{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:45:43Z","timestamp":1773287143793,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:00:00Z","timestamp":1458345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the National Important Sci-Tech Special Projects","award":["2012ZX10004220"],"award-info":[{"award-number":["2012ZX10004220"]}]},{"name":"the National Key Basic Research and Development Project","award":["2010CB530000"],"award-info":[{"award-number":["2010CB530000"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81101270"],"award-info":[{"award-number":["81101270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s00436-016-5012-7","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:43:46Z","timestamp":1458348226000},"page":"2653-2660","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Interleukin-13 is involved in the formation of liver fibrosis in Clonorchis sinensis-infected mice"],"prefix":"10.1007","volume":"115","author":[{"given":"Yanquan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongling","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongdao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinbing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,19]]},"reference":[{"issue":"4","key":"5012_CR1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1165\/rcmb.2002-0009OC","volume":"27","author":"JA Belperio","year":"2002","unstructured":"Belperio JA, Dy M, Burdick MD, Xue YY, Li K, Elias JA, Keane MP (2002) Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 27(4):419\u2013427","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"5012_CR2","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s00436-014-3820-1","volume":"113","author":"M Bian","year":"2014","unstructured":"Bian M, Li S, Wang X, Xu Y, Chen W, Zhou C, Chen X, He L, Xu J, Liang C, Wu Z, Huang Y, Li X, Yu X (2014) Identification, immunolocalization, and immunological characterization of nitric oxide synthase-interacting protein from Clonorchis sinensis. Parasitol Res 113(5):1749\u20131757","journal-title":"Parasitol Res"},{"key":"5012_CR3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1756-3305-5-152","volume":"5","author":"J Chen","year":"2012","unstructured":"Chen J, Xu MJ, Zhou DH, Song HQ, Wang CR, Zhu XQ (2012) Canine and feline parasitic zoonoses in China. Parasit Vectors 5:152","journal-title":"Parasit Vectors"},{"issue":"2","key":"5012_CR4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/jhep.2001.26376","volume":"34","author":"MG Chiaramonte","year":"2001","unstructured":"Chiaramonte MG, Cheever AW, Malley JD, Donaldson DD, Wynn TA (2001) Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology 34(2):273\u2013282","journal-title":"Hepatology"},{"issue":"6","key":"5012_CR5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI7325","volume":"104","author":"MG Chiaramonte","year":"1999","unstructured":"Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA (1999) An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 104(6):777\u2013785","journal-title":"J Clin Invest"},{"issue":"1","key":"5012_CR6","first-page":"58","volume":"28","author":"BR Dixon","year":"1997","unstructured":"Dixon BR, Flohr RB (1997) Fish- and shellfish\u2013borne trematode infections in Canada. Southeast Asian J Trop Med Public Health 28(1):58\u201364","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"5","key":"5012_CR7","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.4049\/jimmunol.161.5.2317","volume":"161","author":"DD Donaldson","year":"1998","unstructured":"Donaldson DD, Whitters MJ, Fitz LJ, Neben TY, Finnerty H, Henderson SL, O\u2019Hara RM Jr, Beier DR, Turner KJ, Wood CR, Collins M (1998) The murine IL-13 receptor \u03b12: molecular cloning, characterization, and comparison with murine IL-13 receptor \u03b11. J Immunol 161(5):2317\u20132324","journal-title":"J Immunol"},{"issue":"5","key":"5012_CR8","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.4049\/jimmunol.164.5.2585","volume":"164","author":"PG Fallon","year":"2000","unstructured":"Fallon PG, Richardson