{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:13:08Z","timestamp":1791137588433,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2003,3,25]],"date-time":"2003-03-25T00:00:00Z","timestamp":1048550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,3,25]],"date-time":"2003-03-25T00:00:00Z","timestamp":1048550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1007\/s00436-002-0780-7","type":"journal-article","created":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T17:53:10Z","timestamp":1067277190000},"page":"264-267","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The monocyte locomotion inhibitory factor produced by Entamoeba histolytica inhibits induced nitric oxide production in human leukocytes"],"prefix":"10.1007","volume":"90","author":[{"given":"G.","family":"Rico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Leandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. R.","family":"Kretschmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,3,25]]},"reference":[{"key":"780_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"M Bradford","year":"1976","unstructured":"Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Ann Biochem 72:248\u2013254","journal-title":"Ann Biochem"},{"key":"780_CR2","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/0008-8749(91)90014-3","volume":"132","author":"M Denis","year":"1991","unstructured":"Denis M (1991) Interferon-gamma-treated murine macrophages inhibit growth of tubercule bacilli via the generation of reactive nitrogen intermediates. Cell Immunol 132:150\u2013157","journal-title":"Cell Immunol"},{"key":"780_CR3","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.4049\/jimmunol.141.7.2407","volume":"141","author":"AH Ding","year":"1988","unstructured":"Ding AH, Nathan CF, Stuehr DJ (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J Immunol 141:2407\u20132412","journal-title":"J Immunol"},{"key":"780_CR4","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/S1369-5274(99)80076-9","volume":"2","author":"CA Gilchrist","year":"1999","unstructured":"Gilchrist CA, Petri WA (1999) Virulence factors of E. histolytica. Curr Opin Microbiol 2:433\u2013437","journal-title":"Curr Opin Microbiol"},{"key":"780_CR5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1093\/infdis\/143.1.83","volume":"143","author":"RL Guerrant","year":"1981","unstructured":"Guerrant RL, Brush J, Ravdin JI, Sullivan JA, Mandell GL (1981) Interaction between Entamoeba histolytica and human polymorphonuclear neutrophils. J Infect Dis 143:83\u201393","journal-title":"J Infect Dis"},{"key":"780_CR6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0014-2999(92)90526-A","volume":"211","author":"A Ialenti","year":"1992","unstructured":"Ialenti A, Ianaro A, Moncada S, Di Rosa M (1992) Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol 211:177\u2013182","journal-title":"Eur J Pharmacol"},{"key":"780_CR7","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/j.1365-3024.1985.tb00097.x","volume":"7","author":"R Kretschmer","year":"1985","unstructured":"Kretschmer R, Collado ML, Pacheco MG, Salinas MC, L\u00f3pez-Osuna M, Leucona M, Castro EM, Arellano J (1985) Inhibition of human monocyte locomotion by products of axenically grown Entamoeba histolytica. Parasite Immunol 7:527\u2013543","journal-title":"Parasite Immunol"},{"key":"780_CR8","first-page":"A660","volume":"13","author":"R Kretschmer","year":"1999","unstructured":"Kretschmer R, Rico G, Leandro E (1999) The monocyte locomotion inhibitory factor (MLIF) produced by Entamoeba histolytica inhibits nitric oxide production in human macrophages. FASEB J 13:A660","journal-title":"FASEB J"},{"key":"780_CR9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0166-6851(00)00367-4","volume":"112","author":"R Kretschmer","year":"2001","unstructured":"Kretschmer R, Rico G, Gim\u00e9nez JA (2001) A novel anti-inflammatory oligopeptide produced by Entamoeba histolytica. Mol Biochem Parasitol 