{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:26:49Z","timestamp":1760783209023},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T00:00:00Z","timestamp":1258502400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s00436-009-1649-9","type":"journal-article","created":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T04:31:35Z","timestamp":1258432295000},"page":"311-323","source":"Crossref","is-referenced-by-count":18,"title":["Fasciola hepatica: disruption of spermatogenesis by the fasciolicide compound alpha"],"prefix":"10.1007","volume":"106","author":[{"given":"Maeve","family":"McConville","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E. B.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard P.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillary W. J.","family":"Edgar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"McConnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Hern\u00e1ndez-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Fairweather","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,11,18]]},"reference":[{"key":"1649_CR1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/vr.113.14.315","volume":"113","author":"JC Boray","year":"1983","unstructured":"Boray JC, Crowfoot PD, Strong MB, Allison JR, Schellenbaum M, Von Orelli M, Sarasin G (1983) Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole. Vet Rec 113:315\u2013317","journal-title":"Vet Rec"},{"key":"1649_CR2","first-page":"297","volume":"7","author":"B Dawes","year":"1966","unstructured":"Dawes B (1966a) Experimental fascioliasis: some effects on Fasciola hepatica of treatment of rat hosts with Bithionol (\u201cActamer\u201d). Helminthologia 7:297\u2013307","journal-title":"Helminthologia"},{"key":"1649_CR3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/209424a0","volume":"209","author":"B Dawes","year":"1966","unstructured":"Dawes B (1966b) Some apparent effects of bithionol (\u201cActamer\u201d) on Fasciola hepatica. Nature 209:424\u2013425","journal-title":"Nature"},{"key":"1649_CR4","first-page":"97","volume":"8","author":"B Dawes","year":"1967","unstructured":"Dawes B (1967) Experimental fascioliasis in small mammals: apparent effects of bithionol on Fasciola hepatica in rats. Helminthologia 8:97\u2013101","journal-title":"Helminthologia"},{"key":"1649_CR5","first-page":"575","volume":"14","author":"B Dawes","year":"1968","unstructured":"Dawes B (1968) Further evidence on the effect of bithionol (\u201cActamer\u201d) on Fasciola hepatica. Wiad Parazytol 14:575\u2013577","journal-title":"Wiad Parazytol"},{"key":"1649_CR6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0031182008005222","volume":"136","author":"C Devine","year":"2009","unstructured":"Devine C, Brennan GP, Lanusse CE, Alvarez LI, Trudgett A, Hoey E, Fairweather I (2009) Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica. Parasitology 136:183\u2013192","journal-title":"Parasitology"},{"key":"1649_CR7","doi-asserted-by":"crossref","unstructured":"Devine C, Brennan GP, Lanusse CE, Alvarez LI, Trudgett A, Hoey E, Fairweather I (2010) Inhibition of cytochrome P450-mediated metabolism enhances ex vivo susceptibility of Fasciola hepatica to triclabendazole. Parasitology (in press)","DOI":"10.1017\/S003118200999148X"},{"key":"1649_CR8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0022149X09321173","volume":"83","author":"I Fairweather","year":"2009","unstructured":"Fairweather I (2009) Triclabendazole progress report, 2005\u20132009: an advancement of learning? J Helminthol 83:139\u2013150","journal-title":"J Helminthol"},{"key":"1649_CR9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/tvjl.1999.0377","volume":"158","author":"I Fairweather","year":"1999","unstructured":"Fairweather I, Boray JC (1999) Fasciolicides: efficacy, actions, resistance and its management. Vet J 158:81\u2013112","journal-title":"Vet J"},{"key":"1649_CR10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1017\/S003118200300427X","volume":"128","author":"HL Fletcher","year":"2004","unstructured":"Fletcher HL, Hoey EM, Orr N, Trudgett A, Fairweather I, Robinson MW (2004) The occurrence and significance of triploidy in the liver fluke, Fasciola hepatica. Parasitology 128:69\u201372","journal-title":"Parasitology"},{"key":"1649_CR11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.vetpar.2008.04.011","volume":"155","author":"L Halferty","year":"2008","unstructured":"Halferty L, Brennan GP, Hanna REB, Edgar HW, Meaney M, McConville M, Trudgett A, Hoey L, Fairweather I (2008) Tegumental surface changes in juvenile Fasciola hepatica in response to treatment in vivo with triclabendazole. Vet Parasitol 