{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:00:02Z","timestamp":1790164802853,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jilin Provincial Special Project for Health Research Talents","award":["2023SCZ36"],"award-info":[{"award-number":["2023SCZ36"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"DOI":"10.1007\/s00432-026-06533-6","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:55:27Z","timestamp":1782957327000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GALNT5 drives colorectal cancer progression and chemoresistance via PI3K\/Akt\/ABCC1 axis"],"prefix":"10.1007","volume":"152","author":[{"given":"Qiong","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liehao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiquan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changmiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"6533_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.6004\/jnccn.2018.0021","volume":"16","author":"AB Benson","year":"2018","unstructured":"Benson AB, Venook AP, Al-Hawary MM et al (2018) NCCN guidelines insights: colon cancer, version 2.2018. J Natl Compr Canc Netw 16:359\u2013369. https:\/\/doi.org\/10.6004\/jnccn.2018.0021","journal-title":"J Natl Compr Canc Netw"},{"key":"6533_CR2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01828","volume":"3","author":"J Chia","year":"2014","unstructured":"Chia J, Tham KM, Gill DJ, Bard-Chapeau EA, Bard FA (2014) ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration. Elife 3:e01828. https:\/\/doi.org\/10.7554\/eLife.01828","journal-title":"Elife"},{"key":"6533_CR3","doi-asserted-by":"publisher","first-page":"6315","DOI":"10.3748\/wjg.v19.i38.6315","volume":"19","author":"RA de Mello","year":"2013","unstructured":"de Mello RA, Marques AM, Ara\u00fajo A (2013) Epidermal growth factor receptor and metastatic colorectal cancer: insights into target therapies. World J Gastroenterol 19:6315\u20136318. https:\/\/doi.org\/10.3748\/wjg.v19.i38.6315","journal-title":"World J Gastroenterol"},{"key":"6533_CR4","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1093\/glycob\/cwz098","volume":"30","author":"M Detarya","year":"2020","unstructured":"Detarya M, Sawanyawisuth K, Aphivatanasiri C et al (2020) The O-GalNAcylating enzyme GALNT5 mediates carcinogenesis and progression of cholangiocarcinoma via activation of AKT\/ERK signaling. Glycobiology 30:312\u2013324. https:\/\/doi.org\/10.1093\/glycob\/cwz098","journal-title":"Glycobiology"},{"key":"6533_CR5","first-page":"4140","volume":"12","author":"M Detarya","year":"2022","unstructured":"Detarya M, Lert-Itthiporn W, Mahalapbutr P et al (2022) Emerging roles of GALNT5 on promoting EGFR activation in cholangiocarcinoma: a mechanistic insight. Am J Cancer Res 12:4140\u20134159","journal-title":"Am J Cancer Res"},{"key":"6533_CR6","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1093\/glycob\/cwab123","volume":"32","author":"MF Festari","year":"2022","unstructured":"Festari MF, da Costa V, Rodr\u00edguez-Zraquia SA et al (2022) The tumor-associated Tn antigen fosters lung metastasis and recruitment of regulatory T cells in triple negative breast cancer. Glycobiology 32:366\u2013379. https:\/\/doi.org\/10.1093\/glycob\/cwab123","journal-title":"Glycobiology"},{"key":"6533_CR7","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s13059-015-0844-5","volume":"16","author":"G Finak","year":"2015","unstructured":"Finak G, McDavid A, Yajima M et al (2015) MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol 16:278. https:\/\/doi.org\/10.1186\/s13059-015-0844-5","journal-title":"Genome Biol"},{"key":"6533_CR8","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.7150\/ijbs.89942","volume":"20","author":"F Fontana","year":"2024","unstructured":"Fontana F, Giannitti G, Marchesi S, Limonta P (2024) The PI3K\/Akt pathway and glucose metabolism: a dangerous liaison in cancer. Int J Biol Sci 20:3113\u20133125. https:\/\/doi.org\/10.7150\/ijbs.89942","journal-title":"Int J Biol Sci"},{"key":"6533_CR9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ctrv.2003.07.007","volume":"30","author":"JA Fresno Vara","year":"2004","unstructured":"Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonz\u00e1lez-Bar\u00f3n M (2004) PI3K\/Akt signalling pathway and cancer. Cancer Treat Rev 30:193\u2013204. https:\/\/doi.org\/10.1016\/j.ctrv.2003.07.007","journal-title":"Cancer