{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:52:05Z","timestamp":1781542325783,"version":"3.54.5"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loneliness in cancer survivors is associated with a variety of negative consequences to physical and mental health. Research regarding the impact of loneliness on health-related quality of life and mental health outcomes in prostate cancer (PC) survivors is scarce. The current study aimed to investigate prevalence and determinants of loneliness in long-term PC survivors following radical prostatectomy (RP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 3127 PC survivors (mean age 79.5 years, SD 6.4) from the multicenter German Familial PC Database returned the study questionnaires during the COVID-19 pandemic, after an average of 17.4 years (SD\u2009=\u20093.8) following RP. Loneliness was assessed using a single item measure. Validated self-reporting questionnaires were used to assess anxiety and depressive symptoms, health related quality of life, and frailty. Descriptive statistics, chi-square tests, and logistic regression analysis were conducted to examine the prevalence, correlates, and determinants of loneliness in PC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 16.6% of patients reported at least some degree of loneliness. Partnership status, depression, and anxiety were significantly associated with loneliness. Individuals living in a partnership experienced lower levels of loneliness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while higher levels of depression and anxiety were associated with increased loneliness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In multivariable logistic regression analysis, having a steady partnership was associated with a significantly lower risk of loneliness (OR 0.18, 95%CI [0.13\u20130.24]). Symptoms of depression (OR 1.49, 95%CI [1.31\u20131.71]) or anxiety (OR 1.29, 95%CI [1.13\u20131.47]) or being frail (OR 3.97, 95%CI [2.99\u20135.28]) were independently associated with an increased risk of being lonely.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nearly one in five PC survivors experienced some to severe loneliness in this study, with notable associations with partnership status, symptoms of depression or anxiety and frailty. The findings emphasize the importance of addressing loneliness as part of comprehensive care for PC survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00432-026-06539-0","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T03:54:31Z","timestamp":1781409271000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loneliness in prostate cancer survivors"],"prefix":"10.1007","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4392-3345","authenticated-orcid":false,"given":"Lukas","family":"Lunger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Schwoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Dinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin H.","family":"Meissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Jahnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen E.","family":"Gschwend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Herkommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"issue":"5","key":"6539_CR33","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"3","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst Mar 3(5):365\u2013376. https:\/\/doi.org\/10.1093\/jnci\/85.5.365","journal-title":"J Natl Cancer Inst Mar"},{"issue":"3","key":"6539_CR31","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s10865-023-00465-z","volume":"47","author":"ES A\u00dfmann","year":"2024","unstructured":"A\u00dfmann ES, Ose J, Hathaway CA et al (2024) Risk factors and health behaviors associated with loneliness among cancer survivors during the COVID-19 pandemic. J Behav Med Jun 