{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:59:39Z","timestamp":1790049579725,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2006,12,19]],"date-time":"2006-12-19T00:00:00Z","timestamp":1166486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1007\/s00436-006-0378-6","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T14:43:46Z","timestamp":1166453026000},"page":"1091-1104","source":"Crossref","is-referenced-by-count":32,"title":["Fasciola hepatica: ultrastructural effects of a combination of triclabendazole and clorsulon against mature fluke"],"prefix":"10.1007","volume":"100","author":[{"given":"M.","family":"Meaney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Allister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"McKinstry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. P.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Fairweather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,12,19]]},"reference":[{"key":"378_CR1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0001-706X(03)00043-3","volume":"86","author":"M Albonico","year":"2003","unstructured":"Albonico M (2003) Methods to sustain drug efficacy in helminth control programmes. Acta Trop 86:233\u2013242","journal-title":"Acta Trop"},{"key":"378_CR2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0169-4758(95)80117-0","volume":"11","author":"EH Barnes","year":"1995","unstructured":"Barnes EH, Dobson RJ, Barger IA (1995) Worm control and anthelmintic resistance: adventures with a model. Parasitol Today 11:56\u201363","journal-title":"Parasitol Today"},{"key":"378_CR3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00436-001-0519-x","volume":"88","author":"N Casado","year":"2002","unstructured":"Casado N, Moreno MJ, Urrea-Paris MA, Rodriguez-Caabeiro F (2002) Could ivermectin have a synergic effect with albendazole in hydatidosis therapy? 1. In vitro studies. Parasitol Res 88:153\u2013159","journal-title":"Parasitol Res"},{"key":"378_CR4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.vetpar.2005.10.008","volume":"135","author":"B Elitok","year":"2006","unstructured":"Elitok B, Elitok OM, Kabu M (2006) Field trial of comparative efficacy of four fasciolicides against natural liver fluke infections in cattle. Vet Parasitol 135:279\u2013285","journal-title":"Vet Parasitol"},{"key":"378_CR5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1079\/JOH2005298","volume":"79","author":"I Fairweather","year":"2005","unstructured":"Fairweather I (2005) Triclabendazole: new skills to unravel an old(ish) enigma. J Helminthol 79:227\u2013234","journal-title":"J Helminthol"},{"key":"378_CR6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/tvjl.1999.0377","volume":"158","author":"I Fairweather","year":"1999","unstructured":"Fairweather I, Boray JC (1999) Fasciolicides: efficacy, actions, resistance and its management. Vet J 158:81\u2013112","journal-title":"Vet J"},{"key":"378_CR7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2885.1987.tb00078.x","volume":"10","author":"DR Hennessy","year":"1987","unstructured":"Hennessy DR, Lacey E, Steel JW, Prichard RK (1987) The kinetics of triclabendazole disposition in sheep. J Vet Pharmacol Ther 10:64\u201372","journal-title":"J Vet Pharmacol Ther"},{"key":"378_CR8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/00480169.2004.36430","volume":"52","author":"PL Hughes","year":"2004","unstructured":"Hughes PL, McKenna PB, Murphy A (2004) Resistance to moxidectin and abamectin in naturally acquired Ostertagia circumcincta infections in sheep. N Z Vet J 52:202\u2013204","journal-title":"N Z Vet J"},{"key":"378_CR9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.vetpar.2004.10.019","volume":"128","author":"LF Jambre Le","year":"2005","unstructured":"Le Jambre LF, Geoghegan J, Lyndal-Murphy M (2005) Characterisation of moxidectin resistant Trichostrongylus colubriformis and Haemonchus contortus. Vet Parasitol 128:83\u201390","journal-title":"Vet Parasitol"},{"key":"378_CR10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.rvsc.2004.05.008","volume":"78","author":"MA