{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:48:51Z","timestamp":1789555731337,"version":"build-2803163510"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004775","name":"the Natural Science Foundation of Gansu Province, China","doi-asserted-by":"crossref","award":["145RJZA234"],"award-info":[{"award-number":["145RJZA234"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s00436-015-4824-1","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:10:13Z","timestamp":1447891813000},"page":"459-468","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Review on the identification and role of Toxoplasma gondii antigenic epitopes"],"prefix":"10.1007","volume":"115","author":[{"given":"Yanhua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"4824_CR1","first-page":"183","volume":"219","author":"J Alexander","year":"1996","unstructured":"Alexander J, Jebbari H, Bluethmann H, Satoskar A, Roberts CW (1996) Immunological control of Toxoplasma gondii and appropriate vaccine design. Curr Top Microbiol Immunol 219:183\u2013195","journal-title":"Curr Top Microbiol Immunol"},{"key":"4824_CR2","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1110\/ps.062405906","volume":"15","author":"H Andersen","year":"2006","unstructured":"Andersen H, Nielsen M, Hund O (2006) Prediction of residues in discontinuous B cell epitopes using protein 3D structures. Protein Sci 15:2558\u20132567","journal-title":"Protein Sci"},{"key":"4824_CR3","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0020-7519(01)00288-0","volume":"31","author":"E Beghetto","year":"2001","unstructured":"Beghetto E, Pucci A, Minenkova O, Spadoni A, Bruno L, Buffolano W, Soldati D, Felici F, Gargano N (2001) Identification of a human immunodominant B-cell epitope within the GRA1 antigen of Toxoplasma gondii by phage display of cDNA libraries. Int J Parasitol 31:1659\u20131668","journal-title":"Int J Parasitol"},{"key":"4824_CR4","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1128\/JCM.41.12.5414-5418.2003","volume":"41","author":"E Beghetto","year":"2003","unstructured":"Beghetto E, Buffolano W, Spadoni A, Del Pezzo M, Di Cristina M, Minenkova O, Petersen E, Felici F, Gargano N (2003a) Use of an immunoglobulin G avidity assay based on recombinant antigens for diagnosis of primary Toxoplasma gondii infection during pregnancy. J Clin Microbiol 41:5414\u20135418","journal-title":"J Clin Microbiol"},{"key":"4824_CR5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0020-7519(02)00256-4","volume":"33","author":"E Beghetto","year":"2003","unstructured":"Beghetto E, Spadoni A, Buffolano W, Del Pezzo M, Minenkova O, Pavoni E, Pucci A, Cortese R, Felici F, Gargano N (2003b) Molecular dissection of the human B-cell response against Toxoplasma gondii infection by lambda display of cDNA libraries. Int J Parasitol 33:163\u2013173","journal-title":"Int J Parasitol"},{"key":"4824_CR6","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1128\/JCM.00237-06","volume":"44","author":"E Beghetto","year":"2006","unstructured":"Beghetto E, Spadoni A, Bruno L, Buffolano W, Gargano N (2006) Chimeric antigens of Toxoplasma gondii: toward standardization of toxoplasmosis serodiagnosis using recombinant products. J Clin Microbiol 44:2133\u20132140","journal-title":"J Clin Microbiol"},{"key":"4824_CR7","doi-asserted-by":"crossref","first-page":"13656","DOI":"10.1128\/JVI.79.21.13656-13666.2005","volume":"79","author":"JN Billaud","year":"2005","unstructured":"Billaud JN, Peterson D, Barr M, Chen A, Sallberg M, Garduno F, Goldstein P, McDowell W, Hughes J, Jones J, Milich D (2005) Combinatorial approach to hepadnavirus-like particle vaccine design. J Virol 79:13656\u201313666","journal-title":"J Virol"},{"key":"4824_CR8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jim.2007.06.011","volume":"325","author":"H Blasco","year":"2007","unstructured":"Blasco H, Lalmanach G, Godat E, Maurel MC, Canepa S, Belghazi M, Paintaud G, Degenne D, Chatelut E, Cartron G, Le Guellec C (2007) Evaluation of a peptide ELISA for the detection of rituximab in serum. J Immunol Methods 325:12\u2013139","journal-title":"J Immunol Methods"},{"key":"4824_CR9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ymeth.2004.06.006","volume":"34","author":"V Brusic","year":"2004","unstructured":"Brusic V, Bajic VB, Petrovsky N (2004) Computational methods for prediction of T-cell epitopes: a framework for modelling, testing, and applications. Methods 34:436\u2013443","journal-title":"Methods"},{"key":"4824_CR10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/prot.21387","volume":"68","author":"EM