47(3):405\u2013421. https:\/\/doi.org\/10.1007\/s10865-023-00465-z","journal-title":"J Behav Med Jun"},{"issue":"3","key":"6539_CR3","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1097\/JU.0000000000000541","volume":"203","author":"M Baunacke","year":"2020","unstructured":"Baunacke M, Schmidt ML, Groeben C et al (2020) Decision regret after radical prostatectomy does not depend on surgical approach: 6-year followup of a large german cohort undergoing routine care. J Urol Mar 203(3):554\u2013561. https:\/\/doi.org\/10.1097\/JU.0000000000000541","journal-title":"J Urol Mar"},{"issue":"1","key":"6539_CR30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12888-017-1262-x","volume":"20","author":"ME Beutel","year":"2017","unstructured":"Beutel ME, Klein EM, Brahler E et al (2017) Loneliness in the general population: prevalence, determinants and relations to mental health. BMC Psychiatry Mar 20(1):97. https:\/\/doi.org\/10.1186\/s12888-017-1262-x","journal-title":"BMC Psychiatry Mar"},{"issue":"12","key":"6539_CR25","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1002\/pon.2045","volume":"21","author":"J Brennan","year":"2012","unstructured":"Brennan J, Gingell P, Brant H, Hollingworth W (2012) Refinement of the distress management problem list as the basis for a holistic therapeutic conversation among UK patients with cancer. Psychooncol Dec 21(12):1346\u20131356. https:\/\/doi.org\/10.1002\/pon.2045","journal-title":"Psychooncol Dec"},{"issue":"1","key":"6539_CR45","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1037\/0882-7974.21.1.140","volume":"21","author":"JT Cacioppo","year":"2006","unstructured":"Cacioppo JT, Hughes ME, Waite LJ, Hawkley LC, Thisted RA (2006) Loneliness as a specific risk factor for depressive symptoms: cross-sectional and longitudinal analyses. Psychol Aging Mar 21(1):140\u2013151. https:\/\/doi.org\/10.1037\/0882-7974.21.1.140","journal-title":"Psychol Aging Mar"},{"issue":"2","key":"6539_CR9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1037\/a0017216","volume":"25","author":"JT Cacioppo","year":"2010","unstructured":"Cacioppo JT, Hawkley LC, Thisted RA (2010) Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago health, aging, and social relations study. Psychol Aging Jun 25(2):453\u2013463. https:\/\/doi.org\/10.1037\/a0017216","journal-title":"Psychol Aging Jun"},{"key":"6539_CR11","doi-asserted-by":"publisher","unstructured":"Chen N, McGrath CB, Stopsack KH et al (2024) Social integration and long-term physical and psychosocial quality of life among prostate cancer survivors in the Health professionals follow-up study. J Cancer Surviv Jul 1. https:\/\/doi.org\/10.1007\/s11764-024-01632-0","DOI":"10.1007\/s11764-024-01632-0"},{"key":"6539_CR41","unstructured":"Cumming E, Henry WE (1961) Growing old: the process of disengagement. (No Title)"},{"issue":"8","key":"6539_CR37","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.bjoms.2020.04.041","volume":"58","author":"A Dahill","year":"2020","unstructured":"Dahill A, Al-Nakishbandi H, Cunningham KB, Humphris GM, Lowe D, Rogers SN (2020) Loneliness and quality of life after head and neck cancer. The Br J Oral Maxillofac Surgery Oct 58(8):959\u2013965. https:\/\/doi.org\/10.1016\/j.bjoms.2020.04.041","journal-title":"The Br J Oral Maxillofac Surg Oct"},{"issue":"5","key":"6539_CR23","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.ejon.2014.05.002","volume":"18","author":"L Deckx","year":"2014","unstructured":"Deckx L, van den Akker M, Buntinx F (2014) Risk factors for loneliness in patients with cancer: a systematic literature review and meta-analysis. Eur J Oncol Nurs Oct 18(5):466\u2013477. https:\/\/doi.org\/10.1016\/j.ejon.2014.05.002","journal-title":"Eur J Oncol Nurs Oct"},{"issue":"9","key":"6539_CR50","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s12603-019-1273-z","volume":"23","author":"E