{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:23:52Z","timestamp":1792002232696,"version":"4.4.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T00:00:00Z","timestamp":1384214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T00:00:00Z","timestamp":1384214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s00436-013-3650-6","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T10:47:18Z","timestamp":1384166838000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Cathepsin L1 mimotopes with adjuvant Quil A induces a Th1\/Th2 immune response and confers significant protection against Fasciola hepatica infection in goats"],"prefix":"10.1007","volume":"113","author":[{"given":"Abel","family":"Villa-Mancera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Reynoso-Palomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Utrera-Quintana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Carre\u00f3n-Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,12]]},"reference":[{"key":"3650_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1136\/vr.113.14.315","volume":"113","author":"JC Boray","year":"1983","unstructured":"Boray JC, Crowfoot PD, Strong MB, Allison JR, Schellenbaum M, Von Orelli M, Sarasin G (1983) Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole. Vet Rec 113:315\u2013317","journal-title":"Vet Rec"},{"key":"3650_CR2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.parint.2009.12.005","volume":"59","author":"L Buffoni","year":"2010","unstructured":"Buffoni L, Zafra R, P\u00e9rez-Ecija A, Mart\u00ednez-Moreno FJ, Mart\u00ednez-Galisteo E, Moreno T, P\u00e9rez J, Mart\u00ednez-Moreno A (2010) Immune response of goats immunised with glutathione S-transferase and experimentally challenged with Fasciola hepatica. Parasitol Int 59:147\u2013153","journal-title":"Parasitol Int"},{"key":"3650_CR3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.vetpar.2011.09.027","volume":"185","author":"L Buffoni","year":"2012","unstructured":"Buffoni L, Mart\u00ednez-Moreno FJ, Zafra R, Mendes RE, P\u00e9rez-\u00c9cija A, Sekiya M, Mulcahy G, P\u00e9rez J, Mart\u00ednez-Moreno A (2012) Humoral immune response in goats immunised with cathepsin L1, peroxiredoxin and Sm14 antigen and experimentally challenged with Fasciola hepatica. Vet Parasitol 185:315\u2013321","journal-title":"Vet Parasitol"},{"key":"3650_CR4","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/0923-2494(92)80064-R","volume":"143","author":"JB Campbell","year":"1992","unstructured":"Campbell JB, Peerbaye YA (1992) Saponin. Res Immunol 143:526\u2013530","journal-title":"Res Immunol"},{"key":"3650_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1590\/S1984-29612013005000005","volume":"22","author":"P Cuervo","year":"2013","unstructured":"Cuervo P, Sidoti L, Fantozzi C, Neira G, Gerbeno L, Sierra RM (2013) Fasciola hepatica infection and association with gastrointestinal parasites in Creole goats from western Argentina. Rev Bras Parasitol Vet 22:53\u201357","journal-title":"Rev Bras Parasitol Vet"},{"key":"3650_CR6","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1007\/s00436-011-2554-6","volume":"109","author":"C Devine","year":"2011","unstructured":"Devine C, Brennan GP, Lanusse CE, Alvarez LI, Trudgett A, Hoey E, Fairweather I (2011) Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica. Parasitol Res 109:1209\u20131223","journal-title":"Parasitol Res"},{"key":"3650_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1365-3024.2011.01317.x","volume":"34","author":"SE Ellis","year":"2012","unstructured":"Ellis SE, Newlands GF, Nisbet AJ, Matthews JB (2012) Phage display library biopanning as a novel approach to identifying nematode vaccine antigens. Parasite Immunol 34:285\u2013295","journal-title":"Parasite Immunol"},{"key":"3650_CR8","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1007\/s00436-012-2832-y","volume":"110","author":"N Foster","year":"2012","unstructured":"Foster N, Elsheikha HM (2012) The immune response to parasitic helminths of veterinary importance and its potential manipulation for future vaccine