Treat Rev"},{"key":"6533_CR10","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1007\/s11427-023-2499-2","volume":"67","author":"K Ganesan","year":"2024","unstructured":"Ganesan K, Xu C, Wu J et al (2024) Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K\/Akt\/mTOR pathway. Sci China Life Sci 67:1849\u20131866. https:\/\/doi.org\/10.1007\/s11427-023-2499-2","journal-title":"Sci China Life Sci"},{"key":"6533_CR11","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.semcancer.2022.03.012","volume":"86","author":"J Gonzalez-Molina","year":"2022","unstructured":"Gonzalez-Molina J, Moyano-Galceran L, Single A, Gultekin O, Alsalhi S, Lehti K (2022) Chemotherapy as a regulator of extracellular matrix-cell communication: implications in therapy resistance. Semin Cancer Biol 86:224\u2013236. https:\/\/doi.org\/10.1016\/j.semcancer.2022.03.012","journal-title":"Semin Cancer Biol"},{"key":"6533_CR12","doi-asserted-by":"publisher","first-page":"4505","DOI":"10.1038\/s41388-018-0266-4","volume":"37","author":"H Guo","year":"2018","unstructured":"Guo H, Zhao L, Shi B, Bao J, Zheng D, Zhou B, Shi J (2018) GALNT5 uaRNA promotes gastric cancer progression through its interaction with HSP90. Oncogene 37:4505\u20134517. https:\/\/doi.org\/10.1038\/s41388-018-0266-4","journal-title":"Oncogene"},{"key":"6533_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clcc.2014.11.002","volume":"14","author":"B Gustavsson","year":"2015","unstructured":"Gustavsson B, Carlsson G, Machover D et al (2015) A review of the evolution of systemic chemotherapy in the management of colorectal cancer. Clin Colorectal Cancer 14:1\u201310. https:\/\/doi.org\/10.1016\/j.clcc.2014.11.002","journal-title":"Clin Colorectal Cancer"},{"key":"6533_CR14","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.1016\/j.csbj.2021.07.014","volume":"19","author":"B Gy\u0151rffy","year":"2021","unstructured":"Gy\u0151rffy B (2021) Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer. Comput Struct Biotechnol J 19:4101\u20134109. https:\/\/doi.org\/10.1016\/j.csbj.2021.07.014","journal-title":"Comput Struct Biotechnol J"},{"key":"6533_CR15","doi-asserted-by":"publisher","first-page":"54067","DOI":"10.18632\/oncotarget.10042","volume":"7","author":"MR Hussain","year":"2016","unstructured":"Hussain MR, Hoessli DC, Fang M (2016) N-acetylgalactosaminyltransferases in cancer. Oncotarget 7:54067\u201354081. https:\/\/doi.org\/10.18632\/oncotarget.10042","journal-title":"Oncotarget"},{"key":"6533_CR16","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.molonc.2015.02.008","volume":"9","author":"NF Jensen","year":"2015","unstructured":"Jensen NF, Stenvang J, Beck MK et al (2015) Establishment and characterization of models of chemotherapy resistance in colorectal cancer: towards a predictive signature of chemoresistance. Mol Oncol 9:1169\u20131185. https:\/\/doi.org\/10.1016\/j.molonc.2015.02.008","journal-title":"Mol Oncol"},{"key":"6533_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07110-w","volume":"15","author":"Q Jia","year":"2024","unstructured":"Jia Q, Zhu Y, Yao H et al (2024) Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9\/ NOTCH\/ DDR axis in pancreatic ductal adenocarcinoma. Cell Death Dis 15:767. https:\/\/doi.org\/10.1038\/s41419-024-07110-w","journal-title":"Cell Death Dis"},{"key":"6533_CR18","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41575-019-0189-8","volume":"16","author":"N Keum","year":"2019","unstructured":"Keum N, Giovannucci E (2019) Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol 16:713\u2013732. https:\/\/doi.org\/10.1038\/s41575-019-0189-8","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"6533_CR19","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","volume":"37","author":"D Kim","year":"2019","unstructured":"Kim D, Paggi JM, Park C, Bennett C, Salzberg SL (2019) Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat Biotechnol 37:907\u2013915. https:\/\/doi.org\/10.1038\/s41587-019-0201-4","journal-title":"Nat Biotechnol"},{"key":"6533_CR20","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2483379","volume":"57","author":"Y Lan","year":"2025","unstructured":"Lan Y, Liu D, Liang B et al (2025) ITGA3-MET interaction promotes papillary thyroid cancer progression via ERK and PI3K\/AKT pathways. Ann Med 