{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:06:45Z","timestamp":1790762805254,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s00436-010-2028-2","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T11:55:30Z","timestamp":1283255730000},"page":"1347-1354","source":"Crossref","is-referenced-by-count":10,"title":["Strong expression of TGF-beta in human host tissues around subcutaneous Dirofilaria repens"],"prefix":"10.1007","volume":"108","author":[{"given":"Norbert W.","family":"Brattig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Racz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich W.","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,9,1]]},"reference":[{"key":"2028_CR1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.0000182903.16652.d7","volume":"97","author":"A Armulik","year":"2010","unstructured":"Armulik A, Abramsson A, Betsholtz C (2010) Endothelial\/pericyte interaction. Circ Res 97:512\u2013523","journal-title":"Circ Res"},{"key":"2028_CR2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s002840010100","volume":"41","author":"C Bazzocchi","year":"2000","unstructured":"Bazzocchi C, Jamnongluk W, O'Neill SL, Anderson TJ, Genchi C, Bandi C (2000) wsp gene sequences from the Wolbachia of filarial nematodes. Curr Microbiol 41:96\u2013100","journal-title":"Curr Microbiol"},{"key":"2028_CR3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.micinf.2003.11.003","volume":"6","author":"NW Brattig","year":"2004","unstructured":"Brattig NW (2004) Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria. Microbes Infect 6:113\u2013128","journal-title":"Microbes Infect"},{"key":"2028_CR4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1286-4579(01)01399-5","volume":"3","author":"NW Brattig","year":"2001","unstructured":"Brattig NW, B\u00fcttner DW, Hoerauf A (2001) Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria. Microbes Infect 3:439\u2013446","journal-title":"Microbes Infect"},{"key":"2028_CR5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.actatropica.2009.07.018","volume":"112","author":"NW Brattig","year":"2009","unstructured":"Brattig NW, Schwohl A, Hoerauf A, B\u00fcttner DW (2009) Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulus. Acta Trop 112:231\u2013235","journal-title":"Acta Trop"},{"key":"2028_CR6","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00436-010-1912-0","volume":"107","author":"N Brattig","year":"2010","unstructured":"Brattig N, Tenner-Racz K, Hoerauf A, Racz P, Korten S, B\u00fcttner DW (2010) Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda). Parasitol Res 107:657\u2013666","journal-title":"Parasitol Res"},{"key":"2028_CR7","first-page":"390","volume":"39","author":"DW B\u00fcttner","year":"1988","unstructured":"B\u00fcttner DW, Albiez EJ, von Essen J, Erichsen J (1988) Histological examination of adult Onchocerca volvulus and comparison with the collagenase technique. Trop Med Parasitol 39:390\u2013417","journal-title":"Trop Med Parasitol"},{"key":"2028_CR8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/sj.icb.7100116","volume":"86","author":"SN Byrne","year":"2008","unstructured":"Byrne SN, Knox MC, Halliday GM (2008) TGF-beta is responsible for skin tumour infiltration by macrophages enabling the tumours to escape immune destruction. Immunol Cell Biol 86:92\u201397","journal-title":"Immunol Cell Biol"},{"key":"2028_CR9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1017\/S0031182002002305","volume":"125","author":"BOL Duke","year":"2002","unstructured":"Duke BOL, Marty AM, Peet DL, Pardon J, Pion SDS, Kamgno J, Boussinesq M (2002) Neoplastic change in Onchocerca volvulus and its relation to ivermectin treatment. Parasitology 125:431\u2013444","journal-title":"Parasitology"},{"key":"2028_CR10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1055\/s-0030-1249232","volume":"39","author":"M Felcht","year":"2010","unstructured":"Felcht M, Augustin HG (2010) Neue Erkenntnisse in der Tumorangiogenese. Klinikarzt 39:12\u201317","journal-title":"Klinikarzt"},{"key":"2028_CR11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.2432664","volume":"235","author":"J Folkman","year":"1987","unstructured":"Folkman J, Klagsbrun M (1987) Angiogenic factors. Science 235:442\u2013447","journal-title":"Science"},{"key":"2028_CR12","first-page":"31","volume":"33","author":"M Franz","year":"1982","unstructured":"Franz M, Volkmer KJ, Lenze W (1982) A case of dirofilariasis in man (subgenus Nochtiella): a scanning electron microscope study. Tropenmed Parasitol 33:31\u201332","journal-title":"Tropenmed Parasitol"},{"key":"2028_CR13","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1128\/IAI.68.11.6402-6410.2000","volume":"68","author":"N Gomez-Escobar","year":"2000","unstructured":"Gomez-Escobar N, Gregory WF, Maizels RM (2000) Identification of tgh-2, a filarial nematode homolog of Caenorhabditis elegans daf-7 and human transforming growth factor beta, expressed in microfilarial and adult stages of Brugia malayi. Infect Immun 68:6402\u20136410","journal-title":"Infect Immun"},{"key":"2028_CR14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/cr.2008.326","volume":"19","author":"M-J Gourmans","year":"2009","unstructured":"Gourmans M-J, Liu Z, ten Dijke P (2009) TGF-beta signalling in vascular biology and dysfunction. Cell Res 19:116\u2013127","journal-title":"Cell Res"},{"key":"2028_CR15","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1645\/GE-1575.1","volume":"94","author":"G Grandi","year":"2008","unstructured":"Grandi G, Morchon R, Kramer L, Kartenshev V, Sim\u00f3n F (2008) Wolbachia in Dirofilaria repens, an agent causing human subcutaneous dirofilariasis. J Parasitol 94:1421\u20131423","journal-title":"J Parasitol"},{"key":"2028_CR16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1286-4579(03)00026-1","volume":"5","author":"A