{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:02:42Z","timestamp":1760299362185,"version":"3.37.3"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107475\/Z\/15\/Z"],"award-info":[{"award-number":["107475\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stiftung der Eheleute Dr. med. vet. Hans-Joachim und Gertrud Engemann"},{"name":"Karl-Enigk-Stiftung"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s00436-016-5146-7","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T16:15:55Z","timestamp":1464279355000},"page":"3831-3842","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Derivatives of biarylalkyl carboxylic acid induce pleiotropic phenotypes in adult Schistosoma mansoni in vitro"],"prefix":"10.1007","volume":"115","author":[{"given":"Ariane S.","family":"Blohm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"M\u00e4der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Quack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Hahnel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schlitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph G.","family":"Grevelding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"issue":"3a","key":"5146_CR1","first-page":"538","volume":"31","author":"P Andrews","year":"1981","unstructured":"Andrews P (1981) A summary of the efficacy of praziquantel against schistosomes in animal experiments and notes on its mode of action. Arzneimittelforschung 31(3a):538\u2013541","journal-title":"Arzneimittelforschung"},{"doi-asserted-by":"crossref","unstructured":"Beckmann S, Buro C, Dissous C, Hirzmann J, Grevelding CG (2010a) The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis. PLoS Pathog 6(2), e1000769","key":"5146_CR2","DOI":"10.1371\/journal.ppat.1000769"},{"issue":"3","key":"5146_CR3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S0031182010000053","volume":"137","author":"S Beckmann","year":"2010","unstructured":"Beckmann S, Quack T, Burmeister C, Buro C, Long T, Dissous C, Grevelding CG (2010b) Schistosoma mansoni: signal transduction processes during the development of the reproductive organs. Parasitology 137(3):497\u2013520","journal-title":"Parasitology"},{"issue":"24","key":"5146_CR4","first-page":"3579","volume":"18","author":"S Beckmann","year":"2012","unstructured":"Beckmann S, Leutner S, Gouignard N, Dissous C, Grevelding CG (2012) Protein kinases as potential targets for novel anti-schistosomal strategies. Curr Pharm Des 18(24):3579\u20133594","journal-title":"Curr Pharm Des"},{"doi-asserted-by":"crossref","unstructured":"Beckmann S, Long T, Scheld C, Geyer R, Caffrey CR, Grevelding CG (2014) Serum albumin and \u03b1-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib. Int J Parasitol Drugs Drug Resist 4(3):287\u2013295","key":"5146_CR5","DOI":"10.1016\/j.ijpddr.2014.07.005"},{"doi-asserted-by":"crossref","unstructured":"Bennett MW, Caulfield JP (1991) Schistosoma mansoni: ingestion of dextrans, serum albumin, and IgG by schistosomula. Exp Parasitol 73(1):52\u201361","key":"5146_CR6","DOI":"10.1016\/0014-4894(91)90007-J"},{"key":"5146_CR7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","volume":"460","author":"M Berriman","year":"2009","unstructured":"Berriman M, Haas BJ, LoVerde PT, Wilson RA et al (2009) The genome of the blood fluke Schistosoma mansoni. Nature 460:352\u2013358","journal-title":"Nature"},{"issue":"s1","key":"5146_CR8","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1517\/17460441.2.S1.S35","volume":"2","author":"SS Botros","year":"2007","unstructured":"Botros SS, Bennett JL (2007) Praziquantel resistance. Expert Opin Drug Discov 2(s1):S35\u201340","journal-title":"Expert Opin Drug Discov"},{"issue":"1","key":"5146_CR9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molbiopara.2014.06.002","volume":"195","author":"D Cioli","year":"2014","unstructured":"Cioli D, Pica-Mattoccia L, Basso A, Guidi A (2014) Schistosomiasis control: praziquantel forever? Mol Biochem Parasitol 195(1):23\u201329","journal-title":"Mol Biochem Parasitol"},{"key":"5146_CR10","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","volume":"383","author":"DG Colley","year":"2014","unstructured":"Colley DG, Bustinduy AL, Secor WE, King CH (2014) Human schistosomiasis. Lancet 383:2253\u20132264","journal-title":"Lancet"},{"key":"5146_CR11","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fgene.2014.00444","volume":"5","author":"JM Correia da Costa","year":"2014","unstructured":"Correia da Costa JM, Vale N, Gouveia MJ, Botelho MC, Sripa B, Santos LL, Santos JH, Rinaldi G, Brindley PJ (2014) Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers. Front Genet 5:444","journal-title":"Front Genet"},{"key":"5146_CR12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0065-308X(08)60426-1","volume":"41","author":"J Bont De","year":"1998","unstructured":"De Bont J, Vercruysse J (1998) Schistosomiasis in cattle. Adv Parasitol 41:285\u2013364","journal-title":"Adv Parasitol"},{"issue":"9948","key":"5146_CR13","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(14)61669-X","volume":"384","author":"F Laval De","year":"2014","unstructured":"De Laval F, Savini H, Biance-Valero E, Simon F (2014) Human schistosomiasis: an emerging threat for Europe. Lancet 384(9948):1094\u20131095","journal-title":"Lancet"},{"key":"5146_CR14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fendo.2015.00118","volume":"6","author":"C Dissous","year":"2015","unstructured":"Dissous C (2015) Venus kinase receptors at the crossroads of insulin signaling: their role in reproduction for helminths and insects. Front Endocrinol (Lausanne) 6:118","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5146_CR15","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/cmdc.200800410","volume":"4","author":"M Eisenmann","year":"2009","unstructured":"Eisenmann M, Steuber H, Zentgraf M, Altenk\u00e4mper M, Ortmann R, Perruchon J, Klebe G, Schlitzer M (2009) Structure-based optimization of aldose reductase inhibitors originating from virtual screening. ChemMedChem 4:809\u2013819","journal-title":"ChemMedChem"},{"issue":"1","key":"5146_CR16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1994.51.83","volume":"51","author":"PG Fallon","year":"1994","unstructured":"Fallon PG, Doenhoff MJ (1994) Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am J Trop Med Hyg 51(1):83\u201388","journal-title":"Am J Trop Med Hyg"},{"issue":"11","key":"5146_CR17","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.bbagen.2006.08.015","volume":"1760","author":"I Fitos","year":"2006","unstructured":"Fitos I, Visy J, Zsila F, M\u00e1dy G, Simonyi M (2006) Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein. Biochim Biophys Acta 1760(11):1704\u20131712","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"5146_CR18","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1432-1033.1989.tb21095.x","volume":"183","author":"S Fournel-Gigleux","year":"1989","unstructured":"Fournel-Gigleux S, Shepherd SR, Carre MC, Burchell B, Siest G, Caubere P (1989) Novel inhibitors and substrates of bilirubin: UDP-glucuronosyltransferase. Arylalkylcarboxylic acids. Eur J Biochem 183(3):653\u2013659","journal-title":"Eur J Biochem"},{"issue":"6","key":"5146_CR19","volume":"4","author":"DJ Gray","year":"2009","unstructured":"Gray DJ, Williams GM, Li Y, Chen H, Forsyth SJ, Li RS, Barnett AG, Guo J, Ross AG, Feng Z, McManus DP (2009) A cluster-randomised intervention trial against Schistosoma japonicum in the Peoples\u2019 Republic of China: bovine and human transmission. PLoS One 4(6), e5900","journal-title":"PLoS One"},{"issue":"3","key":"5146_CR20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijpddr.2014.09.007","volume":"4","author":"RM Greenberg","year":"2014","unstructured":"Greenberg RM (2014) Schistosome ABC multidrug transporters: from pharmacology to physiology. Int J Parasitol Drugs Drug Resist 4(3):301\u2013309","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"5146_CR21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0166-6851(94)00058-U","volume":"71","author":"CG Grevelding","year":"1995","unstructured":"Grevelding CG (1995) The