Dent","year":"2019","unstructured":"Dent E, Morley JE, Cruz-Jentoft AJ et al (2019) Physical frailty: ICFSR international clinical practice guidelines for identification and management. J Nutr Health Aging 23(9):771\u2013787. https:\/\/doi.org\/10.1007\/s12603-019-1273-z","journal-title":"J Nutr Health Aging"},{"key":"6539_CR17","doi-asserted-by":"publisher","first-page":"100826","DOI":"10.1016\/j.ssmph.2021.100826","volume":"15","author":"M Elovainio","year":"2021","unstructured":"Elovainio M, Lumme S, Arffman M, Manderbacka K, Pukkala E, Hakulinen C (2021) Living alone as a risk factor for cancer incidence, case-fatality and all-cause mortality: a nationwide registry study. SSM - Popul Health 15:100826 2021\/09\/01\/. https:\/\/doi.org\/10.1016\/j.ssmph.2021.100826","journal-title":"SSM - Popul Health"},{"issue":"2","key":"6539_CR55","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1158\/1055-9965.epi-03-0065","volume":"13","author":"BR Evans","year":"2004","unstructured":"Evans BR, Peterson BL, Demark-Wahnefried W (2004) No difference in response rate to a mailed survey among prostate cancer survivors using conditional versus unconditional incentives. Cancer Epidemiol Biomarkers Prev Feb 13(2):277\u2013278. https:\/\/doi.org\/10.1158\/1055-9965.epi-03-0065","journal-title":"Cancer Epidemiol Biomarkers Prev Feb"},{"issue":"4","key":"6539_CR13","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00401-014-1377-9","volume":"129","author":"B Friedler","year":"2015","unstructured":"Friedler B, Crapser J, McCullough L (2015) One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition. Acta Neuropathol Apr 129(4):493\u2013509. https:\/\/doi.org\/10.1007\/s00401-014-1377-9","journal-title":"Acta Neuropathol Apr"},{"issue":"3","key":"6539_CR48","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1093\/ageing\/afx188","volume":"47","author":"CR Gale","year":"2018","unstructured":"Gale CR, Westbury L, Cooper C (2018) Social isolation and loneliness as risk factors for the progression of frailty: the english longitudinal study of ageing. Age Ageing 47(3):392\u2013397","journal-title":"Age Ageing"},{"issue":"3","key":"6539_CR47","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1080\/07347332.2020.1853653","volume":"39","author":"S Gallagher","year":"2021","unstructured":"Gallagher S, Bennett KM, Roper L (2021) Loneliness and depression in patients with cancer during COVID-19. J Psychosoc Oncol 39(3):445\u2013451. https:\/\/doi.org\/10.1080\/07347332.2020.1853653","journal-title":"J Psychosoc Oncol"},{"issue":"1669","key":"6539_CR44","doi-asserted-by":"publisher","first-page":"20140114","DOI":"10.1098\/rstb.2014.0114","volume":"370","author":"LC Hawkley","year":"2015","unstructured":"Hawkley LC, Capitanio JP (2015) Perceived social isolation, evolutionary fitness and health outcomes: a lifespan approach. Philosoph Trans Royal Soc B: Biol Sci 370(1669):20140114","journal-title":"Philosoph Trans Royal Soc B: Biol Sci"},{"issue":"6","key":"6539_CR12","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.cpr.2006.04.002","volume":"26","author":"LM Heinrich","year":"2006","unstructured":"Heinrich LM, Gullone E (2006) The clinical significance of loneliness: a literature review. Clin Psychol Rev Oct 26(6):695\u2013718. https:\/\/doi.org\/10.1016\/j.cpr.2006.04.002","journal-title":"Clin Psychol Rev Oct"},{"issue":"1\u20132","key":"6539_CR10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/00223980.2011.613874","volume":"146","author":"B Hensley","year":"2012","unstructured":"Hensley B, Martin P, Margrett JA et al (2012) Life events and personality predicting loneliness among centenarians: findings from the Georgia Centenarian study. J Psychol Jan-Apr 146(1\u20132):173\u2013188. https:\/\/doi.org\/10.1080\/00223980.2011.613874","journal-title":"J Psychol