wang Q, Deng MH, Han QL (2022) LncRNA HCG11 promotes 5-FU resistance of colon cancer cells through reprogramming glucose metabolism by targeting the miR-144-3p-PDK4 axis, Cancer Biomarkers Sect: A Dis Markers 34(1) 41\u201353","DOI":"10.3233\/CBM-210212"},{"issue":"1","key":"6508_CR15","doi-asserted-by":"publisher","first-page":"265","DOI":"10.7150\/thno.36045","volume":"10","author":"X Deng","year":"2020","unstructured":"Deng X, Li S, Kong F, Ruan H, Xu X, Zhang X, Wu Z, Zhang L, Xu Y, Yuan H, Peng H, Yang D, Guan M (2020) Long noncoding RNA PiHL regulates p53 protein stability through GRWD1\/RPL11\/MDM2 axis in colorectal cancer. Theranostics 10(1):265\u2013280","journal-title":"Theranostics"},{"issue":"8","key":"6508_CR16","doi-asserted-by":"publisher","first-page":"e2997","DOI":"10.1038\/cddis.2017.328","volume":"8","author":"J Ding","year":"2017","unstructured":"Ding J, Li J, Wang H, Tian Y, Xie M, He X, Ji H, Ma Z, Hui B, Wang K, Ji G (2017) Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5\/CDKN1A expression. Cell Death Dis 8(8):e2997","journal-title":"Cell Death Dis"},{"key":"6508_CR17","doi-asserted-by":"crossref","unstructured":"Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, Xue C, Marinov GK, Khatun J, Williams BA, Zaleski C, Rozowsky J, R\u00f6der M, Kokocinski F, Abdelhamid RF, Alioto T, Antoshechkin I, Baer MT, Bar NS, Batut P, Bell K, Bell I, Chakrabortty S, Chen X, Chrast J, Curado J, Derrien T, Drenkow J, Dumais E, Dumais J, Duttagupta R, Falconnet E, Fastuca M, Fejes-Toth K, Ferreira P, Foissac S, Fullwood MJ, Gao H, Gonzalez D, Gordon A, Gunawardena H, Howald C, Jha S, Johnson R, Kapranov P, King B, Kingswood C, Luo OJ, Park E, Persaud K, Preall JB, Ribeca P, Risk B, Robyr D, Sammeth M, Schaffer L, See LH, Shahab A, Skancke J, Suzuki AM, Takahashi H, Tilgner H, Trout D, Walters N, Wang H, Wrobel J, Yu Y, Ruan X, Hayashizaki Y, Harrow J, Gerstein M, Hubbard T, Reymond A, Antonarakis SE, Hannon G, Giddings MC, Ruan Y, Wold B (2012) Nature 489(7414):101\u2013108 P. Carninci, R. Guig\u00f3, T.R. Gingeras, Landscape of transcription in human cells","DOI":"10.1038\/nature11233"},{"issue":"40","key":"6508_CR18","first-page":"13242","volume":"57","author":"A Donlic","year":"2018","unstructured":"Donlic A, Morgan BS, Xu JL, Liu A, Roble C Jr., Hargrove AE (2018) Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold, Angewandte Chemie (International ed. English) 57(40):13242\u201313247","journal-title":"English)"},{"issue":"7","key":"6508_CR19","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1097\/CAD.0000000000001478","volume":"34","author":"B Duan","year":"2023","unstructured":"Duan B, Zhang H, Zhu Z, Yan X, Ji Z, Li J (2023) LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy. Anticancer Drugs 34(7):827\u2013836","journal-title":"Anticancer Drugs"},{"issue":"6","key":"6508_CR20","first-page":"8309","volume":"17","author":"H Fan","year":"2018","unstructured":"Fan H, Zhu JH, Yao XQ (2018) Knockdown of long non\u2013coding RNA PVT1 reverses multidrug resistance in colorectal cancer cells. Mol Med Rep 17(6):8309\u20138315","journal-title":"Mol Med Rep"},{"issue":"9","key":"6508_CR21","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1080\/07357907.2021.1923727","volume":"39","author":"Y Fu","year":"2021","unstructured":"Fu Y, Huang R, Li J, Xie X, Deng Y (2021) LncRNA ENSG00000254615 modulates proliferation and 5-FU resistance by regulating p21 and cyclin D1 in colorectal cancer. Cancer Invest 39(9):696\u2013710","journal-title":"Cancer Invest"},{"issue":"34","key":"6508_CR22","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.3748\/wjg.v25.i34.5026","volume":"25","author":"O Galamb","year":"2019","unstructured":"Galamb O, Bart\u00e1k BK, Kalm\u00e1r A, Nagy ZB, Szigeti KA, Tulassay Z, Igaz P, Moln\u00e1r B (2019) Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors. World J Gastroenterol 25(34):5026\u20135048","journal-title":"World J Gastroenterol"},{"key":"6508_CR23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.omto.2021.06.012","volume":"23","author":"SJ Gao","year":"2021","unstructured":"Gao SJ, Ren SN, Liu YT, Yan HW, Chen XB (2021) Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis. Mol therapy oncolytics 23:14\u201325","journal-title":"Mol therapy