{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:08:21Z","timestamp":1770505701180,"version":"3.49.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s00436-013-3387-2","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T02:19:30Z","timestamp":1363832370000},"page":"2269-2280","source":"Crossref","is-referenced-by-count":26,"title":["Studies on the protective and immunomodulatory efficacy of Withania somnifera along with cisplatin against experimental visceral leishmaniasis"],"prefix":"10.1007","volume":"112","author":[{"given":"Heena","family":"Sachdeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhbir","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"issue":"6","key":"3387_CR1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0944-7113(00)80036-7","volume":"7","author":"MA Akbarsha","year":"2000","unstructured":"Akbarsha MA, Vijendrakumar S, Kadalmani B, Girija R, Faridha A (2000) Curative property of Withania somnifera Dunal root in the context of carbendazim-induced histopathological changes in the liver and kidney of rat. Phytomedicine 7(6):499\u2013507","journal-title":"Phytomedicine"},{"key":"3387_CR2","first-page":"607","volume":"38","author":"B Andallu","year":"2000","unstructured":"Andallu B, Radhika B (2000) Hypoglycemic diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera Dunal) root. Indian J Exp Biol 38:607\u2013609","journal-title":"Indian J Exp Biol"},{"key":"3387_CR3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-8741(98)00107-X","volume":"64","author":"R Archana","year":"1999","unstructured":"Archana R, Namasivayam A (1999) Antistressor effect of Withania somnifera. J Ethnopharmacol 64:91\u201393","journal-title":"J Ethnopharmacol"},{"key":"3387_CR4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2006.02.016","volume":"107","author":"S Bani","year":"2006","unstructured":"Bani S, Gautam M, Sheikh FA, Khan B, Satti NK, Suri KA, Qazi GN, Patwardhan B (2006) Selective Thl up-regulating activity of Withania somnifera aqueous extract in an experimental system using flow cytometry. J Ethnopharmacol 107:107\u2013115","journal-title":"J Ethnopharmacol"},{"issue":"10","key":"3387_CR5","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.194.10.1497","volume":"194","author":"Y Belkaid","year":"2001","unstructured":"Belkaid Y, Hoffmann KF, Mendez S, Kamhawi S, Udey MC, Wynn TA, Sacks DL (2001) The role of interleukin (IL-10) in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194(10):1497\u20131506","journal-title":"J Exp Med"},{"key":"3387_CR6","first-page":"297","volume":"35","author":"SK Bhattacharya","year":"1997","unstructured":"Bhattacharya SK, Satyan KS, Chakrabarti A (1997a) Effect of Trasina, an Ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycaemic rats. Indian J Exp Biol 35:297\u2013299","journal-title":"Indian J Exp Biol"},{"key":"3387_CR7","first-page":"236","volume":"35","author":"SK Bhattacharya","year":"1997","unstructured":"Bhattacharya SK, Satyan KS, Ghosal S (1997b) Antioxidant activity of glycowithanolides from Withania somnifera. Indian J Exp Biol 35:236\u2013239","journal-title":"Indian J Exp Biol"},{"key":"3387_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(00)00309-3","volume":"74","author":"A Bhattacharya","year":"2001","unstructured":"Bhattacharya A, Ghosal S, Bhattacharya SK (2001) Anti-oxidant effect of Withania somnifera glycowithanolides in chronic foot shock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J Ethnopharmacol 74:1\u20136","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"3387_CR9","first-page":"119","volume":"30","author":"DJ Bradley","year":"1977","unstructured":"Bradley DJ, Kirkley J (1977) Regulation of Leishmania populations within host. I. The variable course of Leishmania donovani infections in mice. Clin Exp Immunol 30(1):119\u2013129","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"3387_CR10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.etp.2008.09.003","volume":"61","author":"YI Chirino","year":"2009","unstructured":"Chirino YI, Pedraza-Chaverri J (2009) Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Exp Toxicol Pathol 61(3):223\u2013242","journal-title":"Exp Toxicol Pathol"},{"key":"3387_CR11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/1381612023396258","volume":"8","author":"SL Croft","year":"2002","unstructured":"Croft SL, Yardley V (2002) Chemotherapy of leishmaniasis. Curr Pharm Des 8:319\u2013342","journal-title":"Curr Pharm Des"},{"key":"3387_CR12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0378-8741(94)90093-0","volume":"44","author":"A Dafni","year":"1994","unstructured":"Dafni A, Yaniv Z (1994) Solanaceae as medicinal plants in Israel. J Etnopharmacol 44:11\u201318","journal-title":"J Etnopharmacol"},{"key":"3387_CR13","first-page":"169","volume":"30","author":"PU