Jan-Apr"},{"issue":"3","key":"6539_CR21","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/jgs.13308","volume":"63","author":"A Herrera-Badilla","year":"2015","unstructured":"Herrera-Badilla A, Navarrete-Reyes AP, Amieva H, Avila-Funes JA (Mar 2015) Loneliness is associated with frailty in community-dwelling elderly adults. J Am Geriatr Soc 63(3):607\u2013609. https:\/\/doi.org\/10.1111\/jgs.13308","journal-title":"J Am Geriatr Soc"},{"key":"6539_CR42","unstructured":"Hobbs F (2002) Demographic trends in the 20th century. vol 4. US department of commerce, economics and statistics administration, US"},{"issue":"20","key":"6539_CR2","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1200\/JCO.2016.70.6317","volume":"10","author":"RM Hoffman","year":"2017","unstructured":"Hoffman RM, Lo M, Clark JA et al (2017) Treatment decision regret among long-term survivors of localized prostate cancer: results from the prostate cancer outcomes study. J Clin Oncol Jul 10(20):2306\u20132314. https:\/\/doi.org\/10.1200\/JCO.2016.70.6317","journal-title":"J Clin Oncol Jul"},{"issue":"2","key":"6539_CR14","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/1745691614568352","volume":"10","author":"J Holt-Lunstad","year":"2015","unstructured":"Holt-Lunstad J, Smith TB, Baker M, Harris T, Stephenson D (2015) Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspect Psychol Sci Mar 10(2):227\u2013237. https:\/\/doi.org\/10.1177\/1745691614568352","journal-title":"Perspect Psychol Sci Mar"},{"key":"6539_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.maturitas.2015.09.002","volume":"83","author":"EO Hoogendijk","year":"2016","unstructured":"Hoogendijk EO, Suanet B, Dent E, Deeg DJ, Aartsen MJ (2016) Adverse effects of frailty on social functioning in older adults: results from the longitudinal aging study Amsterdam. Maturitas Jan 83:45\u201350. https:\/\/doi.org\/10.1016\/j.maturitas.2015.09.002","journal-title":"Maturitas Jan"},{"issue":"3","key":"6539_CR36","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1007\/s00520-021-06628-5","volume":"30","author":"K Howden","year":"2022","unstructured":"Howden K, Yan AP, Glidden C et al (2022) Loneliness among adolescents and young adults with cancer during the COVID-19 pandemic: a cross-sectional survey. Support Care Cancer Mar 30(3):2215\u20132224. https:\/\/doi.org\/10.1007\/s00520-021-06628-5","journal-title":"Support Care Cancer Mar"},{"issue":"10","key":"6539_CR38","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1017\/s1041610220000988","volume":"32","author":"TJ Hwang","year":"2020","unstructured":"Hwang TJ, Rabheru K, Peisah C, Reichman W, Ikeda M (2020) Loneliness and social isolation during the COVID-19 pandemic. Int psychogeriatr Oct 32(10):1217\u20131220. https:\/\/doi.org\/10.1017\/s1041610220000988","journal-title":"Int Psychogeriatr Oct"},{"issue":"7","key":"6539_CR51","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s00127-019-01681-2","volume":"55","author":"MH Lim","year":"2020","unstructured":"Lim MH, Gleeson JFM, Rodebaugh TL et al (2020) A pilot digital intervention targeting loneliness in young people with psychosis. Soc Psychiatry Psychiatr Epidemiol Jul 55(7):877\u2013889. https:\/\/doi.org\/10.1007\/s00127-019-01681-2","journal-title":"Soc Psychiatry Psychiatr Epidemiol Jul"},{"issue":"1\u20132","key":"6539_CR32","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jad.2009.06.019","volume":"122","author":"B L\u00f6we","year":"2010","unstructured":"L\u00f6we B, Wahl I, Rose M et al (2010) A 4-item measure of depression and anxiety: validation and standardization of the patient health questionnaire-4 (PHQ-4) in the general population. J Affect Disord Apr 122(1\u20132):86\u201395. https:\/\/doi.org\/10.1016\/j.jad.2009.06.019","journal-title":"J Affect Disord Apr"},{"key":"6539_CR43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2307\/2061894","volume":"32","author":"DJ Macunovich","year":"1995","unstructured":"Macunovich DJ, Easterlin RA, Schaeffer CM, Crimmins EM (1995) Echoes of the baby boom and bust: recent and prospective changes in living alone among elderly widows in the United States. Demography 32:17\u201328","journal-title":"Demography"},{"issue":"6","key":"6539_CR40","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s12529-024-10286-2","volume":"31","author":"A Marziliano","year":"2024","unstructured":"Marziliano A, Byakova A, Patel P, Herman SW, Diefenbach MA (2024) The assessment of social isolation and loneliness in cancer patients and survivors in the Pre-COVID-19 period: a systematic review. Int J Behav Med Dec 31(6):871\u2013894. https:\/\/doi.org\/10.1007\/s12529-024-10286-2","journal-title":"Int J Behav Med Dec"},{"key":"6539_CR53","doi-asserted-by":"publisher","DOI":"10.1080\/07347332.2020.1867690","author":"JJ McElfresh","year":"2021","unstructured":"McElfresh JJ, SM B, SC G et al (2021) Interventions for loneliness among adult cancer survivors: a systematic review and meta-analysis. J Psychos Oncol. 07\/13 2021;39(4):509\u2013533. https:\/\/doi.org\/10.1080\/07347332.2020.1867690","journal-title":"J Psychosoc Oncol"},{"issue":"6","key":"6539_CR5","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1007\/s11764-017-0619-y","volume":"11","author":"VH Meissner","year":"2017","unstructured":"Meissner VH, Herkommer K, Marten-Mittag B, Gschwend JE, Dinkel A (2017) Prostate cancer-related anxiety in long-term survivors after radical prostatectomy. J Cancer Surviv Dec 11(6):800\u2013807. https:\/\/doi.org\/10.1007\/s11764-017-0619-y","journal-title":"J Cancer Surviv Dec"},{"issue":"12","key":"6539_CR29","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1007\/s00345-020-03147-6","volume":"38","author":"VH Meissner","year":"2020","unstructured":"Meissner VH, Struh JGH, Kron M et al (2020) The role of fatal family history and mode of inheritance in prostate cancer for long-term outcomes following radical prostatectomy. World J Urol Dec 38(12):3091\u20133099. https:\/\/doi.org\/10.1007\/s00345-020-03147-6","journal-title":"World J Urol Dec"},{"issue":"22","key":"6539_CR6","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.1002\/cncr.33836","volume":"15","author":"VH Meissner","year":"2021","unstructured":"Meissner VH, Olze L, Schiele S et al (2021) Fear of cancer recurrence and disease progression in long-term prostate cancer survivors after radical prostatectomy: a longitudinal study. Cancer Nov 15(22):4287\u20134295. https:\/\/doi.org\/10.1002\/cncr.33836","journal-title":"Cancer Nov"},{"issue":"5","key":"6539_CR4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/bju.15955","volume":"131","author":"VH Meissner","year":"2023","unstructured":"Meissner VH, Simson BW, Dinkel A et al (2023) Treatment decision regret in long-term survivors after radical prostatectomy: a longitudinal study. BJU Int May 131(5):623\u2013630. https:\/\/doi.org\/10.1111\/bju.15955","journal-title":"BJU Int May"},{"issue":"17","key":"6539_CR35","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1002\/cncr.33603","volume":"1","author":"C Miaskowski","year":"2021","unstructured":"Miaskowski C, Paul SM, Snowberg K et al (2021) Loneliness and symptom burden in oncology patients during the COVID-19 pandemic. Cancer Sep 1(17):3246\u20133253. https:\/\/doi.org\/10.1002\/cncr.33603","journal-title":"Cancer Sep"},{"key":"6539_CR1","unstructured":"Mottet N, van den Bergh RCN, Briers E et al EAU-ESTRO-SIOG guidelines on prostate cancer. Accessed 27.07.2022, https:\/\/d56bochluxqnz.cloudfront.net\/documents\/full-guideline\/EAU-EANM-ESTRO-ESUR-ISUP_SIOG-Guidelines-on-Prostate-Cancer-2022_2022-04-25-063938_yfos.pdf"},{"issue":"9","key":"6539_CR46","doi-asserted-by":"publisher","first-page":"We01","DOI":"10.7860\/jcdr\/2014\/10077.4828","volume":"8","author":"R