{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:49:08Z","timestamp":1778705348038,"version":"3.51.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,10,6]],"date-time":"2013-10-06T00:00:00Z","timestamp":1381017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s00436-013-3614-x","type":"journal-article","created":{"date-parts":[[2013,10,5]],"date-time":"2013-10-05T06:57:29Z","timestamp":1380956249000},"page":"4221-4229","source":"Crossref","is-referenced-by-count":15,"title":["Effect of a novel benzimidazole derivative in experimental Schistosoma mansoni infection"],"prefix":"10.1007","volume":"112","author":[{"given":"Serry A.","family":"El Bialy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Taman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar N.","family":"El-Beshbishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basem","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"El-Malky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed A.","family":"Bayoumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan M.","family":"Essa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,6]]},"reference":[{"key":"3614_CR1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1590\/S0074-02762010000600001","volume":"105","author":"IR Aly","year":"2010","unstructured":"Aly IR, Hendawy MA, Ali E, Hassan E, Nosseir MM (2010) Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni. Mem Inst Oswaldo Cruz 105:729\u2013735","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"3614_CR2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1590\/S0036-46651996000600006","volume":"38","author":"LR Barth","year":"1996","unstructured":"Barth LR, Fernandes AP, Rodrigues V (1996) Oviposition by Schistosoma mansoni during in vitro cultivation. Rev Inst Med Trop Sao Paulo 38:423\u2013426","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"3614_CR3","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.ijpara.2011.06.002","volume":"41","author":"RE Blanton","year":"2011","unstructured":"Blanton RE, Blank WA, Costa JM, Carmo TM, Reis EA, Silva LK, Barbosa LM, Test MR, Reis MG (2011) Schistosoma mansoni population structure and persistence after praziquantel treatment in two villages of Bahia, Brazil. Int J Parasitol 41:1093\u20131099","journal-title":"Int J Parasitol"},{"key":"3614_CR4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0035-9203(89)90720-7","volume":"83","author":"S Botros","year":"1989","unstructured":"Botros S, Soliman A, El-Gawhary N, Selim M, Guirguis N (1989) Effect of combined low dose praziquantel and oxamniquine on different stages of schistosome maturity. Trans R Soc Trop Med Hyg 83:86\u201389","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"3614_CR5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4049\/jimmunol.139.1.215","volume":"139","author":"PJ Brindley","year":"1987","unstructured":"Brindley PJ, Sher A (1987) The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response. J Immunol 139:215\u2013220","journal-title":"J Immunol"},{"key":"3614_CR6","first-page":"328","volume":"39","author":"AW Cheever","year":"1968","unstructured":"Cheever AW (1968) Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bull World Health Org 39:328\u2013331","journal-title":"Bull World Health Org"},{"key":"3614_CR7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00436-002-0751-z","volume":"90","author":"D Cioli","year":"2003","unstructured":"Cioli D, Pica-Mattoccia L (2003) Praziquantel. Parasitol Res 90:S3\u2013S9","journal-title":"Parasitol Res"},{"issue":"3","key":"3614_CR8","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1017\/S0022149X00026110","volume":"60","author":"GC Coles","year":"1986","unstructured":"Coles GC (1986) Anthelmintic activity of triclabendazole. J Helminthol 60(3):210\u2013212","journal-title":"J Helminthol"},{"key":"3614_CR9","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/QCO.0b013e328318978f","volume":"21","author":"M Doenhoff","year":"2008","unstructured":"Doenhoff M, Cioli D, Utzinger J (2008) Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr Opin Infect Dis 21:659\u2013667","journal-title":"Curr Opin Infect Dis"},{"key":"3614_CR10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijpara.2010.09.010","volume":"41","author":"MM Eissa","year":"2011","unstructured":"Eissa MM, Mervat Z, Azzouni EL, Baddour NB (2011) Miltefosine, a promising novel agent for Schistosomiasis mansoni. Int J Parasitol 41:235\u2013242","journal-title":"Int J Parasitol"},{"key":"3614_CR11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ijpara.2013.01.007","volume":"43","author":"SN