{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:28:51Z","timestamp":1788899331755,"version":"build-2803163510"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T00:00:00Z","timestamp":1298592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1007\/s00436-011-2284-9","type":"journal-article","created":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T04:33:32Z","timestamp":1298522012000},"page":"559-565","source":"Crossref","is-referenced-by-count":16,"title":["Identification and characterization of cysteine proteinases of Trypanosoma evansi"],"prefix":"10.1007","volume":"109","author":[{"given":"S. C.","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Tatu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,2,25]]},"reference":[{"key":"2284_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(01)00290-0","volume":"116","author":"LC Alves","year":"2001","unstructured":"Alves LC, Judice WAS, St. Hilaire PM, Meldal M, Sanderson SJ, Mottram JC, Coombs GH, Juliano L, Juliano MA (2001) Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana. Mol Biochem Parasitol 116:1\u20139","journal-title":"Mol Biochem Parasitol"},{"key":"2284_CR2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0003-2697(72)90302-8","volume":"47","author":"AJ Barrett","year":"1972","unstructured":"Barrett AJ (1972) Cathepsins B1 from human fetal membranes. Anal Biochem 47:280\u2013293","journal-title":"Anal Biochem"},{"key":"2284_CR3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0014-4894(91)90006-I","volume":"73","author":"MC Bonaldo","year":"1981","unstructured":"Bonaldo MC, d'Escoffier LN, Salles JM, Goldenberg S (1981) Characterization and expression of proteases during Trypanosoma cruzi metacyclogenesis. Exp Parasitol 73:44\u201351","journal-title":"Exp Parasitol"},{"key":"2284_CR4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0300-9629(84)90170-1","volume":"77","author":"E Bontempi","year":"1984","unstructured":"Bontempi E, Franke de Cazzulo BM, Ruiz AM, Cazzulo JJ (1984) Purification and some properties of an acidic protease from epimastigotes of Trypanosoma cruzi. Comp Biochem Physiol 77:599\u2013604","journal-title":"Comp Biochem Physiol"},{"key":"2284_CR5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0166-6851(90)90203-X","volume":"38","author":"JJ Cazzulo","year":"1990","unstructured":"Cazzulo JJ, Hellman U, Couso R, Parodi AJ (1990) Amino acid and carbohydrate composition of a lysosomal cysteine proteinase from Trypanosoma cruzi. Absence of phosphorylated mannose residues. Mol Biochem Parasitol 38:41\u201348","journal-title":"Mol Biochem Parasitol"},{"key":"2284_CR6","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2174\/1381612013397528","volume":"7","author":"JJ Cazzulo","year":"2001","unstructured":"Cazzulo JJ, Stoka V, Turk V (2001) The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease. Curr Pharm Des 7:1143\u20131156","journal-title":"Curr Pharm Des"},{"key":"2284_CR7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1023\/A:1024032024733","volume":"27","author":"S Giardina","year":"2003","unstructured":"Giardina S, Paganico G, Urbani G, Rossi M (2003) A biochemical and immunological comparative study on Trypanosoma equiperdum and Trypanosoma evansi. Vet Res Commun 27:289\u2013300","journal-title":"Vet Res Commun"},{"key":"2284_CR8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00436-009-1446-5","volume":"105","author":"SAO Gomes","year":"2009","unstructured":"Gomes SAO, Misael D, Silva BA, Feder D, Silva CS, Gon\u00e7alves TCM, Santos ALS, Santos-Mallet JR (2009) Major cysteine protease (cruzipain) in Z3 sylvatic isolates of Trypanosoma cruzi from Rio de Janeiro, Brazil. Parasitol Res 105:743\u2013749","journal-title":"Parasitol Res"},{"key":"2284_CR9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0166-6851(93)90086-D","volume":"58","author":"G Harth","year":"1993","unstructured":"Harth G, Andrews N, Mills AA, Engel JC, Smith R, McKerrow JH (1993) Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. Mol Biochem Parasitol 58:17\u201324","journal-title":"Mol Biochem Parasitol"},{"issue":"3","key":"2284_CR10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0925-4439(92)90040-T","volume":"1138","author":"G Huet","year":"1992","unstructured":"Huet G, Richet C, Demeyer D, Bisiau H, Soudan B, Han KK, Degand P (1992) Characterization of different proteolytic activity in Trypanosoma. Biochim Biophys Acta 1138(3):213\u201321","journal-title":"Biochim Biophys