Mushtaq","year":"2014","unstructured":"Mushtaq R, Shoib S, Shah T, Mushtaq S (2014) Relationship between loneliness, psychiatric disorders and physical health ? A review on the psychological aspects of loneliness. J Clin Diagn Res Sep 8(9):We01\u20134. https:\/\/doi.org\/10.7860\/jcdr\/2014\/10077.4828","journal-title":"J Clin Diagn Res Sep"},{"issue":"3","key":"6539_CR54","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s12529-023-10231-9","volume":"31","author":"J Nicoloro-SantaBarbara","year":"2024","unstructured":"Nicoloro-SantaBarbara J, Lobel M (2024) Loneliness and its predictors in rare versus common chronic illnesses. Int J Behav Med Jun 31(3):422\u2013432. https:\/\/doi.org\/10.1007\/s12529-023-10231-9","journal-title":"Int J Behav Med Jun"},{"issue":"4","key":"6539_CR8","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1159\/000441651","volume":"62","author":"AD Ong","year":"2016","unstructured":"Ong AD, Uchino BN, Wethington E (2016) Loneliness and health in older adults: a mini-review and synthesis. Gerontology 62(4):443\u2013449. https:\/\/doi.org\/10.1159\/000441651","journal-title":"Gerontology"},{"key":"6539_CR7","unstructured":"Peplau LA, Perlman D, Loneliness (1982) A sourcebook of current theory, research, and therapy. (No Title)"},{"issue":"3","key":"6539_CR39","doi-asserted-by":"publisher","first-page":"e0279701","DOI":"10.1371\/journal.pone.0279701","volume":"18","author":"AC Reinwarth","year":"2023","unstructured":"Reinwarth AC, Ernst M, Krakau L, Br\u00e4hler E, Beutel ME (2023) Screening for loneliness in representative population samples: validation of a single-item measure. PLoS ONE 18(3):e0279701. https:\/\/doi.org\/10.1371\/journal.pone.0279701","journal-title":"PLoS ONE"},{"issue":"2","key":"6539_CR26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/13548506.2012.689839","volume":"18","author":"A Rokach","year":"2013","unstructured":"Rokach A, Findler L, Chin J, Lev S, Kollender Y (2013) Cancer patients, their caregivers and coping with loneliness. Psychol health Med 18(2):135\u2013144. https:\/\/doi.org\/10.1080\/13548506.2012.689839","journal-title":"Psychol health Med"},{"issue":"2","key":"6539_CR24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1188\/09.ONF.175-183","volume":"36","author":"M Rosedale","year":"2009","unstructured":"Rosedale M (2009) Survivor loneliness of women following breast cancer. Oncol Nurs Forum Mar 36(2):175\u2013183. https:\/\/doi.org\/10.1188\/09.ONF.175-183","journal-title":"Oncol Nurs Forum Mar"},{"issue":"2","key":"6539_CR27","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1188\/12.CJON.145-149","volume":"16","author":"ZA Sahin","year":"2012","unstructured":"Sahin ZA, Tan M (2012) Loneliness, depression, and social support of patients with cancer and their caregivers. Clin J Oncol Nurs Apr 16(2):145\u2013149. https:\/\/doi.org\/10.1188\/12.CJON.145-149","journal-title":"Clin J Oncol Nurs Apr"},{"issue":"Suppl 1","key":"6539_CR28","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/j.1525-1438.2006.00516.x","volume":"16","author":"U Sevil","year":"2006","unstructured":"Sevil U, Ertem G, Kavlak O, Coban A (2006) The loneliness level of patients with gynecological cancer. Int J Gynecol Cancer Jan-Feb 16(Suppl 1):472\u2013477. https:\/\/doi.org\/10.1111\/j.1525-1438.2006.00516.x","journal-title":"Int J Gynecol Cancer Jan-Feb"},{"key":"6539_CR49","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-03044-0","author":"S Sha","year":"2022","unstructured":"Sha S, Pan Y, Xu Y, Chen L (2022) Associations between loneliness and frailty among older adults: evidence from the China health and retirement longitudinal study. BMC Geriatrics. \/07\/01 2022;22(1):537. https:\/\/doi.org\/10.1186\/s12877-022-03044-0","journal-title":"BMC Geriatr"},{"key":"6539_CR34","first-page":"236","volume":"41","author":"N Steverink","year":"2001","unstructured":"Steverink