{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:20:45Z","timestamp":1778260845173,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T00:00:00Z","timestamp":1440806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s00436-015-4674-x","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T07:56:40Z","timestamp":1440748600000},"page":"4371-4379","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The characteristics of NK cells in Schistosoma japonicum-infected mouse spleens"],"prefix":"10.1007","volume":"114","author":[{"given":"Lu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hefei","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuxue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyou","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,8,29]]},"reference":[{"key":"4674_CR1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1365-2567.2005.02235.x","volume":"116","author":"EG Addison","year":"2005","unstructured":"Addison EG, North J, Bakhsh I, Marden C, Haq S, Al-Sarraj S, Malayeri R, Wickremasinghe RG, Davies JK, Lowdell MW (2005) Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity. Immunology 116:354\u2013361","journal-title":"Immunology"},{"key":"4674_CR2","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.jhep.2014.07.005","volume":"61","author":"B Bengsch","year":"2014","unstructured":"Bengsch B, Martin B, Thimme R (2014) Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation. J Hepatol 61:1212\u20131219","journal-title":"J Hepatol"},{"key":"4674_CR3","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.4049\/jimmunol.177.6.3669","volume":"177","author":"HB Bernstein","year":"2006","unstructured":"Bernstein HB, Plasterer MC, Schiff SE, Kitchen CM, Kitchen S, Zack JA (2006) CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration. J Immunol 177:3669\u20133676","journal-title":"J Immunol"},{"key":"4674_CR4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.virol.2009.01.044","volume":"387","author":"HB Bernstein","year":"2009","unstructured":"Bernstein HB, Wang G, Plasterer MC, Zack JA, Ramasastry P, Mumenthaler SM, Kitchen CM (2009) CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function. Virology 387:59\u201366","journal-title":"Virology"},{"key":"4674_CR5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tim.2007.02.006","volume":"15","author":"SD Blackburn","year":"2007","unstructured":"Blackburn SD, Wherry EJ (2007) IL-10, T cell exhaustion and viral persistence. Trends Microbiol 15:143\u2013146","journal-title":"Trends Microbiol"},{"key":"4674_CR6","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/s00436-014-3858-0","volume":"113","author":"AL Chen","year":"2014","unstructured":"Chen AL, Qiu XY, Wang W, Zhou CL, Zeng X, Liu XJ, Qiu JF, Wang Y (2014) The quantitative and functional changes of NK cells in mice infected with Angiostrongylus cantonensis. Parasitol Res 113:2087\u20132094","journal-title":"Parasitol Res"},{"key":"4674_CR7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/imm.12105","volume":"139","author":"D Chen","year":"2013","unstructured":"Chen D, Luo X, Xie H, Gao Z, Fang H, Huang J (2013) Characteristics of IL-17 induction by Schistosoma japonicum infection in C57BL\/6 mouse liver. Immunology 139:523\u2013532","journal-title":"Immunology"},{"key":"4674_CR8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nri2800","volume":"10","author":"DJ Cua","year":"2010","unstructured":"Cua DJ, Tato CM (2010) Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 10:479\u2013489","journal-title":"Nat Rev Immunol"},{"key":"4674_CR9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/gene.2015.15","volume":"16","author":"SE Dunphy","year":"2015","unstructured":"Dunphy SE, Guinan KJ, Chorcora CN, Jayaraman J, Traherne JA, Trowsdale J, Pende D, Middleton D, Gardiner CM (2015) 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells. Genes Immun 16:301\u2013310","journal-title":"Genes Immun"},{"key":"4674_CR10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1385\/IR:30:1:029","volume":"30","author":"A Gunturi","year":"2004","unstructured":"Gunturi A, Berg RE, Forman J (2004) The role of CD94\/NKG2 in innate and adaptive immunity. Immunol Res 30:29\u201334","journal-title":"Immunol Res"},{"key":"4674_CR11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1034\/j.1600-065X.2001.1810101.x","volume":"181","author":"E Hofer","year":"2001","unstructured":"Hofer E, Sobanov Y, Brostjan C, Lehrach H, Duchler M (2001) The centromeric part of the human natural killer (NK) receptor complex: lectin-like receptor genes expressed in NK, dendritic and endothelial