oncolytics"},{"issue":"5","key":"6508_CR24","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/PAT.0000000000000125","volume":"46","author":"Y Han","year":"2014","unstructured":"Han Y, Yang YN, Yuan HH, Zhang TT, Sui H, Wei XL, Liu L, Huang P, Zhang WJ, Bai YX (2014) UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. Pathology 46(5):396\u2013401","journal-title":"Pathology"},{"issue":"4561","key":"6508_CR25","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/179663a0","volume":"179","author":"C Heidelberger","year":"1957","unstructured":"Heidelberger C, Chaudhuri NK, Danneberg P, Mooren D, Griesbach L, Duschinsky R, Schnitzer RJ, Pleven E, Scheiner J (1957) Fluorinated pyrimidines, a new class of tumour-inhibitory compounds. Nature 179(4561):663\u2013666","journal-title":"Nature"},{"issue":"10","key":"6508_CR26","first-page":"714","volume":"13","author":"C Holohan","year":"2013","unstructured":"Holohan C, Van Schaeybroeck S, Longley DB, Johnston PG (2013) Cancer drug resistance: an evolving paradigm, Nature reviews. Cancer 13(10):714\u2013726","journal-title":"Cancer"},{"key":"6508_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-319-42059-2_1","volume":"937","author":"S Hombach","year":"2016","unstructured":"Hombach S, Kretz M (2016) Non-coding RNAs: classification, biology and functioning. Adv Exp Med Biol 937:3\u201317","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"6508_CR28","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s13046-022-02319-z","volume":"41","author":"W Huang","year":"2022","unstructured":"Huang W, Li H, Yu Q, Xiao W, Wang DO (2022) LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond. J Exp Clin Cancer Res: CR 41(1):100","journal-title":"J experimental Clin cancer research: CR"},{"key":"6508_CR30","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.2147\/OTT.S192290","volume":"12","author":"X Jiang","year":"2019","unstructured":"Jiang X, Li Q, Zhang S, Song C, Zheng P (2019) Long noncoding RNA GIHCG induces cancer progression and chemoresistance and indicates poor prognosis in colorectal cancer. OncoTargets therapy 12:1059\u20131070","journal-title":"OncoTargets therapy"},{"key":"6508_CR29","doi-asserted-by":"publisher","first-page":"109483","DOI":"10.1016\/j.cellsig.2019.109483","volume":"66","author":"Z Jiang","year":"2020","unstructured":"Jiang Z, Li L, Hou Z, Liu W, Wang H, Zhou T, Li Y, Chen S (2020) LncRNA HAND2-AS1 inhibits 5-fluorouracil resistance by modulating miR-20a\/PDCD4 axis in colorectal cancer. Cell Signal 66:109483","journal-title":"Cell Signal"},{"issue":"10","key":"6508_CR31","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1111\/cas.13342","volume":"108","author":"Y Kondo","year":"2017","unstructured":"Kondo Y, Shinjo K, Katsushima K (2017) Long non-coding RNAs as an epigenetic regulator in human cancers. Cancer Sci 108(10):1927\u20131933","journal-title":"Cancer Sci"},{"issue":"1","key":"6508_CR33","doi-asserted-by":"publisher","first-page":"2298058","DOI":"10.1080\/15592294.2023.2298058","volume":"19","author":"J Lai","year":"2024","unstructured":"Lai J, Zhou Z, Hu K, Yu H, Su X, Niu X, Li H, Mao S (2024) N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells. Epigenetics 19(1):2298058","journal-title":"Epigenetics"},{"issue":"13","key":"6508_CR32","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1042\/CS20190156","volume":"133","author":"Y Lai","year":"2019","unstructured":"Lai Y, Li J, Zhong L, He X, Si X, Sun Y, Chen Y, Zhong J, Hu Y, Li B, Liao W, Liu C, Liao Y, Xiu J, Bin J (2019) The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA. Clin Sci (London England: 1979) 133(13):1439\u20131455","journal-title":"Clin Sci (London England: 1979)"},{"issue":"1","key":"6508_CR34","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/biomedicines11010058","volume":"11","author":"H Lee","year":"2022","unstructured":"Lee H, Kang H, Kim C, Ku JL, Nam S, Lee EK (2022) Long non-coding RNA GAS5 promotes BAX expression by competing with microRNA-128-3p in response to 5-fluorouracil. Biomedicines 11(1):58","journal-title":"Biomedicines"},{"issue":"7","key":"6508_CR35","doi-asserted-by":"publisher","first-page":"540","DOI":"10.14348\/molcells.2014.0151","volume":"37","author":"H Lee","year":"2014","unstructured":"Lee H, Kim C, Ku