control strategies. Parasitol Res 110:1587\u20131599","journal-title":"Parasitol Res"},{"key":"3650_CR9","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1016\/j.vaccine.2010.06.039","volume":"28","author":"O Golden","year":"2010","unstructured":"Golden O, Flynn RJ, Read C, Sekiya M, Donnelly SM, Stack C, Dalton JP, Mulcahy G (2010) Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1). Vaccine 28:5551\u20135557","journal-title":"Vaccine"},{"key":"3650_CR10","first-page":"334","volume":"32","author":"A G\u00fcl","year":"2008","unstructured":"G\u00fcl A, Aydin A (2008) Prevalence of liver flukes in hair goats slaughtered in Hakkari (Y\u00fcksekova) Province. Turkiye Parazitol Derg 32:334\u2013336","journal-title":"Turkiye Parazitol Derg"},{"key":"3650_CR11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.vaccine.2008.10.035","volume":"27","author":"O Ha\u00e7ariz","year":"2009","unstructured":"Ha\u00e7ariz O, Sayers G, McCullough M, Garrett M, O'Donovan J, Mulcahy G (2009) The effect of Quil A adjuvant on the course of experimental Fasciola hepatica infection in sheep. Vaccine 27:45\u201350","journal-title":"Vaccine"},{"key":"3650_CR12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1079\/JOH2005304","volume":"79","author":"GV Hillyer","year":"2005","unstructured":"Hillyer GV (2005) Fasciola antigens as vaccines against fascioliasis and schistosomiasis. J Helminthol 79:241\u2013247","journal-title":"J Helminthol"},{"key":"3650_CR13","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.vetpar.2009.07.011","volume":"165","author":"L Issia","year":"2009","unstructured":"Issia L, Pietrokovsky S, Sousa-Figueiredo J, Stothard JR, Wisnivesky-Colli C (2009) Fasciola hepatica infections in livestock flock, guanacos and coypus in two wildlife reserves in Argentina. Vet Parasitol 165:341\u2013344","journal-title":"Vet Parasitol"},{"key":"3650_CR14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0065-308X(09)69004-7","volume":"69","author":"M Kasn\u00fd","year":"2009","unstructured":"Kasn\u00fd M, Mike\u0161 L, Hampl V, Dvor\u00e1k J, Caffrey CR, Dalton JP, Hor\u00e1k P (2009) Peptidases of trematodes (chapter 4). Adv Parasitol 69:205\u2013297","journal-title":"Adv Parasitol"},{"key":"3650_CR15","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1128\/CMR.00012-09","volume":"22","author":"J Keiser","year":"2009","unstructured":"Keiser J, Utzinger J (2009) Food-borne trematodiases. Clin Microbiol Rev 22:466\u2013483","journal-title":"Clin Microbiol Rev"},{"key":"3650_CR16","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.vetpar.2009.03.027","volume":"163","author":"F Kenyon","year":"2009","unstructured":"Kenyon F, Sargison ND, Skuce PJ, Jackson F (2009) Sheep helminth parasitic disease in south eastern Scotland arising as a possible consequence of climate change. Vet Parasitol 163:293\u2013297","journal-title":"Vet Parasitol"},{"key":"3650_CR17","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1016\/j.vaccine.2007.01.057","volume":"25","author":"M Kesik","year":"2007","unstructured":"Kesik M, Jedlina-Panasiuk L, Kozak-Cieszczyk M, P\u0142ucienniczak A, Wedrychowicz H (2007) Enteral vaccination of rats against Fasciola hepatica using recombinant cysteine proteinase (cathepsin L1). Vaccine 25:3619\u20133628","journal-title":"Vaccine"},{"key":"3650_CR18","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s00436-010-1931-x","volume":"107","author":"MN Khan","year":"2010","unstructured":"Khan MN, Sajid MS, Khan MK, Iqbal Z, Hussain A (2010) Gastrointestinal helminthiasis: prevalence and associated determinants in domestic ruminants of district Toba Tek Singh, Punjab, Pakistan. Parasitol Res 107:787\u2013794","journal-title":"Parasitol Res"},{"key":"3650_CR19","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1007\/s00436-013-3464-6","volume":"112","author":"MK Khan","year":"2013","unstructured":"Khan MK, Sajid MS, Riaz H, Ahmad NE, He L, Shahzad M, Hussain A, Khan MN, Iqbal Z, Zhao J (2013) The global burden of fasciolosis in domestic animals with an outlook on the contribution of new approaches for diagnosis