{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:56:55Z","timestamp":1757703415001},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T00:00:00Z","timestamp":1234828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1007\/s00436-009-1341-0","type":"journal-article","created":{"date-parts":[[2009,2,16]],"date-time":"2009-02-16T13:23:48Z","timestamp":1234790628000},"page":"1407-1416","source":"Crossref","is-referenced-by-count":28,"title":["Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine"],"prefix":"10.1007","volume":"104","author":[{"given":"Chao-Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Hua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrg","family":"Utzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Chollet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Tanner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,2,17]]},"reference":[{"key":"1341_CR1","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1371\/journal.pmed.0040014","volume":"4","author":"MH Abdulla","year":"2007","unstructured":"Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR (2007) Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med 4:e14","journal-title":"PLoS Med"},{"key":"1341_CR2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cbpa.2007.05.031","volume":"11","author":"CR Caffrey","year":"2007","unstructured":"Caffrey CR (2007) Chemotherapy of schistosomiasis: present and future. Curr Opin Chem Biol 11:433\u2013439","journal-title":"Curr Opin Chem Biol"},{"key":"1341_CR3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.actatropica.2005.07.011","volume":"96","author":"MG Chen","year":"2005","unstructured":"Chen MG (2005) Use of praziquantel for clinical treatment and morbidity control of schistosomiasis japonica in China: a review of 30\u00a0years\u2019 experience. Acta Trop 96:168\u2013176","journal-title":"Acta Trop"},{"key":"1341_CR4","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00436-002-0751-z","volume":"90","author":"D Cioli","year":"2003","unstructured":"Cioli D, Pica-Mattoccia L (2003) Praziquantel. Parasitol Res 90:S3\u2013S9","journal-title":"Parasitol Res"},{"key":"1341_CR5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.pt.2008.05.006","volume":"24","author":"D Cioli","year":"2008","unstructured":"Cioli D, Valle C, Angelucci F, Miele AE (2008) Will new antischistosomal drugs finally emerge? Trends Parasitol 24:379\u2013382","journal-title":"Trends Parasitol"},{"key":"1341_CR6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/QCO.0b013e328318978f","volume":"21","author":"MJ Doenhoff","year":"2008","unstructured":"Doenhoff MJ, Cioli D, Utzinger J (2008) Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr Opin Infect Dis 21:659\u2013667","journal-title":"Curr Opin Infect Dis"},{"key":"1341_CR7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.pt.2003.09.005","volume":"19","author":"A Fenwick","year":"2003","unstructured":"Fenwick A, Savioli L, Engels D, Bergquist NR, Todd MH (2003) Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends Parasitol 19:509\u2013515","journal-title":"Trends Parasitol"},{"key":"1341_CR8","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI34261","volume":"118","author":"PJ Hotez","year":"2008","unstructured":"Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J (2008) Helminth infections: the great neglected tropical diseases. J Clin Invest 118:1311\u20131321","journal-title":"J Clin Invest"},{"key":"1341_CR9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/QCO.0b013e3282f19ec4","volume":"20","author":"J Keiser","year":"2007","unstructured":"Keiser J, Utzinger J (2007a) Artemisinins and synthetic trioxolanes for treatment of helminth infections. Curr Opin Infect Dis 20:605\u2013612","journal-title":"Curr Opin Infect Dis"},{"key":"1341_CR10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.pt.2007.07.012","volume":"23","author":"J Keiser","year":"2007","unstructured":"Keiser J, Utzinger J (2007b) Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes. Trends Parasitol 23:555\u2013562","journal-title":"Trends Parasitol"},{"key":"1341_CR11","doi-asserted-by":"crossref","first-page":"e350","DOI":"10.1371\/journal.pntd.0000350","volume":"3","author":"J Keiser","year":"2009","unstructured":"Keiser J, Chollet J, Xiao SH, Mei JY, Jiao PY, Utzinger J, Tanner M (2009) Mefloquine-an aminoalcohol with promising antischistosomal properties in mice. PLoS Negl Trop Dis 3:e350","journal-title":"PLoS Negl Trop Dis"},{"key":"1341_CR12","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1371\/journal.pmed.0040206","volume":"4","author":"AN Kuntz","year":"2007","unstructured":"Kuntz