JL, Kim W, Yoon SK, Kuh HJ, Lee JH, Nam SW, Lee EK (2014) A long non-coding RNA snaR contributes to 5-fluorouracil resistance in human colon cancer cells. Mol Cells 37(7):540\u2013546","journal-title":"Mol Cells"},{"key":"6508_CR41","doi-asserted-by":"publisher","first-page":"11103","DOI":"10.3389\/bjbs.2023.11103","volume":"80","author":"XL Liau","year":"2023","unstructured":"Liau XL, Salvamani S, Gunasekaran B, Chellappan DK, Rhodes A, Ulaganathan V, Tiong YL (2023) CCAT 1- A Pivotal Oncogenic Long Non-Coding RNA in Colorectal Cancer. Br J Biomed Sci 80:11103","journal-title":"Br J Biomed Sci"},{"issue":"1","key":"6508_CR36","first-page":"217","volume":"39","author":"J Li","year":"2018","unstructured":"Li J, Li X, Cen C, Ai X, Lin C, Hu G (2018) The long non-coding RNA ENST00000547547 reduces 5-fluorouracil resistance of colorectal cancer cells via competitive binding to microRNA-31. Oncol Rep 39(1):217\u2013226","journal-title":"Oncol Rep"},{"key":"6508_CR37","doi-asserted-by":"publisher","first-page":"154480","DOI":"10.1016\/j.prp.2023.154480","volume":"246","author":"M Li","year":"2023","unstructured":"Li M, Sun S, Bian Z, Yao S, Liu M, You X, Li M (2023) SNHG15 promotes chemoresistance and glycolysis in colorectal cancer. Pathol Res Pract 246:154480","journal-title":"Pathol Res Pract"},{"issue":"4","key":"6508_CR40","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1158\/1535-7163.MCT-16-0591","volume":"16","author":"P Li","year":"2017","unstructured":"Li P, Zhang X, Wang H, Wang L, Liu T, Du L, Yang Y, Wang C (2017) MALAT1 Is associated with poor response to oxaliplatin-based chemotherapy in colorectal cancer patients and promotes chemoresistance through EZH2. Mol Cancer Ther 16(4):739\u2013751","journal-title":"Mol Cancer Ther"},{"key":"6508_CR39","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.omtn.2017.07.007","volume":"8","author":"P Li","year":"2017","unstructured":"Li P, Zhang X, Wang L, Du L, Yang Y, Liu T, Li C, Wang C (2017) lncRNA HOTAIR contributes to 5FU resistance through suppressing miR-218 and activating NF-\u03baB\/TS signaling in colorectal cancer, molecular therapy. Nucleic acids 8:356\u2013369","journal-title":"Nucleic acids"},{"issue":"1","key":"6508_CR46","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1186\/s13046-018-0994-x","volume":"37","author":"B Liu","year":"2018","unstructured":"Liu B, Pan S, Xiao Y, Liu Q, Xu J, Jia L (2018) LINC01296\/miR-26a\/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K\/AKT pathway. J Exper Clin Cancer Res: CR 37(1):316","journal-title":"J experimental Clin cancer research: CR"},{"issue":"3","key":"6508_CR42","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1002\/cam4.2746","volume":"9","author":"F Liu","year":"2020","unstructured":"Liu F, Ai FY, Zhang DC, Tian L, Yang ZY, Liu SJ (2020) LncRNA NEAT1 knockdown attenuates autophagy to elevate 5-FU sensitivity in colorectal cancer via targeting miR-34a. Cancer Med 9(3):1079\u20131091","journal-title":"Cancer Med"},{"issue":"38","key":"6508_CR43","doi-asserted-by":"publisher","first-page":"62927","DOI":"10.18632\/oncotarget.17757","volume":"8","author":"F Liu","year":"2017","unstructured":"Liu F, Chen N, Gong Y, Xiao R, Wang W, Pan Z (2017) The long non-coding RNA NEAT1 enhances epithelial-to-mesenchymal transition and chemoresistance via the miR-34a\/c-Met axis in renal cell carcinoma. Oncotarget 8(38):62927\u201362938","journal-title":"Oncotarget"},{"issue":"2","key":"6508_CR45","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3233\/CBM-171011","volume":"22","author":"L Liu","year":"2018","unstructured":"Liu L, Meng T, Yang XH, Sayim P, Lei C, Jin B, Ge L, Wang HJ (2018) Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion. Cancer Biomark A 22(2):283\u2013299","journal-title":"Cancer Biomark A"},{"key":"6508_CR44","doi-asserted-by":"publisher","first-page":"119569","DOI":"10.1016\/j.lfs.2021.119569","volume":"277","author":"SJ Liu","year":"2021","unstructured":"Liu SJ, Li ZQ, Wang XY, Liu F, Xiao ZM, Zhang DC (2021) lncRNA UCA1 induced by SP1 and SP3 forms a positive feedback loop to facilitate malignant phenotypes of colorectal cancer via targeting miR-495. Life Sci 277:119569","journal-title":"Life