female-specific W1 sequence of the Puerto Rican strain of Schistosoma mansoni occurs in both genders of a Liberian strain. Mol Biochem Parasitol 71:269\u2013272","journal-title":"Mol Biochem Parasitol"},{"issue":"12","key":"5146_CR22","volume":"8","author":"JET Grimes","year":"2014","unstructured":"Grimes JET, Croll D, Harrison WE, Utzinger J, Freeman MC, Templeton MR (2014) The relationship between water, sanitation and schistosomiasis: a systematic review and meta-analysis. PLoS Negl Trop Di 8(12), e3296","journal-title":"PLoS Negl Trop Di"},{"issue":"3","key":"5146_CR23","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2310\/7060.2003.35759","volume":"10","author":"MP Grobusch","year":"2003","unstructured":"Grobusch MP, M\u00fchlberger N, Jelinek T, Bisoffi Z, Corach\u00e1n M, Harms G, Matteelli A, Fry G, Hatz C, Gj\u00f8rup I, Schmid ML, Knobloch J, Puente S, Bronner U, Kapaun A, Clerinx J, Nielsen LN, Fleischer K, Beran J, da Cunha S, Schulze M, Myrvang B, Hellgren U (2003) Imported schistosomiasis in Europe: sentinel surveillance data from TropNetEurop. J Travel Med 10(3):164\u2013169","journal-title":"J Travel Med"},{"issue":"1","key":"5146_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2310\/7060.2005.00001","volume":"12","author":"CFR Hatz","year":"2005","unstructured":"Hatz CFR (2005) Schistosomiasis: an underestimated problem in industrialized countries? J Travel Med 12(1):1\u20132","journal-title":"J Travel Med"},{"issue":"6383","key":"5146_CR25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/358209a0","volume":"358","author":"XM He","year":"1992","unstructured":"He XM, Carter DC (1992) Atomic structure and chemistry of human serum albumin. Nature 358(6383):209\u2013215","journal-title":"Nature"},{"doi-asserted-by":"crossref","unstructured":"Holtfreter MC, Loebermann M, Frei E, Riebold D, Wolff D, Hartung G, Kinzelbach R, Reisinger EC (2010) Schistosomula, pre-adults and adults of Schistosoma mansoni ingest fluorescence-labelled albumin in vitro and in vivo: implication for a drug-targeting model. Parasitology 137(11):1645\u20131652","key":"5146_CR26","DOI":"10.1017\/S0031182010000405"},{"issue":"2\u20133","key":"5146_CR27","first-page":"223","volume":"96","author":"Y-X Huang","year":"2005","unstructured":"Huang Y-X, Manderson L (2005) The social and economic context and determinants of schistosomiasis japonica. Acta Trop 96(2\u20133):223\u2013231","journal-title":"Acta Trop"},{"issue":"5","key":"5146_CR28","first-page":"65","volume":"2014","author":"MT Inobaya","year":"2014","unstructured":"Inobaya MT, Olveda RM, Chau TN, Olveda DU, Ross AG (2014) Prevention and control of schistosomiasis: a current perspective. Res Rep Trop Med 2014(5):65\u201375","journal-title":"Res Rep Trop Med"},{"issue":"2","key":"5146_CR29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1081\/DMR-100104402","volume":"33","author":"ZH Israili","year":"2001","unstructured":"Israili ZH, Dayton PG (2001) Human alpha-1-glycoprotein and its interactions with drugs. Drug Metab Rev 33(2):161\u2013235","journal-title":"Drug Metab Rev"},{"issue":"6","key":"5146_CR30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.freeradbiomed.2010.12.021","volume":"50","author":"ES Kang","year":"2011","unstructured":"Kang ES, Iwata K, Ikami K, Ham SA, Kim HJ, Chang KC, Lee JH, Kim JH, Park SB, Kim JH, Yabe-Nishimura C, Seo HG (2011) Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation. Free Radic Biol Med 50(6):680\u2013688","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"5146_CR31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003265","volume":"8","author":"RS Kasinathan","year":"2014","unstructured":"Kasinathan RS, Sharma LK, Cunningham C, Webb TR, Greenberg RM (2014) Inhibition or knockdown of ABC transporters enhances susceptibility of adult and juvenile schistosomes to Praziquantel. PLoS Negl Trop Dis 8(10), e3265","journal-title":"PLoS Negl Trop Dis"},{"key":"5146_CR32","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.378","volume":"5","author":"H Landmann","year":"2014","unstructured":"Landmann