Bublil","year":"2007","unstructured":"Bublil EM, Freund NT, Mayrose I, Penn O, Roitburd-Berman A, Rubinstein ND, Pupko T, Gershoni JM (2007) Stepwise prediction of conformational discontinuous B-cell epitopes using the Mapitope algorithm. Proteins 68:294\u2013304","journal-title":"Proteins"},{"key":"4824_CR11","first-page":"3584","volume":"141","author":"JL Burg","year":"1988","unstructured":"Burg JL, Perelman D, Kasper LH, Ware PL, Boothroyd JC (1988) Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii. Immunology 141:3584\u20133591","journal-title":"Immunology"},{"key":"4824_CR12","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1016\/j.vaccine.2007.04.085","volume":"25","author":"QL Cai","year":"2007","unstructured":"Cai QL, Peng GY, Bu LY, Zhang L, Lustigmen S, Wang H (2007) Immunogenicity and in vitro protective efficacy of a polyepitope Plasmodium falciparum candidate vaccine constructed by epitope shuffling. Vaccine 25:5155\u20135165","journal-title":"Vaccine"},{"key":"4824_CR13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.exppara.2009.06.017","volume":"123","author":"N Cardona","year":"2009","unstructured":"Cardona N, de-la-Torre A, Siachoque H, Patarroyo MA, Gomez-Marin JE (2009) Toxoplasma gondii: P30 peptides recognition pattern in human toxoplasmosis. Exp Parasitol 123:199\u2013202","journal-title":"Exp Parasitol"},{"key":"4824_CR14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0166-0934(94)90045-0","volume":"49","author":"J Cason","year":"1994","unstructured":"Cason J (1994) Strategies for mapping and viral B-cell epitopes. J Virol Methods 49:209\u2013220","journal-title":"J Virol Methods"},{"issue":"1","key":"4824_CR15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2105-8-S1-S6","volume":"8","author":"T Castrignano","year":"2007","unstructured":"Castrignano T, Demeo PDO, Carrabino D, Orsini M, Floris M, Tramontano A (2007) The MEPS server for identifying protein conformational epitopes. BMC Bioinformatics 8(1):6\u201310","journal-title":"BMC Bioinformatics"},{"key":"4824_CR16","first-page":"45","volume":"47","author":"PY Chou","year":"1987","unstructured":"Chou PY, Fasman GD (1987) Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol 47:45\u2013148","journal-title":"Adv Enzymol"},{"key":"4824_CR17","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1016\/j.vaccine.2008.04.046","volume":"26","author":"H Cong","year":"2008","unstructured":"Cong H, Gu QM, Yin HE, Wang JW, Zhao QL, Zhou HY, Li Y, Zhang JQ (2008) Multi-epitope DNA vaccine linked to the A2\/B subunit of cholera toxin protect mice against Toxoplasma gondii. Vaccine 26:3913\u20133921","journal-title":"Vaccine"},{"key":"4824_CR18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.imbio.2009.01.008","volume":"215","author":"JP Cunha-J\u00fanior","year":"2010","unstructured":"Cunha-J\u00fanior JP, Silva DA, Silva NM, Souza MA, Souza GR, Prudencio CR (2010) A4D12 monoclonal antibody recognizes a new linear epitope from SAG2A Toxoplasma gondii tachyzoites, identified by phage display bioselection. Immunobiology 215:26\u201337","journal-title":"Immunobiology"},{"key":"4824_CR19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1128\/CVI.05553-11","volume":"19","author":"JF Dai","year":"2012","unstructured":"Dai JF, Jiang M, Wang YY, Qu LL, Gong RJ, Si J (2012) Evaluation of a recombinant multiepitope peptide for serodiagnosis of Toxoplasma gondii infection. Clin Vaccine Immunol 19:338\u2013342","journal-title":"Clin Vaccine Immunol"},{"key":"4824_CR20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.exppara.2012.10.016","volume":"133","author":"JF Dai","year":"2013","unstructured":"Dai JF, Jiang M, Qu LL, Sun L, Wang YY, Gong LL, Gong RJ, Si J (2013) Toxoplasma gondii: enzyme-linked immunosorbent assay based on a recombinant multi-epitope peptide for distinguishing recent from past infection in human sera. Exp Parasitol 133:95\u2013100","journal-title":"Exp Parasitol"},{"key":"4824_CR21","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.trstmh.2007.11.008","volume":"102","author":"EJ Oliveiraa de","year":"2008","unstructured":"de Oliveiraa EJ, Kanamura HY, Takei K, Hirata RD, Valli LC, Nguyen NY, de Carvalho RI, de Jesus AR, Hirata MH (2008) Synthetic peptides as an antigenic base in an ELISA for laboratory diagnosis of schistosomiasis mansoni. T Roy Soc Trop Med H 102:360\u2013366","journal-title":"T Roy Soc Trop Med H"},{"key":"4824_CR22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2307\/3283961","volume":"81","author":"JP