Sci"},{"issue":"51","key":"6508_CR47","doi-asserted-by":"publisher","first-page":"85551","DOI":"10.18632\/oncotarget.13465","volume":"7","author":"T Liu","year":"2016","unstructured":"Liu T, Zhang X, Gao S, Jing F, Yang Y, Du L, Zheng G, Li P, Li C, Wang C (2016) Exosomal long noncoding RNA CRNDE-h as a novel serum-based biomarker for diagnosis and prognosis of colorectal cancer. Oncotarget 7(51):85551\u201385563","journal-title":"Oncotarget"},{"key":"6508_CR38","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ijbiomac.2017.07.053","volume":"105Pt 1","author":"X Li","year":"2017","unstructured":"Li X, Wang S, Li Z, Long X, Guo Z, Zhang G, Zu J, Chen Y, Wen L (2017) The lncRNA NEAT1 facilitates cell growth and invasion via the miR-211\/HMGA2 axis in breast cancer. Int J Biol Macromol 105Pt 1:346\u2013353","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"6508_CR48","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3892\/ol.2022.13400","volume":"24","author":"Z Luo","year":"2022","unstructured":"Luo Z, Chen R, Hu S, Huang X, Huang Z (2022) PVT1 promotes resistance to 5-FU in colon cancer via the miR-486-5p\/CDK4 axis. Oncol Lett 24(2):280","journal-title":"Oncol Lett"},{"issue":"10","key":"6508_CR49","doi-asserted-by":"publisher","first-page":"8325","DOI":"10.1002\/jcb.26883","volume":"119","author":"H Ma","year":"2018","unstructured":"Ma H, Yuan L, Li W, Xu K, Yang L (2018) The LncRNA H19\/miR-193a-3p axis modifies the radio-resistance and chemotherapeutic tolerance of hepatocellular carcinoma cells by targeting PSEN1. J Cell Biochem 119(10):8325\u20138335","journal-title":"J Cell Biochem"},{"issue":"6","key":"6508_CR50","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s12094-017-1788-x","volume":"20","author":"SN Nasir","year":"2018","unstructured":"Nasir SN, Abu N, Ab Mutalib NS, Ishak M, Sagap I, Mazlan L, Rose IM, Jamal R (2018) LOC285629 regulates cell proliferation and motility in colorectal cancer cells. Clin translational oncology: official publication Federation Span Oncol Soc Natl Cancer Inst Mexico 20(6):775\u2013784","journal-title":"Clin translational oncology: official publication Federation Span Oncol Soc Natl Cancer Inst Mexico"},{"issue":"10","key":"6508_CR51","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1080\/15476286.2019.1637697","volume":"16","author":"F Oehme","year":"2019","unstructured":"Oehme F, Krahl S, Gyorffy B, Muessle B, Rao V, Greif H, Ziegler N, Lin K, Thepkaysone ML, Polster H, Tonn T, Schneider M, Weitz J, Baenke F, Kahlert C (2019) Low level of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer. RNA Biol 16(10):1339\u20131345","journal-title":"RNA Biol"},{"key":"6508_CR52","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jconrel.2021.01.027","volume":"331","author":"S Padmakumar","year":"2021","unstructured":"Padmakumar S, Jones G, Pawar G, Khorkova O, Hsiao J, Kim J, Amiji MM, Bleier BS (2021) Minimally Invasive Nasal Depot (MIND) technique for direct BDNF AntagoNAT delivery to the brain. J controlled release: official J Controlled Release Soc 331:176\u2013186","journal-title":"J controlled release: official J Controlled Release Soc"},{"issue":"6","key":"6508_CR53","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1007\/s11010-021-04098-1","volume":"476","author":"T Peng","year":"2021","unstructured":"Peng T, Ji D, Jiang Y (2021) Long non-coding RNA GAS5 suppresses rheumatoid arthritis progression via miR-128-3p\/HDAC4 axis, Mol Cellular Biochem. 476(6):2491\u20132501","journal-title":"Mol Cellular Biochem"},{"key":"6508_CR55","doi-asserted-by":"publisher","first-page":"658736","DOI":"10.3389\/fgene.2021.658736","volume":"12","author":"F Qin","year":"2021","unstructured":"Qin F, Xu H, Wei G, Ji Y, Yu J, Hu C, Yuan C, Ma Y, Qian J, Li L, Huo J (2021) A Prognostic Model Based on the Immune-Related lncRNAs in Colorectal Cancer. Front Genet 12:658736","journal-title":"Front Genet"},{"issue":"1","key":"6508_CR54","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12943-016-0524-4","volume":"15","author":"P Qi","year":"2016","unstructured":"Qi P, Zhou XY, Du X (2016) Circulating long non-coding RNAs in cancer: current status and future perspectives. Mol Cancer 15(1):39","journal-title":"Mol Cancer"},{"issue":"10","key":"6508_CR56","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1002\/ijc.23822","volume":"123","author":"LX