H, Proia DA, He S, Ogawa LS, Kramer F, Bei\u00dfbarth T, Grade M, Gaedcke M, Ghadimi M, Moll U, Dobbelstein M (2014) UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib. Cell Death and Dis 5, e1411","journal-title":"Cell Death and Dis"},{"doi-asserted-by":"crossref","unstructured":"Leutner S, Beckmann S, Grevelding CG (2011) Characterization of the cGMP-dependent protein kinase SmcGK1 of Schistosoma mansoni. An Acad Bras Cienc 83(2):637\u2013648","key":"5146_CR33","DOI":"10.1590\/S0001-37652011000200023"},{"issue":"2","key":"5146_CR34","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00436-012-3166-5","volume":"112","author":"J Liu","year":"2013","unstructured":"Liu J, Wang J, Wang S, Xu B, Liu X, Wang X, Hu W (2013a) Molecular cloning and characterization of Schistosoma japonicum aldose reductase. Parasitol Res 112(2):549\u2013558","journal-title":"Parasitol Res"},{"doi-asserted-by":"crossref","unstructured":"Liu J, Dyer DH, Cheng J, Wang J, Wang S, Yang Z, Wang X, Hu W (2013b) Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds. Parasit Vectors 6:162","key":"5146_CR35","DOI":"10.1186\/1756-3305-6-162"},{"doi-asserted-by":"crossref","unstructured":"Lu Z, Quack T, Hahnel S, Gelmedin V, Pouokam E, Diener M, Hardt M, Michel G, Baal N, Hackstein H, Grevelding CG (2015) Isolation, enrichment and primary characterisation of vitelline cells from Schistosoma mansoni obtained by the organ isolation method. Int J Parasitol 45(9\u201310):663\u2013672","key":"5146_CR36","DOI":"10.1016\/j.ijpara.2015.04.002"},{"doi-asserted-by":"publisher","unstructured":"M\u00e4der P, Blohm S, Quack T, Lange-Gr\u00fcnweller K, Gr\u00fcnweller A, Hartmann RK, Grevelding CG, Schlitzer M. (2016) Biarylalkyl carboxylic acid derivates as novel antischistosomal agents. ChemMedChem (in press; doi: 10.1002\/cmdc.201600127 )","key":"5146_CR37","DOI":"10.1002\/cmdc.201600127"},{"key":"5146_CR38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S0031182009990965","volume":"137","author":"T Manneck","year":"2010","unstructured":"Manneck T, Haggenmuller Y, Keiser J (2010) Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni. Parasitology 137:85\u201398","journal-title":"Parasitology"},{"key":"5146_CR39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molstruc.2004.01.003","volume":"692","author":"J Min","year":"2004","unstructured":"Min J, Meng-Xia X, Dong Z, Yuan L, Xiao-Yu L, Xing C (2004) Spectroscopic studies on the interaction of cinnamic acid and its hydroxyl derivatives with human serum albumin. J Mol Struct 692:71\u201380","journal-title":"J Mol Struct"},{"issue":"3","key":"5146_CR40","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijpddr.2014.09.006","volume":"4","author":"IN Mwangi","year":"2014","unstructured":"Mwangi IN, Sanchez MC, Mkoji GM, Agola LE, Runo SM, Cupit PM, Cunningham C (2014) Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug. Int J Parasitol Drugs Drug Resist 4(3):296\u2013300","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"5146_CR41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00436-004-1241-2","volume":"95","author":"RH Neves","year":"2005","unstructured":"Neves RH, de Lamare BC, Machado-Silva JR, Carvalho JJ, Branquinho TB, Lenzi HL, Hulstijn M, Gomes DC (2005) A new description of the reproductive system of Schistosoma mansoni (Trematoda: Schistosomatidae) analyzed by confocal laser scanning microscopy. Parasitol Res 95:43\u201349","journal-title":"Parasitol Res"},{"key":"5146_CR42","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijid.2013.09.011","volume":"18","author":"DU Olveda","year":"2014","unstructured":"Olveda DU, Olveda RM, McManus DP, Cai P, Chau TN, Lam AK, Li Y, Harn DA, Vinluan ML, Ross AG (2014) Bilharzia in the Philippines: past, present, and future. Int J Infect Dis 18:52\u201356","journal-title":"Int J Infect Dis"},{"issue":"3","key":"5146_CR43","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2165\/00003088-198005030-00004","volume":"5","author":"KM Piafsky","year":"1980","unstructured":"Piafsky KM (1980) Disease-induced changes in the plasma binding of basic drugs. Clin Pharmacokinet 5(3):246\u2013262","journal-title":"Clin Pharmacokinet"},{"issue":"9","key":"5146_CR44","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ijpara.2010.04.013","volume":"40","author":"T Quack","year":"2010","unstructured":"Quack T, Wippersteg V, Grevelding CG (2010) Cell cultures for schistosomes\u2014chances of success or wishful thinking? Int J Parasitol 40(9):991\u20131002","journal-title":"Int J Parasitol."