Dubey","year":"1995","unstructured":"Dubey JP, Weigel RM, Siegel AM, Thulliez P, Kitron UD, Mitchell MA, Mannelli A, Mateus-Pinilla NE, Shen SK, Kwok OC, Todd KS (1995) Sources and reservoirs of Toxoplasma gondii infection on 47 swine farms in Illinois. J Parasitol 81:723\u2013729","journal-title":"J Parasitol"},{"issue":"26","key":"4824_CR23","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1016\/j.vaccine.2014.03.092","volume":"32","author":"K Bissati El","year":"2014","unstructured":"El Bissati K, Zhou Y, Dasgupta D, Cobb D, Dubey JP, Burkhard P, Lanar DE, McLeod R (2014) Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice. Vaccine 32(26):3243\u20133248","journal-title":"Vaccine"},{"key":"4824_CR24","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1007\/s00436-014-3882-0","volume":"113","author":"MA EL-Malky","year":"2014","unstructured":"EL-Malky MA, Al-Harthi SA, Mohamed RT, EL Bali MA, Saudy NS (2014) Vaccination with toxoplasma lysate antigen and CpG oligodeoxynucleotides: comparison of immune responses in intranasal versus intramuscular administrations. Parasitol Res 113:2277\u20132284","journal-title":"Parasitol Res"},{"key":"4824_CR25","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/JVI.55.3.836-839.1985","volume":"55","author":"EA Emini","year":"1985","unstructured":"Emini EA, Hughes JV, Perlow DS, Boger J (1985) Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol 55:836\u2013839","journal-title":"J Virol"},{"key":"4824_CR26","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.4049\/jimmunol.156.10.3579","volume":"156","author":"C Ert","year":"1996","unstructured":"Ert C, Xiang Z (1996) Novel vaccine approach. J Immunol 156:3579\u20133584","journal-title":"J Immunol"},{"issue":"6","key":"4824_CR27","doi-asserted-by":"crossref","first-page":"e1003449","DOI":"10.1371\/journal.ppat.1003449","volume":"9","author":"V Feliu","year":"2013","unstructured":"Feliu V, Vasseur V, Grover HS, Chu HH, Brown MJ, Wang J, Boyle JP, Robey EA, Shastri N, Blanchard N (2013) Location of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite. PLoS Pathog 9(6):e1003449","journal-title":"PLoS Pathog"},{"key":"4824_CR28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-1759(02)00137-0","volume":"267","author":"R Frank","year":"2002","unstructured":"Frank R (2002) The SPOT-synthesis technique. synthetic peptide arrays on membrane supports\u2013principles and applications. J Immunol Methods 267:13\u201326","journal-title":"J Immunol Methods"},{"key":"4824_CR29","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1086\/593019","volume":"198","author":"EM Frickel","year":"2008","unstructured":"Frickel EM, Sahoo N, Hopp J, Gubbels MJ, Craver MP, Knoll LJ, Ploegh HL, Grotenbreg GM (2008) Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. J Infect Dis 198:1625\u20131633","journal-title":"J Infect Dis"},{"key":"4824_CR30","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/S0264-410X(99)00374-6","volume":"18","author":"L Gagnon","year":"2000","unstructured":"Gagnon L, DiMarco M, Kirby R, Zacharie B, Penney CL (2000) DLysAsnProTyr tetrapeptide: a novel B cell stimulant and stabilized bursin mimetic. Vaccine 18:1886\u20131892","journal-title":"Vaccine"},{"key":"4824_CR31","doi-asserted-by":"crossref","first-page":"p417","DOI":"10.1007\/978-1-4613-1571-1_10","volume-title":"Prediction of protein structure and the principles of protein conformation","author":"J Garnier","year":"1989","unstructured":"Garnier J, Robson B (1989) The GOR method for predicting secondary structures in proteins. In: Fasman GD (ed) Prediction of protein structure and the principles of protein conformation. Plenum press, New York, pp p417\u2013p465"},{"key":"4824_CR32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.281.5373.96","volume":"281","author":"P Garside","year":"1998","unstructured":"Garside P, Ingulli E, Merica RR, Johnson JG, Noelle RJ, Jenkins MK (1998) Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281:96\u201399","journal-title":"Science"},{"key":"4824_CR33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1286-4579(03)00048-0","volume":"5","author":"MB Girish","year":"2003","unstructured":"Girish MB (2003) Development of a vaccine for toxoplasmosis: current status. Microb Infect 5:457\u2013462","journal-title":"Microb Infect"},{"key":"4824_CR34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/156720105774370302","volume":"2","author":"R Gluck","year":"2005","unstructured":"Gluck R, Burri KG, Metcalfe I (2005) Adjuvant