Qiu","year":"2008","unstructured":"Qiu LX, Tang QY, Bai JL, Qian XP, Li RT, Liu BR, Zheng MH (2008) Predictive value of thymidylate synthase expression in advanced colorectal cancer patients receiving fluoropyrimidine-based chemotherapy: evidence from 24 studies. Int J Cancer 123(10):2384\u20132389","journal-title":"Int J Cancer"},{"key":"6508_CR57","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.omto.2021.01.003","volume":"20","author":"L Qu","year":"2021","unstructured":"Qu L, Chen Y, Zhang F, He L (2021) The lncRNA DLGAP1-AS1\/miR-149-5p\/TGFB2 axis contributes to colorectal cancer progression and 5-FU resistance by regulating smad2 pathway. Mol therapy oncolytics 20:607\u2013624","journal-title":"Mol therapy oncolytics"},{"issue":"2","key":"6508_CR58","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s11033-017-4103-6","volume":"44","author":"A Rao","year":"2017","unstructured":"Rao A, Rajkumar T, Mani S (2017) Perspectives of long non-coding RNAs in cancer. Mol Biol Rep 44(2):203\u2013218","journal-title":"Mol Biol Rep"},{"key":"6508_CR59","doi-asserted-by":"crossref","unstructured":"Ren T, Hou J, Liu C, Shan F, Xiong X, Qin A, Chen J, Ren W (2019) The long non-coding RNA HOTAIRM1 suppresses cell progression via sponging endogenous miR-17-5p\/ B-cell translocation gene 3 (BTG3) axis in 5-fluorouracil resistant colorectal cancer cells, vol 117. Biomedicine & pharmacotherapy\u2009=\u2009Biomedecine & pharmacotherapie, p 109171","DOI":"10.1016\/j.biopha.2019.109171"},{"issue":"2","key":"6508_CR60","first-page":"2050","volume":"18","author":"Y Ren","year":"2019","unstructured":"Ren Y, Zhao C, He Y, Xu H, Min X (2019) Long non-coding RNA bladder cancer-associated transcript 2 contributes to disease progression, chemoresistance and poor survival of patients with colorectal cancer. Oncol Lett 18(2):2050\u20132058","journal-title":"Oncol Lett"},{"key":"6508_CR61","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","volume":"81","author":"JL Rinn","year":"2012","unstructured":"Rinn JL, Chang HY (2012) Genome regulation by long noncoding RNAs. Annu Rev Biochem 81:145\u2013166","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"6508_CR62","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s13046-019-1169-0","volume":"38","author":"M Saeinasab","year":"2019","unstructured":"Saeinasab M, Bahrami AR, Gonz\u00e1lez J, Marchese FP, Martinez D, Mowla SJ, Matin MM, Huarte M (2019) SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF. J Exper Clin Cancer Res: CR 38(1):172","journal-title":"J experimental Clin cancer research: CR"},{"issue":"3","key":"6508_CR63","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.chembiol.2018.11.012","volume":"26","author":"Y Shi","year":"2019","unstructured":"Shi Y, Parag S, Patel R, Lui A, Murr M, Cai J, Patel NA (2019) Stabilization of lncRNA GAS5 by a small molecule and its implications in diabetic adipocytes. Cell Chem Biol 26(3):319\u2013330e6","journal-title":"Cell Chem biology"},{"key":"6508_CR64","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.semcancer.2019.01.003","volume":"58","author":"C Sole","year":"2019","unstructured":"Sole C, Arnaiz E, Manterola L, Otaegui D, Lawrie CH (2019) The circulating transcriptome as a source of cancer liquid biopsy biomarkers. Sem Cancer Biol 58:100\u2013108","journal-title":"Sem Cancer Biol"},{"issue":"2","key":"6508_CR65","first-page":"96","volume":"22","author":"L Statello","year":"2021","unstructured":"Statello L, Guo CJ, Chen LL, Huarte M (2021) Gene regulation by long non-coding RNAs and its biological functions, Nature reviews. Mol cell biology 22(2):96\u2013118","journal-title":"Mol cell biology"},{"key":"6508_CR67","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cellsig.2019.01.013","volume":"57","author":"D Tang","year":"2019","unstructured":"Tang D, Yang Z, Long F, Luo L, Yang B, Zhu R, Sang X, Cao G (2019) Inhibition of MALAT1 reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer. Cell Signal 57:21\u201328","journal-title":"Cell Signal"},{"key":"6508_CR66","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.canlet.2017.01.010","volume":"391","author":"Y Tang","year":"2017","unstructured":"Tang Y, Cheung BB, Atmadibrata B, Marshall GM, Dinger ME, Liu PY, Liu T (2017) The regulatory