McCoy","year":"2005","unstructured":"McCoy MA, Fairweather I, Brennan GP, Kenny JM, Forbes AB (2005) The efficacy of nitroxynil and triclabendazole administered synchronously against juvenile triclabendazole-resistant Fasciola hepatica in sheep. Res Vet Sci 78:33","journal-title":"Res Vet Sci"},{"key":"378_CR11","unstructured":"Meaney M (2005) The morphological response of Fasciola species to clorsulon and triclabendazole, their uptake and synergistic interaction. Ph.D. Thesis, The Queen\u2019s University of Belfast"},{"key":"378_CR12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00436-003-0863-0","volume":"91","author":"M Meaney","year":"2003","unstructured":"Meaney M, Fairweather I, Brennan GP, McDowell LSL, Forbes AB (2003) Fasciola hepatica: effects of the fasciolicide clorsulon in vitro and in vivo on the tegumental surface, and a comparison of the effects on young- and old-mature flukes. Parasitol Res 91:238\u2013250","journal-title":"Parasitol Res"},{"key":"378_CR13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s00436-003-1036-x","volume":"92","author":"M Meaney","year":"2004","unstructured":"Meaney M, Fairweather I, Brennan GP, Forbes AB (2004) Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res 92:232\u2013241","journal-title":"Parasitol Res"},{"key":"378_CR14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00436-004-1272-8","volume":"95","author":"M Meaney","year":"2005","unstructured":"Meaney M, Haughey S, Brennan GP, Fairweather I (2005) Ultrastructural observations on oral ingestion and trans-tegumental uptake of clorsulon by the liver fluke, Fasciola hepatica. Parasitol Res 95:201\u2013212","journal-title":"Parasitol Res"},{"key":"378_CR15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00436-006-0222-z","volume":"99","author":"M Meaney","year":"2006","unstructured":"Meaney M, Allister J, McKinstry B, McLaughlin K, Brennan GP, Forbes AB, Fairweather I (2006) Fasciola hepatica: morphological effects of a combination of triclabendazole and clorsulon against mature fluke. Parasitol Res 99:609\u2013621","journal-title":"Parasitol Res"},{"key":"378_CR16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00436-003-0889-3","volume":"90","author":"H Mehlhorn","year":"2003","unstructured":"Mehlhorn H, Hanser E, Harder A, Hansen O, Mencke N, Schaper R (2003) A light and electron microscopic study on the synergistic effect of pyrantel and the febantel metabolite febendazole on adult Toxocara canis in vitro. Parasitol Res 90:305\u2013313","journal-title":"Parasitol Res"},{"key":"378_CR17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s004360000334","volume":"87","author":"MJ Moreno","year":"2001","unstructured":"Moreno MJ, Urrea-Paris MA, Casado N, Rodriguez-Caabeiro F (2001) Praziquantel and albendazole in the combined treatment of experimental hydatid disease. Parasitol Res 87:235\u2013238","journal-title":"Parasitol Res"},{"key":"378_CR18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00436-002-0623-6","volume":"88","author":"MJ Moreno","year":"2002","unstructured":"Moreno MJ, Casado N, Urrea-Paris MA, Rodriguez-Caabeiro F (2002) Could ivermectin have a synergic effect with albendazole in hydatidosis therapy? 2. In vivo studies. Parasitol Res 88:563\u2013567","journal-title":"Parasitol Res"},{"key":"378_CR19","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/PL00008530","volume":"86","author":"F Nicolay","year":"2000","unstructured":"Nicolay F, Harder A, von Samson-Himmelstjerna G, Mehlhorn H (2000) Synergistic action of a cyclic depsipeptide and piperazine on nematodes. Parasitol Res 86:982\u2013992","journal-title":"Parasitol Res"},{"key":"378_CR20","first-page":"213","volume":"126","author":"RJ Richards","year":"1990","unstructured":"Richards RJ, Bowen FL, Essenwein F, Steiger RF, Buscher G (1990) The efficacy of triclabendazole and other anthelmintics against Fasciola hepatica in controlled studies in cattle. Vet Rec 126:213\u2013216","journal-title":"Vet Rec"},{"key":"378_CR21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S003118200100124X","volume":"124","author":"MW