and control. Parasitol Res 112:2421\u20132430","journal-title":"Parasitol Res"},{"key":"3650_CR20","doi-asserted-by":"publisher","first-page":"9057","DOI":"10.1016\/j.vaccine.2011.09.020","volume":"29","author":"G Maggioli","year":"2011","unstructured":"Maggioli G, Acosta D, Silveira F, Rossi S, Giacaman S, Basika T, Gayo V, Rosadilla D, Roche L, Tort J, Carmona C (2011) The recombinant gut-associated M17 leucine aminopeptidase in combination with different adjuvants confers a high level of protection against Fasciola hepatica infection in sheep. Vaccine 29:9057\u20139063","journal-title":"Vaccine"},{"key":"3650_CR21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-308X(09)69002-3","volume":"69","author":"S Mas-Coma","year":"2009","unstructured":"Mas-Coma S, Valero MA, Bargues MD (2009a) Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. Adv Parasitol 69:41\u2013146","journal-title":"Adv Parasitol"},{"key":"3650_CR22","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.vetpar.2009.03.024","volume":"163","author":"S Mas-Coma","year":"2009","unstructured":"Mas-Coma S, Valero MA, Bargues MD (2009b) Climate change effects on trematodiases, with emphasis on zoonotic fascioliasis and schistosomiasis. Vet Parasitol 163:264\u2013280","journal-title":"Vet Parasitol"},{"key":"3650_CR23","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1017\/S0031182006001806","volume":"133","author":"DP McManus","year":"2006","unstructured":"McManus DP, Dalton JP (2006) Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica. Parasitology 133:S43\u2013S61","journal-title":"Parasitology"},{"key":"3650_CR24","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.1016\/j.vaccine.2010.01.055","volume":"28","author":"RE Mendes","year":"2010","unstructured":"Mendes RE, P\u00e9rez-Ecija RA, Zafra R, Buffoni L, Mart\u00ednez-Moreno A, Dalton JP, Mulcahy G, P\u00e9rez J (2010a) Evaluation of hepatic changes and local and systemic immune responses in goats immunized with recombinant Peroxiredoxin (Prx) and challenged with Fasciola hepatica. Vaccine 28:2832\u20132840","journal-title":"Vaccine"},{"key":"3650_CR25","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1590\/S0074-02762010000500017","volume":"105","author":"RE Mendes","year":"2010","unstructured":"Mendes RE, Zafra R, P\u00e9rez-Ecija RA, Buffoni L, Mart\u00ednez-Moreno A, Tendler M, P\u00e9rez J (2010b) Evaluation of local immune response to Fasciola hepatica experimental infection in the liver and hepatic lymph nodes of goats immunized with Sm14 vaccine antigen. Mem Inst Oswaldo Cruz 105:698\u2013705","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"3650_CR26","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1136\/inpract.24.7.378","volume":"24","author":"GB Mitchell","year":"2002","unstructured":"Mitchell GB (2002) Update on fascioliasis in cattle and sheep. In Pract 24:378\u2013385","journal-title":"In Pract"},{"key":"3650_CR27","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/S0264-410X(97)00289-2","volume":"16","author":"G Mulcahy","year":"1998","unstructured":"Mulcahy G, O\u2019Connor F, McGonigle S, Dowd A, Clery DG, Andrews SJ, Dalton JP (1998) Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica. Vaccine 16:932\u2013939","journal-title":"Vaccine"},{"key":"3650_CR28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00436-006-0438-y","volume":"101","author":"JA Mungu\u00eda-X\u00f3chihua","year":"2007","unstructured":"Mungu\u00eda-X\u00f3chihua JA, Ibarra-Velarde F, Ducoing-Watty A, Montenegro-Cristino N, Quiroz-Romero H (2007) Prevalence of Fasciola hepatica (ELISA and fecal analysis) in ruminants from a semi-desert area in the northwest of Mexico. Parasitol Res 101:127\u2013130","journal-title":"Parasitol Res"},{"key":"3650_CR29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.vetpar.2013.01.001","volume":"195","author":"P Ortiz","year":"2013","unstructured":"Ortiz P, Scarcella S, Cerna C, Rosales C, Cabrera M, Guzm\u00e1n M, Lamenza P, Solana H (2013) Resistance of Fasciola hepatica against Triclabendazole in cattle in Cajamarca (Peru): a clinical trial