},{"issue":"3","key":"5146_CR45","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/COH.0b013e328351b9e3","volume":"7","author":"WE Secor","year":"2012","unstructured":"Secor WE (2012) The effects of schistosomiasis on HIV\/AIDS infection, progression and transmission. Curr Opin HIV AIDS 7(3):254\u2013259","journal-title":"Curr Opin HIV AIDS"},{"doi-asserted-by":"crossref","unstructured":"Shaw MK, Erasmus DA (1983) Schistosoma mansoni: the effects of a subcurative dose of praziquantel on the ultrastructure of worms in vivo. Z Parasitenkd 69(1):73\u201390","key":"5146_CR46","DOI":"10.1007\/BF00934012"},{"issue":"6","key":"5146_CR47","first-page":"824","volume":"11","author":"G Sudlow","year":"1975","unstructured":"Sudlow G, Birkett DJ, Wade DN (1975) The characterization of two specific drug binding sites on human serum albumin. Mol Pharmacol 11(6):824\u2013832","journal-title":"Mol Pharmacol"},{"issue":"6","key":"5146_CR48","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2165\/00003088-198611060-00003","volume":"11","author":"CK Svensson","year":"1986","unstructured":"Svensson CK, Woodruff MN, Baxter JG, Lalka D (1986) Free drug concentration monitoring in clinical practice. Rationale and current status. Clin Pharmacokinet 11(6):450\u2013469","journal-title":"Clin Pharmacokinet"},{"issue":"2","key":"5146_CR49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1056\/NEJMoa0800135","volume":"360","author":"LD Wang","year":"2009","unstructured":"Wang LD, Chen HG, Guo JG, Zeng XJ, Hong XL, Xiong JJ, Wu XH, Wang XH, Wang LY, Xia G, Hao Y, Chin DP, Zhou XN (2009) A strategy to control transmission of Schistosoma japonicum in China. N Engl J Med 360(2):121\u2013128","journal-title":"N Engl J Med"},{"unstructured":"WHO. Global Health Estimates. (2014). Available from: http:\/\/www.who.int\/healthinfo\/global_burden_disease\/en\/","key":"5146_CR50"},{"issue":"10","key":"5146_CR51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109431","volume":"9","author":"E Yepes","year":"2014","unstructured":"Yepes E, Varela-M RE, L\u00f3pez-Ab\u00e1n J, Dakir ELH, Mollinedo F, Muro A (2014) In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog Edelfosine. PLoS ONE 9(10), e109431","journal-title":"PLoS ONE"},{"issue":"11","key":"5146_CR52","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1007\/s00436-013-3559-0","volume":"112","author":"SH Xiao","year":"2013","unstructured":"Xiao SH (2013) Mefloquine, a new type of compound against schistosomes and other helminthes in experimental studies. Parasitol Res 112(11):3723\u20133740","journal-title":"Parasitol Res"},{"doi-asserted-by":"crossref","unstructured":"Xiao S, Shen B, Utzinger J, Chollet J, Tanner M (2002) Ultrastructural alterations in adult Schistosoma mansoni caused by artemether. Mem Inst Oswaldo Cruz 97(5):717\u2013724","key":"5146_CR53","DOI":"10.1590\/S0074-02762002000500023"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-016-5146-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-016-5146-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-016-5146-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-016-5146-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T19:00:16Z","timestamp":1567969216000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-016-5146-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["5146"],"URL":"https:\/\/doi.org\/10.1007\/s00436-016-5146-7","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"type":"print","value":"0932-0113"},{"type":"electronic","value":"1432-1955"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}