{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:52:45Z","timestamp":1771865565498,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T00:00:00Z","timestamp":1429315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1007\/s00436-015-4480-5","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T05:55:57Z","timestamp":1429250157000},"page":"2735-2742","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Immunomodulatory and antiparasitic effects of garlic extract on Eimeria vermiformis-infected mice"],"prefix":"10.1007","volume":"114","author":[{"given":"Atef Mohammed","family":"Khalil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman Samir","family":"Farid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ibrahim","family":"Desouky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouchira Mohammed","family":"Mohi-Eldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohie","family":"Haridy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Horii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,18]]},"reference":[{"issue":"2","key":"4480_CR1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1286-4579(99)80003-3","volume":"1","author":"S Ankri","year":"1999","unstructured":"Ankri S, Mirelman D (1999) Antimicrobial properties of allicin from garlic. Microbes Infect 1(2):125\u2013129","journal-title":"Microbes Infect"},{"issue":"10","key":"4480_CR2","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1128\/AAC.41.10.2286","volume":"41","author":"S Ankri","year":"1997","unstructured":"Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D (1997) Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob Agents Chemother 41(10):2286\u20132288","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"4480_CR3","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.pt.2005.08.004","volume":"21","author":"JP Anthony","year":"2005","unstructured":"Anthony JP, Fyfe L, Smith H (2005) Plant active components\u2014a resource for antiparasitic agents? Trends Parasitol 21(10):462\u2013468","journal-title":"Trends Parasitol"},{"issue":"6","key":"4480_CR4","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1046\/j.1525-1500.1999.99050.x","volume":"23","author":"S Balasenthil","year":"1999","unstructured":"Balasenthil S, Arivazhagan S, Ramachandran CR, Nagini S (1999) Effects of garlic on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Cancer Detect Prev 23(6):534\u2013538","journal-title":"Cancer Detect Prev"},{"issue":"6","key":"4480_CR5","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1084\/jem.174.6.1549","volume":"174","author":"C Bogdan","year":"1991","unstructured":"Bogdan C, Vodovotz Y, Nathan C (1991) Macrophage deactivation by interleukin 10. J Exp Med 174(6):1549\u20131555","journal-title":"J Exp Med"},{"issue":"6","key":"4480_CR6","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2174\/1871520614666140521120811","volume":"14","author":"HX Cao","year":"2014","unstructured":"Cao HX, Zhu KX, Fan JG, Qiao L (2014) Garlic-derived allyl sulfides in cancer therapy. Anti Cancer Agents Med Chem 14(6):793\u2013799","journal-title":"Anti Cancer Agents Med Chem"},{"issue":"2","key":"4480_CR7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/03079459708419208","volume":"26","author":"HD Chapman","year":"1997","unstructured":"Chapman HD (1997) Biochemical, genetic and applied aspects of drug resistance in Eimeria parasites of the fowl. Avian Pathol 26(2):221\u2013244","journal-title":"Avian Pathol"},{"key":"4480_CR8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-immunol-032713-120216","volume":"32","author":"YH Chien","year":"2014","unstructured":"Chien YH, Meyer C, Bonneville M (2014) \u03b3\u03b4 T cells: first line of defense and beyond. Annu Rev Immunol 32:121\u2013155","journal-title":"Annu Rev Immunol"},{"issue":"2","key":"4480_CR9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/jmf.2006.9.205","volume":"9","author":"LY Chung","year":"2006","unstructured":"Chung LY (2006) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food 9(2):205\u2013213","journal-title":"J Med Food"},{"issue":"5","key":"4480_CR10","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1128\/AAC.50.5.1731-1737.2006","volume":"50","author":"A Coppi","year":"2006","unstructured":"Coppi A, Cabinian M, Mirelman D, Sinnis P (2006) Antimalarial activity of allicin, a biologically active compound from garlic cloves. Antimicrob Agents