role of long noncoding RNAs in cancer. Cancer Lett 391:12\u201319","journal-title":"Cancer Lett"},{"issue":"11","key":"6508_CR68","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.3390\/biomedicines10112748","volume":"10","author":"P Ulivi","year":"2022","unstructured":"Ulivi P, Indraccolo S (2022) Liquid biopsies in cancer diagnosis, monitoring and prognosis. Biomedicines 10(11):2748","journal-title":"Biomedicines"},{"key":"6508_CR69","doi-asserted-by":"publisher","first-page":"107447","DOI":"10.1016\/j.pharmthera.2019.107447","volume":"206","author":"S Vodenkova","year":"2020","unstructured":"Vodenkova S, Buchler T, Cervena K, Veskrnova V, Vodicka P, Vymetalkova V (2020) 5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future. Pharmacol Ther 206:107447","journal-title":"Pharmacol Ther"},{"issue":"10","key":"6508_CR74","doi-asserted-by":"publisher","first-page":"7899","DOI":"10.18632\/oncotarget.3219","volume":"6","author":"F Wang","year":"2015","unstructured":"Wang F, Ying HQ, He BS, Pan YQ, Deng QW, Sun HL, Chen J, Liu X, Wang SK (2015) Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1\/ERK signaling pathway. Oncotarget 6(10):7899\u20137917","journal-title":"Oncotarget"},{"issue":"1","key":"6508_CR76","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1186\/s12935-021-02353-5","volume":"21","author":"J Wang","year":"2021","unstructured":"Wang J, Zhang X, Zhang J, Chen S, Zhu J, Wang X (2021) Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p. Cancer Cell Int 21(1):638","journal-title":"Cancer Cell Int"},{"key":"6508_CR70","doi-asserted-by":"publisher","first-page":"6757","DOI":"10.2147\/OTT.S176354","volume":"11","author":"L Wang","year":"2018","unstructured":"Wang L, Du L, Duan W, Yan S, Xie Y, Wang C (2018) Overexpression of long noncoding RNA NORAD in colorectal cancer associates with tumor progression. OncoTargets Therapy 11:6757\u20136766","journal-title":"OncoTargets therapy"},{"issue":"17","key":"6508_CR75","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1097\/WNR.0000000000001730","volume":"32","author":"L Wang","year":"2021","unstructured":"Wang L, Zhang Z, Wang H (2021) Downregulation of lncRNA GAS5 prevents mitochondrial apoptosis and hypoxic-ischemic brain damage in neonatal rats through the microRNA-128-3p\/Bax\/Akt\/GSK-3\u03b2 axis. NeuroReport 32(17):1395\u20131402","journal-title":"NeuroReport"},{"issue":"12","key":"6508_CR71","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/s41419-018-1187-4","volume":"9","author":"M Wang","year":"2018","unstructured":"Wang M, Han D, Yuan Z, Hu H, Zhao Z, Yang R, Jin Y, Zou C, Chen Y, Wang G, Gao X, Wang X (2018) Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy. Cell Death Dis 9(12):1149","journal-title":"Cell Death Dis"},{"issue":"19","key":"6508_CR72","doi-asserted-by":"publisher","first-page":"4603","DOI":"10.7150\/jca.32065","volume":"10","author":"M Wang","year":"2019","unstructured":"Wang M, Hu H, Wang Y, Huang Q, Huang R, Chen Y, Ma T, Qiao T, Zhang Q, Wu H, Chen Q, Han D, Wang G, Wang X (2019) Long non-coding RNA TUG1 mediates 5-fluorouracil resistance by acting as a ceRNA of miR-197-3p in colorectal cancer. J Cancer 10(19):4603\u20134613","journal-title":"J Cancer"},{"key":"6508_CR73","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12935-019-0951-6","volume":"19","author":"X Wang","year":"2019","unstructured":"Wang X, Lan Z, He J, Lai Q, Yao X, Li Q, Liu Y, Lai H, Gu C, Yan Q, Fang Y, Zhang Y, Li A, Liu S (2019) LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells. Cancer Cell Int 19:234","journal-title":"Cancer Cell Int"},{"issue":"6","key":"6508_CR77","first-page":"757","volume":"42","author":"L Wei","year":"2019","unstructured":"Wei L, Wang X, Lv L, Zheng Y, Zhang N, Yang M (2019) The emerging role of noncoding RNAs in colorectal cancer chemoresistance, Cellular oncology (Dordrecht. Netherlands) 42(6):757\u2013768","journal-title":"Netherlands)"},{"issue":"8","key":"6508_CR78","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/s41573-021-00219-z","volume":"20","author":"M Winkle","year":"2021","unstructured":"Winkle M, El-Daly SM, Fabbri M, Calin GA (2021) Noncoding RNA therapeutics - challenges and potential solutions, Nature reviews. Drug Discov 20(8):629\u2013651","journal-title":"Drug