and an in vivo efficacy test in sheep. Vet Parasitol 195:118\u2013121","journal-title":"Vet Parasitol"},{"key":"3650_CR30","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.biotechadv.2010.07.004","volume":"28","author":"J Pande","year":"2010","unstructured":"Pande J, Szewczyk MM, Grover AK (2010) Phage display: concept, innovations, applications and future. Biotechnol Adv 28:849\u2013858","journal-title":"Biotechnol Adv"},{"key":"3650_CR31","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.tvjl.2009.07.004","volume":"185","author":"RA P\u00e9rez-Ecija","year":"2010","unstructured":"P\u00e9rez-Ecija RA, Mendes RE, Zafra R, Buffonni L, Mart\u00ednez-Moreno A, P\u00e9rez J (2010) Pathological and parasitological protection in goats immunised with recombinant cathepsin L1 and challenged with Fasciola hepatica. Vet J 185:351\u2013353","journal-title":"Vet J"},{"key":"3650_CR32","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jmb.2012.01.038","volume":"417","author":"H Qi","year":"2012","unstructured":"Qi H, Lu H, Qiu HJ, Petrenko V, Liu A (2012) Phagemid vectors for phage display: properties, characteristics and construction. J Mol Biol 417:129\u2013143","journal-title":"J Mol Biol"},{"key":"3650_CR33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ijpara.2012.11.004","volume":"43","author":"MW Robinson","year":"2013","unstructured":"Robinson MW, Dalton JP, O'Brien BA, Donnelly S (2013) Fasciola hepatica: the therapeutic potential of a worm secretome. Int J Parasitol 43:283\u2013291","journal-title":"Int J Parasitol"},{"key":"3650_CR34","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0732-8893(02)00431-5","volume":"44","author":"MB Rokni","year":"2002","unstructured":"Rokni MB, Massoud J, O'Neill SM, Parkinson M, Dalton JP (2002) Diagnosis of human fasciolosis in the Gilan province of Northern Iran: application of cathepsin L-ELISA. Diagn Microbiol Infect Dis 44:175\u2013179","journal-title":"Diagn Microbiol Infect Dis"},{"key":"3650_CR35","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.sbi.2007.08.007","volume":"17","author":"SS Sidhu","year":"2007","unstructured":"Sidhu SS, Koide S (2007) Phage display for engineering and analyzing protein interaction interfaces. Curr Opin Struct Biol 17:481\u2013487","journal-title":"Curr Opin Struct Biol"},{"key":"3650_CR36","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/msb.2011.75","volume":"7","author":"F Sievers","year":"2011","unstructured":"Sievers F, Wilm A, Dineen D, Gibson TJ, Karplus K, Li W, Lopez R, McWilliam H, Remmert M, S\u00f6ding J, Thompson JD, Higgins DG (2011) Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol 7:539","journal-title":"Mol Syst Biol"},{"key":"3650_CR37","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1016\/j.vaccine.2009.01.091","volume":"27","author":"HX Sun","year":"2009","unstructured":"Sun HX, Xie Y, Ye YP (2009) Advances in saponin-based adjuvants. Vaccine 27:1787\u20131796","journal-title":"Vaccine"},{"key":"3650_CR38","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3389\/fimmu.2012.00419","volume":"3","author":"RR Tonelli","year":"2013","unstructured":"Tonelli RR, Colli W, Alves MJ (2013) Selection of binding targets in parasites using phage-display and aptamer libraries in vivo and in vitro. Front Immunol 3:419","journal-title":"Front Immunol"},{"key":"3650_CR39","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s00436-011-2341-4","volume":"109","author":"E Toner","year":"2011","unstructured":"Toner E, Brennan GP, Hanna RE, Edgar HW, Fairweather I (2011) Fasciola hepatica: time-dependent disruption of spermatogenesis following in vivo treatment with triclabendazole. Parasitol Res 109:1035\u20131043","journal-title":"Parasitol Res"},{"key":"3650_CR40","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.tvjl.2012.03.003","volume":"194","author":"A Villa-Mancera","year":"2012","unstructured":"Villa-Mancera A, M\u00e9ndez-Mendoza M (2012) Protection and antibody isotype responses against Fasciola hepatica with specific antibody to pIII-displayed peptide mimotopes of cathepsin L1 in sheep. Vet J 