and antigen delivery properties of virosomes. Curr Drug Deliv 2:395\u2013400","journal-title":"Curr Drug Deliv"},{"key":"4824_CR35","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/0161-5890(94)90054-X","volume":"31","author":"I Godard","year":"1994","unstructured":"Godard I, Estaquier J, Zenner L, Bossus M, Auriault C, Darcy F, Gras-Masse H, Capron A (1994) Antigenicity and immunogenicity of P30-derived peptides in experimental models of toxoplasmosis. Mol Immunol 31:1353\u20131363","journal-title":"Mol Immunol"},{"key":"4824_CR36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1084\/jem.20082108","volume":"206","author":"RS Goldszmid","year":"2009","unstructured":"Goldszmid RS, Coppens I, Lev A, Caspar P, Mellman I, Sher A (2009) Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells. J Exp Med 206:399\u2013410","journal-title":"J Exp Med"},{"key":"4824_CR37","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jmb.2005.09.028","volume":"354","author":"M Graille","year":"2005","unstructured":"Graille M, Stura EA, Bossus M, Muller BH, Letourneur O, Battail-Poirot N, Siba\u00ef G, Gauthier M, Rolland D, Le Du MH, Ducancel F (2005) Crystal structure of the complex between the monomeric form of Toxoplasma gondii surface antigen 1 (SAG1) and a monoclonal antibody that mimics the human immune response. J Mol Biol 354:447\u2013458","journal-title":"J Mol Biol"},{"key":"4824_CR38","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/BF00931842","volume":"81","author":"J Grimwood","year":"1995","unstructured":"Grimwood J, Smith JE (1995) Toxoplasma gondii: redistribution of tachyzoite surface protein during host cell invasion and intracellular development. Parasitol Res 81:657\u2013661","journal-title":"Parasitol Res"},{"key":"4824_CR39","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.celrep.2014.04.031","volume":"7","author":"HS Grover","year":"2014","unstructured":"Grover HS, Chu HH, Kelly FD, Yang SJ, Reese ML, Blanchard N, Gonzalez F, Chan SW, Boothroyd JC, Shastri N, Robey EA (2014) Impact of regulated secretion on antiparasitic CD8 T cell responses. Cell Rep 7:1716\u20131728","journal-title":"Cell Rep"},{"key":"4824_CR40","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1007\/s00436-015-4701-y","volume":"114","author":"MM Grzybowski","year":"2015","unstructured":"Grzybowski MM, Dziadek B, Gatkowska JM, Dzitko K, D\u0142ugo\u0144ska H (2015) Towards vaccine against toxoplasmosis: evaluation of the immunogenic and protective activity of recombinant ROP5 and ROP18 Toxoplasma gondii proteins. Parasitol Res 114:4553\u20134563","journal-title":"Parasitol Res"},{"key":"4824_CR41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1128\/CDLI.3.3.355-357.1996","volume":"3","author":"D Harning","year":"1996","unstructured":"Harning D, Spenter J, Metsis A, Vuust J, Petersen E (1996) Recombinant Toxoplasma gondii surface antigen 1 (P30) expressed in Escherichia coli is recognized by human Toxoplasma-specific immunoglobulin M (IgM) and IgG antibodies. Clin Diagn Lab Immunol 3:355\u2013357","journal-title":"Clin Diagn Lab Immunol"},{"key":"4824_CR42","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF00930914","volume":"77","author":"A Hassl","year":"1991","unstructured":"Hassl A, Muller WA, Aspock H (1991) An identical epitope in Pneumocystis carinii and Toxoplasma gondii causing serological cross reactions. Parasitol Res 77:351\u2013352","journal-title":"Parasitol Res"},{"key":"4824_CR43","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1128\/JCM.35.12.3313-3315.1997","volume":"35","author":"SR Hofgartner Swanzy","year":"1997","unstructured":"Hofgartner Swanzy SR, Bacina RM, Condon J, Gupta M, Matlock PE, Bergeron DL, Plorde JJ, Fritsche TR (1997) Detection of immunoglobulin G (IgG) and IgM antibodies to Toxoplasma gondii: evaluation of four commercial immunoassay systems. J Clin Microbiol 35:3313\u20133315","journal-title":"J Clin Microbiol"},{"key":"4824_CR44","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1128\/CVI.00117-13","volume":"20","author":"L Holec-Gasior","year":"2013","unstructured":"Holec-Gasior L (2013) Toxoplasma gondii recombinant antigens as tools for serodiagnosis of human toxoplasmosis: current status of studies. Clin Vaccine Immunol 20:1343\u20131351","journal-title":"Clin Vaccine Immunol"},{"key":"4824_CR45","first-page":"3824","volume":"78","author":"JP Hoop","year":"1981","unstructured":"Hoop JP, Wood KR (1981) Prediction of protein antigenic determinants from amino acid sequences. Immunology 