discovery"},{"issue":"5","key":"6508_CR79","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1002\/cam4.1809","volume":"8","author":"H Wu","year":"2019","unstructured":"Wu H, Zou Q, He H, Liang Y, Lei M, Zhou Q, Fan D, Shen L (2019) Long non-coding RNA PCAT6 targets miR-204 to modulate the chemoresistance of colorectal cancer cells to 5-fluorouracil-based treatment through HMGA2 signaling. Cancer Med 8(5):2484\u20132495","journal-title":"Cancer Med"},{"issue":"47","key":"6508_CR80","doi-asserted-by":"publisher","first-page":"83171","DOI":"10.18632\/oncotarget.20487","volume":"8","author":"Y Xiao","year":"2017","unstructured":"Xiao Y, Yurievich UA, Yosypovych SV (2017) Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression. Oncotarget 8(47):83171\u201383182","journal-title":"Oncotarget"},{"issue":"8","key":"6508_CR81","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.7314\/APJCP.2015.16.8.3395","volume":"16","author":"W Xiong","year":"2015","unstructured":"Xiong W, Jiang YX, Ai YQ, Liu S, Wu XR, Cui JG, Qin JY, Liu Y, Xia YX, Ju YH, He WJ, Wang Y, Li YF, Hou Y, Wang L, Li WH (2015) Microarray analysis of long non-coding RNA expression profile associated with 5-fluorouracil-based chemoradiation resistance in colorectal cancer cells. Asian Pac J cancer prevention: APJCP 16(8):3395\u20133402","journal-title":"Asian Pac J cancer prevention: APJCP"},{"issue":"7","key":"6508_CR82","doi-asserted-by":"publisher","first-page":"4136","DOI":"10.1111\/jcmm.15070","volume":"24","author":"G Xu","year":"2020","unstructured":"Xu G, Zhu H, Xu J, Wang Y, Zhang Y, Zhang M, Zhu D (2020) Long non-coding RNA POU6F2-AS2 promotes cell proliferation and drug resistance in colon cancer by regulating miR-377\/BRD4. J Cell Mol Med 24(7):4136\u20134149","journal-title":"J Cell Mol Med"},{"issue":"1","key":"6508_CR84","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12860-019-0188-1","volume":"20","author":"C Yang","year":"2019","unstructured":"Yang C, Pan Y, Deng SP (2019) Downregulation of lncRNA CCAT1 enhances 5-fluorouracil sensitivity in human colon cancer cells. BMC Mol cell biology 20(1):9","journal-title":"BMC Mol cell biology"},{"issue":"4","key":"6508_CR83","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.cell.2011.08.054","volume":"147","author":"L Yang","year":"2011","unstructured":"Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG (2011) ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 147(4):773\u2013788","journal-title":"Cell"},{"key":"6508_CR85","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.canlet.2021.01.009","volume":"504","author":"Y Yang","year":"2021","unstructured":"Yang Y, Yan X, Li X, Ma Y, Goel A (2021) Long non-coding RNAs in colorectal cancer: Novel oncogenic mechanisms and promising clinical applications. Cancer Lett 504:67\u201380","journal-title":"Cancer Lett"},{"issue":"9","key":"6508_CR86","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/carcin\/bgac065","volume":"43","author":"F Yao","year":"2022","unstructured":"Yao F, Huang X, Xie Z, Chen J, Zhang L, Wang Q, Long H, Jiang J, Wu Q (2022) LINC02418 upregulates EPHA2 by competitively sponging miR-372-3p to promote 5-Fu\/DDP chemoresistance in colorectal cancer. Carcinogenesis 43(9):895\u2013907","journal-title":"Carcinogenesis"},{"key":"6508_CR87","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.2147\/CMAR.S158712","volume":"10","author":"Y Yu","year":"2018","unstructured":"Yu Y, Feng X, Cang S (2018) A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma. Cancer Manage Res 10:1507\u20131515","journal-title":"Cancer Manage Res"},{"key":"6508_CR92","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.canlet.2017.03.018","volume":"396","author":"CL Zhang","year":"2017","unstructured":"Zhang CL, Zhu KP, Ma XL (2017) Antisense lncRNA FOXC2-AS1 promotes doxorubicin resistance in osteosarcoma by increasing the expression of FOXC2. Cancer Lett 396:66\u201375","journal-title":"Cancer Lett"},{"key":"6508_CR88","doi-asserted-by":"publisher","first-page":"776","DOI":"10.3389\/fonc.2019.00776","volume":"9","author":"LH Zhang","year":"2019","unstructured":"Zhang LH, Li LH, Zhang PF, Cai YF, Hua D (2019) LINC00957 Acted as prognostic marker was associated with fluorouracil resistance in human colorectal cancer. Front Oncol 