112:201\u2013209","journal-title":"Mol Biochem Parasitol"},{"key":"780_CR10","doi-asserted-by":"publisher","first-page":"4794","DOI":"10.4049\/jimmunol.144.12.4794","volume":"144","author":"FY Liew","year":"1990","unstructured":"Liew FY, Millott S, Parkinson C, Palmer RMJ, Moncada S (1990) Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J Immunol 144:4794\u20134797","journal-title":"J Immunol"},{"key":"780_CR11","doi-asserted-by":"publisher","first-page":"3999","DOI":"10.4049\/jimmunol.148.12.3999","volume":"148","author":"JY Lin","year":"1992","unstructured":"Lin JY, Chadee K (1992) Macrophage cytotoxicity against Entamoeba histolytica trophozoites is mediated by nitric oxide from L-arginine. J Immunol 148:3999\u20134005","journal-title":"J Immunol"},{"key":"780_CR12","first-page":"243","volume":"17","author":"M L\u00f3pez-Osuna","year":"1986","unstructured":"L\u00f3pez-Osuna M, Contreras BA, Kretschmer RR (1986) In vitro studies of the interaction of polimorphonuclear leucocytes and Entamoeba histolytica. Arch Invest Med 17:243\u2013246","journal-title":"Arch Invest Med"},{"key":"780_CR13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","volume":"15","author":"J MacMicking","year":"1997","unstructured":"MacMicking J, Xie QW, Nathan C (1997) Nitric oxide and macrophage function. Annu Rev Immunol 15:323\u2013335","journal-title":"Annu Rev Immunol"},{"key":"780_CR14","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.4049\/jimmunol.150.8.3478","volume":"150","author":"JHJ Martin","year":"1993","unstructured":"Martin JHJ, Edwards SW (1993) Changes in mechanisms of monocyte-macrophages mediated cytotoxicity during culture. J Immunol 150:3478\u20133486","journal-title":"J Immunol"},{"key":"780_CR15","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1748-1716.1992.tb09359.x","volume":"145","author":"S Moncada","year":"1992","unstructured":"Moncada S (1992) The L-arginine: nitric oxide pathway. Acta Physiol Scand 145:201\u2013227","journal-title":"Acta Physiol Scand"},{"key":"780_CR16","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","volume":"329","author":"S Moncada","year":"1993","unstructured":"Moncada S, Higgs A (1993) The L-arginine nitric oxide pathway. N Engl J Med 329:2002\u20132007","journal-title":"N Engl J Med"},{"key":"780_CR17","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0165-2478(95)02444-1","volume":"48","author":"B Mridula","year":"1995","unstructured":"Mridula B, Parissa F (1995) Proinflammatory cytokines can significantly induce human mononuclear phagocytes to produce nitric oxide by a cell maturation-dependent process. Immunol Lett 48:59\u201364","journal-title":"Immunol Lett"},{"key":"780_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0165-2478(92)90090-B","volume":"33","author":"MA Mu\u00f1oz-Fern\u00e1ndez","year":"1992","unstructured":"Mu\u00f1oz-Fern\u00e1ndez MA, Fern\u00e1ndez MA, Fresno M (1992) Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-\u03b1 and IFN-\u03b3 through a nitric oxide-dependent mechanism. Immunol Lett 33:35\u201340","journal-title":"Immunol Lett"},{"key":"780_CR19","unstructured":"P\u00e9rez-Tamayo R, Brandt H (1971) Amebiasis. In: Marcial-Rojas (ed) Pathology of protozoan and helminthic diseases. Williams and Wilkins, Baltimore, pp 145\u2013188"},{"key":"780_CR20","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1084\/jem.166.6.1734","volume":"166","author":"SG Reed","year":"1987","unstructured":"Reed SG, Nathan CF, Phil DL (1987) Recombinant granulocyte\/ macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and releases hydrogen peroxide: comparison with interferon-gamma. J Exp Med 166:1734\u20131746","journal-title":"J Exp Med"},{"key":"780_CR21","first-page":"157","volume":"23","author":"G Rico","year":"1992","unstructured":"Rico G, D\u00edaz-Guerra O, Gim\u00e9nez-Scherer JA, Kretschmer R (1992) Effect of the monocyte locomotion inhibitory factor (MLIF) produced by Entamoeba histolytica upon the respiratory burst of human leucocytes. Arch