78:3824\u20133828","journal-title":"Immunology"},{"key":"4824_CR46","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/1471-2105-7-451","volume":"7","author":"J Huang","year":"2006","unstructured":"Huang J, Gutteridge A, Honda W, Kanehisa M (2006) MIMOX: a web tool for phage display based epitope mapping. BMC Bioinform 7:451\u2013460","journal-title":"BMC Bioinform"},{"key":"4824_CR47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1386-6532(01)00170-6","volume":"22","author":"R Kannangai","year":"2001","unstructured":"Kannangai R, Ramalingam S, Prakash KJ, Abraham OC, George R, Castillo RC, Schwartz DH, Jesudason MV, Sridharan G (2001) A peptide enzyme linked immunosorbent assay (ELISA) for the detection of human immunodeficiency virus type-2 (HIV-2) antibodies: an evaluation on polymerase chain reaction (PCR) confirmed samples. J Clin Virol 22:41\u201346","journal-title":"J Clin Virol"},{"key":"4824_CR48","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF01195768","volume":"72","author":"PA Karplus","year":"1985","unstructured":"Karplus PA, Schulz GE (1985) Prediction of chain flexibility in proteins: a tool for the selection of peptide antigens. Naturwissenschaften 72:212\u2013213","journal-title":"Naturwissenschaften"},{"key":"4824_CR49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.1178590","volume":"328","author":"O Kirak","year":"2010","unstructured":"Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, Ploegh HL (2010) Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science 328:243\u2013248","journal-title":"Science"},{"key":"4824_CR50","doi-asserted-by":"crossref","first-page":"W168","DOI":"10.1093\/nar\/gki460","volume":"3","author":"U Kulkami-kale","year":"2005","unstructured":"Kulkami-kale U, Bhosle S, Kolaskar AS (2005) CEP: a conformational epitope prediction server. Nucleic Acids Res 3:W168\u2013W171","journal-title":"Nucleic Acids Res"},{"key":"4824_CR51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","volume":"157","author":"J Kyte","year":"1982","unstructured":"Kyte J, Doolittle RF (1982) A simple method for displaying the hydropathic character of a protein. J Mol Biol 157:105\u2013132","journal-title":"J Mol Biol"},{"key":"4824_CR52","first-page":"34","volume":"19","author":"YX Li","year":"2003","unstructured":"Li YX, Zhang JH, Tao KH, Huang PT (2003) Expression, purification and serological reactivity of a chimeric antigen of GRA6 with P30 from Toxoplasma gondii. Chin J Biotechnol 19:34\u201339","journal-title":"Chin J Biotechnol"},{"key":"4824_CR53","first-page":"685","volume":"4","author":"YP Lin","year":"2004","unstructured":"Lin YP, Wu ST, Weng YB, Yuan SS, Wen JX, Zhang RL, Guo ST, Huang DN, Lei MJ, Pan HR, Qin L (2004) Studies on the identification of antigenic epitopes of Toxplasmoa gondiiand its protective effect in mice. Chin Tropic Med 4:685\u2013688","journal-title":"Chin Tropic Med"},{"key":"4824_CR54","first-page":"529","volume":"17","author":"FL Lv","year":"2001","unstructured":"Lv FL, He F (2001) Research progress on adjuvant for peptide vaccine. J Cell Mol Immunol 17:529\u2013530","journal-title":"J Cell Mol Immunol"},{"key":"4824_CR55","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1128\/CVI.00119-12","volume":"19","author":"P Maksimov","year":"2012","unstructured":"Maksimov P, Zerweck J, Maksimov A, Hotop A, Gross U, Pleyer U, Spekker K, D\u00e4ubener W, Werdermann S, Niederstrasser O, Petri E, Mertens M, Ulrich RG, Conraths FJ, Schares G (2012) Peptide microarray analysis of in silico-predicted epitopes for serological diagnosis of Toxoplasma gondii infection in humans. Clin Vaccine Immunol 19:865\u2013874","journal-title":"Clin Vaccine Immunol"},{"key":"4824_CR56","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.immuni.2011.08.008","volume":"35","author":"M Mashayekhi","year":"2011","unstructured":"Mashayekhi M, Sandau MM, Dunay IR, Frickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM (2011) CD8 (+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity 35:249\u2013259","journal-title":"Immunity"},{"key":"4824_CR57","first-page":"183","volume":"20","author":"MN Mevelec","year":"1998","unstructured":"Mevelec MN, Mercereau-Puijalon O, Buzoni-Gatel D, Bourguin I, Chard\u00e8s T, Dubremetz JF, Bout D (1998) Mapping of B epitopes in GRA4, a dense granule antigen of Toxoplasma gondii and protection studies using recombinant proteins administered by the oral route. Parasite Immunol 20:183\u2013195","journal-title":"Parasite Immunol"},{"key":"4824_CR58","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1016\/j.vaccine.2005.04.025","volume":"23","author":"MN