{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:29:27Z","timestamp":1778905767430,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s00436-013-3390-7","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T05:00:54Z","timestamp":1364274054000},"page":"2207-2213","source":"Crossref","is-referenced-by-count":12,"title":["Inhibitory effect of cyclophilin A from the hard tick Haemaphysalis longicornis on the growth of Babesia bovis and Babesia bigemina"],"prefix":"10.1007","volume":"112","author":[{"given":"Hiroki","family":"Maeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damdinsuren","family":"Boldbaatar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kodai","family":"Kusakisako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remil Linggatong","family":"Galay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyaw Min","family":"Aung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Umemiya-Shirafuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozo","family":"Fujisaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,27]]},"reference":[{"key":"3390_CR1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.parint.2010.02.006","volume":"59","author":"M AbouLaila","year":"2010","unstructured":"AbouLaila M, Sivakumar T, Yokoyama N, Igarashi I (2010) Inhibitory effect of terpene nerolidol on the growth of Babesia parasites. Parasitol Int 59:278\u2013282","journal-title":"Parasitol Int"},{"key":"3390_CR2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00436-009-1443-8","volume":"105","author":"FK Adham","year":"2009","unstructured":"Adham FK, Abd-el-Samie EM, Gabre RM, el-Hussein H (2009) Detection of tick blood parasites in Egypt using PCR assay I-Babesia bovis and Babesia bigemina. Parasitol Res 105:721\u2013730","journal-title":"Parasitol Res"},{"key":"3390_CR3","doi-asserted-by":"crossref","first-page":"e33504","DOI":"10.1371\/journal.pone.0033504","volume":"7","author":"KM Aung","year":"2012","unstructured":"Aung KM, Boldbaatar D, Umemiya-Shirafuji R, Liao M, Tsuji N, Xuan X, Suzuki H, Kume A, Galay RL, Tanaka T, Fujisaki K (2012) HlSRB, a Class B scavenger receptor, is key to the granulocyte-mediated microbial phagocytosis in ticks. PLoS One 7:e33504","journal-title":"PLoS One"},{"key":"3390_CR4","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1007\/s00018-006-6215-3","volume":"63","author":"S Barik","year":"2006","unstructured":"Barik S (2006) Immunophilins: for the love of proteins. Cell Mol Life Sci 63:2889\u20132900","journal-title":"Cell Mol Life Sci"},{"key":"3390_CR5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1756-3305-2-57","volume":"2","author":"RG Bastos","year":"2009","unstructured":"Bastos RG, Ueti MW, Guerrero FD, Knowles DP, Scoles GA (2009) Silencing of a putative immunophilin gene in the cattle tick Rhipicephalus (Boophilus) microplus increases the infection rate of Babesia bovis in larval progeny. Parasit Vectors 2:57","journal-title":"Parasit Vectors"},{"key":"3390_CR6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijpara.2005.11.003","volume":"36","author":"A Bell","year":"2006","unstructured":"Bell A, Monaghan P, Page AP (2006) Peptidyl-prolyl cis\u2013trans isomerases (immunophilins) and their roles in parasite biochemistry, host\u2013parasite interaction and antiparasitic drug action. Int J Parasitol 36:261\u2013276","journal-title":"Int J Parasitol"},{"key":"3390_CR7","doi-asserted-by":"crossref","first-page":"S247","DOI":"10.1017\/S0031182004005190","volume":"129","author":"R Bock","year":"2004","unstructured":"Bock R, Jackson L, De Vos A, Jorgensen W (2004) Babesiosis of cattle. Parasitology 129:S247\u2013S269","journal-title":"Parasitology"},{"key":"3390_CR8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.procbio.2008.01.026","volume":"43","author":"D