{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:41:14Z","timestamp":1767987674341,"version":"3.49.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T00:00:00Z","timestamp":1431043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s00436-015-4505-0","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T05:05:33Z","timestamp":1430975133000},"page":"3027-3040","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Acetylcholinesterase 1 in populations of organophosphate-resistant North American strains of the cattle tick, Rhipicephalus microplus (Acari: Ixodidae)"],"prefix":"10.1007","volume":"114","author":[{"given":"Kylie G.","family":"Bendele","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix D.","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto A.","family":"Barrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula M.","family":"Moolhuijzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K.","family":"McCooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew I.","family":"Bellgard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,8]]},"reference":[{"key":"4505_CR1","doi-asserted-by":"crossref","first-page":"W573","DOI":"10.1093\/nar\/gks485","volume":"40","author":"B Alix","year":"2012","unstructured":"Alix B, Boubacar DA, Vladimir M (2012) T-REX: a web server for inferring, validating and visualizing phylogenetic trees and networks. Nucleic Acids Res 40:W573\u2013W579","journal-title":"Nucleic Acids Res"},{"key":"4505_CR2","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389\u20133402","journal-title":"Nucleic Acids Res"},{"key":"4505_CR3","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1111\/j.1742-4658.2005.04945.x","volume":"272","author":"SF Altschul","year":"2005","unstructured":"Altschul SF, Wootton JC, Gertz EM, Agarwala R, Morgulis A, Schaffer AA, Yu YK (2005) Protein database searches using compositionally adjusted substitution matrices. FEBS J 272:5101\u20135109","journal-title":"FEBS J"},{"key":"4505_CR4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0965-1748(98)00034-4","volume":"28","author":"GD Baxter","year":"1998","unstructured":"Baxter GD, Barker SC (1998) Acetylcholinesterase cDNA of the cattle tick, Boophilus microplus: characterisation and role in organophosphate resistance. Insect Biochem Mol Biol 28:581\u2013589","journal-title":"Insect Biochem Mol Biol"},{"key":"4505_CR5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0965-1748(01)00168-0","volume":"32","author":"GD Baxter","year":"2002","unstructured":"Baxter GD, Barker SC (2002) Analysis of the sequence and expression of a second putative acetylcholinesterase cDNA from organophosphate-susceptible and organophosphate-resistant cattle ticks. Insect Biochem Mol Biol 32:815\u2013820","journal-title":"Insect Biochem Mol Biol"},{"key":"4505_CR6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijpara.2011.11.006","volume":"42","author":"MI Bellgard","year":"2012","unstructured":"Bellgard MI, Moolhuijzen PM, Guerrero FD, Schibeci D, Rodriguez-Valle M, Peterson DG, Dowd SE, Barrero R, Hunter A, Miller RJ, Lew-Tabor AE (2012) CattleTickBase: an integrated internet-based bioinformatics resource for Rhipicephalus (Boophilus) microplus. Int J Parasitol 42:161\u2013169","journal-title":"Int J Parasitol"},{"key":"4505_CR7","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1101\/gr.1865504","volume":"14","author":"E Birney","year":"2004","unstructured":"Birney E, Clamp M, Durbin R (2004) GeneWise and genomewise. Genome Res 14:988\u2013995","journal-title":"Genome Res"},{"key":"4505_CR8","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1006\/jmbi.1999.3310","volume":"294","author":"N Blom","year":"1999","unstructured":"Blom N, Gammeltoft S, Brunak S (1999) Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 294:1351\u20131362","journal-title":"J Mol Biol"},{"key":"4505_CR9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nprot.2007.131","volume":"2","author":"O Emanuelsson","year":"2007","unstructured":"Emanuelsson O, Brunak S, von Heijne G, Nielsen H (2007) Locating proteins in the cell using TargetP, SignalP, and related tools. Nat Protoc 2:953\u2013971","journal-title":"Nat Protoc"},{"issue":"83","key":"4505_CR10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0378-4274(95)03470-6","volume":"82","author":"R Feyereisen","year":"1995","unstructured":"Feyereisen R (1995) Molecular biology of