cells. Immunol Rev 181:5\u201319","journal-title":"Immunol Rev"},{"key":"4674_CR12","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.4049\/jimmunol.164.12.6406","volume":"164","author":"KF Hoffmann","year":"2000","unstructured":"Hoffmann KF, Cheever AW, Wynn TA (2000) IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol 164:6406\u20136416","journal-title":"J Immunol"},{"key":"4674_CR13","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/hep.22725","volume":"49","author":"X Hou","year":"2009","unstructured":"Hou X, Zhou R, Wei H, Sun R, Tian Z (2009) NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. Hepatology 49:940\u2013949","journal-title":"Hepatology"},{"key":"4674_CR14","volume":"6","author":"X Hou","year":"2012","unstructured":"Hou X, Yu F, Man S, Huang D, Zhang Y, Liu M, Ren C, Shen J (2012) Negative regulation of Schistosoma japonicum egg-induced liver fibrosis by natural killer cells. PLoS Negl Trop Dis 6, e1456","journal-title":"PLoS Negl Trop Dis"},{"key":"4674_CR15","doi-asserted-by":"crossref","unstructured":"Kwilasz AJ, Grace PM, Serbedzija P, Maier SF, Watkins LR (2014) The therapeutic potential of interleukin-10 in neuroimmune diseases. Neuropharmacology 96:55\u201369","DOI":"10.1016\/j.neuropharm.2014.10.020"},{"key":"4674_CR16","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0952-7915(03)00039-6","volume":"15","author":"LL Lanier","year":"2003","unstructured":"Lanier LL (2003) Natural killer cell receptor signaling. Curr Opin Immunol 15:308\u2013314","journal-title":"Curr Opin Immunol"},{"key":"4674_CR17","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ni1581","volume":"9","author":"LL Lanier","year":"2008","unstructured":"Lanier LL (2008) Up on the tightrope: natural killer cell activation and inhibition. Nat Immunol 9:495\u2013502","journal-title":"Nat Immunol"},{"key":"4674_CR18","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.immuni.2013.07.020","volume":"39","author":"P Licona-Limon","year":"2013","unstructured":"Licona-Limon P, Henao-Mejia J, Temann AU, Gagliani N, Licona-Limon I, Ishigame H, Hao L, Herbert DR, Flavell RA (2013) Th9 cells drive host immunity against gastrointestinal worm infection. Immunity 39:744\u2013757","journal-title":"Immunity"},{"key":"4674_CR19","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00436-013-3732-5","volume":"113","author":"X Luo","year":"2014","unstructured":"Luo X, Xie H, Chen D, Yu X, Wu F, Li L, Wu C, Huang J (2014) Changes in NK and NKT cells in mesenteric lymph nodes after a Schistosoma japonicum infection. Parasitol Res 113:1001\u20131009","journal-title":"Parasitol Res"},{"key":"4674_CR20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1128\/CMR.00044-09","volume":"23","author":"DP McManus","year":"2010","unstructured":"McManus DP, Gray DJ, Li Y, Feng Z, Williams GM, Stewart D, Rey-Ladino J, Ross AG (2010) Schistosomiasis in the People\u2019s Republic of China: the era of the Three Gorges Dam. Clin Microbiol Rev 23:442\u2013466","journal-title":"Clin Microbiol Rev"},{"key":"4674_CR21","doi-asserted-by":"crossref","unstructured":"O\u2019Sullivan TE, Sun JC (2015) Generation of natural killer cell memory during viral infection. J Innate Immun. doi: 10.1159\/000375494","DOI":"10.1159\/000375494"},{"key":"4674_CR22","volume":"6","author":"AD Pandya","year":"2011","unstructured":"Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA (2011) Identification of human NK17\/NK1 cells. PLoS One 6, e26780","journal-title":"PLoS One"},{"key":"4674_CR23","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1073\/pnas.1309378110","volume":"110","author":"F Raczkowski","year":"2013","unstructured":"Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Hocker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrucker HW, Huber M (2013) The transcription factor interferon regulatory factor 4 is required for the generation of protective effector CD8+ T cells. Proc Natl Acad Sci U S A 110:15019\u201315024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4674_CR24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002567","volume":"8","author":"V Rodrigues","year":"2014","unstructured":"Rodrigues V, Cordeiro-da-Silva A, Laforge M, Ouaissi A, Akharid K, Silvestre R, Estaquier J (2014) Impairment of T cell function in parasitic infections. PLoS Negl Trop Dis 8, e2567","journal-title":"PLoS Negl Trop Dis"},{"key":"4674_CR25","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00436-008-1112-3","volume":"103","author":"M Saunders","year":"2008","unstructured":"Saunders M, Taubert A, Dafa'Alla T, Zahner H (2008) Effect of chemotherapeutic