57:2483379. https:\/\/doi.org\/10.1080\/07853890.2025.2483379","journal-title":"Ann Med"},{"key":"6533_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00868","volume":"10","author":"R Li","year":"2020","unstructured":"Li R, Liang M, Liang X, Yang L, Su M, Lai KP (2020) Chemotherapeutic effectiveness of combining Cetuximab for metastatic colorectal cancer treatment: a system review and meta-analysis. Front Oncol 10:868. https:\/\/doi.org\/10.3389\/fonc.2020.00868","journal-title":"Front Oncol"},{"key":"6533_CR22","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W (2014) featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30:923\u2013930. https:\/\/doi.org\/10.1093\/bioinformatics\/btt656","journal-title":"Bioinformatics"},{"key":"6533_CR23","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/s41419-020-02998-6","volume":"11","author":"R Liu","year":"2020","unstructured":"Liu R, Chen Y, Liu G et al (2020) PI3K\/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death Dis 11:797. https:\/\/doi.org\/10.1038\/s41419-020-02998-6","journal-title":"Cell Death Dis"},{"key":"6533_CR24","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.18632\/aging.204609","volume":"15","author":"Y Liu","year":"2023","unstructured":"Liu Y, Chen P, Xu L, Wang B, Zhang S, Wang X (2023) GALNT2 sustains glioma stem cells by promoting CD44 expression. Aging 15:2208\u20132220. https:\/\/doi.org\/10.18632\/aging.204609","journal-title":"Aging"},{"key":"6533_CR25","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8","journal-title":"Genome Biol"},{"key":"6533_CR26","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","volume":"8","author":"CS McGinnis","year":"2019","unstructured":"McGinnis CS, Murrow LM, Gartner ZJ (2019) DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors. Cell Syst 8:329-337.e324. https:\/\/doi.org\/10.1016\/j.cels.2019.03.003","journal-title":"Cell Syst"},{"key":"6533_CR27","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nrc3982","volume":"15","author":"SS Pinho","year":"2015","unstructured":"Pinho SS, Reis CA (2015) Glycosylation in cancer: mechanisms and clinical implications. Nat Rev Cancer 15:540\u2013555. https:\/\/doi.org\/10.1038\/nrc3982","journal-title":"Nat Rev Cancer"},{"key":"6533_CR28","doi-asserted-by":"publisher","DOI":"10.1172\/jci183366","author":"D Song","year":"2024","unstructured":"Song D, Wu Y, Li J et al (2024) Insulin-like growth factor 2 drives fibroblast-mediated tumor immunoevasion and confers resistance to immunotherapy. J Clin Investig. https:\/\/doi.org\/10.1172\/jci183366","journal-title":"J Clin Investig"},{"key":"6533_CR29","doi-asserted-by":"publisher","first-page":"5255","DOI":"10.1158\/1078-0432.Ccr-17-0023","volume":"23","author":"V Stiegelbauer","year":"2017","unstructured":"Stiegelbauer V, Vychytilova-Faltejskova P, Karbiener M et al (2017) miR-196b-5p regulates colorectal cancer cell migration and metastases through interaction with HOXB7 and GALNT5. Clin Cancer Res 23:5255\u20135266. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-17-0023","journal-title":"Clin Cancer Res"},{"key":"6533_CR30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"6533_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129899","author":"SY Tam","year":"2023","unstructured":"Tam SY, Islam Khan MZ, Chen JY, Yip JH, Yan HY, Tam TY, Law HK (2023) Proteomic profiling of chemotherapy responses in FOLFOX-resistant colorectal cancer cells. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24129899","journal-title":"Int J Mol Sci"},{"key":"6533_CR32","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/sj.leu.2404523","volume":"21","author":"PL Tazzari","year":"2007","unstructured":"Tazzari PL, Cappellini A, Ricci F et al (2007) Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase\/Akt signal transduction network in human acute myelogenous leukemia blasts. Leukemia 21:427\u2013438. https:\/\/doi.org\/10.1038\/sj.leu.2404523","journal-title":"Leukemia"},{"key":"6533_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14122928","author":"Q Wang","year":"2022","unstructured":"Wang Q, Shen X, Chen G, Du J (2022) Drug resistance in colorectal cancer: from mechanism to clinic. Cancers. https:\/\/doi.org\/10.3390\/cancers14122928","journal-title":"Cancers"},{"key":"6533_CR34","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3322\/canjclin.57.3.168","volume":"57","author":"BM