Chemother 50(5):1731\u20131737","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"4480_CR11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12263-007-0051-4","volume":"2","author":"YE Dommels","year":"2007","unstructured":"Dommels YE, Butts CA, Zhu S, Davy M, Martell S, Hedderley D, Barnett MP, McNabb WC, Roy NC (2007) Characterization of intestinal inflammation and identification of related gene expression changes in mdr1a(\u2212\/\u2212) mice. Genes Nutr 2(2):209\u2013223","journal-title":"Genes Nutr"},{"key":"4480_CR12","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/1475-2875-11-268","volume":"11","author":"Y Feng","year":"2012","unstructured":"Feng Y, Zhu X, Wang Q, Jiang Y, Shang H, Cui L, Cao Y (2012) Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection. Malar J 11:268","journal-title":"Malar J"},{"issue":"1","key":"4480_CR13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1440-1711.2001.00788.x","volume":"79","author":"JT Ford","year":"2001","unstructured":"Ford JT, Wong CW, Colditz IG (2001) Effects of dietary protein types on immune responses and levels of infection with Eimeria vermiformis in mice. Immunol Cell Biol 79(1):23\u201328","journal-title":"Immunol Cell Biol"},{"issue":"6","key":"4480_CR14","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.4049\/jimmunol.148.6.1792","volume":"148","author":"RT Gazzinelli","year":"1992","unstructured":"Gazzinelli RT, Oswald IP, James SL, Sher A (1992) IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages. J Immunol 148(6):1792\u20131796","journal-title":"J Immunol"},{"issue":"5","key":"4480_CR15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-3083.2000.00803.x","volume":"52","author":"T Ghazanfari","year":"2000","unstructured":"Ghazanfari T, Hassan ZM, Ebtekar M, Ahmadiani A, Naderi G, Azar A (2000) Garlic induces a shift in cytokine pattern in Leishmania major-infected BALB\/c mice. Scand J Immunol 52(5):491\u2013495","journal-title":"Scand J Immunol"},{"issue":"3","key":"4480_CR16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jep.2005.08.026","volume":"103","author":"T Ghazanfari","year":"2006","unstructured":"Ghazanfari T, Hassan ZM, Khamesipour A (2006) Enhancement of peritoneal macrophage phagocytic activity against Leishmania major by garlic (Allium sativum) treatment. J Ethnopharmacol 103(3):333\u2013337","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"4480_CR17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/abio.1995.1124","volume":"225","author":"J Han","year":"1995","unstructured":"Han J, Lawson L, Han G, Han P (1995) A spectrophotometric method for quantitative determination of allicin and total garlic thiosulfinates. Anal Biochem 225(1):157\u2013160","journal-title":"Anal Biochem"},{"issue":"3","key":"4480_CR18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-5699(99)01575-3","volume":"21","author":"RM Hershberg","year":"2000","unstructured":"Hershberg RM, Mayer LF (2000) Antigen processing and presentation by intestinal epithelial cells\u2014polarity and complexity. Immunol Today 21(3):123\u2013128","journal-title":"Immunol Today"},{"issue":"3","key":"4480_CR19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00436-007-0523-x","volume":"101","author":"F Ibarra-Velarde","year":"2007","unstructured":"Ibarra-Velarde F, Alcala-Canto Y (2007) Downregulation of the goat beta-defensin-2 gene by IL-4 in caprine intestinal epithelial cells infected with Eimeria spp. Parasitol Res 101(3):613\u2013618","journal-title":"Parasitol Res"},{"issue":"9","key":"4480_CR20","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1128\/IAI.02024-05","volume":"74","author":"K Inagaki-Ohara","year":"2006","unstructured":"Inagaki-Ohara K, Dewi FN, Hisaeda H, Smith AL, Jimi F, Miyahira M, Abdel-Aleem AS, Horii Y, Nawa Y (2006) Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection. Infect Immun 74(9):5292\u20135301","journal-title":"Infect Immun"},{"issue":"3 Suppl","key":"4480_CR21","doi-asserted-by":"crossref","first-page":"816S","DOI":"10.1093\/jn\/136.3.816S","volume":"136","author":"H Ishikawa","year":"2006","unstructured":"Ishikawa H, Saeki T, Otani T, Suzuki T, Shimozuma K, Nishino H, Fukuda S, Morimoto K (2006) Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr 136(3 Suppl):816S\u2013820S","journal-title":"J Nutr"},{"issue":"3\u20134","key":"4480_CR22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0304-4017(01)00557-X","volume":"101","author":"MC