{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:54:31Z","timestamp":1792652071704,"version":"4.5.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"S1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s00436-015-4522-z","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T18:33:36Z","timestamp":1436294016000},"page":"165-174","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Laboratory Evaluation of the Efficacy of 10 % Imidacloprid + 2.5 % Moxidectin Topical Solution (Advantage\u00ae Multi, Advocate\u00ae) for the Treatment of Dirofilaria immitis Circulating Microfilariae in Dogs"],"prefix":"10.1007","volume":"114","author":[{"given":"Dwight D.","family":"Bowman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel D.","family":"Charles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Arther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Settje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,9]]},"reference":[{"key":"4522_CR1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/bdd.572","volume":"28","author":"SI Al-Azzam","year":"2007","unstructured":"Al-Azzam SI, Fleckenstein L, Cheng KJ, Dzimanski MT, McCall JW (2007) Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Biopharm Drug Dispos 28:431\u2013438","journal-title":"Biopharm Drug Dispos"},{"key":"4522_CR2","unstructured":"American Heartworm Society 2014 Current canine guidelines for the diagnosis, prevention and management of heartworm (Dirofilaria immitis) infections in dogs. Available at http:\/\/www.heartwormsociety.org\/veterinary-resources\/canineguidelines.html#7"},{"issue":"suppl.1","key":"4522_CR3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00436-005-1448-x","volume":"97","author":"RG Arther","year":"2005","unstructured":"Arther RG, Bowman DD, Slone RL, Travis LE (2005) Imidacloprid plus moxidectin topical solution for the prevention of heartworm disease (Dirofilaria immitis) in dogs. Parasitology Res 97(suppl1):76\u201380","journal-title":"Parasitology Res"},{"key":"4522_CR4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.vetpar.2010.12.049","volume":"176","author":"BL Blagburn","year":"2011","unstructured":"Blagburn BL, Dillon AR, Arther RG, Butler JM, Newton JC (2011) Comparative efficacy of four commercially available heartworm preventive products against the MP3 laboratory strain of Dirofilaria immitis. Vet Parasitology 176:189\u2013194","journal-title":"Vet Parasitology"},{"key":"4522_CR5","unstructured":"Bowman DD (2009) Diagnostic Parasitology. In: Georgis\u2019 Parasitology for Veterinarians, 9th Edition. Elsevier, St. Louis, pp 318"},{"key":"4522_CR6","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cvsm.2009.06.003","volume":"39","author":"DD Bowman","year":"2009","unstructured":"Bowman DD, Atkins CE (2009) Heartworm biology, treatment and control. Vet Clin Small Anim 39:1127\u20131158","journal-title":"Vet Clin Small Anim"},{"key":"4522_CR7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1756-3305-5-138","volume":"5","author":"DD Bowman","year":"2012","unstructured":"Bowman DD (2012) Heartworm, macrocyclic lactones, and the specter of resistance to prevention in the United States. Parasites and Vectors 5:138","journal-title":"Parasites and Vectors"},{"issue":"3B","key":"4522_CR8","first-page":"15","volume":"25","author":"LR Cruthers","year":"2008","unstructured":"Cruthers LR, Arther RG, Basel CL, Charles SD, Hostetler JA, Settje TL (2008) New developments in parasite prevention. Bayer selected proceedings. NAVC 2008 Suppl Vet Forum 25(3B):15\u201320","journal-title":"NAVC 2008 Suppl Vet Forum"},{"issue":"8","key":"4522_CR9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1586\/eri.11.76","volume":"9","author":"TG Geary","year":"2011","unstructured":"Geary TG, Mackenzie CD (2011) Progress and challenges in the discovery of macrofilaricidal drugs. Expert Rev Anti Infect Ther 9(8):681\u2013695","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"suppl.1","key":"4522_CR10","first-page":"77","volume":"109","author":"K Hellmann","year":"2011","unstructured":"Hellmann K, Heine J, Braun G, Paran-Dobesova R, Svobodava V (2011) Evaluation of the therapeutic and preventive efficacy of 2.5 % moxidectin\/10 % imidacloprid (Advocate\u00ae. Bayer Animal Health) in dogs naturally infected or at risk of natural infection by Dirofilaria repens Parasitology Res 109(suppl1):77\u201386","journal-title":"Bayer Animal Health) in dogs naturally infected or at risk of natural infection by Dirofilaria repens Parasitology Res"},{"key":"4522_CR11","unstructured":"Hendrix CM, Blagburn BL, Bowles JV, Spano JS, Aguilar R (1992) The safety of moxidectin in dogs with microfilariae and adults of Dirofilaria immitis. In: Soll, MD (ed) Proceedings the American Heartworm Symposium Austin TX: pp 183 \u2013 187"},{"key":"4522_CR12","unstructured":"Louisiana State University School of Veterinary Medicine, Heartworm disease. 2015 available at: http:\/\/www1.vetmed.lsu.edu\/VTHC\/Shared%20Services\/Shared%20 Services\/\u2026\/item41535.html"},{"key":"4522_CR13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.vetpar.2014.09.011","volume":"206","author":"JW McCall","year":"2014","unstructured":"McCall JW, Arther R, Davis W, Settje T (2014) Safety and efficacy of 10 % imidacloprid + 2.5 % moxidectin for the treatment of Dirofilaria immitis circulating microfilariae in experimentally infected dogs. Veterinary Parasitol 206:86\u201392","journal-title":"Veterinary Parasitol"},{"key":"4522_CR14","unstructured":"Prichard R, Roulet A (2005) Moxidectin Pharmacodynamics: Impact on resistance mechanisms to macrocyclic lactones in laboratory and field strains of nematode parasites. In: Moxidectin: Continued innovation in parasite control 20th WAAVP: pp 19 \u2013 26"},{"key":"4522_CR15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijpddr.2012.04.001","volume":"2","author":"R Prichard","year":"2012","unstructured":"Prichard R, M\u00e9nez C, Lespine A (2012) Moxidectin and the avermectins: Consanguinity but not identity. Int J Parasitol Drugs and Drug Resist 2:134\u2013153","journal-title":"Int J Parasitol Drugs and Drug Resist"},{"key":"4522_CR16","doi-asserted-by":"crossref","unstructured":"Traversa D, Aste G, Di Cesare A, Paoletti B, Di Tommaso M, Di Giulio E, Pampurini F, Tunesi C, Boari A (2011) Efficacy of a single administration of a spot-on solution containing imidacloprid 10 %\/moxidectin 2.5 % in eliminating Dirofilaria repens microfilariae in naturally infected dogs","DOI":"10.1016\/j.vetpar.2011.02.018"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-015-4522-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T22:20:55Z","timestamp":1566944455000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-015-4522-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,9]]},"references-count":16,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["4522"],"URL":"https:\/\/doi.org\/10.1007\/s00436-015-4522-z","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,9]]}}}