Devi","year":"1992","unstructured":"Devi PU, Sharada AC, Solomon FE, Kamath MS (1992) In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor Sarcoma 180. Indian J Exp Biol 30:169\u2013172","journal-title":"Indian J Exp Biol"},{"key":"3387_CR14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0378-8741(97)00151-7","volume":"60","author":"JN Dhuley","year":"1998","unstructured":"Dhuley JN (1998) Effect of ashwagandha on lipid peroxidation in stress-induced animals. J Ethnopharmacol 60:173\u2013178","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"3387_CR15","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1155\/2008\/589394","volume":"5","author":"B Harikrishnan","year":"2008","unstructured":"Harikrishnan B, Subramanian P, Subash S (2008) Effect of Withania somnifera root powder on the levels of circulatory lipid peroxidation and liver marker enzymes in chronic hyperammonemia. E - J Chem 5(4):872\u2013877","journal-title":"E - J Chem"},{"key":"3387_CR16","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3109\/08860220903150320","volume":"31","author":"T Jeyanti","year":"2009","unstructured":"Jeyanti T, Subramanian P (2009) Nephroprotective effect of Withania somnifera: a dose-dependent study. Ren Fail 31:814\u2013821","journal-title":"Ren Fail"},{"key":"3387_CR17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.parint.2009.10.006","volume":"59","author":"S Kaur","year":"2010","unstructured":"Kaur S, Sachdeva H, Dhuria S, Sharma M, Kaur T (2010) Antileishmanial effect of cisplatin against murine visceral leishmaniasis. Parasitol Int 59:62\u201369","journal-title":"Parasitol Int"},{"issue":"1","key":"3387_CR18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.actatropica.2011.04.007","volume":"119","author":"J Kaur","year":"2011","unstructured":"Kaur J, Kaur T, Kaur S (2011a) Studies on the protective efficacy and immunogenicity of Hsp70 and Hsp83 based vaccine formulations in Leishmania donovani infected BALB\/c mice. Acta Trop 119(1):50\u201356","journal-title":"Acta Trop"},{"key":"3387_CR19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-3024.2010.01253.x","volume":"33","author":"T Kaur","year":"2011","unstructured":"Kaur T, Sobti RS, Kaur S (2011b) Cocktail of gp63 and Hsp70 induces protection against Leishmania donovani in BALB\/c mice. Parasite Immunol 33:95\u2013103","journal-title":"Parasite Immunol"},{"key":"3387_CR20","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.4049\/jimmunol.146.8.2763","volume":"146","author":"PM Kaye","year":"1991","unstructured":"Kaye PM, Curry AJ, Blackwell JM (1991) Differential production of Th1 and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis. J Immunol 146:2763\u20132770","journal-title":"J Immunol"},{"key":"3387_CR21","first-page":"208","volume":"35","author":"SK Kulkarni","year":"1998","unstructured":"Kulkarni SK, George B, Mathur R (1998) Neuroprotection by Withania somnifera root extract against lithium-pilocarpine-induced seizures. Indian Drugs 35:208\u2013215","journal-title":"Indian Drugs"},{"key":"3387_CR22","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.lfs.2007.01.029","volume":"80","author":"F Malik","year":"2007","unstructured":"Malik F, Singh J, Khajuria A, Suri KA, Satti NK, Singh S, Kaul MK, Kumar A, Bhatia A, Qazi GN (2007) A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Thl-dominant polarization in BALB\/c mice. Life Sci 80:1525\u20131538","journal-title":"Life Sci"},{"key":"3387_CR23","first-page":"334","volume":"5","author":"LC Mishra","year":"2000","unstructured":"Mishra LC, Singh BB, Dagenais S (2000) Scientific basis for the therapeutic use of Withania somnifera (ashwagandha) a review. Altern Med Rev 5:334\u2013346","journal-title":"Altern Med Rev"},{"key":"3387_CR24","doi-asserted-by":"crossref","unstructured":"Mohan R, Hammers HJ, Bargagna-Mohan P, Zhan XH, Herbstritt CJ, Ruiz A, Zhang L, Hanson AD, Conner BP, Rougas J, Pribula VS (2004) Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 7:115\u2013122","DOI":"10.1007\/s10456-004-1026-3"},{"key":"3387_CR25","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1002\/1521-4141(2001010)31:10<2848::AID-IMMU2848>3.0.CO;2-T","volume":"31","author":"ML Murphy","year":"2001","unstructured":"Murphy ML, Wille U, Villegas EN, Hunter CA, Farrell JP (2001) IL-10 mediates susceptibility to Leishmania donovani infection. Eur J Immunol 31:2848\u20132856","journal-title":"Eur J Immunol"},{"key":"3387_CR26","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)67629-5","volume":"366","author":"HW Murray","year":"2005","unstructured":"Murray HW, Berman JD, Davies CR, Saravia NG (2005) Advances in leishmaniasis. Lancet 366:1561\u20131577","journal-title":"Lancet"},{"key":"3387_CR27","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.2042-7158.1998.tb06923.x","volume":"50","author":"S