155:49\u201358","journal-title":"Vet Parasitol"},{"key":"1649_CR12","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.vetpar.2008.10.007","volume":"159","author":"L Halferty","year":"2009","unstructured":"Halferty L, Brennan GP, Trudgett A, Hoey L, Fairweather I (2009) Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica. Vet Parasitol 159:126\u2013138","journal-title":"Vet Parasitol"},{"key":"1649_CR13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.vetpar.2006.06.025","volume":"142","author":"REB Hanna","year":"2006","unstructured":"Hanna REB, Cromie L, Taylor SM, Couper A (2006) The effect of a parenteral ivermectin\/closantel injection on the growth and reproductive development of early immature Fasciola hepatica in cattle. Vet Parasitol 142:78\u201390","journal-title":"Vet Parasitol"},{"key":"1649_CR14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.vetpar.2008.07.022","volume":"157","author":"REB Hanna","year":"2008","unstructured":"Hanna REB, Edgar H, Moffett D, McConnell S, Fairweather I, Brennan GP, Hoey TA, EM CL, Taylor SM, Daniel R (2008) Fasciola hepatica: histology of the testis in egg-producing adults of several laboratory-maintained isolates of flukes grown to maturity in cattle and sheep and in flukes from naturally infected hosts. Vet Parasitol 157:222\u2013234","journal-title":"Vet Parasitol"},{"key":"1649_CR15","doi-asserted-by":"crossref","unstructured":"Hanna REB, Edgar HWJ, McConnell S, Toner E, McConville M, Brennan GP, Devine C, Flanagan A, Halferty L, Meaney M, Shaw L, Moffett D, McCoy M, Fairweather I (2010) Fasciola hepatica: histological changes in the reproductive structures of triclabendazole (TCBZ)-sensitive and TCBZ-resistant flukes collected from experimentally-infected sheep one to four days after treatment with TCBZ and the related benzimidazole derivative, compound alpha. Vet Parasitol (in press)","DOI":"10.1016\/j.vetpar.2009.11.014"},{"key":"1649_CR16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1751-0813.1969.tb05012.x","volume":"45","author":"FA Happich","year":"1969","unstructured":"Happich FA, Boray JC (1969) Quantitative diagnosis of chronic fascioliosis. 2. The estimation of daily total egg production of Fasciola hepatica and the number of adult flukes in sheep by faecal egg counts. Aust Vet J 45:329\u2013331","journal-title":"Aust Vet J"},{"key":"1649_CR17","first-page":"291","volume":"28","author":"VF Ibarra","year":"1997","unstructured":"Ibarra VF, Garc\u00eda SE, Fern\u00e1ndez RM, Vera MY, Castillo BR, Hern\u00e1ndez CA (1997a) Eficacia fasciolicida de dos compuestos de s\u00edntesis qu\u00edmica in vitro e in vivo en ovinos. Vet M\u00e9x 28:291\u2013296","journal-title":"Vet M\u00e9x"},{"key":"1649_CR18","first-page":"297","volume":"28","author":"VF Ibarra","year":"1997","unstructured":"Ibarra VF, Vera MY, Hern\u00e1ndez CA, Castillo BR (1997b) Eficacia fasciolicida del compuesto \u201calfa\u201d contra estadios juveniles y adultos en ovinos. Vet M\u00e9x 28:297\u2013301","journal-title":"Vet M\u00e9x"},{"key":"1649_CR19","first-page":"47","volume":"31","author":"VF Ibarra","year":"2000","unstructured":"Ibarra VF, Montenegro CN, Flores CJ, Hern\u00e1ndez CA, Castillo BR (2000) Evaluac\u00edon de cuatro veh\u00edculos para formular un fasciolicida experimental. Vet M\u00e9x 31:47\u201351","journal-title":"Vet M\u00e9x"},{"key":"1649_CR20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.vetpar.2003.12.005","volume":"120","author":"F Ibarra","year":"2004","unstructured":"Ibarra F, Vera Y, Quiroz H, Cant\u00f3 J, Castillo R, Hern\u00e1ndez A, Ochoa P (2004) Determination of the effective dose of an experimental fasciolicide in naturally and experimentally infected cattle. Vet Parasitol 120:65\u201374","journal-title":"Vet Parasitol"},{"key":"1649_CR21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.vetpar.2009.03.027","volume":"163","author":"F Kenyon","year":"2009","unstructured":"Kenyon F, Sargison ND, Skuce PJ, Jackson F (2009) Sheep helminth parasitic disease in south eastern Scotland arising as a possible consequence of climate change. Vet Parasitol 163:293\u2013297","journal-title":"Vet Parasitol"},{"key":"1649_CR22","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.ijpara.2005.07.010","volume":"35","author":"S Mas-Coma","year":"2005","unstructured":"Mas-Coma S, Bargues MD, Valero MA (2005) Fascioliasis and other plant-borne trematode zoonoses. Int J Parasitol 35:1255\u20131278","journal-title":"Int J Parasitol"},{"key":"1649_CR23","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vetpar.2009.03.024","volume":"163","author":"S Mas-Coma","year":"2009","unstructured":"Mas-Coma S, Valero MA, Bargues MD (2009) Climate