Med Res 23 [Suppl]:157\u2013159","journal-title":"Arch Med Res"},{"key":"780_CR22","first-page":"233","volume":"28","author":"G Rico","year":"1997","unstructured":"Rico G, Kretschmer R (1997) The monocyte locomotion inhibitory factor (MLIF) produced by axenically grown Entamoeba histolytica fails to affect the locomotion and the respiratory burst of human eosinophils in vitro. Arch Med Res 28 [Suppl]:233\u2013234","journal-title":"Arch Med Res"},{"key":"780_CR23","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s004360050441","volume":"84","author":"G Rico","year":"1998","unstructured":"Rico G, Arellano J, Kretschmer R (1998) The human monocyte locomotion inhibitory factor (MLIF) produced by Entamoeba histolytica does not inhibit the locomotion of human eosinophils. Parasitol Res 84:522\u2013523","journal-title":"Parasitol Res"},{"key":"780_CR24","doi-asserted-by":"crossref","unstructured":"Roos D, De Boer M (1986) Purification and cryopreservation of phagocytes from human blood. In: Disabato G (ed) Methods of enzymology. Academic Press, New York, pp 225\u2013233","DOI":"10.1016\/S0076-6879(86)32010-X"},{"key":"780_CR25","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1172\/JCI111998","volume":"76","author":"RA Salata","year":"1985","unstructured":"Salata RA, Pearson RD, Ravdin JI (1985) Interaction of human leucocytes and Entamoeba histolytica. Killing of virulent amoebae by the activated macrophage. J Clin Invest 76:491\u2013499","journal-title":"J Clin Invest"},{"key":"780_CR26","unstructured":"Sep\u00falveda B, Martinez Palomo A (1982) Immunology of amebiasis by E. histolytica. In: Cohen S, Warren KS (eds) Immunology of parasitic diseases. Blackwell, Oxford"},{"key":"780_CR27","unstructured":"Siegel S (1956) Non-parametric statistics for behavioral sciences. McGraw Hill, New York"},{"key":"780_CR28","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1084\/jem.183.4.1501","volume":"183","author":"S Stenger","year":"1996","unstructured":"Stenger S, Donhauser N, Thuring H, Rollinghoff M, Bogdan C (1996) Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase. J Exp Med 183:1501\u20131514","journal-title":"J Exp Med"},{"key":"780_CR29","first-page":"112","volume":"130","author":"V Tsutsumi","year":"1988","unstructured":"Tsutsumi V, Mart\u00ednez-Palomo A (1988) Inflammatory reaction in experimental hepatic amebiasis. An ultrastructural study. Am J Pathol 130:112\u2013119","journal-title":"Am J Pathol"},{"key":"780_CR30","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1365-3024.1998.00128.x","volume":"20","author":"C Velazquez","year":"1997","unstructured":"Velazquez C, Shibayama SM, Aguirre GJ, Tsutsumi V, Calder\u00f3n J (1997) Role of neutrophil in innate resistance to Entamoeba histolytica liver infection in mice. Parasite Immunol 20:255\u2013262","journal-title":"Parasite Immunol"},{"key":"780_CR31","first-page":"601","volume":"83","author":"W Wang","year":"1994","unstructured":"Wang W, Keller K, Chadee K (1994) Entamoeba histolytica modulates the nitric oxide synthase gene and nitric oxide production by macrophages for cytotoxicity against amoebae and tumor cells. Immunology 83:601\u2013610","journal-title":"Immunology"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-002-0780-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-002-0780-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-002-0780-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-002-0780-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T06:05:59Z","timestamp":1700546759000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-002-0780-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,25]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["780"],"URL":"https:\/\/doi.org\/10.1007\/s00436-002-0780-7","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,25]]},"assertion":[{"value":"16 April 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2003","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}