AN, Davioud-Charvet E, Sayed AA, Califf LL, Dessolin J, Arn\u00e9r ES, Williams DL (2007) Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med 4:e206","journal-title":"PLoS Med"},{"key":"1341_CR13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2307\/3278572","volume":"59","author":"JD Lawrence","year":"1973","unstructured":"Lawrence JD (1973) The ingestion of red blood cell by Schistosoma mansoni. J Parasitol 59:50\u201363","journal-title":"J Parasitol"},{"key":"1341_CR14","first-page":"654","volume":"6","author":"RS Rozman","year":"1978","unstructured":"Rozman RS, Molek NA, Koby R (1978) The absorption, distribution, and excretion in mice of the antimalarial mefloquine. Drug Metab Dispos 6:654\u2013658","journal-title":"Drug Metab Dispos"},{"key":"1341_CR15","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0014-4894(86)90184-0","volume":"61","author":"AA Sabah","year":"1986","unstructured":"Sabah AA, Fletcher C, Webbe G, Doenhoff MJ (1986) Schistosoma mansoni: chemotherapy of infections of different ages. Exp Parasitol 61:294\u2013303","journal-title":"Exp Parasitol"},{"key":"1341_CR16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nm1737","volume":"14","author":"AA Sayed","year":"2008","unstructured":"Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL (2008) Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med 14:407\u2013412","journal-title":"Nat Med"},{"key":"1341_CR17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00934012","volume":"69","author":"MK Shaw","year":"1983","unstructured":"Shaw MK, Erasmus DA (1983) Schistosoma mansoni: the effects of a subcurative dose of praziquantel on the ultrastructure of worms in vivo. Z Parasitenkd 69:73\u201390","journal-title":"Z Parasitenkd"},{"key":"1341_CR18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","volume":"6","author":"P Steinmann","year":"2006","unstructured":"Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J (2006) Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis 6:411\u2013425","journal-title":"Lancet Infect Dis"},{"key":"1341_CR19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1517\/14656566.5.2.263","volume":"5","author":"J Utzinger","year":"2004","unstructured":"Utzinger J, Keiser J (2004) Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control. Expert Opin Pharmacother 5:263\u2013285","journal-title":"Expert Opin Pharmacother"},{"key":"1341_CR20","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0020-7519(01)00297-1","volume":"31","author":"J Utzinger","year":"2001","unstructured":"Utzinger J, Xiao SH, N\u2019Goran EK, Bergquist R, Tanner M (2001) The potential of artemether for the control of schistosomiasis. Int J Parasitol 31:1549\u20131562","journal-title":"Int J Parasitol"},{"key":"1341_CR21","first-page":"105","volume":"8","author":"J Utzinger","year":"2007","unstructured":"Utzinger J, Xiao SH, Tanner M, Keiser J (2007) Artemisinins for schistosomiasis and beyond. Curr Opin Investig Drugs 8:105\u2013116","journal-title":"Curr Opin Investig Drugs"},{"key":"1341_CR22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tmaid.2008.06.006","volume":"6","author":"L Nassauw Van","year":"2008","unstructured":"Van Nassauw L, Toovey S, Van Op den Bosch J, Timmermans JP, Vercruysse J (2008) Schistosomicidal activity of the antimalarial drug, mefloquine, in Schistosoma mansoni-infected mice. Travel Med Infect Dis 6:253\u2013258","journal-title":"Travel Med Infect Dis"},{"key":"1341_CR23","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nature02779","volume":"430","author":"JL Vennerstrom","year":"2004","unstructured":"Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN (2004) Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430:900\u2013904","journal-title":"Nature"},{"key":"1341_CR24","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1007\/s00018-006-6071-1","volume":"63","author":"CJ Woodrow","year":"2006","unstructured":"Woodrow CJ, Krishna S (2006) Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significance. Cell Mol Life Sci 63:1586\u20131596","journal-title":"Cell Mol Life Sci"},{"key":"1341_CR25","first-page":"7","volume":"18","author":"LJ Wu","year":"1983","unstructured":"Wu LJ, Yang HZ, Yang YQ (1983) Histological and histochemical changes of Schistosoma japonicum and host liver caused by artemether. Acta Pharmaceut Sin 18:7\u201314","journal-title":"Acta Pharmaceut Sin"},{"key":"1341_CR26","first-page":"310","volume":"17","author":"SH Xiao","year":"2005","unstructured":"Xiao SH (2005) Study on prevention and cure of artemether against schistosomiasis. Chin J Schistosomiasis Cont 17:310\u2013320","journal-title":"Chin J Schistosomiasis