change effects on trematodiases, with emphasis on zoonotic fascioliasis and schistosomiasis. Vet Parasitol 163:264\u2013280","journal-title":"Vet Parasitol"},{"key":"1649_CR24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0031182006000114","volume":"133","author":"M McConville","year":"2006","unstructured":"McConville M, Brennan GP, McCoy M, Castillo R, Hern\u00e1ndez-Campos A, Ibarra F, Fairweather I (2006) Adult triclabendazole-resistant Fasciola hepatica: surface and subsurface tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha. Parasitology 133:195\u2013208","journal-title":"Parasitology"},{"key":"1649_CR25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00436-006-0270-4","volume":"100","author":"M McConville","year":"2007","unstructured":"McConville M, Brennan GP, McCoy M, Castillo R, Hern\u00e1ndez-Campos A, Ibarra F, Fairweather I (2007) Immature triclabendazole-resistant Fasciola hepatica: tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha. Parasitol Res 100:365\u2013377","journal-title":"Parasitol Res"},{"key":"1649_CR26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.vetpar.2008.01.022","volume":"153","author":"M McConville","year":"2008","unstructured":"McConville M, Brennan GP, Flanagan A, Edgar HWJ, McCoy M, Castillo R, Hern\u00e1ndez-Campos A, Fairweather I (2008) Surface and internal tegumental changes in juvenile Fasciola hepatica following treatment in vivo with the experimental fasciolicide, compound alpha. Vet Parasitol 153:52\u201364","journal-title":"Vet Parasitol"},{"key":"1649_CR27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.vetpar.2009.02.004","volume":"162","author":"M McConville","year":"2009","unstructured":"McConville M, Brennan GP, Flanagan A, Edgar HWJ, Hanna REB, McCoy M, Gordon AW, Castillo R, Hern\u00e1ndez-Campos A, Fairweather I (2009a) An evaluation of the efficacy of compound alpha and triclabendazole against two isolates of Fasciola hepatica. Vet Parasitol 162:75\u201388","journal-title":"Vet Parasitol"},{"key":"1649_CR28","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00436-009-1453-6","volume":"105","author":"M McConville","year":"2009","unstructured":"McConville M, Brennan GP, Flanagan A, Hanna REB, Edgar HWJ, Castillo R, Hern\u00e1ndez-Campos A, Fairweather I (2009b) Surface changes in adult Fasciola hepatica following treatment in vivo with the experimental fasciolicide, compound alpha. Parasitol Res 105:757\u2013767","journal-title":"Parasitol Res"},{"key":"1649_CR29","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1017\/S0031182009005678","volume":"136","author":"M McConville","year":"2009","unstructured":"McConville M, Brennan GP, Edgar HWJ, Castillo R, Hern\u00e1ndez-Campos A, Fairweather I (2009c) Ultrastructural changes to the tegumental system and the gastrodermal cells in adult Fasciola hepatica following in vivo treatment with the experimental fasciolicide, compound alpha. Parasitology 136:655\u2013680","journal-title":"Parasitology"},{"key":"1649_CR30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.rvsc.2004.05.008","volume":"78","author":"MA McCoy","year":"2005","unstructured":"McCoy MA, Fairweather I, Brennan GP, Kenny JM, Ellison S, Forbes AF (2005) The efficacy of nitroxynil and triclabendazole administered synchronously against juvenile triclabendazole-resistant Fasciola hepatica in sheep. Res Vet Sci 78:33","journal-title":"Res Vet Sci"},{"key":"1649_CR31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00436-006-0222-z","volume":"99","author":"M Meaney","year":"2006","unstructured":"Meaney M, Allister J, McKinstry B, McLaughlin K, Brennan GP, Forbes AB, Fairweather I (2006) Fasciola hepatica: morphological effects of a combination of triclabendazole and clorsulon against mature fluke. Parasitol Res 99:609\u2013621","journal-title":"Parasitol Res"},{"key":"1649_CR32","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00436-006-0378-6","volume":"100","author":"M Meaney","year":"2007","unstructured":"Meaney M, Allister J, McKinstry B, McLaughlin K, Brennan GP, Forbes AB, Fairweather I (2007) Fasciola hepatica: ultrastructural effects of a combination of triclabendazole and clorsulon against mature fluke. Parasitol Res 100:1091\u20131104","journal-title":"Parasitol Res"},{"key":"1649_CR33","first-page":"55","volume":"33","author":"FN Rivera","year":"2002","unstructured":"Rivera FN, Ibarra VF, Olazar\u00e0n JS, Vera MY, Castillo BR, Hern\u00e1ndez CA (2002) Efficacy of 5-chloro-2-methylthio-6-(1-naftiloxi)-ih-benzimidazole against different stages of Fasciola hepatica in Pelibuey sheep. Vet M\u00e9x 33:55\u201361","journal-title":"Vet