insecticide resistance. Toxicol Lett 82(83):83\u201390","journal-title":"Toxicol Lett"},{"key":"4505_CR11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0749-0720(02)00030-0","volume":"18","author":"JE George","year":"2002","unstructured":"George JE, Davey RB, Pound JM (2002) Introduced ticks and tick-borne diseases: the threat and approaches to eradication. Vet Clin N Am Food Anim Pract 18:401\u2013416","journal-title":"Vet Clin N Am Food Anim Pract"},{"key":"4505_CR12","doi-asserted-by":"crossref","first-page":"W695","DOI":"10.1093\/nar\/gkq313","volume":"38","author":"M Goujon","year":"2010","unstructured":"Goujon M, McWilliam H, Li W, Valentin F, Squizzato S, Paern J, Lopez R (2010) A new bioinformatic analysis tools framework at EMBL-EBI. Nucleic Acids Res 38:W695\u2013W699","journal-title":"Nucleic Acids Res"},{"key":"4505_CR13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/jmedent\/13.6.629","volume":"13","author":"OH Graham","year":"1977","unstructured":"Graham OH, Hourrigan JL (1977) Eradication programs for the arthropod parasites of livestock. J Med Entomol 13:629\u2013658","journal-title":"J Med Entomol"},{"key":"4505_CR14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1603\/0022-2585-38.1.44","volume":"38","author":"FD Guerrero","year":"2001","unstructured":"Guerrero FD, Davey RB, Miller RJ (2001) Use of an allele-specific polymerase chain reaction assay to genotype pyrethroid resistant strains of Boophilus microplus (Acari: Ixodidae). J Med Entomol 38:44\u201350","journal-title":"J Med Entomol"},{"key":"4505_CR15","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1186\/1471-2164-11-374","volume":"11","author":"FD Guerrero","year":"2010","unstructured":"Guerrero FD, Moolhuijzen P, Peterson DG, Bidwell S, Caler E, Bellgard M, Nene VM, Djikeng A (2010) Reassociation kinetics-based approach for partial genome sequencing of the cattle tick, Rhipicephalus (Boophilus) microplus. BMC Genomics 11:374","journal-title":"BMC Genomics"},{"key":"4505_CR16","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/genetics\/155.3.1149","volume":"155","author":"CJ Hanrahan","year":"2000","unstructured":"Hanrahan CJ, Palladino MJ, Ganetzky B, Reenan RA (2000) RNA editing of the Drosophila para Na+ channel transcript: evolutionary conservation and developmental regulation. Genetics 155:1149\u20131160","journal-title":"Genetics"},{"key":"4505_CR17","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/jmedent\/36.6.764","volume":"36","author":"R Hernandez","year":"1999","unstructured":"Hernandez R, He H, Chen A, Ivie GW, George JE, Wagner GG (1999) Cloning and sequencing of a putative acetylcholinesterase cDNA from Boophilus microplus (Acari: Ixodidae). J Med Entomol 36:764\u2013770","journal-title":"J Med Entomol"},{"key":"4505_CR18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pt.2005.02.004","volume":"21","author":"CA Hill","year":"2005","unstructured":"Hill CA, Wikel SK (2005) The Ixodes scapularis genome project: an opportunity for advancing tick research. Trends Parasitol 21:151\u2013153","journal-title":"Trends Parasitol"},{"key":"4505_CR19","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/bioinformatics\/14.4.378","volume":"14","author":"T Hirokawa","year":"1998","unstructured":"Hirokawa T, Boon-Chieng S, Mitaku S (1998) SOSUI: classification and secondary structure prediction system for membrane proteins. Bioinformatics 14:378\u2013379","journal-title":"Bioinformatics"},{"key":"4505_CR20","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0022-1910(99)00157-2","volume":"46","author":"RC Jamroz","year":"2000","unstructured":"Jamroz RC, Guerrero FD, Pruett JH, Oehler DD, Miller RJ (2000) Molecular and biochemical survey of acaricide resistance mechanisms in larvae from Mexican strains of the southern cattle tick, Boophilus microplus. J Insect Physiol 46:685\u2013695","journal-title":"J Insect Physiol"},{"key":"4505_CR21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/glycob\/cwh151","volume":"15","author":"K Julenius","year":"2004","unstructured":"Julenius K, Molgaard A, Gupta R, Brunak S (2004) Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites. Glycobiology 15:153\u2013164","journal-title":"Glycobiology"},{"key":"4505_CR22","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1101\/gr.119974.110","volume":"21","author":"I Jungreis","year":"2014","unstructured":"Jungreis I, Lin