Jenkins","year":"2001","unstructured":"Jenkins MC (2001) Advances and prospects for subunit vaccines against protozoa of veterinary importance. Vet Parasitol 101(3\u20134):291\u2013310","journal-title":"Vet Parasitol"},{"issue":"3","key":"4480_CR23","first-page":"223","volume":"8","author":"P Kidd","year":"2003","unstructured":"Kidd P (2003) Th1\/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 8(3):223\u2013246","journal-title":"Altern Med Rev"},{"issue":"5","key":"4480_CR24","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1165\/rcmb.4682","volume":"27","author":"M Kondo","year":"2002","unstructured":"Kondo M, Tamaoki J, Takeyama K, Nakata J, Nagai A (2002) Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epithelium. Am J Respir Cell Mol Biol 27(5):536\u2013541","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3s","key":"4480_CR25","doi-asserted-by":"crossref","first-page":"1075S","DOI":"10.1093\/jn\/131.3.1075S","volume":"131","author":"E Kyo","year":"2001","unstructured":"Kyo E, Uda N, Kasuga S, Itakura Y (2001) Immunomodulatory effects of aged garlic extract. J Nutr 131(3s):1075S\u20131079S","journal-title":"J Nutr"},{"issue":"2","key":"4480_CR26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.copbio.2011.08.004","volume":"23","author":"KH Kyung","year":"2012","unstructured":"Kyung KH (2012) Antimicrobial properties of allium species. Curr Opin Biotechnol 23(2):142\u2013147","journal-title":"Curr Opin Biotechnol"},{"issue":"4","key":"4480_CR27","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00436-008-1256-1","volume":"104","author":"BK Linh","year":"2009","unstructured":"Linh BK, Hayashi T, Horii Y (2009) Eimeria vermiformis infection reduces goblet cells by multiplication in the crypt cells of the small intestine of C57BL\/6 mice. Parasitol Res 104(4):789\u2013794","journal-title":"Parasitol Res"},{"issue":"1","key":"4480_CR28","first-page":"51","volume":"74","author":"ZR Lun","year":"1994","unstructured":"Lun ZR, Burri C, Menzinger M, Kaminsky R (1994) Antiparasitic activity of diallyl trisulfide (Dasuansu) on human and animal pathogenic protozoa (Trypanosoma sp., Entamoeba histolytica and Giardia lamblia) in vitro. Ann Soc Belg Med Trop 74(1):51\u201359","journal-title":"Ann Soc Belg Med Trop"},{"issue":"3","key":"4480_CR29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1590\/S0036-46652011000300007","volume":"53","author":"MM Mantawy","year":"2011","unstructured":"Mantawy MM, Ali HF, Rizk MZ (2011) Therapeutic effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infection. Rev Inst Med Trop Sao Paulo 53(3):155\u2013163","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"2","key":"4480_CR30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00436-012-2887-9","volume":"111","author":"MS Metwaly","year":"2012","unstructured":"Metwaly MS, Dkhil MA, Al-Quraishy S (2012) The potential role of Phoenix dactylifera on Eimeria papillata-induced infection in mice. Parasitol Res 111(2):681\u2013687","journal-title":"Parasitol Res"},{"issue":"Pt 1","key":"4480_CR31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S0031182000054330","volume":"88","author":"ME Rose","year":"1984","unstructured":"Rose ME, Owen DG, Hesketh P (1984) Susceptibility to coccidiosis: effect of strain of mouse on reproduction of Eimeria vermiformis. Parasitology 88(Pt 1):45\u201354","journal-title":"Parasitology"},{"issue":"Pt 3","key":"4480_CR32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1017\/S0031182000074515","volume":"105","author":"ME Rose","year":"1992","unstructured":"Rose ME, Hesketh P, Wakelin D (1992) Immune control of murine coccidiosis: CD4+ and CD8+ T lymphocytes contribute differentially in resistance to primary and secondary infections. Parasitology 105(Pt 3):349\u2013354","journal-title":"Parasitology"},{"issue":"4","key":"4480_CR33","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.4049\/jimmunol.173.4.2675","volume":"173","author":"L Rothwell","year":"2004","unstructured":"Rothwell L, Young JR, Zoorob R, Whittaker CA, Hesketh P, Archer A, Smith AL, Kaiser P (2004) Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima. J Immunol 173(4):2675\u20132682","journal-title":"J Immunol"},{"issue":"6","key":"4480_CR34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3(6):1101\u20131108","journal-title":"Nat Protoc"},{"issue":"5","key":"4480_CR35","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/jac\/dkh174","volume":"53","author":"Y