M\u00e9x"},{"key":"1649_CR34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S003118200100124X","volume":"124","author":"MW Robinson","year":"2002","unstructured":"Robinson MW, Trudgett A, Hoey EM, Fairweather I (2002) Triclabendazole-resistant Fasciola hepatica: \u03b2-tubulin and response to in vitro treatment with triclabendazole. Parasitology 124:325\u2013338","journal-title":"Parasitology"},{"key":"1649_CR35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00389956","volume":"46","author":"BM Stammers","year":"1975","unstructured":"Stammers BM (1975a) The effects of rafoxanide and nitroxynil on the survival, growth and morphology of Fasciola hepatica in rabbits. Z Parasitenk 46:153\u2013161","journal-title":"Z Parasitenk"},{"key":"1649_CR36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00382637","volume":"47","author":"BM Stammers","year":"1975","unstructured":"Stammers BM (1975b) Disruption of spermatogenesis in Fasciola hepatica by some anthelmintics. Z Parasitenk 47:145\u2013150","journal-title":"Z Parasitenk"},{"key":"1649_CR37","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0034-5288(18)33452-0","volume":"20","author":"BM Stammers","year":"1976","unstructured":"Stammers BM (1976) The effects of nitroxynil on the survival, growth and morphology of Fasciola hepatica in sheep. Res Vet Sci 20:174\u2013179","journal-title":"Res Vet Sci"},{"key":"1649_CR38","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1017\/S0031182000060595","volume":"101","author":"AW Stitt","year":"1990","unstructured":"Stitt AW, Fairweather I (1990) Spermatogenesis and the fine structure of the mature spermatozoon of the live fluke, Fasciola hepatica (Trematoda: Digenea). Parasitology 101:395\u2013407","journal-title":"Parasitology"},{"key":"1649_CR39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/07924259.1992.9672266","volume":"22","author":"AW Stitt","year":"1992","unstructured":"Stitt AW, Fairweather I (1992) Spermatogenesis in Fasciola hepatica: an ultrastructural comparison of the effects of the anthelmintic, triclabendazole (\u201cFasinex\u201d) and the microtubule inhibitor, tubulozole. Invertebr Reprod Dev 22:139\u2013150","journal-title":"Invertebr Reprod Dev"},{"key":"1649_CR40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00935425","volume":"77","author":"AW Stitt","year":"1991","unstructured":"Stitt AW, Fairweather I, Johnston CF (1991) Fasciola hepatica: disruption of spermatogenesis by the microfilament inhibitor cytochalasin B. Parasitol Res 77:123\u2013128","journal-title":"Parasitol Res"},{"key":"1649_CR41","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1017\/S0031182009005642","volume":"136","author":"E Toner","year":"2009","unstructured":"Toner E, McConvery F, Brennan GP, Meaney M, Fairweather I (2009a) A scanning electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica. Parasitology 136:523\u2013535","journal-title":"Parasitology"},{"key":"1649_CR42","doi-asserted-by":"crossref","unstructured":"Toner E, Brennan GP, McConvery F, Meaney M, Fairweather I (2009b) A transmission electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica. Parasitology (in press)","DOI":"10.1017\/S0031182009005642"},{"key":"1649_CR43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00436-003-0901-y","volume":"91","author":"Y Vera Montenegro","year":"2003","unstructured":"Vera Montenegro Y, Ibarra Velarde F, Quiroz Romero H, Hern\u00e1ndez Campos A, Castillo R (2003) Field trial on the efficacy of an experimental fasciolicide compared with some commercial compounds in naturally infected cattle. Parasitol Res 91:1\u20134","journal-title":"Parasitol Res"},{"key":"1649_CR44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00436-003-1007-2","volume":"92","author":"Y Vera Montenegro","year":"2004","unstructured":"Vera Montenegro Y, Ibarra Velarde F, Li\u00e9bano Hern\u00e0ndez E, Quiroz Romero H, Castillo Bocanegra R, Hern\u00e1ndez Campos A, Ochoa Galv\u00e1n P (2004) Efficacy of an experimental fasciolicide against immature and mature Fasciola hepatica in artificially infected calves. Parasitol Res 92:211\u2013214","journal-title":"Parasitol Res"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-009-1649-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-009-1649-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-009-1649-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T18:56:11Z","timestamp":1559069771000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-009-1649-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,18]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["1649"],"URL":"https:\/\/doi.org\/10.1007\/s00436-009-1649-9","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,18]]}}}