MF, Spokony R, Chan CS, Negre N, Victorsen A, White KP, Kellis M (2014) Evidence of abundant stop codon readthrough in Drosophila and other metazoa. Genome Res 21:2096\u20132113","journal-title":"Genome Res"},{"key":"4505_CR23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ibmb.2012.11.004","volume":"43","author":"YH Kim","year":"2013","unstructured":"Kim YH, Lee SH (2013) Which acetylcholinesterase functions as the main catalytic enzyme in the Class Insecta? Insect Biochem Mol Biol 43:47\u201353","journal-title":"Insect Biochem Mol Biol"},{"key":"4505_CR24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ibmb.2014.03.001","volume":"48","author":"YH Kim","year":"2014","unstructured":"Kim YH, Kwon DH, Ahn HM, Koh YH, Lee SH (2014) Induction of soluble AChE expression via alternative splicing by chemical stress in Drosophila melanogaster. Insect Biochem Mol Biol 48:75\u201382","journal-title":"Insect Biochem Mol Biol"},{"key":"4505_CR25","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","volume":"23","author":"MA Larkin","year":"2007","unstructured":"Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG (2007) Clustal W and Clustal X version 2.0. Bioinformatics 23:2947\u20132948","journal-title":"Bioinformatics"},{"key":"4505_CR26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1603\/0022-2585-40.4.482","volume":"40","author":"AY Li","year":"2003","unstructured":"Li AY, Davey RB, Miller RJ, George JE (2003) Resistance to coumaphos and diazinon in Boophilus microplus (Acari: Ixodidae) and evidence for the involvement of an oxidative detoxification mechanism. J Med Entomol 40:482\u2013490","journal-title":"J Med Entomol"},{"key":"4505_CR27","first-page":"216","volume":"2","author":"L Lovis","year":"2012","unstructured":"Lovis L, Guerrero FD, Miller RJ, Bodine DM, Betschart B, Sager H (2012) Distribution patterns of three sodium channel mutations associated with pyrethroid resistance in Rhipicephalus (Boophilus) microplus populations from North and South America, South Africa and Australia. Int J Parasitol: Drugs Drug Resist 2:216\u2013224","journal-title":"Int J Parasitol: Drugs Drug Resist"},{"key":"4505_CR28","doi-asserted-by":"crossref","first-page":"W327","DOI":"10.1093\/nar\/gkh454","volume":"32","author":"A Marchler-Bauer","year":"2004","unstructured":"Marchler-Bauer A, Bryant S (2004) CD-Search: protein domain annotations on the fly. Nucleic Acids Res 32:W327\u2013W331","journal-title":"Nucleic Acids Res"},{"key":"4505_CR29","doi-asserted-by":"crossref","first-page":"D205","DOI":"10.1093\/nar\/gkn845","volume":"37","author":"A Marchler-Bauer","year":"2009","unstructured":"Marchler-Bauer A, Anderson JB, Chitsaz F, Derbyshire MK, DeWeese-Scott C, Fong JH, Geer LY, Geer RC, Gonzales NR, Gwadz M, He S, Hurwitz DI, Jackson JD, Ke Z, Lanczycki CJ, Liebert CA, Liu C, Lu F, Lu S, Marchler GH, Mullokandov M, Song JS, Tasneem A, Thanki N, Yamashita RA, Zhang D, Zhang N, Bryant SH (2009) CDD: specific functional annotation with the conserved domain database. Nucleic Acids Res 37:D205\u2013D210","journal-title":"Nucleic Acids Res"},{"key":"4505_CR30","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1093\/jmedent\/42.5.912","volume":"45","author":"R Miller","year":"2005","unstructured":"Miller R, Davey RB, George JE (2005) First report of organophosphate-resistant Boophilus microplus (Acari: Ixodidae) within the United States of America. J Med Entomol 45:912\u2013917","journal-title":"J Med Entomol"},{"key":"4505_CR31","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/protein\/12.11.953","volume":"12","author":"S Mitaku","year":"1999","unstructured":"Mitaku S, Hirokawa T (1999) Physiochemical factors for discriminating between soluble and membrane proteins: hydrophobicity of helical segments and protein length. Protein Eng 12:953\u2013957","journal-title":"Protein Eng"},{"key":"4505_CR32","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/bioinformatics\/18.4.608","volume":"18","author":"S Mitaku","year":"2002","unstructured":"Mitaku S, Hirokawa T, Tsuji T (2002) Amphiphilicity index of polar amino acids as an aid in the characterization of amino acid preference at membrane-water interfaces. Bioinformatics 18:608\u2013616","journal-title":"Bioinformatics"},{"key":"4505_CR33","doi-asserted-by":"crossref","first-page":"5922","DOI":"10.1073\/pnas.91.13.5922","volume":"91","author":"A Mutero","year":"1994","unstructured":"Mutero