M\u00e9v\u00e9lec","year":"2005","unstructured":"M\u00e9v\u00e9lec MN, Sandau MM, Dunay IR, Frickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM (2005) Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in mice. Vaccine 23:4489\u20134499","journal-title":"Vaccine"},{"key":"4824_CR59","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.immuni.2007.07.007","volume":"27","author":"JJ Moon","year":"2007","unstructured":"Moon JJ, Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK (2007) Naive CD4 (+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27:203\u2013213","journal-title":"Immunity"},{"key":"4824_CR60","first-page":"235","volume":"34","author":"A Murray","year":"1993","unstructured":"Murray A, Mercier C, Decoster A, Lecordier L, Capron A, Cesbron-Delauw MF (1993) Multiple B-cell epitopes in a recombinant GRA2 secreted antigen of Toxoplasma gondii. Appl Parasitol 34:235\u2013244","journal-title":"Appl Parasitol"},{"key":"4824_CR61","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3347\/kjp.1996.34.2.135","volume":"34","author":"HW Nam","year":"1996","unstructured":"Nam HW, Im KS, Baek EJ, Choi WY, Cho SY (1996) Analysis of antigenic domain of GST fused major surface protein (p30) fragments of Toxoplasma gondii. Korean J Parasitol 34:135\u2013141","journal-title":"Korean J Parasitol"},{"key":"4824_CR62","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.immuni.2008.04.010","volume":"28","author":"JJ Obar","year":"2008","unstructured":"Obar JJ, Khanna KM, Lefrancois L (2008) Endogenous naive CD8\u2009+\u2009T cell precursor frequency regulates primary and memory responses to infection. Immunity 28:859\u2013869","journal-title":"Immunity"},{"key":"4824_CR63","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0378-1119(88)90495-7","volume":"73","author":"SF Parmley","year":"1988","unstructured":"Parmley SF, Smith GP (1988) Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene 73:305\u2013318","journal-title":"Gene"},{"key":"4824_CR64","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0952-7915(99)80033-8","volume":"11","author":"C Pinilla","year":"1999","unstructured":"Pinilla C, Martin R, Gran B, Appel JR, Boggiano C, Wilson DB, Houghten RA (1999) Exploring immunological specificity using synthetic peptide combinatorial libraries. Curr Opin Immunol 11:193\u2013202","journal-title":"Curr Opin Immunol"},{"key":"4824_CR65","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jviromet.2005.12.003","volume":"134","author":"PGW Plagemann","year":"2006","unstructured":"Plagemann PGW (2006) Peptide ELISA for measuring antibodies to N-protein of porcine reproductive and respiratory syndrome virus. J Virol Methods 134:99\u2013118","journal-title":"J Virol Methods"},{"key":"4824_CR66","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/infdis\/132.1.44","volume":"132","author":"RE Raizman","year":"1975","unstructured":"Raizman RE, Neva FA (1975) Detection of circulating antigen in acute experimental infections with Toxoplasma gondii. Infect Dis 132:44\u201348","journal-title":"Infect Dis"},{"key":"4824_CR67","doi-asserted-by":"crossref","first-page":"17544","DOI":"10.1074\/jbc.M110275200","volume":"277","author":"J Robben","year":"2002","unstructured":"Robben J, Hertveldt K, Bosmans E, Volckaert G (2002) Selection and identification of dense granule antigen GRA3 by Toxoplasma gondii whole genome phage display. J Biol Chem 277:17544\u201317547","journal-title":"J Biol Chem"},{"key":"4824_CR68","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1128\/IAI.64.9.3858-3862.1996","volume":"64","author":"R Saavedra","year":"1996","unstructured":"Saavedra R, Becerril MA, Dubeaux C, Lippens R, De Vos MJ, H\u00e9rion P, Bollen A (1996) Epitopes recognized by human T lymphocytes in the ROP2 protein antigen of Toxoplasma gondii. Infect Immun 64:3858\u20133862","journal-title":"Infect Immun"},{"key":"4824_CR69","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/prot.21078","volume":"65","author":"S Saha","year":"2006","unstructured":"Saha S, Raghava GPS (2006) Prediction of continuous B-cell epitopes in an antigen using recurrent neural network. Proteins 65:40\u201348","journal-title":"Proteins"},{"key":"4824_CR70","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-60327-118-9_7","volume":"409","author":"S Saha","year":"2007","unstructured":"Saha S, Raghava GP (2007) Searching and mapping of B-cell epitopes in Bcipep database. Methods Mol Biol 409:113\u2013124","journal-title":"Methods