EJ, McKenzie GJ, McKenzie AN (2000) Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. J Immunol 164(5):2585\u20132591","journal-title":"J Immunol"},{"issue":"1","key":"5012_CR9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nm1332","volume":"12","author":"S Fichtner-Feigl","year":"2006","unstructured":"Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A (2006) IL-13 signaling through the IL-13\u03b12 receptor is involved in induction of TGF-\u03b21 production and fibrosis. Nat Med 12(1):99\u2013106","journal-title":"Nat Med"},{"issue":"6","key":"5012_CR10","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s00436-010-1807-0","volume":"106","author":"B Fried","year":"2010","unstructured":"Fried B, Abruzzi A (2010) Food-borne trematode infections of humans in the United States of America. Parasitol Res 106(6):1263\u20131280","journal-title":"Parasitol Res"},{"issue":"1","key":"5012_CR11","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/art.37706","volume":"65","author":"P Fuschiotti","year":"2013","unstructured":"Fuschiotti P, Larregina AT, Ho J, Feghali-Bostwick C, Medsger TA Jr (2013) Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis. Arthritis Rheum 65(1):236\u2013246","journal-title":"Arthritis Rheum"},{"issue":"5","key":"5012_CR12","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00436-014-3816-x","volume":"113","author":"L Huang","year":"2014","unstructured":"Huang L, Lv X, Huang Y, Hu Y, Yan H, Zheng M, Zeng H, Li X, Liang C, Wu Z, Yu X (2014) Identification, sequence analysis, and characterization of serine\/threonine protein kinase 17A from Clonorchis sinensis. Parasitol Res 113(5):1713\u20131723","journal-title":"Parasitol Res"},{"issue":"6","key":"5012_CR13","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.4049\/jimmunol.173.6.4020","volume":"173","author":"M Kaviratne","year":"2004","unstructured":"Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, Wakefield LM, Letterio JJ, Wynn TA (2004) IL-13 activates a mechanism of tissue fibrosis that is completely TGF-\u03b2 independent. J Immunol 173(6):4020\u20134029","journal-title":"J Immunol"},{"key":"5012_CR14","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1128\/CMR.00012-09","volume":"22","author":"J Keiser","year":"2009","unstructured":"Keiser J, Utzinger J (2009) Food-borne trematodiases. Clin Microbiol Rev 22:466\u2013483","journal-title":"Clin Microbiol Rev"},{"issue":"7","key":"5012_CR15","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.4049\/jimmunol.172.7.4068","volume":"172","author":"JE Kolodsick","year":"2004","unstructured":"Kolodsick JE, Toews GB, Jakubzick C, Hogaboam C, Moore TA, McKenzie A, Wilke CA, Chrisman CJ, Moore BB (2004) Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts. J Immunol 172(7):4068\u20134076","journal-title":"J Immunol"},{"issue":"5","key":"5012_CR16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000098208","volume":"73","author":"G Lakos","year":"2006","unstructured":"Lakos G, Melichian D, Wu M, Varga J (2006) Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet. Pathobiology 73(5):224\u2013237","journal-title":"Pathobiology"},{"issue":"6","key":"5012_CR17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1084\/jem.194.6.809","volume":"194","author":"CG Lee","year":"2001","unstructured":"Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM, Elias JA (2001) Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor \u03b2 1 . J Exp Med 194(6):809\u2013821","journal-title":"J Exp Med"},{"issue":"1","key":"5012_CR18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1473-3099(04)01252-6","volume":"5","author":"ZR Lun","year":"2005","unstructured":"Lun ZR, Gasser RB, Lai DH, Li AX, Zhu XQ, Yu XB, Fang YY (2005) Clonorchiasis: a key foodborne zoonosis in China. Lancet Infect Dis 5(1):31\u201341","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"5012_CR19","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0168-8278(96)80147-4","volume":"24","author":"X Ma","year":"1996","unstructured":"Ma X, Zhao J, Lieber CS (1996) Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regression. J Hepatol 24(5):604\u2013613","journal-title":"J Hepatol"},{"issue":"4","key":"5012_CR20","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0016-5085(00)70134-X","volume":"118","author":"DR Nelson","year":"2000","unstructured":"Nelson DR, Lauwers GY, Lau JY, Davis GL (2000) Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology 118(4):655\u2013660","journal-title":"Gastroenterology"},{"issue":"1","key":"5012_CR21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1006\/cimm.1999.1537","volume":"196","author":"CJ Ong","year":"1999","unstructured":"Ong CJ, Ip S, Teh SJ, Wong C, Jirik FR, Grusby MJ, Teh HS (1999) A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice. Cell Immunol 196(1):60\u201368","journal-title":"Cell Immunol"},{"issue":"3","key":"5012_CR22","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0022-3565(24)35380-7","volume":"292","author":"A Oriente","year":"2000","unstructured":"Oriente A, Fedarko NS, Pacocha SE, Huang SK, Lichtenstein LM, Essayan DM (2000) Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts. J Pharmacol Exp Ther 292(3):988\u2013994","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"5012_CR23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1079\/JOH2005300","volume":"79","author":"HJ Rim","year":"2005","unstructured":"Rim HJ (2005) Clonorchiasis: an update. J Helminthol 79(3):269\u2013281","journal-title":"J Helminthol"},{"issue":"3","key":"5012_CR24","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3892\/etm.2014.2158","volume":"9","author":"AM Safer","year":"2015","unstructured":"Safer AM, Afzal M, Hanafy N, Mousa S (2015) Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: a histopathological study. Exp Ther Med 9(3):787\u2013794","journal-title":"Exp Ther Med"},{"issue":"9615","key":"5012_CR25","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","volume":"371","author":"D Schuppan","year":"2008","unstructured":"Schuppan D, Afdhal NH (2008) Liver cirrhosis. Lancet 371(9615):838\u2013851","journal-title":"Lancet"},{"issue":"7","key":"5012_CR26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.7326\/0003-4819-132-7-200004040-00002","volume":"132","author":"Y Shiratori","year":"2000","unstructured":"Shiratori Y, Imazeki F, Moriyama M, Yano M, Arakawa Y, Yokosuka O, Kuroki T, Nishiguchi S, Sata M, Yamada G, Fujiyama S, Yoshida H, Omata M (2000) Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med 132(7):517\u2013524","journal-title":"Ann Intern Med"},{"issue":"5","key":"5012_CR27","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1371\/journal.pntd.0000232","volume":"2","author":"B Sripa","year":"2008","unstructured":"Sripa B (2008) Concerted action is needed to tackle liver fluke infections in Asia. PLoS Negl Trop Dis 2(5):e232","journal-title":"PLoS Negl Trop Dis"},{"key":"5012_CR28","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0065-308X(10)72011-X","volume":"72","author":"B Sripa","year":"2010","unstructured":"Sripa B, Kaewkes S, Intapan PM, Maleewong W, Brindley PJ (2010) Food-borne trematodiases in Southeast Asia: epidemiology, pathology, clinical manifestation and control. Adv Parasitol 72:305\u2013350","journal-title":"Adv Parasitol"},{"key":"5012_CR29","first-page":"100","volume":"587","author":"P Tangkijvanich","year":"2002","unstructured":"Tangkijvanich P, Yee HF Jr (2002) Cirrhosis\u2014can we reverse hepatic fibrosis? Eur J Surg Suppl 587:100\u2013112","journal-title":"Eur J Surg Suppl"},{"issue":"9930","key":"5012_CR30","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","volume":"383","author":"EA Tsochatzis","year":"2014","unstructured":"Tsochatzis EA, Bosch J, Burroughs AK (2014) Liver cirrhosis. Lancet 383(9930):1749\u20131761","journal-title":"Lancet"},{"issue":"10","key":"5012_CR31","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2011-12-10-r107","volume":"12","author":"X Wang","year":"2011","unstructured":"Wang X, Chen W, Huang Y, Sun J, Men J, Liu H, Luo F, Guo L, Lv X, Deng C, Zhou C, Fan Y, Li X, Huang L, Hu Y, Liang C, Hu X, Xu J, Yu X (2011) The draft genome of the carcinogenic human liver fluke Clonorchis sinensis. Genome Biol 12(10):R107","journal-title":"Genome Biol"},{"key":"5012_CR32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00436-009-1622-7","volume":"106","author":"X Wang","year":"2009","unstructured":"Wang X, Liang C, Chen W, Fan Y, Hu X, Xu J, Yu X (2009) Experimental model in rats for study on transmission dynamics and evaluation of Clonorchis sinensis infection immunologically, morphologically, and pathologically. Parasitol Res 106:15\u201321","journal-title":"Parasitol Res"},{"key":"5012_CR33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-immunol-032712-095937","volume":"31","author":"G Wick","year":"2013","unstructured":"Wick G, Grundtman C, Mayerl C, Wimpissinger TF, Feichtinger J, Zelger B, Sgonc R, Wolfram D (2013) The immunology of fibrosis. Annu Rev Immunol 31:107\u2013135","journal-title":"Annu Rev Immunol"},{"key":"5012_CR34","first-page":"1","volume":"849","author":"WHO","year":"1995","unstructured":"WHO (1995) Control of foodborne trematode infections. WHO Technical Report Series 849:1\u2013157","journal-title":"WHO Technical Report Series"},{"issue":"6541","key":"5012_CR35","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/376594a0","volume":"376","author":"TA Wynn","year":"1995","unstructured":"Wynn TA, Cheever AW, Jankovic D, Poindexter RW, Caspar P, Lewis FA, Sher A (1995) An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376(6541):594\u2013596","journal-title":"Nature"},{"key":"5012_CR36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.immunol.21.120601.141142","volume":"21","author":"TA Wynn","year":"2003","unstructured":"Wynn TA (2003) IL-13 effector functions. Annu Rev Immunol 21:425\u2013456","journal-title":"Annu Rev Immunol"},{"issue":"8","key":"5012_CR37","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","volume":"4","author":"TA Wynn","year":"2004","unstructured":"Wynn TA (2004) Fibrotic disease and the T(H)1\/T(H)2 paradigm. Nat Rev Immunol 4(8):583\u2013594","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"5012_CR38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","volume":"214","author":"TA Wynn","year":"2008","unstructured":"Wynn TA (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214(2):199\u2013210","journal-title":"J Pathol"},{"key":"5012_CR39","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/1756-3305-6-360","volume":"6","author":"Y Xu","year":"2013","unstructured":"Xu Y, Chen W, Bian M, Wang X, Sun J, Sun H, Jia F, Liang C, Li X, Zhou X, Huang Y, Yu X (2013) Molecular characterization and immune modulation properties of Clonorchis sinensis-derived RNASET2. Parasit Vectors 6:360","journal-title":"Parasit Vectors"},{"issue":"6","key":"5012_CR40","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1007\/s00436-015-4435-x","volume":"114","author":"Y Xu","year":"2015","unstructured":"Xu Y, Lin J, Bian M, Chen W, Liang P, Wang X, Shang M, Qu H, Wu Z, Huang Y, Yu X (2015) CsRNASET2 is an important component of Clonorchis sinensis responsible for eliciting Th2 immune response. Parasitol Res 114(6):2371\u20132379","journal-title":"Parasitol Res"},{"issue":"7","key":"5012_CR41","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/j.1460-2075.1993.tb05927.x","volume":"12","author":"SM Zurawski","year":"1993","unstructured":"Zurawski SM, Vega F Jr, Huyghe B, Zurawski G (1993) Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J 12(7):2663\u20132670","journal-title":"EMBO J"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-016-5012-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-016-5012-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-016-5012-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T21:12:41Z","timestamp":1748812361000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-016-5012-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,19]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["5012"],"URL":"https:\/\/doi.org\/10.1007\/s00436-016-5012-7","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,19]]}}}