treatment on cytokine (IFN-gamma, IL-2, IL-4, IL-5, IL-10) gene transcription in response to specific antigens in Brugia malayi-infected Mastomys coucha. Parasitol Res 103:1163\u20131176","journal-title":"Parasitol Res"},{"key":"4674_CR26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.tube.2014.01.005","volume":"94","author":"A Singh","year":"2014","unstructured":"Singh A, Dey AB, Mohan A, Mitra DK (2014) Programmed death-1 receptor suppresses gamma-IFN producing NKT cells in human tuberculosis. Tuberculosis (Edinb) 94:197\u2013206","journal-title":"Tuberculosis (Edinb)"},{"key":"4674_CR27","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrc928","volume":"2","author":"MJ Smyth","year":"2002","unstructured":"Smyth MJ, Hayakawa Y, Takeda K, Yagita H (2002) New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2:850\u2013861","journal-title":"Nat Rev Cancer"},{"key":"4674_CR28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cyto.2013.09.016","volume":"65","author":"H Sun","year":"2014","unstructured":"Sun H, Sun C, Xiao W (2014) Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine 65:33\u201341","journal-title":"Cytokine"},{"key":"4674_CR29","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1053\/j.gastro.2004.08.055","volume":"127","author":"R Sun","year":"2004","unstructured":"Sun R, Gao B (2004) Negative regulation of liver regeneration by innate immunity (natural killer cells\/interferon-gamma). Gastroenterology 127:1525\u20131539","journal-title":"Gastroenterology"},{"key":"4674_CR30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","volume":"9","author":"E Vivier","year":"2008","unstructured":"Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S (2008) Functions of natural killer cells. Nat Immunol 9:503\u2013510","journal-title":"Nat Immunol"},{"key":"4674_CR31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.1198687","volume":"331","author":"E Vivier","year":"2011","unstructured":"Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S (2011) Innate or adaptive immunity? The example of natural killer cells. Science 331:44\u201349","journal-title":"Science"},{"key":"4674_CR32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","volume":"25","author":"CT Weaver","year":"2007","unstructured":"Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821\u2013852","journal-title":"Annu Rev Immunol"},{"key":"4674_CR33","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","volume":"12","author":"EJ Wherry","year":"2011","unstructured":"Wherry EJ (2011) T cell exhaustion. Nat Immunol 12:492\u2013499","journal-title":"Nat Immunol"},{"key":"4674_CR34","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","volume":"85","author":"MS Wilson","year":"2007","unstructured":"Wilson MS, Mentink-Kane MM, Pesce JT, Ramalingam TR, Thompson R, Wynn TA (2007) Immunopathology of schistosomiasis. Immunol Cell Biol 85:148\u2013154","journal-title":"Immunol Cell Biol"},{"key":"4674_CR35","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s00436-013-3350-2","volume":"112","author":"H Xie","year":"2013","unstructured":"Xie H, Chen D, Luo X, Gao Z, Fang H, Huang J (2013) Some characteristics of IL-5-producing T cells in mouse liver induced by Schistosoma japonicum infection. Parasitol Res 112:1945\u20131951","journal-title":"Parasitol Res"},{"key":"4674_CR36","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1007\/s00018-011-0797-0","volume":"68","author":"B Zafirova","year":"2011","unstructured":"Zafirova B, Wensveen FM, Gulin M, Polic B (2011) Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci 68:3519\u20133529","journal-title":"Cell Mol Life Sci"},{"key":"4674_CR37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00436-011-2458-5","volume":"110","author":"H Zhou","year":"2012","unstructured":"Zhou H, Sun X, Lv Z, Shen Y, Peng H, Yang L, Zheng H, Fung MC, Cao J, Wu Z (2012) The secretions products from invading cercariae of S. japonicum (0-3hRP) restrain mouse dendritic cells to mature. Parasitol Res 110:119\u2013126","journal-title":"Parasitol Res"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-015-4674-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-015-4674-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-015-4674-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T23:07:23Z","timestamp":1559084843000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-015-4674-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,29]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["4674"],"URL":"https:\/\/doi.org\/10.1007\/s00436-015-4674-x","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,29]]}}}