El-Beshbishi","year":"2013","unstructured":"El-Beshbishi SN, Taman A, El-Malky MA, Azab MS, El-Hawary AK, El-Tantawy DA (2013) First insight into the effect of single oral dose therapy with artemisinin-naphthoquine phosphate combination in a mouse model of Schistosoma mansoni infection. Int J Parasitol 43:521\u2013530","journal-title":"Int J Parasitol"},{"key":"3614_CR12","first-page":"143","volume":"27","author":"MH El-Sayed","year":"1997","unstructured":"El-Sayed MH, Allam AF (1997) Effect of triclabendazole on the tegument of Schistosoma mansoni: a scanning electron microscopic study. J Egypt Soc Parasitol 27:143\u2013152","journal-title":"J Egypt Soc Parasitol"},{"key":"3614_CR13","first-page":"225","volume-title":"Fascioliasis","author":"I Fairweather","year":"1999","unstructured":"Fairweather I, Boray JC (1999) Mechanisms of fasciolicide action and drug resistance in Fasciola hepatica. In: Dalton JP (ed) Fascioliasis. CABI, Wallingford, pp 225\u2013276"},{"key":"3614_CR14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1994.51.83","volume":"51","author":"PG Fallon","year":"1994","unstructured":"Fallon PG, Doenhoff MJ (1994) Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am J Trop Med Hyg 51:83\u201388","journal-title":"Am J Trop Med Hyg"},{"key":"3614_CR15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/S0031182000065069","volume":"112","author":"PG Fallon","year":"1996","unstructured":"Fallon PG, Fookes RE, Wharton GA (1996) Temporal differences in praziquantel and oxamniquine-induced tegumental damage to adult Schistosoma mansoni: implications for drug-antibody synergy. Parasitology 112:47\u201358","journal-title":"Parasitology"},{"key":"3614_CR16","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1046\/j.1365-3156.2001.00811.x","volume":"6","author":"B Gryseels","year":"2001","unstructured":"Gryseels B, Mbaye A, De Vlas SJ, Stelma FF, Guiss\u00e9 F, van Lieshout L, Faye D, Diop M, Ly A, Tchuem-Tchuent\u00e9 LA, Engels D, Polman K (2001) Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence. Trop Med Int Health 6:864\u2013873","journal-title":"Trop Med Int Health"},{"key":"3614_CR17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.vetpar.2008.10.007","volume":"159","author":"L Halferty","year":"2009","unstructured":"Halferty L, Brennan GP, Trudgett A, Hoey L, Fairweather I (2009) Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica. Vet Parasitol 159:126\u2013138","journal-title":"Vet Parasitol"},{"key":"3614_CR18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.vetpar.2011.08.023","volume":"184","author":"REB Hanna","year":"2012","unstructured":"Hanna REB, Scarcella S, Solana H, McConnell S, Fairweather I (2012) Early onset of changes to the reproductive system of Fasciola hepatica following in vivo treatment with triclabendazole. Vet Parasitol 184:341\u2013347","journal-title":"Vet Parasitol"},{"key":"3614_CR19","doi-asserted-by":"crossref","first-page":"932","DOI":"10.4269\/ajtmh.1999.60.932","volume":"60","author":"M Ismail","year":"1999","unstructured":"Ismail M, Botros S, Metwally A, William S, Farghally A, Tao LF, Day TA, Bennett JL (1999) Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am J Trop Med Hyg 60:932\u2013935","journal-title":"Am J Trop Med Hyg"},{"key":"3614_CR20","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1517\/13543784.14.12.1513","volume":"14","author":"J Keiser","year":"2005","unstructured":"Keiser J, Engels D, B\u00fcscher G, Utzinger J (2005) Triclabendazole for the treatment of fascioliasis and paragonimiasis. Expert Opin Investig Drugs 14:1513\u20131526","journal-title":"Expert Opin Investig Drugs"},{"issue":"2","key":"3614_CR21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4269\/ajtmh.2006.75.287","volume":"75","author":"J Keiser","year":"2006","unstructured":"Keiser J, El Ela NA, El Komy E, El Lakkany N, Diab T, Chollet J, Utzinger J, Barakat R (2006) Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model. Am J Trop Med Hyg 75(2):287\u2013291","journal-title":"Am J Trop Med Hyg"},{"key":"3614_CR22","first-page":"799","volume":"30","author":"SS Khalil","year":"2000","unstructured":"Khalil SS (2000) On the schistosomicidal effect of triclabendazole an experimental study. J Egypt Soc Parasitol 30:799\u2013808","journal-title":"J Egypt Soc Parasitol"},{"key":"3614_CR23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.fitote.2004.08.003","volume":"76","author":"WS Koko","year":"2005","unstructured":"Koko WS, Abdalla HS, Galal M, Khalid HS (2005) Evaluation of oral therapy on mansonial schistosomiasis using single dose of Balanites aegyptiaca fruits and praziquantel. Fitoterapia 76:30\u201334","journal-title":"Fitoterapia"},{"key":"3614_CR24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0020-7519(88)90175-0","volume":"18","author":"E Lacey","year":"1988","unstructured":"Lacey E (1988) The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles. Int J Parasitol 18:885\u2013936","journal-title":"Int J Parasitol"},{"key":"3614_CR25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0035-9203(03)90038-1","volume":"97","author":"SD Lawn","year":"2003","unstructured":"Lawn SD, Lucas SB, Chiodini PL (2003) Case report: Schistosoma mansoni infection: failure of standard treatment with praziquantel in a returned traveler. Trans R Soc Trop Med Hyg 97:100\u2013101","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"3614_CR26","first-page":"711","volume":"41","author":"VF Lichtenberg","year":"1962","unstructured":"Lichtenberg VF (1962) Host response to eggs of Schistosoma mansoni I. Granuloma formation in the unsensitized laboratory mouse. Am J Pathol 41:711\u2013731","journal-title":"Am J Pathol"},{"key":"3614_CR27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.exppara.2007.06.002","volume":"117","author":"P LoVerde","year":"2007","unstructured":"LoVerde P, Osman A, Hinck A (2007) Schistosoma mansoni: TGF-beta signaling pathways. Exp Parasitol 117:304\u2013317","journal-title":"Exp Parasitol"},{"key":"3614_CR28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S0031182009990965","volume":"137","author":"T Manneck","year":"2010","unstructured":"Manneck T, Haggenm\u00fcer Y, Keiser J (2010) Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni. Parasitology 137:85\u201398","journal-title":"Parasitology"},{"key":"3614_CR29","first-page":"233","volume":"27","author":"ST Mansoury","year":"1997","unstructured":"Mansoury ST (1997) Effect of two trematodicidal drugs on the morphology and tegumentary ultrastructure of Schistosoma mansoni. J Egypt Soc Parasitol 27:233\u2013241","journal-title":"J Egypt Soc Parasitol"},{"key":"3614_CR30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.actatropica.2008.11.014","volume":"109","author":"A M\u00e1rquez-Navarro","year":"2009","unstructured":"M\u00e1rquez-Navarro A, Nogueda-Torresa B, Hern\u00e1ndez-Camposb A, Soria-Artechec O, Castillob R, Rodr\u00edguez-Moralesb S, Y\u00e9pez-Muliad L, Hern\u00e1ndez-Luis F (2009) Anthelmintic activity of benzimidazole derivatives against Toxocara canis second-stage larvae and Hymenolepis nana adults. Acta Trop 109:232\u2013235","journal-title":"Acta Trop"},{"key":"3614_CR31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.4269\/ajtmh.1956.5.831","volume":"5","author":"DV Moore","year":"1956","unstructured":"Moore DV, Sandground JH (1956) The relative egg producing capacity of Schistosoma mansoni and Schistosoma japonicum. Am J Trop Med Hyg 5:831\u2013840","journal-title":"Am J Trop Med Hyg"},{"key":"3614_CR32","first-page":"1129","volume":"50","author":"NG Nessim","year":"2000","unstructured":"Nessim NG, Hassan SI, William S, el-Baz H (2000) Effect of the broad spectrum anthelmintic drug flubendazole upon Schistosoma mansoni experimentally infected mice. Arzneim Forsch 50:1129\u20131133","journal-title":"Arzneim Forsch"},{"key":"3614_CR33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","volume":"2","author":"E Pearce","year":"2002","unstructured":"Pearce E, MacDonald A (2002) The immunobiology of schistosomiasis. Nat Rev Immunol 2:499\u2013511","journal-title":"Nat Rev Immunol"},{"key":"3614_CR34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4269\/ajtmh.1962.11.201","volume":"11","author":"J Pellegrino","year":"1962","unstructured":"Pellegrino J, Oliveira CA, Faria J, Cunha A (1962) New approach to the screening of drugs in experimental Schistosoma mansoni in mice. Am J Trop Med Hyg 11:201\u2013215","journal-title":"Am J Trop Med Hyg"},{"key":"3614_CR35","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s004360050411","volume":"84","author":"J Schmidt","year":"1988","unstructured":"Schmidt J (1988) Effects of benzimidazole anthemintics as microtubule-active drugs on the synthesis and transport of surface glucoconjugates in Hymenolepis nana, Echinostoma caproni, and Schistosoma mansoni. Parasitol Res 84:362\u2013368","journal-title":"Parasitol Res"},{"key":"3614_CR36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4269\/ajtmh.2011.10-0542","volume":"85","author":"EY Seto","year":"2011","unstructured":"Seto EY, Wong BK, Lu D, Zhong