Robinson","year":"2002","unstructured":"Robinson MW, Trudgett A, Hoey EM, Fairweather I (2002) Triclabendazole-resistant Fasciola hepatica: \u03b2-tubulin and response to in vitro treatment with triclabendazole. Parasitology 124:325\u2013338","journal-title":"Parasitology"},{"key":"378_CR22","doi-asserted-by":"crossref","unstructured":"Sangster NC (2001) Managing parasiticide resistance. Vet Parasitol 98:89\u2013109","DOI":"10.1016\/S0304-4017(01)00425-3"},{"key":"378_CR23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2307\/3280320","volume":"65","author":"MD Schulman","year":"1979","unstructured":"Schulman MD, Valentino D, Cifelli S, Lang R, Ostlind DA (1979) A pharmacokinetic basis for the efficacy of 4-amino-6-trichlororoethenyl-1,3-benzenedisulfonamide against Fasciola hepatica in the rat. J Parasitol 65:555\u2013561","journal-title":"J Parasitol"},{"key":"378_CR24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ijpara.2004.01.006","volume":"34","author":"M Stettler","year":"2004","unstructured":"Stettler M, Rossignol JF, Fink R, Walker M, Gottstein B, Merli M, Theurillat R, Thormann W, Dricot E, Segers R, Hemphill A (2004) Secondary and primary murine alveolar echinococcosis: combined albendazole\/nitazoxanide chemotherapy exhibits profound anti-parasitic activiy. Int J Parasitol 34:615\u2013624","journal-title":"Int J Parasitol"},{"key":"378_CR25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S0031182000077428","volume":"108","author":"AW Stitt","year":"1994","unstructured":"Stitt AW, Fairweather I (1994) The effect of the sulphoxide metabolite of triclabendazole (\u2018Fasinex\u2019) on the tegument of mature and immature stages of the liver fluke, Fasciola hepatica. Parasitology 108:555\u2013567","journal-title":"Parasitology"},{"key":"378_CR26","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/PL00008526","volume":"86","author":"MA Urrea-Paris","year":"2000","unstructured":"Urrea-Paris MA, Moreno MJ, Casado N, Rodriguez-Caabeiro F (2000) In vitro effect of praziquantel and albendazole combination therapy on the larval stage of Echinococcus granulosus. Parasitol Res 86:957\u2013964","journal-title":"Parasitol Res"},{"key":"378_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/14656566.5.2.263","volume":"5","author":"J Utzinger","year":"2004","unstructured":"Utzinger J, Keiser J (2004) Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control. Expert Opin Pharmacother 5:1\u201323","journal-title":"Expert Opin Pharmacother"},{"key":"378_CR28","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1128\/AAC.47.5.1487-1495.2003","volume":"47","author":"J Utzinger","year":"2003","unstructured":"Utzinger J, Keiser J, Shuhua X, Tanner M, Singer BH (2003) Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials. Antimicrob Agents Chemother 47:1487\u20131495","journal-title":"Antimicrob Agents Chemother"},{"key":"378_CR29","unstructured":"Wrigley J (2005) Combination drenches to combat parasite resistance in sheep. In: Proceedings of the 20th International Conference of the WAAVP, Christchurch 2005, pp 73"},{"key":"378_CR30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/00480169.2006.36604","volume":"54","author":"J Wrigley","year":"2006","unstructured":"Wrigley J, McArthur M, McKenna PB, Mariadass B (2006) Resistance to a triple combination of broad-spectrum anthelmintics in naturally-acquired Ostertagia circumcincta infections in sheep. N Z Vet J 54:47\u201349","journal-title":"N Z Vet J"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-006-0378-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-006-0378-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-006-0378-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T22:55:28Z","timestamp":1559084128000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-006-0378-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,19]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["378"],"URL":"https:\/\/doi.org\/10.1007\/s00436-006-0378-6","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,19]]}}}