194:108\u2013112","journal-title":"Vet J"},{"key":"3650_CR41","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1017\/S003118200800471X","volume":"135","author":"A Villa-Mancera","year":"2008","unstructured":"Villa-Mancera A, Quiroz-Romero H, Correa D, Ibarra F, Reyes-P\u00e9rez H, Reyes-Vivas H, L\u00f3pez-Vel\u00e1zquez G, Gazarian K, Gazarian T, Alonso RA (2008) Induction of immunity in sheep to Fasciola hepatica with mimotopes of cathepsin L selected from a phage display library. Parasitology 135:1437\u20131445","journal-title":"Parasitology"},{"key":"3650_CR42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1017\/S0022149X1000026X","volume":"85","author":"A Villa-Mancera","year":"2011","unstructured":"Villa-Mancera A, Quiroz-Romero H, Correa D, Alonso RA (2011) Proteolytic activity in Fasciola hepatica is reduced by the administration of cathepsin L mimotopes. J Helminthol 85:51\u201355","journal-title":"J Helminthol"},{"key":"3650_CR43","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jcpa.2008.06.004","volume":"139","author":"R Zafra","year":"2008","unstructured":"Zafra R, Buffoni L, Mart\u00ednez-Moreno A, P\u00e9rez-Ecija A, Martinez-Moreno FJ, P\u00e9rez J (2008) A study of the liver of goats immunized with a synthetic peptide of the Sm14 antigen and challenged with Fasciola hepatica. J Comp Pathol 139:169\u2013176","journal-title":"J Comp Pathol"},{"key":"3650_CR44","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.rvsc.2009.02.013","volume":"87","author":"R Zafra","year":"2009","unstructured":"Zafra R, Buffoni L, P\u00e9rez-Ecija RA, Mendes RE, Mart\u00ednez-Moreno A, Mart\u00ednez-Moreno FJ, P\u00e9rez J (2009) Study of the local immune response to Fasciola hepatica in the liver and hepatic lymph nodes of goats immunised with a peptide of the Sm14 antigen. Res Vet Sci 87:226\u2013232","journal-title":"Res Vet Sci"},{"key":"3650_CR45","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jcpa.2010.01.011","volume":"143","author":"R Zafra","year":"2010","unstructured":"Zafra R, P\u00e9rez-Ecija RA, Buffoni L, Mendes RE, Mart\u00ednez-Moreno A, Mart\u00ednez-Moreno FJ, Galisteo ME, P\u00e9rez J (2010) Evaluation of hepatic damage and local immune response in goats immunized with native glutathione S-transferase of Fasciola hepatica. J Comp Pathol 143:110\u2013119","journal-title":"J Comp Pathol"},{"key":"3650_CR46","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.jcpa.2012.08.007","volume":"148","author":"R Zafra","year":"2013","unstructured":"Zafra R, P\u00e9rez-\u00c9cija RA, Buffoni L, Moreno P, Bautista MJ, Mart\u00ednez-Moreno A, Mulcahy G, Dalton JP, P\u00e9rez J (2013a) Early and late peritoneal and hepatic changes in goats immunized with recombinant cathepsin L1 and infected with Fasciola hepatica. J Comp Pathol 148:373\u2013384","journal-title":"J Comp Pathol"},{"key":"3650_CR47","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.rvsc.2012.10.026","volume":"94","author":"R Zafra","year":"2013","unstructured":"Zafra R, P\u00e9rez-\u00c9cija RA, Buffoni L, Pacheco IL, Mart\u00ednez-Moreno A, LaCourse EJ, Perally S, Brophy PM, P\u00e9rez J (2013b) Early hepatic and peritoneal changes and immune response in goats vaccinated with a recombinant glutathione transferase sigma class and challenged with Fasciola hepatica. Res Vet Sci 94:602\u2013609","journal-title":"Res Vet Sci"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-013-3650-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-013-3650-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-013-3650-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-013-3650-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T21:56:26Z","timestamp":1744149386000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-013-3650-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,12]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["3650"],"URL":"https:\/\/doi.org\/10.1007\/s00436-013-3650-6","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,12]]},"assertion":[{"value":"13 September 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}