Hoerauf","year":"2003","unstructured":"Hoerauf A, Mand S, Volkmann L, B\u00fcttner M, Marfo-Debrekyei Y, Taylor M, Adjei O, B\u00fcttner DW (2003) Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms. Microbes Infect 5:261\u2013273","journal-title":"Microbes Infect"},{"key":"2028_CR17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-3024.2005.00792.x","volume":"27","author":"A Hoerauf","year":"2005","unstructured":"Hoerauf A, Satoguina J, Saeftel M, Specht S (2005) Immunomodulation by filarial nematode. Parasite Immunol 27:417\u2013429","journal-title":"Parasite Immunol"},{"key":"2028_CR18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.micinf.2007.12.004","volume":"10","author":"S Korten","year":"2008","unstructured":"Korten S, Badusche M, B\u00fcttner DW, Hoerauf A, Brattig N, Fleischer B (2008) Natural death of adult Onchocerca volvulus and filaricidal effects of doxycycline induce local FOXP3+\/CD4+ regulatory T cells and granzyme expression. Microbes Infect 10:313\u2013324","journal-title":"Microbes Infect"},{"key":"2028_CR19","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00436-009-1450-9","volume":"105","author":"S Korten","year":"2009","unstructured":"Korten S, B\u00fcttner DW, Schmetz C, Hoerauf A, Mand S, Brattig N (2009) The nematode parasite Onchocerca volvulus generates the transforming growth factor-beta (TGF-beta). Parasitol Res 105:731\u2013741","journal-title":"Parasitol Res"},{"key":"2028_CR20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.micinf.2010.03.011","volume":"12","author":"S Korten","year":"2010","unstructured":"Korten S, Kaifi JT, B\u00fcttner DW, Hoerauf A (2010) Transforming growth factor beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia. Microbes Infect 12:555\u2013564","journal-title":"Microbes Infect"},{"key":"2028_CR21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","volume":"24","author":"MO Li","year":"2006","unstructured":"Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA (2006) Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 24:99\u2013146","journal-title":"Annu Rev Immunol"},{"key":"2028_CR22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0065-308X(08)00204-2","volume":"66","author":"JW McCall","year":"2008","unstructured":"McCall JW, Genchi C, Kramer LH, Guerrero J, Venco L (2008) Heartworm disease in animals and humans. Adv Parasitol 66:193\u2013285","journal-title":"Adv Parasitol"},{"key":"2028_CR23","first-page":"275","volume-title":"Pathology of infectious diseases. Vol. 1, Helminthiases, 2nd edn","author":"AM Marty","year":"2000","unstructured":"Marty AM, Neafi RC Dirofilariasis (2000) In: Meyers WM (ed) Pathology of infectious diseases. Vol. 1, Helminthiases, 2nd edn. Armed Forces Institute of Pathology, Washington D. C, pp 275\u2013285"},{"key":"2028_CR24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1146\/annurev.cb.06.110190.003121","volume":"6","author":"J Massagu\u00e9","year":"1990","unstructured":"Massagu\u00e9 J (1990) The transforming growth factor-beta family. Annu Rev Cell Biol 6:597\u2013641","journal-title":"Annu Rev Cell Biol"},{"key":"2028_CR25","first-page":"375","volume":"30","author":"N Ratnatunga","year":"1999","unstructured":"Ratnatunga N, de Witesundera MS (1999) Histopathological diagnosis of subcutaneous Dirofilaria repens infection in humans. Southeast Asian J Trop Med Public Health 30:375\u2013378","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"2028_CR26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.vetpar.2008.09.010","volume":"158","author":"F Sim\u00f3n","year":"2008","unstructured":"Sim\u00f3n F, Morch\u00f3n R, Rodr\u00edguez-Barbero A, L\u00f3pez-Belmonte J, Grandi G, Genchi C (2008) Dirofilaria immitis and Wolbachia-derived antigens: its effect on endothelial mammal cells. Vet Parasitol 158:223\u2013231","journal-title":"Vet Parasitol"},{"key":"2028_CR27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.pt.2009.06.003","volume":"25","author":"F Sim\u00f3n","year":"2009","unstructured":"Sim\u00f3n F, Morch\u00f3n R, Gonz\u00e1lez-Miguel J, Marcos-Atxutegi C, Siles-Lucas M (2009) What is new about animal and human dirofilariosis? Trends Parasitol 25:404\u2013409","journal-title":"Trends Parasitol"},{"key":"2028_CR28","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00436-009-1588-5","volume":"105","author":"S Specht","year":"2009","unstructured":"Specht S, Brattig N, B\u00fcttner M, B\u00fcttner DW (2009) Criteria for the differentiation between young and old Onchocerca volvulus filariae. Parasitol Res 105:1531\u20131538","journal-title":"Parasitol Res"},{"key":"2028_CR29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1189\/jlb.0708415","volume":"85","author":"AW Taylor","year":"2009","unstructured":"Taylor AW (2009) Review of the activation of TGF-{beta} in immunity. J Leukoc Biol 85:29\u201333","journal-title":"J Leukoc Biol"},{"key":"2028_CR30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s004360050081","volume":"82","author":"G Wildenburg","year":"1996","unstructured":"Wildenburg G, Kr\u00f6mer M, B\u00fcttner DW (1996) Dependence of eosinophil granulocyte infiltration into nodules on the presence of microfilariae producing Onchocerca volvulus. Parasitol Res 82:117\u2013124","journal-title":"Parasitol Res"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s00436-010-2028-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T18:41:14Z","timestamp":1559500874000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-010-2028-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,1]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["2028"],"URL":"https:\/\/doi.org\/10.1007\/s00436-010-2028-2","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,1]]}}}