Panda","year":"1998","unstructured":"Panda S, Kar A (1998) Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 50:1065\u20131068","journal-title":"J Pharm Pharmacol"},{"key":"3387_CR28","doi-asserted-by":"crossref","first-page":"896","DOI":"10.4049\/jimmunol.165.2.896","volume":"165","author":"AY Park","year":"2000","unstructured":"Park AY, Hondowicz BD, Scott P (2000) IL-12 is required to maintain a Th-1 response during Leishmania major infection. J Immunol 165:896\u2013902","journal-title":"J Immunol"},{"key":"3387_CR29","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1254\/jphs.93.458","volume":"93","author":"D Rai","year":"2003","unstructured":"Rai D, Bhatia G, Sen T, Palit G (2003) Anti-stress effects of Ginkgo biloba and Panax ginseng a comparative study. J Pharmacol Sci 93:458\u2013464","journal-title":"J Pharmacol Sci"},{"key":"3387_CR30","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/0006-2952(92)90725-X","volume":"43","author":"Y Sadzuka","year":"1992","unstructured":"Sadzuka Y, Shoji T, Takino Y (1992) Effect of cisplatin on the activities of enzymes which protect against lipid peroxidation. Biochem Pharmacol 43:1873\u20131875","journal-title":"Biochem Pharmacol"},{"key":"3387_CR31","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/sj.cdd.4402002","volume":"14","author":"N Sen","year":"2007","unstructured":"Sen N, Banerjee B, Das BB, Ganguly A, Sen R, Pramanik S (2007) Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I\u2013DNA complex. Cell Death Differ 14:358\u2013367","journal-title":"Cell Death Differ"},{"key":"3387_CR32","doi-asserted-by":"crossref","unstructured":"Sharma U, Velpandian T, Sharma P, Singh S (2009) Evaluation of antileishmanial activity of selected Indian plants to have antimicrobial properties. Parasitol Res 105(5):1287\u20131293","DOI":"10.1007\/s00436-009-1554-2"},{"key":"3387_CR33","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1517\/13543784.17.5.787","volume":"17","author":"S Sundar","year":"2008","unstructured":"Sundar S, Chakravarty J (2008) Paromomycin in the treatment of leishmaniasis. Exp Opin Investig Drugs 17:787\u2013794","journal-title":"Exp Opin Investig Drugs"},{"key":"3387_CR34","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1517\/14656566.6.16.2821","volume":"16","author":"S Sundar","year":"2005","unstructured":"Sundar S, Rai M (2005) Treatment of visceral leishmaniasis. Expert Opin Pharmacother 16:2821\u20132829","journal-title":"Expert Opin Pharmacother"},{"key":"3387_CR35","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1056\/NEJMoa066536","volume":"356","author":"S Sundar","year":"2007","unstructured":"Sundar S, Jha TK, Thakur CP, Sinha PK, Bhattacharya SK (2007) Injectable paromomycin for visceral leishmaniasis in India. N Engl J Med 356:2571\u20132581","journal-title":"N Engl J Med"},{"key":"3387_CR36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.actatropica.2007.05.017","volume":"103","author":"J Tavaers","year":"2007","unstructured":"Tavaers J, Quaissi M, Quaissi A, Cordeiro-da-Silva A (2007) Characterization of anti-Leishmania effect induced by cisplatin, an anticancer drug. Acta Trop 103:133\u2013141","journal-title":"Acta Trop"},{"key":"3387_CR37","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/0006-2952(93)90192-Y","volume":"45","author":"JG Zhang","year":"1993","unstructured":"Zhang JG, Lindup WE (1993) Role of mitochondria in cisplatin induced oxidative damage exhibited by rat renal cortical slides. Biochem Pharmacol 45:2215\u20132222","journal-title":"Biochem Pharmacol"},{"key":"3387_CR38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0378-8741(95)01318-0","volume":"50","author":"M Ziauddin","year":"1996","unstructured":"Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B (1996) Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol 50:69\u201376","journal-title":"J Ethnopharmacol"},{"key":"3387_CR39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0014-2999(02)01537-6","volume":"442","author":"A Zicca","year":"2004","unstructured":"Zicca A, Cafaggi S, Mariggio MA, Vannozzi MO, Ottone M, Bocchini V, Caviglioli G, Viale M (2004) Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats. Eur J Pharmacol 442:265\u2013272","journal-title":"Eur J Pharmacol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-013-3387-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-013-3387-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-013-3387-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T11:50:42Z","timestamp":1688125842000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-013-3387-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["3387"],"URL":"https:\/\/doi.org\/10.1007\/s00436-013-3387-2","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]}}}