Boldbaatar","year":"2008","unstructured":"Boldbaatar D, Kilonzo RM, Battur B, Umemiya R, Liao M, Tanaka T, Xuan X, Fujisaki K (2008) Identification of two forms of cyclophilin from the hard tick Haemaphysalis longicornis. Process Biochem 43:615\u2013625","journal-title":"Process Biochem"},{"key":"3390_CR9","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4269\/ajtmh.2003.68.334","volume":"68","author":"S Bork","year":"2003","unstructured":"Bork S, Yokoyama N, Matsuo T, Claveria FG, Fujisaki K, Igarashi I (2003) Growth inhibitory effect of triclosan on equine and bovine Babesia parasites. AmJTrop Med Hyg 68:334\u2013340","journal-title":"AmJTrop Med Hyg"},{"key":"3390_CR10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1128\/AAC.48.1.236-241.2004","volume":"48","author":"S Bork","year":"2004","unstructured":"Bork S, Yokoyama N, Ikehara Y, Kumar S, Sugimoto C, Igarashi I (2004) Growth-inhibitory effect of heparin on Babesia parasites. Antimicrob Agents Chemother 48:236\u2013241","journal-title":"Antimicrob Agents Chemother"},{"key":"3390_CR11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1051\/vetres\/2009020","volume":"40","author":"A Chauvin","year":"2009","unstructured":"Chauvin A, Moreau E, Bonnet S, Plantard O, Malandrin L (2009) Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission. Vet Res 40:37","journal-title":"Vet Res"},{"key":"3390_CR12","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.2741\/3435","volume":"14","author":"M Florin-Christensen","year":"2009","unstructured":"Florin-Christensen M, Schnittger L (2009) Piroplasmids and ticks: a long-lasting intimate relationship. Front Biosci 14:3064\u20133073","journal-title":"Front Biosci"},{"key":"3390_CR13","first-page":"27","volume":"18","author":"K Fujisaki","year":"1978","unstructured":"Fujisaki K (1978) Development of acquired resistance precipitating antibody in rabbits experimentally infested with females of Haemaphysalis longicornis (Ixodoidea: Ixodidae). Natl Inst Anim Health Q (Tokyo) 18:27\u201338","journal-title":"Natl Inst Anim Health Q (Tokyo)"},{"key":"3390_CR14","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1432-1033.1993.tb18189.x","volume":"216","author":"A Galat","year":"1993","unstructured":"Galat A (1993) Peptidylproline cis\u2013trans isomerases: immunophilins. Eur J Biochem 216:689\u2013707","journal-title":"Eur J Biochem"},{"key":"3390_CR15","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/prot.20156","volume":"56","author":"A Galat","year":"2004","unstructured":"Galat A (2004) Function-dependent clustering of orthologues and paralogues of cyclophilins. Proteins 56:808\u2013820","journal-title":"Proteins"},{"key":"3390_CR16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11250-011-0027-7","volume":"44","author":"RL Galay","year":"2012","unstructured":"Galay RL, Maeda H, Aung KM, Umemiya-Shirafuji R, Xuan X, Igarashi I, Tsuji N, Tanaka T, Fujisaki K (2012) Anti-babesial activity of a potent peptide fragment derived from longicin of Haemaphysalis longicornis. Trop Anim Health Prod 44:343\u2013348","journal-title":"Trop Anim Health Prod"},{"key":"3390_CR17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.parint.2010.06.004","volume":"59","author":"YK Goo","year":"2010","unstructured":"Goo YK, Terkawi MA, Jia H, Aboge GO, Ooka H, Nelson B, Kim S, Sunaga F, Namikawa K, Igarashi I, Nishikawa Y, Xuan X (2010) Artesunate, a potential drug for treatment of Babesia infection. Parasitol Int 59:481\u2013486","journal-title":"Parasitol Int"},{"key":"3390_CR18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/CMR.13.3.451-469.2000","volume":"13","author":"MJ Homer","year":"2000","unstructured":"Homer MJ, Aguilar-Delfin I, Telford SR 3rd, Krause PJ, Persing DH (2000) Babesiosis. Clin Microbiol Rev 13:451\u2013469","journal-title":"Clin Microbiol Rev"},{"key":"3390_CR19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00436-012-2910-1","volume":"1","author":"Z Hub\u00e1lek","year":"2012","unstructured":"Hub\u00e1lek Z, Rudolf I (2012) Tick-borne viruses in Europe. Parasitol Res 1:9\u201336","journal-title":"Parasitol Res"},{"key":"3390_CR20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1756-3305-2-27","volume":"2","author":"J Kr\u00fccken","year":"2009","unstructured":"Kr\u00fccken J, Greif G, von Samson-Himmelstjerna G (2009) In silico analysis of the cyclophilin repertoire of apicomplexan parasites. Parasit Vectors 2:27","journal-title":"Parasit Vectors"},{"key":"3390_CR21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680\u2013685","journal-title":"Nature"},{"key":"3390_CR22","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1462-5822.2009.01286.x","volume":"11","author":"X Liu","year":"2009","unstructured":"Liu X, Sun L, Yu M, Wang Z, Xu C, Xue Q, Zhang K, Ye X, Kitamura Y, Liu W (2009) Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication. Cell Microbiol 11:730\u2013741","journal-title":"Cell Microbiol"},{"key":"3390_CR23","doi-asserted-by":"crossref","first-page":"e31063","DOI":"10.1371\/journal.pone.0031063","volume":"7","author":"X Liu","year":"2012","unstructured":"Liu X, Zhao Z, Xu C, Sun L, Chen J, Zhang L, Liu W (2012) Cyclophilin A restricts influenza A virus replication through degradation of the M1 protein. PLoS One 7:e31063","journal-title":"PLoS One"},{"key":"3390_CR24","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1128\/JVI.01519-06","volume":"81","author":"J Luban","year":"2007","unstructured":"Luban J (2007) Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. J Virol 81:1054\u20131061","journal-title":"J Virol"},{"key":"3390_CR25","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1128\/AAC.47.2.800-803.2003","volume":"47","author":"A Nagai","year":"2003","unstructured":"Nagai A, Yokoyama N, Matsuo T, Bork S, Hirata H, Xuan X, Zhu Y, Claveria FG, Fujisaki K, Igarashi I (2003) Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures. Antimicrob Agents Chemother 47:800\u2013803","journal-title":"Antimicrob Agents Chemother"},{"key":"3390_CR26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.virol.2010.12.061","volume":"411","author":"PD Nagy","year":"2011","unstructured":"Nagy PD, Wang RY, Pogany J, Hafren A, Makinen K (2011) Emerging picture of host chaperone and cyclophilin roles in RNA virus replication. Virology 411:374\u2013382","journal-title":"Virology"},{"key":"3390_CR27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1292\/jvms.09-0167","volume":"72","author":"M Rahman","year":"2010","unstructured":"Rahman M, Tsuji N, Boldbaatar D, Battur B, Liao M, Umemiya-Shirafuji R, You M, Tanaka T, Fujisaki K (2010) Structural characterization and cytolytic activity of a potent antimicrobial motif in longicin, a defensin-like peptide in the tick Haemaphysalis longicornis. J Vet Med Sci 72:149\u2013156","journal-title":"J Vet Med Sci"},{"key":"3390_CR28","doi-asserted-by":"crossref","unstructured":"Salama AA, Aboulaila M, Moussa AA, Nayel MA, El-Sify A, Terkawi MA, Hassan HY, Yokoyama N, Igarashi I (2012) Evaluation of in vitro and in vivo inhibitory effects of fusidic acid on Babesia and Theileria parasites. Vet Parasitol (in press)","DOI":"10.1016\/j.vetpar.2012.08.022"},{"key":"3390_CR29","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.meegid.2012.07.004","volume":"12","author":"L Schnittger","year":"2012","unstructured":"Schnittger L, Rodriguez AE, Florin-Christensen M, Morrison DA (2012) Babesia: a world emerging. Infect Genet Evol 12:1788\u20131809","journal-title":"Infect Genet