Acta"},{"key":"2284_CR11","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/227630a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227:630\u2013684","journal-title":"Nature"},{"key":"2284_CR12","doi-asserted-by":"crossref","unstructured":"Lalmanach G, Boulang\u00e9 A, Serveau C, Lecaille F, Scharfstein J, Gauthier F, Authi\u00e9 E (2002) Congopain from Trypanosoma congolense: drug target and vaccine candidate. Bchm 383:739\u2013749","DOI":"10.1515\/BC.2002.077"},{"key":"2284_CR13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0014-4894(70)90120-7","volume":"28","author":"SM Lanham","year":"1970","unstructured":"Lanham SM, Godfrey DG (1970) Isolation of salivarian trypanosomes from man and other animals using DEAE cellulose. Exp Parasitol 28:521\u2013534","journal-title":"Exp Parasitol"},{"key":"2284_CR14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1986.tb09513.x","volume":"155","author":"JD Lonsdale-Eccles","year":"1986","unstructured":"Lonsdale-Eccles JD, Mpimbaza GWN (1986) Thiol-dependent proteases of African trypanosomes. Analysis by electrophoresis in sodium dodecyl sulphate\/polyacrylamide gels co-polymerized with fibrinogen. Eur J Biochem 155:469\u2013473","journal-title":"Eur J Biochem"},{"key":"2284_CR15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-4894(89)90016-7","volume":"68","author":"JH McKerrow","year":"1989","unstructured":"McKerrow JH (1989) Mini review: parasite proteases. Exp Parasitol 68:111\u2013115","journal-title":"Exp Parasitol"},{"key":"2284_CR16","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1146\/annurev.pathol.1.110304.100151","volume":"1","author":"JH McKerrow","year":"2006","unstructured":"McKerrow JH, Caffery C, Kelly B, Sajid M (2006) Proteases in parasitic diseases. Annu Rev Patho Mech Dis 1:497\u2013536","journal-title":"Annu Rev Patho Mech Dis"},{"key":"2284_CR17","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1074\/jbc.M410066200","volume":"280","author":"RE Morty","year":"2005","unstructured":"Morty RE, Pelle R, Vadasz I, Uzcanga GL, Seeger W (2005) Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts. J Biol Chem 280:10925\u201310937","journal-title":"J Biol Chem"},{"key":"2284_CR18","first-page":"401","volume":"373","author":"MJ North","year":"1992","unstructured":"North MJ (1992) The characteristics of cysteine proteases of parasitic protozoa. Biol Chem 373:401\u2013406","journal-title":"Biol Chem"},{"key":"2284_CR19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0166-6851(92)90050-T","volume":"52","author":"M Nazareth","year":"1992","unstructured":"Nazareth M, Meirelles L, Juliano L, Carmona E, Silva SG, Costa EM, Murta ACM, Scharfstein J (1992) Inhibitors of the major cysteinyl proteinase (GP57\/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro. Mol Biochem Parasitol 52:175\u2013184","journal-title":"Mol Biochem Parasitol"},{"key":"2284_CR20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00229598","volume":"47","author":"P Rautenberg","year":"1982","unstructured":"Rautenberg P, Schadler R, Reinwald E, Risse HJ (1982) Study on a proteolytic enzyme from Trypanosoma congolense. Purification and some biochemical properties. Mol Cell Biochem 47:151\u2013159","journal-title":"Mol Cell Biochem"},{"key":"2284_CR21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/expr.1997.4220","volume":"87","author":"PM Selzer","year":"1997","unstructured":"Selzer PM, Chen X, Chan VJ, Cheng M, Kenyon GL, Kuntz ID, Sakanari JA, Cohen FE, McKerrow JH (1997) Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors. Expl Parasitol 87:212\u2013221","journal-title":"Expl Parasitol"},{"key":"2284_CR22","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/0264-6021:3600481","volume":"360","author":"PS Sijwali","year":"2001","unstructured":"Sijwali PS, Shenai BR, Gut J, Singh A, Rosenthal PJ (2001) Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. Biochem J 360:481\u2013489","journal-title":"Biochem J"},{"key":"2284_CR23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1242\/jcs.102.1.157","volume":"102","author":"MJ Soares","year":"1992","unstructured":"Soares MJ, Souto-Padr\u00f3n T, De Souza W (1992) Identification of a large pre-lysosomal compartment in the pathogenic protozoon Trypanosoma cruzi. J Cell Sci 102:157\u2013167","journal-title":"J Cell Sci"},{"key":"2284_CR24","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1242\/jcs.96.3.485","volume":"96","author":"T Souto-Padr\u00f3n","year":"1990","unstructured":"Souto-Padr\u00f3n T, Campetella OE, Cazzulo JJ, De Souza W (1990) Cysteine proteinase in Trypanosoma cruzi: immunocytochemical