9:776","journal-title":"Front Oncol"},{"issue":"1","key":"6508_CR91","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1080\/21655979.2021.2015530","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang L, Wu H, Zhang Y, Xiao X, Chu F, Zhang L (2022) Induction of lncRNA NORAD accounts for hypoxia-induced chemoresistance and vasculogenic mimicry in colorectal cancer by sponging the miR-495-3p\/ hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1). Bioengineered 13(1):950\u2013962","journal-title":"Bioengineered"},{"issue":"5","key":"6508_CR90","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1111\/jcmm.14148","volume":"23","author":"R Zhang","year":"2019","unstructured":"Zhang R, Wang Z, Yu Q, Shen J, He W, Zhou D, Yu Q, Fan J, Gao S, Duan L (2019) Atractylenolide II reverses the influence of lncRNA XIST\/miR-30a-5p\/ROR1 axis on chemo-resistance of colorectal cancer cells. J Cell Mol Med 23(5):3151\u20133165","journal-title":"J Cell Mol Med"},{"issue":"11","key":"6508_CR89","doi-asserted-by":"publisher","first-page":"e23176","DOI":"10.1002\/jbt.23176","volume":"36","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Wang X, Wang Y, Zhou D, Wu H, Cheng W, Wang Q, Zheng G, Wang J, Gu J (2022) Effect of long noncoding RNA CCAT2 on drug sensitivity to 5-fluorouracil of breast cancer cells through microRNA-145 meditated by p53. J Biochem Mol Toxicol 36(11):e23176","journal-title":"J Biochem Mol Toxicol"},{"issue":"4","key":"6508_CR93","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3233\/CBM-201740","volume":"30","author":"H Zheng","year":"2021","unstructured":"Zheng H, Zhang M, Ke X, Deng X, Li D, Wang Q, Yan S, Xue Y, Wang Q (2021) LncRNA XIST\/miR-137 axis strengthens chemo-resistance and glycolysis of colorectal cancer cells by hindering transformation from PKM2 to PKM1. Cancer Biomark A 30(4):395\u2013406","journal-title":"Cancer Biomark A"},{"issue":"3","key":"6508_CR95","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1002\/jcb.29473","volume":"121","author":"H Zhou","year":"2020","unstructured":"Zhou H, Xiong Y, Peng L, Wang R, Zhang H, Fu Z (2020) LncRNA-cCSC1 modulates cancer stem cell properties in colorectal cancer via activation of the Hedgehog signaling pathway. J Cell Biochem 121(3):2510\u20132524","journal-title":"J Cell Biochem"},{"issue":"5","key":"6508_CR94","first-page":"3431","volume":"19","author":"X Zhou","year":"2020","unstructured":"Zhou X, Xiao D (2020) Long non-coding RNA GAS5 is critical for maintaining stemness and induces chemoresistance in cancer stem-like cells derived from HCT116. Oncol Lett 19(5):3431\u20133438","journal-title":"Oncol Lett"},{"key":"6508_CR96","doi-asserted-by":"publisher","first-page":"1275833","DOI":"10.3389\/fphar.2023.1275833","volume":"14","author":"C Zichittella","year":"2023","unstructured":"Zichittella C, Loria M, Celesia A, Di Liberto D, Corrado C, Alessandro R, Emanuele S, Conigliaro A (2023) Long non-coding RNA H19 enhances the pro-apoptotic activity of ITF2357 (a histone deacetylase inhibitor) in colorectal cancer cells. Front Pharmacol 14:1275833","journal-title":"Front Pharmacol"},{"key":"6508_CR97","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biochi.2018.05.021","volume":"151","author":"OL Zinovieva","year":"2018","unstructured":"Zinovieva OL, Grineva EN, Prokofjeva MM, Karpov DS, Zheltukhin AO, Krasnov GS, Snezhkina AV, Kudryavtseva AV, Chumakov PM, Mashkova TD, Prassolov VS, Lisitsyn NA (2018) Expression of long non-coding RNA LINC00973 is consistently increased upon treatment of colon cancer cells with different chemotherapeutic drugs. Biochimie 151:67\u201372","journal-title":"Biochimie"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-026-06508-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-026-06508-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-026-06508-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:03:31Z","timestamp":1784693011000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-026-06508-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":97,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["6508"],"URL":"https:\/\/doi.org\/10.1007\/s00432-026-06508-7","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"25 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"145"}}