A, Pralavorio M, Bride J-M, Fournier D (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. Proc Natl Acad Sci U S A 91:5922\u20135926","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4505_CR34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0048-3575(72)90010-7","volume":"2","author":"J Nolan","year":"1972","unstructured":"Nolan J, Schnitzerling HJ, Schuntner CA (1972) Multiple forms of acetylcholinesterase from resistant and susceptible strains of the cattle tick, Boophilus microplus (Can.). Pestic Biochem Physiol 2:85\u201394","journal-title":"Pestic Biochem Physiol"},{"key":"4505_CR35","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.ijpara.2007.05.011","volume":"37","author":"J Pagel Van Zee","year":"2007","unstructured":"Pagel Van Zee J, Geraci NS, Guerrero FD, Wikel SK, Stuart JJ, Nene VM, Hill CA (2007) Tick genomics: the Ixodes genome project and beyond. Int J Parasitol 37:1297\u20131305","journal-title":"Int J Parasitol"},{"key":"4505_CR36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/S1984-29612014044","volume":"23","author":"RI Rodriguez-Vivas","year":"2014","unstructured":"Rodriguez-Vivas RI, Perez-Cogollo LC, Rosado-Aguilar JA, Ojeda-Chi MM, Trinidad-Martinez I, Miller RJ, Li AY, Perez de Leon A, Guerrero F, Klafke G (2014) Rhipicephalus (Boophilus) microplus resistant to acaricides and ivermectin in cattle farms of Mexico. Braz J Vet Parasitol Jaboticabal 23:113\u2013122","journal-title":"Braz J Vet Parasitol Jaboticabal"},{"key":"4505_CR37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1126\/science.143.3602.129","volume":"143","author":"HR Smissaert","year":"1964","unstructured":"Smissaert HR (1964) Cholinesterase inhibition in spider mites susceptible and resistant to organophosphate. Science 143:129\u2013131","journal-title":"Science"},{"key":"4505_CR38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1603\/0022-2585-41.3.259","volume":"41","author":"KB Temeyer","year":"2004","unstructured":"Temeyer KB, Davey RB, Chen AC (2004) Identification of a third Boophilus microplus (Acari: Ixodidae) cDNA presumptively encoding an acetylcholinesterase. J Med Entomol 41:259\u2013268","journal-title":"J Med Entomol"},{"key":"4505_CR39","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.vetpar.2010.04.016","volume":"172","author":"KB Temeyer","year":"2010","unstructured":"Temeyer KB, Pruett JH, Olafson PU (2010) Baculovirus expression, biochemical characterization and organophosphate sensitivity of rBmAChE1, rBmAChE2, and rBmAChE3 of Rhipicephalus (Boophilus) microplus. Vet Parasitol 172:114\u2013121","journal-title":"Vet Parasitol"},{"key":"4505_CR40","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1603\/ME11215","volume":"49","author":"KB Temeyer","year":"2012","unstructured":"Temeyer KB, Olafson PU, Pruett JH (2012) Sequence polymorphism in acetylcholinesterase transcripts and genotyping survey of BmAChE1 in laboratory and Mexican strains of Rhipicephalus (Boophilus) microplus. J Med Entomol 49:555\u2013562","journal-title":"J Med Entomol"},{"key":"4505_CR41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/0264-6021:3590175","volume":"359","author":"SB Walsh","year":"2001","unstructured":"Walsh SB, Dolden TA, Moores GD, Kristensen M, Lewis T, Devonshire AL, Williamson MS (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase involved in insecticide resistance. Biochem J 359:175\u2013181","journal-title":"Biochem J"},{"key":"4505_CR42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/jmedent\/25.4.234","volume":"25","author":"FC Wright","year":"1988","unstructured":"Wright FC, Ahrens EH (1988) Cholinesterase insensitivity: a mechanism of resistance in Mexican strains of Boophilus microplus (Acari: Ixodidae) against coumaphos. J Med Entomol 25:234\u2013239","journal-title":"J Med Entomol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-015-4505-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-015-4505-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-015-4505-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T11:49:15Z","timestamp":1651924155000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-015-4505-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,8]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["4505"],"URL":"https:\/\/doi.org\/10.1007\/s00436-015-4505-0","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,8]]}}}