B (2011) Human schistosomiasis resistance to praziquantel in china: should we be worried? Am J Trop Med Hyg 85:74\u201382","journal-title":"Am J Trop Med Hyg"},{"key":"3614_CR37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1017\/S0031182000053920","volume":"94","author":"MK Shaw","year":"1987","unstructured":"Shaw MK, Erasmus DA (1987) Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel. Parasitology 94:243\u2013254","journal-title":"Parasitology"},{"key":"3614_CR38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0065-308X(06)63003-0","volume":"63","author":"PJ Skelly","year":"2006","unstructured":"Skelly PJ, Alan Wilson R (2006) Making sense of the schistosome surface. Adv Parasitol 63:185\u2013284","journal-title":"Adv Parasitol"},{"key":"3614_CR39","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1017\/S0031182000086248","volume":"55","author":"SR Smithers","year":"1965","unstructured":"Smithers SR, Terry RJ (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 55:695\u2013700","journal-title":"Parasitology"},{"key":"3614_CR40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0020-7519(86)90113-X","volume":"16","author":"M Tendler","year":"1986","unstructured":"Tendler M, Pinto RM, Oliveira Lima A, Gebara G, Katz N (1986) Schistosoma mansoni: vaccination with adult worm antigens. Int J Parasitol 16:347\u2013352","journal-title":"Int J Parasitol"},{"key":"3614_CR41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.vetpar.2010.11.032","volume":"177","author":"E Toner","year":"2011","unstructured":"Toner E, Brennan GP, Hanna REB, Edgar HWJ, Fairweather I (2011) Disruption of egg formation by Fasciola hepatica following treatment in vivo with triclabendazole in the sheep host. Vet Parasitol 177:79\u201389","journal-title":"Vet Parasitol"},{"key":"3614_CR42","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0020-7519(01)00297-1","volume":"31","author":"J Utzinger","year":"2001","unstructured":"Utzinger J, Shuhua X, N\u2019Goran EK, Bergquist R, Tanner M (2001) The potential of artemether for the control of schistosomiasis. Int J Parasitol 31:1549\u20131562","journal-title":"Int J Parasitol"},{"key":"3614_CR43","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.actatropica.2010.08.020","volume":"120","author":"J Utzinger","year":"2011","unstructured":"Utzinger J, N\u2019Goran E, Caffrey C, Keiser J (2011) From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Trop 120:S121\u2013S137","journal-title":"Acta Trop"},{"key":"3614_CR44","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1517\/14656560902722463","volume":"10","author":"E Enden van den","year":"2009","unstructured":"van den Enden E (2009) Pharmacotherapy of helminth infection. Expert Opin Pharmacother 10:435\u2013451","journal-title":"Expert Opin Pharmacother"},{"key":"3614_CR45","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ijpara.2006.01.007","volume":"36","author":"J Hellemond Van","year":"2006","unstructured":"Van Hellemond J, Retra K, Brouwers JFH, van Balkom BWM, Yazdanbakhsh M, Shoemaker C, Tielens AGM (2006) Functions of the tegument of schistosomes: clues from the proteome and lipidome. Int J Parasitol 36:691\u2013699","journal-title":"Int J Parasitol"},{"key":"3614_CR46","first-page":"532","volume":"53","author":"S William","year":"2003","unstructured":"William S, Guirguis F, Nessim NG (2003) Effect of simultaneous and\/or consecutive administration of the broad spectrum anthelmintic flubendazole together with praziquantel in experimental Schistosoma mansoni infection. Arzneim Forsch 53:532\u2013537","journal-title":"Arzneim Forsch"},{"key":"3614_CR47","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1645\/0022-3395(2000)086[0193:TLOASF]2.0.CO;2","volume":"86","author":"S Xiao","year":"2000","unstructured":"Xiao S, Shen B, Chollet J, Utzinger J, Tanner M (2000) Tegumental changes in adult Schistosoma mansoni harbored in mice treated with artemether. J Parasitol 86:1125\u20131132","journal-title":"J Parasitol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-013-3614-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-013-3614-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-013-3614-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T02:03:05Z","timestamp":1688522585000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-013-3614-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,6]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["3614"],"URL":"https:\/\/doi.org\/10.1007\/s00436-013-3614-x","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,6]]}}}