Shadkchan","year":"2004","unstructured":"Shadkchan Y, Shemesh E, Mirelman D, Miron T, Rabinkov A, Wilchek M, Osherov N (2004) Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. J Antimicrob Chemother 53(5):832\u2013836","journal-title":"J Antimicrob Chemother"},{"issue":"8","key":"4480_CR36","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.4049\/jimmunol.161.8.4283","volume":"161","author":"Y Shibata","year":"1998","unstructured":"Shibata Y, Foster LA, Kurimoto M, Okamura H, Nakamura RM, Kawajiri K, Justice JP, Van Scott MR, Myrvik QN, Metzger WJ (1998) Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-gamma-inducing factors but enhances NK cell production of IFN-gamma. J Immunol 161(8):4283\u20134288","journal-title":"J Immunol"},{"issue":"4","key":"4480_CR37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0020-7519(02)00268-0","volume":"33","author":"JM Shields","year":"2003","unstructured":"Shields JM, Olson BH (2003) Cyclospora cayetanensis: a review of an emerging parasitic coccidian. Int J Parasitol 33(4):371\u2013391","journal-title":"Int J Parasitol"},{"issue":"7","key":"4480_CR38","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0020-7519(98)00081-2","volume":"28","author":"AL Smith","year":"1998","unstructured":"Smith AL, Hayday AC (1998) Genetic analysis of the essential components of the immunoprotective response to infection with Eimeria vermiformis. Int J Parasitol 28(7):1061\u20131069","journal-title":"Int J Parasitol"},{"issue":"2","key":"4480_CR39","first-page":"497","volume":"21","author":"SA Soffar","year":"1991","unstructured":"Soffar SA, Mokhtar GM (1991) Evaluation of the antiparasitic effect of aqueous garlic (Allium sativum) extract in hymenolepiasis nana and giardiasis. J Egypt Soc Parasitol 21(2):497\u2013502","journal-title":"J Egypt Soc Parasitol"},{"issue":"18","key":"4480_CR40","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1016\/j.bmcl.2010.07.062","volume":"20","author":"T Waag","year":"2010","unstructured":"Waag T, Gelhaus C, Rath J, Stich A, Leippe M, Schirmeister T (2010) Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett 20(18):5541\u20135543","journal-title":"Bioorg Med Chem Lett"},{"issue":"3","key":"4480_CR41","first-page":"160","volume":"47","author":"BW Wabwoba","year":"2010","unstructured":"Wabwoba BW, Anjili CO, Ngeiywa MM, Ngure PK, Kigondu EM, Ingonga J, Makwali J (2010) Experimental chemotherapy with Allium sativum (Liliaceae) methanolic extract in rodents infected with Leishmania major and Leishmania donovani. J Vector Borne Dis 47(3):160\u2013167","journal-title":"J Vector Borne Dis"},{"issue":"8","key":"4480_CR42","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0020-7519(99)00086-7","volume":"29","author":"RB Williams","year":"1999","unstructured":"Williams RB (1999) A compartmentalised model for the estimation of the cost of coccidiosis to the world\u2019s chicken production industry. Int J Parasitol 29(8):1209\u20131229","journal-title":"Int J Parasitol"},{"issue":"3","key":"4480_CR43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0147-9571(98)00007-1","volume":"21","author":"M Yasuda","year":"1998","unstructured":"Yasuda M, Taura Y, Yokomizo Y, Ekino S (1998) A comparative study of germinal center: fowls and mammals. Comp Immunol Microbiol Infect Dis 21(3):179\u2013189","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"1","key":"4480_CR44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0928-8244(02)00460-1","volume":"35","author":"CH Yun","year":"2003","unstructured":"Yun CH, Estrada A, Van Kessel A, Park BC, Laarveld B (2003) Beta-glucan, extracted from oat, enhances disease resistance against bacterial and parasitic infections. FEMS Immunol Med Microbiol 35(1):67\u201375","journal-title":"FEMS Immunol Med Microbiol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-015-4480-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-015-4480-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-015-4480-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T14:50:54Z","timestamp":1691592654000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-015-4480-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,18]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["4480"],"URL":"https:\/\/doi.org\/10.1007\/s00436-015-4480-5","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,18]]}}}