Mol Biol"},{"key":"4824_CR71","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/jcc.20229","volume":"26","author":"A Schreiber","year":"2005","unstructured":"Schreiber A, Humbert M, Benz A, Dietrich U (2005) 3D-epitope explorer (3DEX): localization of conformational epitopes with in three-dimensional structures of proteins. J Comput Chem 26:879\u2013887","journal-title":"J Comput Chem"},{"key":"4824_CR72","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1696028","volume":"249","author":"JK Scott","year":"1990","unstructured":"Scott JK, Smith GP (1990) Searching for peptide ligands with an epitope library. Science 249:386\u2013390","journal-title":"Science"},{"key":"4824_CR73","first-page":"228","volume":"26","author":"DH Shao","year":"2008","unstructured":"Shao DH, Feng XG (2008) Prediction for helper T cell epitopes and its application in vaccine development against parasite infection. Chin J Parasitol Parasit Dis 26:228\u2013233","journal-title":"Chin J Parasitol Parasit Dis"},{"key":"4824_CR74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00436-014-4176-2","volume":"114","author":"M Sharif","year":"2015","unstructured":"Sharif M, Sarvi S, Shokri A, Hosseini Teshnizi S, Rahimi MT, Mizani A, Ahmadpour E, Daryani A (2015) Toxoplasma gondii infection among sheep and goats in Iran: a systematic review and meta-analysis. Parasitol Res 114:1\u201316","journal-title":"Parasitol Res"},{"key":"4824_CR75","first-page":"689","volume":"24","author":"L Shi","year":"2008","unstructured":"Shi L, Liu S, Cheng YB, Fan GX, Yuan YK, Ai L (2008) Construction of multi epitope DNA vaccine for Toxoplasma gondii and the study on protective immunity response in mice. Chin J Cell Mol Immunol 24:689\u2013691","journal-title":"Chin J Cell Mol Immunol"},{"key":"4824_CR76","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exppara.2006.02.005","volume":"114","author":"H Siachoque","year":"2006","unstructured":"Siachoque H, Guzman F, Burgos J, Patarroyo ME, Marin JEG (2006) Toxoplasma gondii: immunogenicity and protection by P30 peptides in a murine model. Exp Parasitol 114:62\u201365","journal-title":"Exp Parasitol"},{"key":"4824_CR77","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1126\/science.4001944","volume":"228","author":"GP Smith","year":"1985","unstructured":"Smith GP (1985) Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228:1315\u20131317","journal-title":"Science"},{"key":"4824_CR78","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S1046-2023(02)00346-8","volume":"29","author":"M Sospedra","year":"2003","unstructured":"Sospedra M, Pinilla C, Martin R (2003) Use of combinatorial peptide libraries for T-cell epitope mapping. Methods 29:236\u2013247","journal-title":"Methods"},{"key":"4824_CR79","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1073\/pnas.85.15.5409","volume":"85","author":"JP Tam","year":"1988","unstructured":"Tam JP (1988) Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc Natl Acad Sci U S A 85:5409\u20135413","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4824_CR80","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1550-7408.1990.tb01262.x","volume":"37","author":"DW Taylor","year":"1990","unstructured":"Taylor DW, Evans CB, Aley SB, Barta JR, Danforth HD (1990) Identification of an apically-located antigen that is conserved in sporozoan parasites. Protozoology 37:540\u2013545","journal-title":"Protozoology"},{"key":"4824_CR81","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1745-7580-1-4","volume":"1","author":"CP Toseland","year":"2005","unstructured":"Toseland CP, Clayton DJ, McSparron H, Hemsley SL, Blythe MJ, Paine K, Doytchinova IA, Guan P, Hattotuwagama CK, Flower DR (2005) AntiJen: a quantitative immunology database integrating functional, thermodynamic, kinetic, biophysical, and cellular data. Immunome Res 1:4","journal-title":"Immunome Res"},{"key":"4824_CR82","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0167-5699(89)90140-0","volume":"10","author":"MH Regenmortel Van","year":"1989","unstructured":"Van Regenmortel MH (1989) Structural and functional approaches to the study of protein antigenicity. Immunol Today 10:266\u2013272","journal-title":"Immunol Today"},{"key":"4824_CR83","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0166-6851(94)90033-7","volume":"66","author":"F Velge-Roussel","year":"1994","unstructured":"Velge-Roussel F, Chard\u00e8s T, M\u00e9v\u00e9lec P, Brillard M, Hoebeke J, Bout D (1994) Epitopic analysis of the Toxoplasma gondii major surface antigen