localization and involvement in parasite\u2013host cell interaction. J Cell Sci 96:485\u2013490","journal-title":"J Cell Sci"},{"key":"2284_CR25","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2307\/3281841","volume":"72","author":"CK Sung","year":"1986","unstructured":"Sung CK, Dresden MH (1986) Cysteinyl proteinases of Schistosoma mansoni eggs: purification and partial characterization. J Parasitol 72:891\u2013900","journal-title":"J Parasitol"},{"key":"2284_CR26","first-page":"13","volume":"30","author":"C Staak","year":"1979","unstructured":"Staak C, Lohding A (1979) The complement fixation test and African trypanosomiasis. Experimental infection and reinfection in cattle before and after treatment. Trop Med Parasit 30:13\u201318","journal-title":"Trop Med Parasit"},{"key":"2284_CR27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1432-1033.1979.tb04211.x","volume":"101","author":"A Suhar","year":"1979","unstructured":"Suhar A, Marks N (1979) Purification and properties of brain cathepsin B. Evidence for cleavage of pituitary lipotropins. Eur J Biochem 101:23\u201330","journal-title":"Eur J Biochem"},{"key":"2284_CR28","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","volume":"76","author":"H Towbin","year":"1979","unstructured":"Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350","journal-title":"Proc Natl Acad Sci USA"},{"key":"2284_CR29","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/expr.1994.1014","volume":"78","author":"GL Wiffels","year":"1994","unstructured":"Wiffels GL, Salvatore L, Dosen M, Wadington J, Thompson C, Campbell N, Sexton J, Wicker J, Bowen F, Friedel T, Spithill TW (1994) Vaccination of sheep with purified cysteine proteinase of Fasciola hepatica decreases worm fecundity. Expl Parasitol 78:132\u2013148","journal-title":"Expl Parasitol"},{"key":"2284_CR30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj2270521","volume":"227","author":"F Willenbrock","year":"1985","unstructured":"Willenbrock F, Brockleehurst K (1985) Preparation of cathepsins B and H by covalent chromatography and characterization of their catalytic sites by reaction with a thiol-specific two-protonic-state reactivity probe. Kinetic study of cathepsins B and H extending into alkaline media and a rapid spectroscopic titration of cathepsin H at pH\u00a03\u20134. Biochem J 227:521\u2013528","journal-title":"Biochem J"},{"key":"2284_CR31","first-page":"269","volume-title":"Parasitic protozoa","author":"PTK Woo","year":"1977","unstructured":"Woo PTK (1977) Salivarian trypanosomes producing disease in livestock outside of sub-saharan Africa. In: Kreier JP (ed) Parasitic protozoa, vol 1. Academic, New York, pp 269\u2013296"},{"key":"2284_CR32","unstructured":"Yadav SC, Kumar R, Kumar S, Gupta AK (2010) Identification of immunodominant Trypanosoma evansi antigens by western blot analysis in chronic experimental infections. Proceedings XX National Congress of Veterinary Parasitology on \u201cParasitology today\u2014ecology to molecular biology\u201d organized by the Dept. of Vet. Parasitology, CCSHAU, Hisar w.e.f. Feb. 18\u201320, 2010, pp 42\u201343"},{"key":"2284_CR33","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00436-005-1466-8","volume":"97","author":"SC Yadav","year":"2004","unstructured":"Yadav SC, Saini M, Raina OK, Nambi PA, Jadav K, Sriveny D (2004) Fasciola gigantica cathepsin-L cysteine proteinase in the detection of early experimentational fasciolosis in ruminants. Parasitol Res 97:527\u2013534","journal-title":"Parasitol Res"},{"key":"2284_CR34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4269\/ajtmh.2004.71.87","volume":"71","author":"SH Yang","year":"2004","unstructured":"Yang SH, Park JO, Lee JH, Jeon BH, Kim WS, Kim SI, Yun KI, Jeong ET, Lee KW, Kim YM, Lee MH, Park H (2004) Cloning and characterization of a new cysteine proteinase secreted by Paragonimus westermani adult worms. Am J Trop Med Hyg 71:87\u201392","journal-title":"Am J Trop Med Hyg"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-011-2284-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-011-2284-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-011-2284-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T11:23:24Z","timestamp":1637321004000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-011-2284-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,25]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["2284"],"URL":"https:\/\/doi.org\/10.1007\/s00436-011-2284-9","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,25]]}}}