Cont"},{"key":"1341_CR27","first-page":"305","volume":"27","author":"SH Xiao","year":"1981","unstructured":"Xiao SH, Yang YQ, Shu YS, Wang ZW (1981) Ultrastructural changes of the tegument, syncithium, vitelline cells and muscles of Schistosoma japonicum caused by pyquiton. Acta Zoo Sin 27:305\u2013309","journal-title":"Acta Zoo Sin"},{"key":"1341_CR28","first-page":"241","volume":"18","author":"SH Xiao","year":"1983","unstructured":"Xiao SH, Yang YQ, Yang HZ, Guo HF, Shao BR (1983) Observation on tegument damage of Schistosoma japonicum and penetration of host leucocytes into the worm body caused by pyquiton. Acta Pharmaceut Sin 18:241\u2013246","journal-title":"Acta Pharmaceut Sin"},{"key":"1341_CR29","first-page":"839","volume":"97","author":"SH Xiao","year":"1984","unstructured":"Xiao SH, Shao BR, Yu YG (1984a) Preliminary studies on the mode of action of pyquiton against Schistosoma japonicum. Chin Med J 97:839\u2013848","journal-title":"Chin Med J"},{"key":"1341_CR30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2307\/3281955","volume":"70","author":"SH Xiao","year":"1984","unstructured":"Xiao SH, Friedman PA, Catto BA, Webster LT Jr (1984b) Praziquantel-induced vesicle formation in the tegument of male Schistosoma mansoni is calcium dependent. J Parasitol 70:177\u2013179","journal-title":"J Parasitol"},{"key":"1341_CR31","first-page":"759","volume":"100","author":"SH Xiao","year":"1987","unstructured":"Xiao SH, Yue WJ, Yang YQ, You JQ (1987a) Susceptibility of Schistosoma japonicum of different developmental stages to praziquantel. Chin Med J 100:759\u2013768","journal-title":"Chin Med J"},{"key":"1341_CR32","first-page":"285","volume":"7","author":"SH Xiao","year":"1987","unstructured":"Xiao SH, Guo HF, You JQ, Qiu LZ (1987b) Impact on neutrophil chemotaxis induced by Schistosoma japonicum after activity of praziquantel. Shanghai J Immunol 7:285\u2013286","journal-title":"Shanghai J Immunol"},{"key":"1341_CR33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0169-4758(99)01601-4","volume":"16","author":"SH Xiao","year":"2000","unstructured":"Xiao SH, Booth M, Tanner M (2000) The prophylactic effects of artemether against Schistosoma japonicum infections. Parasitol Today 16:122\u2013126","journal-title":"Parasitol Today"},{"key":"1341_CR34","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1590\/S0074-02762002000500023","volume":"97","author":"SH Xiao","year":"2002","unstructured":"Xiao SH, Shen BG, Utzinger J, Chollet J, Tanner M (2002) Ultrastructural alterations in adult Schistosoma mansoni caused by artemether. Mem Inst Oswaldo Cruz 97:717\u2013724","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"1341_CR35","first-page":"148","volume":"22","author":"SH Xiao","year":"2004","unstructured":"Xiao SH, Guo J, Chollet J, Wu JT, Tanner M, Utzinger J (2004) Effect of artemether on Schistosoma mansoni: dose-efficacy relationship, and changes in worm morphology and histopathology. Chin J Parasitol Parasit Dis 22:148\u2013153","journal-title":"Chin J Parasitol Parasit Dis"},{"key":"1341_CR36","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1128\/AAC.01537-06","volume":"51","author":"SH Xiao","year":"2007","unstructured":"Xiao SH, Keiser J, Chollet J, Utzinger J, Dong Y, Endriss Y, Vennerstrom JL, Tanner M (2007) In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species. Antimicrob Agents Chemother 51:1440\u20131445","journal-title":"Antimicrob Agents Chemother"},{"key":"1341_CR37","first-page":"7","volume":"1","author":"YQ Yang","year":"1979","unstructured":"Yang YQ, Yang HZ, Xiao SH, Shao BR (1979) Observation on the histopathological changes of Schistosoma japonicum and host liver caused by pyquiton in experimental chemotherapy. Acta Acad Med Sin 1:7\u201312","journal-title":"Acta Acad Med Sin"},{"key":"1341_CR38","first-page":"186","volume":"6","author":"WJ Yue","year":"1985","unstructured":"Yue WJ, You JQ, Mei JY (1985) Prophylactic activity of praziquantel in animals infected with Schistosoma japonicum. Acta Pharmacol Sin 6:186\u2013188","journal-title":"Acta Pharmacol Sin"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-009-1341-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-009-1341-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-009-1341-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T20:40:32Z","timestamp":1589575232000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-009-1341-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,17]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["1341"],"URL":"https:\/\/doi.org\/10.1007\/s00436-009-1341-0","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,17]]}}}