Evol"},{"key":"3390_CR30","doi-asserted-by":"crossref","first-page":"7046","DOI":"10.2741\/3209","volume":"13","author":"DE Sonenshine","year":"2008","unstructured":"Sonenshine DE, Hynes WL (2008) Molecular characterization and related aspects of the innate immune response in ticks. Front Biosci 13:7046\u20137063","journal-title":"Front Biosci"},{"key":"3390_CR31","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1128\/AAC.46.11.3585-3590.2002","volume":"46","author":"M Stark","year":"2002","unstructured":"Stark M, Liu LP, Deber CM (2002) Cationic hydrophobic peptides with antimicrobial activity. Antimicrob Agents Chemother 46:3585\u20133590","journal-title":"Antimicrob Agents Chemother"},{"key":"3390_CR32","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.peptides.2011.07.027","volume":"34","author":"T Tanaka","year":"2012","unstructured":"Tanaka T, Maeda H, Matsuo T, Boldbattar D, Umemiya-Shirafuji R, Kume A, Suzuki H, Xuan X, Tsuji N, Fujisaki (2012) Parasiticidal activity of Haemaphysalis longicornis longicin P4 peptide against Toxoplasma gondii. Peptides 34:242\u2013250","journal-title":"Peptides"},{"key":"3390_CR33","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1128\/IAI.00256-07","volume":"75","author":"N Tsuji","year":"2007","unstructured":"Tsuji N, Battsetseg B, Boldbaatar D, Miyoshi T, Xuan X, Oliver JH Jr, Fujisaki K (2007) Babesial vector tick defensin against Babesia sp. parasites. Infect Immun 75:3633\u20133640","journal-title":"Infect Immun"},{"key":"3390_CR34","doi-asserted-by":"crossref","first-page":"e1000062","DOI":"10.1371\/journal.ppat.1000062","volume":"4","author":"N Tsuji","year":"2008","unstructured":"Tsuji N, Miyoshi T, Battsetseg B, Matsuo T, Xuan X, Fujisaki K (2008) A cysteine protease is critical for Babesia spp. transmission in Haemaphysalis longocornis ticks. PLoS Pathog 4:e1000062","journal-title":"PLoS Pathog"},{"key":"3390_CR35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ibmb.2011.12.001","volume":"42","author":"R Umemiya-Shirafuji","year":"2012","unstructured":"Umemiya-Shirafuji R, Tanaka T, Boldbaatar D, Tanaka T, Fujisaki K (2012) Akt is an essential player in regulating cell\/organ growth at the adult stage in the hard tick Haemaphysalis longicornis. Insect Biochem Mol Biol 42:164\u2013173","journal-title":"Insect Biochem Mol Biol"},{"key":"3390_CR36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.idc.2008.03.010","volume":"22","author":"E Vannier","year":"2008","unstructured":"Vannier E, Gewurz BE, Krause PJ (2008) Human babesiosis. Infect Dis Clin North Am 22:469\u2013488","journal-title":"Infect Dis Clin North Am"},{"key":"3390_CR37","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/1743-422X-7-372","volume":"7","author":"C Xu","year":"2010","unstructured":"Xu C, Meng S, Liu X, Sun L, Liu W (2010) Chicken cyclophilin A is an inhibitory factor to influenza virus replication. Virol J 7:372","journal-title":"Virol J"},{"key":"3390_CR38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bbrc.2012.07.024","volume":"424","author":"D Zhou","year":"2012","unstructured":"Zhou D, Mei Q, Li J, He H (2012) Cyclophilin A and viral infections. Biochem Biophys Res Commun 424:647\u2013650","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-013-3390-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-013-3390-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-013-3390-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T06:35:55Z","timestamp":1562826955000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-013-3390-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,27]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["3390"],"URL":"https:\/\/doi.org\/10.1007\/s00436-013-3390-7","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,27]]}}}