N (2001) Measuring frailty: developing and testing the GFI (Groningen Frailty Indicator). Gerontologist 41:236","journal-title":"Gerontologist"},{"key":"6539_CR52","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.jad.2022.04.084","volume":"2022\/07\/15","author":"AR Sutin","year":"2022","unstructured":"Sutin AR, Luchetti M, Aschwanden D et al (2022) Sense of purpose in life and concurrent loneliness and risk of incident loneliness: an individual-participant meta-analysis of 135,227 individuals from 36 cohorts. J Affect Disord 2022\/07\/15:309:211\u2013220. https:\/\/doi.org\/10.1016\/j.jad.2022.04.084","journal-title":"J Affect Disord"},{"issue":"1\u20132","key":"6539_CR18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/00223980.2011.613875","volume":"146","author":"CR Victor","year":"2012","unstructured":"Victor CR, Yang K (2012) The prevalence of loneliness among adults: a case study of the United Kingdom. J Psychol Jan-Apr 146(1\u20132):85\u2013104. https:\/\/doi.org\/10.1080\/00223980.2011.613875","journal-title":"J Psychol Jan-Apr"},{"key":"6539_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-023-01617-6","author":"F Wang","year":"2023","unstructured":"Wang F, Gao Y, Han Z et al (2023) A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality. Nature Human Behaviour. \/08\/01 2023;7(8):1307\u20131319. https:\/\/doi.org\/10.1038\/s41562-023-01617-6","journal-title":"Nat Human Behav"},{"issue":"5","key":"6539_CR22","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.ejon.2008.11.003","volume":"12","author":"M Wells","year":"2008","unstructured":"Wells M, Kelly D (2008) The loneliness of cancer. Eur J Oncol Nurs Dec 12(5):410\u2013411. https:\/\/doi.org\/10.1016\/j.ejon.2008.11.003","journal-title":"Eur J Oncol Nurs Dec"},{"issue":"3","key":"6539_CR15","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1002\/ijc.32786","volume":"1","author":"Z Wu","year":"2020","unstructured":"Wu Z, Nguyen NH, Wang D et al (2020) Social connectedness and mortality after prostate cancer diagnosis: a prospective cohort study. Int J Cancer Aug 1(3):766\u2013776. https:\/\/doi.org\/10.1002\/ijc.32786","journal-title":"Int J Cancer Aug"},{"issue":"3","key":"6539_CR19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/gps.3998","volume":"29","author":"A Zebhauser","year":"2014","unstructured":"Zebhauser A, Hofmann-Xu L, Baumert J et al (2014) How much does it hurt to be lonely? Mental and physical differences between older men and women in the KORA-Age Study. Int J Geriatr Psychiatry Mar 29(3):245\u2013252. https:\/\/doi.org\/10.1002\/gps.3998","journal-title":"Int J Geriatr Psychiatry Mar"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00432-026-06539-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-026-06539-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-026-06539-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:53:04Z","timestamp":1781538784000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00432-026-06539-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,14]]},"references-count":55,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["6539"],"URL":"https:\/\/doi.org\/10.1007\/s00432-026-06539-0","relation":{},"ISSN":["1432-1335"],"issn-type":[{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,14]]},"assertion":[{"value":"8 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"LL is affiliated with the Department of Urology, School of Medicine, Technical University of Munich, and is also associated with Boehringer Ingelheim, Ingelheim, Germany. All other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The study was approved by the ethical review committee of Technical University of Munich.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Individual consent was obtained from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"119"}}