Wolpin","year":"2007","unstructured":"Wolpin BM, Meyerhardt JA, Mamon HJ, Mayer RJ (2007) Adjuvant treatment of colorectal cancer. CA Cancer J Clin 57:168\u2013185. https:\/\/doi.org\/10.3322\/canjclin.57.3.168","journal-title":"CA Cancer J Clin"},{"key":"6533_CR35","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3978\/j.issn.2078-6891.2014.112","volume":"6","author":"P Yaffee","year":"2015","unstructured":"Yaffee P, Osipov A, Tan C, Tuli R, Hendifar A (2015) Review of systemic therapies for locally advanced and metastatic rectal cancer. J Gastrointest Oncol 6:185\u2013200. https:\/\/doi.org\/10.3978\/j.issn.2078-6891.2014.112","journal-title":"J Gastrointest Oncol"},{"key":"6533_CR36","first-page":"4579","volume":"13","author":"J Yan","year":"2023","unstructured":"Yan J, Gong H, Han S, Liu J, Wu Z, Wang Z, Wang T (2023) GALNT5 functions as a suppressor of ferroptosis and a predictor of poor prognosis in pancreatic adenocarcinoma. Am J Cancer Res 13:4579\u20134596","journal-title":"Am J Cancer Res"},{"key":"6533_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13059-020-1950-6","volume":"21","author":"S Yang","year":"2020","unstructured":"Yang S, Corbett SE, Koga Y, Wang Z, Johnson WE, Yajima M, Campbell JD (2020) Decontamination of ambient RNA in single-cell RNA-seq with DecontX. Genome Biol 21:57. https:\/\/doi.org\/10.1186\/s13059-020-1950-6","journal-title":"Genome Biol"},{"key":"6533_CR38","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/neuonc\/noae222","volume":"27","author":"R Yang","year":"2025","unstructured":"Yang R, Zhang G, Meng Z et al (2025) Glutamate dehydrogenase 1-catalytic glutaminolysis feedback activates EGFR\/PI3K\/AKT pathway and reprograms glioblastoma metabolism. Neuro-Oncol 27:668\u2013681. https:\/\/doi.org\/10.1093\/neuonc\/noae222","journal-title":"Neuro-Oncol"},{"key":"6533_CR39","doi-asserted-by":"publisher","first-page":"262","DOI":"10.7150\/jca.7988","volume":"5","author":"PE Young","year":"2014","unstructured":"Young PE, Womeldorph CM, Johnson EK et al (2014) Early detection of colorectal cancer recurrence in patients undergoing surgery with curative intent: current status and challenges. J Cancer 5:262\u2013271. https:\/\/doi.org\/10.7150\/jca.7988","journal-title":"J Cancer"},{"key":"6533_CR40","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16:284\u2013287. https:\/\/doi.org\/10.1089\/omi.2011.0118","journal-title":"OMICS"},{"key":"6533_CR41","doi-asserted-by":"publisher","first-page":"6068","DOI":"10.7150\/ijbs.73431","volume":"18","author":"J Zhang","year":"2022","unstructured":"Zhang J, Wang H, Wu J et al (2022) GALNT1 enhances malignant phenotype of gastric cancer via modulating CD44 glycosylation to activate the Wnt\/\u03b2-catenin signaling pathway. Int J Biol Sci 18:6068\u20136083. https:\/\/doi.org\/10.7150\/ijbs.73431","journal-title":"Int J Biol Sci"},{"key":"6533_CR42","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41392-022-00881-8","volume":"7","author":"X Zheng","year":"2022","unstructured":"Zheng X, Song J, Yu C et al (2022) Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis. Signal Transduct Target Ther 7:60. https:\/\/doi.org\/10.1038\/s41392-022-00881-8","journal-title":"Signal Transduct Target Ther"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-026-06533-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-026-06533-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-026-06533-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:03:25Z","timestamp":1790161405000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-026-06533-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["6533"],"URL":"https:\/\/doi.org\/10.1007\/s00432-026-06533-6","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"6 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have consented to the publication of the research findings.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our study conformed to the principles of the Declaration of Helsinki. The research involving animals was approved by the Institutional Animal Care and Use Committee of Wuhan Myhalic Biotechnology Co., Ltd. (approval ID: HLK-20250526\u2013001). All procedures were conducted in accordance with the local legislation and institutional requirements.","order":3,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"183"}}