SAG1. Mol Biochem Parasit 66:31\u201338","journal-title":"Mol Biochem Parasit"},{"key":"4824_CR84","doi-asserted-by":"crossref","first-page":"D854","DOI":"10.1093\/nar\/gkp1004","volume":"38","author":"R Vita","year":"2010","unstructured":"Vita R, Zarebski L, Greenbaum JA, Emami H, Hoof I, Salimi N, Damle R, Sette A, Peters B (2010) The immune epitope database 2.0. Nucleic Acids Res 38:D854\u2013D862","journal-title":"Nucleic Acids Res"},{"key":"4824_CR85","first-page":"571","volume":"8","author":"HM Vordermeier","year":"2001","unstructured":"Vordermeier HM, Whelan A, Cockle PJ, Farrant L, Palmer N, Hewinson RG (2001) Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle. Clin DiagLab Immunol 8:571\u2013578","journal-title":"Clin DiagLab Immunol"},{"key":"4824_CR86","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/1756-3305-7-180","volume":"7","author":"YH Wang","year":"2014","unstructured":"Wang YH, Yin H (2014) Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii. Parasit Vectors 7:180","journal-title":"Parasit Vectors"},{"key":"4824_CR87","first-page":"938","volume":"39","author":"YH Wang","year":"2009","unstructured":"Wang YH, Zhang DL, Yin H, Fu BQ (2009) Advances in predicting methods of antigen epitopes. Chin Vet Sci 39:938\u2013940","journal-title":"Chin Vet Sci"},{"key":"4824_CR88","doi-asserted-by":"crossref","first-page":"8619","DOI":"10.1016\/j.vaccine.2011.09.016","volume":"29","author":"YH Wang","year":"2011","unstructured":"Wang YH, Wang M, Wang GX, Pang AN, Fu BQ, Yin H, Zhang DL (2011) Increased survival time in mice vaccinated with a branched lysine multiple antigenic peptide containing B- and T-cell epitopes from T. gondii antigens. Vaccine 29:8619\u20138623","journal-title":"Vaccine"},{"key":"4824_CR89","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1756-3305-6-125","volume":"6","author":"YH Wang","year":"2013","unstructured":"Wang YH, Wang GX, Zhang DL, Yin H, Wang M (2013a) Screening and identification of novel B cell epitopes of Toxoplasma gondii SAG1. Parasit Vectors 6:125","journal-title":"Parasit Vectors"},{"key":"4824_CR90","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.exppara.2013.09.019","volume":"135","author":"YH Wang","year":"2013","unstructured":"Wang YH, Wang GX, Zhang DL, Yin H, Wang M (2013b) Identification of novel B cell epitopes within Toxoplasma gondii GRA1. Exp Parasitol 135:606\u2013610","journal-title":"Exp Parasitol"},{"key":"4824_CR91","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1007\/s00436-013-3571-4","volume":"112","author":"YH Wang","year":"2013","unstructured":"Wang YH, Zhang DL, Wang GX, Yin H, Wang M (2013c) Immunization with excreted-secreted antigens reduces tissue cyst formation in pigs. Parasitol Res 112:3835\u20133842","journal-title":"Parasitol Res"},{"key":"4824_CR92","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1756-3305-6-125","volume":"6","author":"YH Wang","year":"2014","unstructured":"Wang YH, Wang GX, Ou JT, Yin H, Zhang DL (2014) Analyzing and identifying novel B cell epitopes within Toxoplasma gondii GRA4. Parasit Vectors 6:125","journal-title":"Parasit Vectors"},{"key":"4824_CR93","doi-asserted-by":"crossref","first-page":"e1000815","DOI":"10.1371\/journal.ppat.1000815","volume":"6","author":"DC Wilson","year":"2010","unstructured":"Wilson DC, Grotenbreg GM, Liu K, Zhao Y, Frickel EM, Gubbels MJ, Ploegh HL, Yap GS (2010) Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells. PLoS Pathog 6:e1000815","journal-title":"PLoS Pathog"},{"key":"4824_CR94","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3748\/wjg.v11.i4.492","volume":"11","author":"HJ Yang","year":"2005","unstructured":"Yang HJ, Chen M, Cheng T, He SZ, Li SW, Guan BQ, Zhu ZH, Gu Y, Zhang J, Xia NS (2005) Expression and immunoactivity of chimeric particulate antigens of receptor binding site core antigen of hepatitis B virus. World J Gastroenterol 11:492\u2013497","journal-title":"World J Gastroenterol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-015-4824-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-015-4824-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-015-4824-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T22:23:01Z","timestamp":1692138181000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-015-4824-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,19]]},"references-count":94,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["4824"],"URL":"https:\/\/doi.org\/10.1007\/s00436-015-4824-1","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,19]]}}}